#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102775|imex:IM-29301-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2C-E, 7J, Supp. Fig. 4H|comment:Interaction observed in STAT3 and TP53 knockout cells. Cells expressing oncogenic RAS in 1% oxygen led to an increase in HTC foci formation compared with IMR90 RAS cells in normoxia. The foci were dissolved by 1,6-hexanediol, suggesting that they formed via liquid-liquid phase separation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102775|imex:IM-29301-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2C-E, 7J, Supp. Fig. 4H|comment:Interaction observed in STAT3 and TP53 knockout cells. Cells expressing oncogenic RAS in 1% oxygen led to an increase in HTC foci formation compared with IMR90 RAS cells in normoxia. The foci were dissolved by 1,6-hexanediol, suggesting that they formed via liquid-liquid phase separation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118506|imex:IM-29301-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2B, 7B, Supp Fig. 4G|comment:Interaction observed in STAT3 and TP53 knockout cells. Cells expressing oncogenic RAS in 1% oxygen led to an increase in HTC foci formation compared with IMR90 RAS cells in normoxia|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/29	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118506|imex:IM-29301-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2B, 7B, Supp Fig. 4G|comment:Interaction observed in STAT3 and TP53 knockout cells. Cells expressing oncogenic RAS in 1% oxygen led to an increase in HTC foci formation compared with IMR90 RAS cells in normoxia|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/29	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	ha tag:?-?	-	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102787|imex:IM-29301-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2I|comment:Interaction observed in STAT3 and TP53 knockout cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102787|imex:IM-29301-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2I|comment:Interaction observed in STAT3 and TP53 knockout cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102804|imex:IM-29301-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2F|comment:Interaction observed in STAT3 and TP53 knockout cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:IxJ1MEwLsoGxxpmjAeFiFdAAsp4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118540|imex:IM-29301-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2F|comment:Interaction observed in STAT3 and TP53 knockout cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/29	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:PMos2Q9I3AX8v4YDHUzWEOyl9w4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P40763	uniprotkb:Q9NVI7	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118572|imex:IM-29301-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N	-	crc64:6C00632211C8012D	-	figure legend:Supp. Fig.  1P, 1S|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/29	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rogid:IZKJEVLLS/DFINgBgO5frizN1P49606	rigid:hEHaHIlBlbzei7qH+k0QVSOkxiE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102818|imex:IM-29301-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2J, Supp. Figs. 5C, 5I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	ha tag:?-?|sufficient binding region:1-191	myc tag:?-?|sufficient binding region:430-1178	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102818|imex:IM-29301-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 2J, Supp. Figs. 5C, 5I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/06	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	ha tag:?-?|sufficient binding region:1-191	flag tag:?-?|sufficient binding region:1-90	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11498	uniprotkb:P48163	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102931|imex:IM-29301-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/07	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	flag tag:?-?	ha tag:?-?|sufficient binding region:1-191	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11498	uniprotkb:P40925	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102931|imex:IM-29301-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/07	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40925	uniprotkb:P11498	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102984|imex:IM-29301-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	-	-	-	figure legend:Supp. Figs. 5A, 5G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/07	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	flag tag:?-?	myc tag:?-?|sufficient binding region:430-1178	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40925	uniprotkb:P48163	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27102984|imex:IM-29301-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Supp. Figs. 5A, 5G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/07	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11498	uniprotkb:P48163	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27103019|imex:IM-29301-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Supp. Figs. