#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1-PRO_0000449629	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-25475885	intact:EBI-25475877	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27064811|imex:IM-29165-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)	chain-seq-start:4393|chain-seq-end:5324	chain-seq-start:4141|chain-seq-end:4253	figure legend:1 C/D, 3C, Supp. figure 5, 3|comment:Preincubation of nsp12 with a three-fold molar excess of GSNnsp9 only slightly inhibited modification of Nnsp9.|comment:The N-terminus of nsp9 is modified by GMP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/12	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	rigid:/yiBKgD7G6Ok0urAp9/POHo1oM0	false	mutation with no effect:760-760|mutation disrupting interaction rate:218-218|mutation disrupting interaction rate:50-50|mutation disrupting interaction rate:116-116|mutation decreasing interaction rate:129-129	guanylated residue:1-1|mutation disrupting interaction rate:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTD1-PRO_0000449627	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-25475877	intact:EBI-25475885	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065479|imex:IM-29165-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)	chain-seq-start:4141|chain-seq-end:4253	chain-seq-start:4393|chain-seq-end:5324	figure legend:2 B/C, 3B,4B|antagonist:"As well as PPi,  several nucleotides or their analogues acted as competitors or inhibitors of the interaction, notably; NTPs, GDP, GMP, ITP, and GMPCPP. The  bisphosphonates  Foscarnet (Fos- CHEBI:127780) and Risedronate (Ris-CHEBI:8868) inhibit nsp9 NMPylation, although less efficiently than PPi."|comment:"ppGpp and RTP (Remdesivir triphosphate) were poor competitors/ inhibitors."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	-	false	guanylated residue:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:71240"	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-27065502	intact:EBI-25475877	psi-mi:sodium diphosphate(display_short)|psi-mi:"CHEBI:71240"(display_long)|intact:Diphosphoric acid, tetrasodium salt(synonym)|intact:Natrium pyrophosphat(synonym)|intact:Pyrophosphoric acid tetrasodium salt(synonym)|intact:Sodium pyrophosphate(synonym)|intact:Tetrasodium pyrophosphate(synonym)|intact:TSPP(synonym)|intact:sodium diphosphate(iupac name)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065479|imex:IM-29165-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)	-	chain-seq-start:4141|chain-seq-end:4253	figure legend:2 B/C, 3B,4B|antagonist:"As well as PPi,  several nucleotides or their analogues acted as competitors or inhibitors of the interaction, notably; NTPs, GDP, GMP, ITP, and GMPCPP. The  bisphosphonates  Foscarnet (Fos- CHEBI:127780) and Risedronate (Ris-CHEBI:8868) inhibit nsp9 NMPylation, although less efficiently than PPi."|comment:"ppGpp and RTP (Remdesivir triphosphate) were poor competitors/ inhibitors."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	-	false	-	guanylated residue:1-1	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
wwpdb:7ctt	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	intact:EBI-25475877	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065875|imex:IM-29165-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	chain-seq-start:4141|chain-seq-end:4253	figure legend:Supp. figure  3B|comment:The N-terminus of nsp9 is modified by GMP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	-	false	-	guanylated residue:1-1|mutation disrupting interaction rate:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification)
wwpdb:7ctt	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	intact:EBI-25475877	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065899|imex:IM-29165-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	chain-seq-start:4141|chain-seq-end:4253	figure legend:Supp. figure  3B|comment:The N-terminus of nsp9 is modified by GMP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	-	false	-	guanylated residue:1-1|mutation disrupting interaction rate:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification)
wwpdb:7ctt	intact:EBI-27065560	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:rna scaffold(display_short)|psi-mi:EBI-27065560(display_long)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065899|imex:IM-29165-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	-	figure legend:Supp. figure  3B|comment:The N-terminus of nsp9 is modified by GMP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0661"(experimental participant identification)
wwpdb:7ctt	intact:EBI-27065560	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:rna scaffold(display_short)|psi-mi:EBI-27065560(display_long)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065557|imex:IM-29165-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	-	figure legend:3A LHS|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	-	cy5 label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:177382"	wwpdb:7ctt	intact:EBI-27065588	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:sodium pyrophosphate decahydrate(display_short)|psi-mi:"CHEBI:177382"(display_long)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065557|imex:IM-29165-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:3A LHS|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:17326"	wwpdb:7ctt	intact:EBI-9663972|chebi:"CHEBI:13411"|chebi:"CHEBI:17035"|chebi:"CHEBI:14677"|chebi:"CHEBI:7655"|chebi:"CHEBI:7442"|chebi:"CHEBI:25610"	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:nucleoside triphosphate(display_short)|psi-mi:"CHEBI:17326"(display_long)|intact:NTP(synonym)|intact:Nucleoside triphosphate(synonym)|intact:nucleoside triphosphates(synonym)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065592|imex:IM-29165-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:3A  LHS, Supp. figure 6|comment:In the presence of non-cognate NTPs, SARS-CoV-2 RdRp did not cleave nascent RNA.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