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/07	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:PMos2Q9I3AX8v4YDHUzWEOyl9w4	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40925	uniprotkb:P11498	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27107615|imex:IM-29301-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	-	-	-	figure legend:Supp. Figs. 5A, 5H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/19	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	flag tag:?-?|sufficient binding region:1-90	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40925	uniprotkb:P48163	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27107615|imex:IM-29301-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Supp. Figs. 5A, 5H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/06	2021/10/19	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	flag tag:?-?|sufficient binding region:1-90	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11498	uniprotkb:P48163	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104012|imex:IM-29301-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Fig. 3C, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/11	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	biotin tag:?-?|sufficient binding region:468-1178	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11498	uniprotkb:P40925	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104012|imex:IM-29301-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3C, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/11	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	biotin tag:?-?|sufficient binding region:468-1178	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104185|imex:IM-29301-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3E, Supp. Figs 5K-M|comment:Mol wt.=1Mda|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	-	false	his tag:n-n	his tag:n-n	8	4	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
chebi:"CHEBI:57945"	uniprotkb:P48163	intact:EBI-27104279	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:"nadh(2-)"(display_short)|psi-mi:"CHEBI:57945"(display_long)|intact:NADH(synonym)|intact:NADH dianion(synonym)|intact:"adenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}"(iupac name)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104185|imex:IM-29301-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Fig. 3E, Supp. Figs 5K-M|comment:Mol wt.=1Mda|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	-	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	-	false	-	his tag:n-n	-	8	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104185|imex:IM-29301-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3E, Supp. Figs 5K-M|comment:Mol wt.=1Mda|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	-	false	his tag:n-n	biotin tag:?-?|sufficient binding region:468-1178	8	8	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P48163	uniprotkb:P48163	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104212|imex:IM-29301-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Fig. 3E, Supp. Figs 5K-M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:bfahST8AJ7FZkOFLrDasm5qvS1Q	false	his tag:n-n	his tag:n-n	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48163	uniprotkb:P48163	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104217|imex:IM-29301-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Fig, 3E Supp. Figs. 5K-M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:bfahST8AJ7FZkOFLrDasm5qvS1Q	false	his tag:n-n	his tag:n-n	4	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40925	uniprotkb:P40925	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104244|imex:IM-29301-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3E, Supp. Figs 5K-M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:wZEfF3F5xglA05phkqHVs9kACQg	false	his tag:n-n	his tag:n-n	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11498	uniprotkb:P11498	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104294|imex:IM-29301-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3E, Supp. Figs. 5K-M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/11	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:6sZLVjf8xABAqj6jB74FNj/+VJU	false	biotin tag:?-?|sufficient binding region:486-1178	biotin tag:?-?|sufficient binding region:486-1178	4	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104332|imex:IM-29301-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3E, Supp. Figs. 5K-M|comment:Mol wt.=590kDa|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	-	false	his tag:n-n	his tag:n-n	4	2	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:57945"	uniprotkb:P48163	intact:EBI-27104279	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:"nadh(2-)"(display_short)|psi-mi:"CHEBI:57945"(display_long)|intact:NADH(synonym)|intact:NADH dianion(synonym)|intact:"adenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}"(iupac name)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104332|imex:IM-29301-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Fig. 3E, Supp. Figs. 5K-M|comment:Mol wt.=590kDa|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	-	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	-	false	-	his tag:n-n	-	4	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104332|imex:IM-29301-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	-	-	-	figure legend:Fig. 3E, Supp. Figs. 5K-M|comment:Mol wt.=590kDa|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/06	2021/10/19	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	-	false	his tag:n-n	biotin tag:?-?|sufficient binding region:468-1178	4	4	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104705|imex:IM-29301-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Supp. Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma)	-	2021/10/06	2021/10/12	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104705|imex:IM-29301-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Supp. Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma)	-	2021/10/06	2021/10/12	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11498	uniprotkb:P48163	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104720|imex:IM-29301-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Supp. Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma)	-	2021/10/06	2021/11/01	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11498	uniprotkb:P40925	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27104720|imex:IM-29301-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Supp. Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma)	-	2021/10/06	2021/11/01	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11498	uniprotkb:P48163	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27119185|imex:IM-29301-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	-	-	-	figure legend:Supp. Fig. 5F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2021/10/06	2021/11/01	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11498	uniprotkb:P40925	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27119185|imex:IM-29301-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	-	-	-	figure legend:Supp. Fig. 5F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2021/10/06	2021/11/01	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVJ4	uniprotkb:P40763	intact:EBI-7007454|ensembl:ENSRNOP00000009119|intact:MINT-1216281|uniprotkb:A0JN00	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:syj2b_rat(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:NPW16(gene name synonym)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118524|imex:IM-29301-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000006399(gene)|ensembl:ENSRNOT00000009122(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rgd:69400|refseq:NP_072121.2	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	go:"GO:0005739"(mitochondrion)	comment:mint	crc64:6C00632211C8012D	figure legend:Supp. Fig 1O|comment:Endogenous STAT3 was reduced in cells that undergo oncogene-induced senescence|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/29	rogid:7sdA4a6pd1W35wxHkRhUcOMDQr410116	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	rigid:TWrwKTqPdDILsmgbJ8j3GUYGkQY	false	sufficient binding region:109-145|enhanced green fluorescent protein tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVJ4	uniprotkb:Q15388	intact:EBI-7007454|ensembl:ENSRNOP00000009119|intact:MINT-1216281|uniprotkb:A0JN00	intact:EBI-711636|uniprotkb:A8K195|uniprotkb:Q498B3|uniprotkb:Q6IBT4|ensembl:ENSP00000355566	psi-mi:syj2b_rat(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:NPW16(gene name synonym)	psi-mi:tom20_human(display_long)|uniprotkb:Outer mitochondrial membrane receptor Tom20(gene name synonym)|uniprotkb:TOMM20(gene name)|psi-mi:TOMM20(display_short)|uniprotkb:KIAA0016(gene name synonym)|uniprotkb:Mitochondrial 20 kDa outer membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118524|imex:IM-29301-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000006399(gene)|ensembl:ENSRNOT00000009122(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rgd:69400|refseq:NP_072121.2	refseq:NP_055580.1|dip:DIP-46735N|ensembl:ENSG00000173726(gene)|ensembl:ENST00000366607(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016031"(tRNA import into mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|interpro:IPR002056(Protein import receptor MAS20)|interpro:IPR022422|interpro:IPR023392|rcsb pdb:4APO|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880	go:"GO:0005739"(mitochondrion)	comment:mint	-	figure legend:Supp. Fig 1O|comment:Endogenous STAT3 was reduced in cells that undergo oncogene-induced senescence|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-imr_90)|taxid:9606(Homo sapiens embryonic fetal lung fibroblast)	-	2021/10/06	2021/10/29	rogid:7sdA4a6pd1W35wxHkRhUcOMDQr410116	rogid:+wNh1qTU0NtgQekYJjhfj6O3UoA9606	rigid:TWrwKTqPdDILsmgbJ8j3GUYGkQY	false	sufficient binding region:109-145|enhanced green fluorescent protein tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05920	uniprotkb:P14152	intact:EBI-773565	intact:EBI-494462|uniprotkb:Q3TP22|uniprotkb:Q80Y13|uniprotkb:Q9DB45|ensembl:ENSMUSP00000099938|ensembl:ENSMUSP00000159017	psi-mi:pyc_mouse(display_long)|uniprotkb:Pyruvic carboxylase(gene name synonym)|uniprotkb:Pc(gene name)|psi-mi:Pc(display_short)|uniprotkb:Pcx(gene name synonym)	psi-mi:mdhc_mouse(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:Mdh1(gene name)|psi-mi:Mdh1(display_short)|uniprotkb:Mor2(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118552|imex:IM-29301-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR001882(Biotin-binding site)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011053(Single hybrid motif)|mint:Q05920|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|reactome:R-MMU-196780|reactome:R-MMU-70263	refseq:NP_032644.3|refseq:NP_001303604.1|ensembl:ENSMUSG00000020321(gene)|ensembl:ENSMUST00000102874(transcript)|ensembl:ENSMUST00000239073(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|go:"GO:0006108"(malate metabolic process)|interpro:IPR022383|interpro:IPR036291|mint:P14152|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 6H|comment:Interaction observed in STAT3 and PTEN knockout cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-prostate)|taxid:10090(Mus musculus prostate)	-	2021/10/06	2021/11/01	rogid:lsSatV0UMI9POKETZcn4gD/gp1Q10090	rogid:Yq74ALpVIoaMM9Y2LUS4Sdmfztg10090	rigid:hTesB55UmPohHDErIx3oBfbZpcU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06801	uniprotkb:Q05920	intact:EBI-8319363|intact:MINT-4101136|uniprotkb:Q9DBF9|intact:MINT-1855632|ensembl:ENSMUSP00000034989	intact:EBI-773565	psi-mi:maox_mouse(display_long)|uniprotkb:Me1(gene name)|psi-mi:Me1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)|uniprotkb:Mod-1(gene name synonym)|uniprotkb:Mod1(gene name synonym)	psi-mi:pyc_mouse(display_long)|uniprotkb:Pyruvic carboxylase(gene name synonym)|uniprotkb:Pc(gene name)|psi-mi:Pc(display_short)|uniprotkb:Pcx(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118558|imex:IM-29301-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032641.2|refseq:NP_001185862.1|ensembl:ENSMUSG00000032418(gene)|ensembl:ENSMUST00000034989(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009725"(response to hormone)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|mint:P06801|reactome:R-MMU-70268	interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR001882(Biotin-binding site)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011053(Single hybrid motif)|mint:Q05920|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|reactome:R-MMU-196780|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 6H|comment:Interaction observed in STAT3 and PTEN knockout cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-prostate)|taxid:10090(Mus musculus prostate)	-	2021/10/06	2021/10/29	rogid:YzLCyb8PSHaXV8r8CdFF0ryWYJw10090	rogid:lsSatV0UMI9POKETZcn4gD/gp1Q10090	rigid:os2VcawR5sAj71ERM8b45jQJ5ec	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48163	uniprotkb:P11498	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-2211322|uniprotkb:Q16705|uniprotkb:B4DN00|ensembl:ENSP00000377527|ensembl:ENSP00000377530|ensembl:ENSP00000377532|ensembl:ENSP00000435905|ensembl:ENSP00000498302|ensembl:ENSP00000498406|ensembl:ENSP00000498994	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:pyc_human(display_long)|uniprotkb:PC(gene name)|psi-mi:PC(display_short)|uniprotkb:Pyruvic carboxylase(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118584|imex:IM-29301-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:XP_011543388.1|refseq:XP_016873357.1|refseq:XP_016873358.1|refseq:XP_016873359.1|refseq:XP_016873360.1|refseq:XP_016873361.1|refseq:NP_000911.2|refseq:NP_001035806.1|refseq:NP_071504.2|refseq:XP_005274088.1|refseq:XP_005274089.1|refseq:XP_006718641.1|dip:DIP-46372N|ensembl:ENSG00000173599(gene)|ensembl:ENST00000393955(transcript)|ensembl:ENST00000393958(transcript)|ensembl:ENST00000393960(transcript)|ensembl:ENST00000529047(transcript)|ensembl:ENST00000651036(transcript)|ensembl:ENST00000651854(transcript)|ensembl:ENST00000652125(transcript)|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR001882(Biotin-binding site)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016185(PreATP-grasp-like fold)|mint:P11498|rcsb pdb:3BG3|rcsb pdb:3BG9|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2021/10/06	2021/10/29	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:0xXv1wxe0AC1EO7wxSDVhBpHCUU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48163	uniprotkb:P40925	intact:EBI-11958484|ensembl:ENSP00000358719|uniprotkb:B4DZ70|uniprotkb:Q16797|uniprotkb:Q16855|uniprotkb:Q53F72|uniprotkb:Q5VWA2|uniprotkb:Q9BWX8|uniprotkb:Q9H1W3|uniprotkb:Q9UIY4	intact:EBI-709625|uniprotkb:B7Z3I7|uniprotkb:Q6I9V0|uniprotkb:B2R5V5|uniprotkb:B4DUN2|uniprotkb:F5H098|ensembl:ENSP00000233114|ensembl:ENSP00000446395	psi-mi:maox_human(display_long)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)|uniprotkb:Malic enzyme 1(gene name synonym)	psi-mi:mdhc_human(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:MDH1(gene name)|psi-mi:MDH1(display_short)|uniprotkb:MDHA(gene name synonym)|uniprotkb:Diiodophenylpyruvate reductase(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Igelmann et al. (2021)	imex:IM-29301|pubmed:34547241	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27118584|imex:IM-29301-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000065833(gene)|ensembl:ENST00000369705(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|rcsb pdb:2AW5|rcsb pdb:3WJA|reactome:R-HSA-1989781|reactome:R-HSA-70268|go:"GO:0005829"(cytosol)|refseq:NP_002386.1|refseq:XP_011534138.1	refseq:NP_001186040.1|refseq:NP_001186041.1|refseq:NP_005908.1|refseq:NP_001303303.1|ensembl:ENSG00000014641(gene)|ensembl:ENST00000233114(transcript)|ensembl:ENST00000544381(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0047860"(diiodophenylpyruvate reductase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40925|reactome:R-HSA-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2021/10/06	2021/10/29	rogid:ZzJSLIhqYovI88seL2e7e9ADjXY9606	rogid:SbY7B81CiCRe8tXpVpSdT1sKGOU9606	rigid:HEGi149H4WMgB+u5bY0cR2m9V8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)