wwpdb:7ctt	intact:EBI-27065560	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:rna scaffold(display_short)|psi-mi:EBI-27065560(display_long)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065592|imex:IM-29165-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	-	figure legend:3A  LHS, Supp. figure 6|comment:In the presence of non-cognate NTPs, SARS-CoV-2 RdRp did not cleave nascent RNA.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	-	cy5 label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:177382"	wwpdb:7ctt	intact:EBI-27065588	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:sodium pyrophosphate decahydrate(display_short)|psi-mi:"CHEBI:177382"(display_long)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065592|imex:IM-29165-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:3A  LHS, Supp. figure 6|comment:In the presence of non-cognate NTPs, SARS-CoV-2 RdRp did not cleave nascent RNA.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:17326"	wwpdb:7ctt	intact:EBI-9663972|chebi:"CHEBI:13411"|chebi:"CHEBI:17035"|chebi:"CHEBI:14677"|chebi:"CHEBI:7655"|chebi:"CHEBI:7442"|chebi:"CHEBI:25610"	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:nucleoside triphosphate(display_short)|psi-mi:"CHEBI:17326"(display_long)|intact:NTP(synonym)|intact:Nucleoside triphosphate(synonym)|intact:nucleoside triphosphates(synonym)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065609|imex:IM-29165-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:3A RHS, Supp. figure 1|comment:"No cleavage was seen in the presence of PPi (-CHEBI:177382)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	-	mutation disrupting interaction rate:760-760|mutation with no effect:218-218|mutation with no effect:116-116|mutation with no effect:50-50|mutation decreasing interaction rate:129-129	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
wwpdb:7ctt	intact:EBI-27065560	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:rna scaffold(display_short)|psi-mi:EBI-27065560(display_long)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065609|imex:IM-29165-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	-	figure legend:3A RHS, Supp. figure 1|comment:"No cleavage was seen in the presence of PPi (-CHEBI:177382)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	mutation disrupting interaction rate:760-760|mutation with no effect:218-218|mutation with no effect:116-116|mutation with no effect:50-50|mutation decreasing interaction rate:129-129	cy5 label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:15422"	wwpdb:7ctt	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065957|imex:IM-29165-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:Supp. figure 6|comment:RdRp misincorporates some AMP to generate a 40 residue product.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:15422"	intact:EBI-27065560	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	-	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rna scaffold(display_short)|psi-mi:EBI-27065560(display_long)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065957|imex:IM-29165-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0320"(ribonucleic acid)	-	-	-	-	-	figure legend:Supp. figure 6|comment:RdRp misincorporates some AMP to generate a 40 residue product.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	-	-	false	-	cy5 label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:17345"	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-25475877	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065635|imex:IM-29165-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	chain-seq-start:4141|chain-seq-end:4253	figure legend:3C, Supp. figure 7|comment:GMP is removed from Nsp9.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	-	false	32p radiolabel:?-?|sufficient binding region:?-?	sufficient binding region:1-1	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:17345"	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-25475885	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065635|imex:IM-29165-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	chain-seq-start:4393|chain-seq-end:5324	figure legend:3C, Supp. figure 7|comment:GMP is removed from Nsp9.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	-	false	32p radiolabel:?-?|sufficient binding region:?-?	mutation with no effect:760-760|mutation decreasing interaction rate:218-218	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17345"	chebi:"CHEBI:71240"	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-27065502	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:sodium diphosphate(display_short)|psi-mi:"CHEBI:71240"(display_long)|intact:Diphosphoric acid, tetrasodium salt(synonym)|intact:Natrium pyrophosphat(synonym)|intact:Pyrophosphoric acid tetrasodium salt(synonym)|intact:Sodium pyrophosphate(synonym)|intact:Tetrasodium pyrophosphate(synonym)|intact:TSPP(synonym)|intact:sodium diphosphate(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27065635|imex:IM-29165-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:1343"(enzyme regulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	-	figure legend:3C, Supp. figure 7|comment:GMP is removed from Nsp9.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/13	-	-	-	false	32p radiolabel:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:17345"	wwpdb:7ctt	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066026|imex:IM-29165-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:Supp. figure 7|comment:GMP is removed from Nsp9.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	-	-	false	32p radiolabel:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17345"	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-25475877	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066026|imex:IM-29165-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	chain-seq-start:4141|chain-seq-end:4253	figure legend:Supp. figure 7|comment:GMP is removed from Nsp9.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	-	false	32p radiolabel:?-?|sufficient binding region:?-?	sufficient binding region:1-1	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:17345"	chebi:"CHEBI:71240"	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-27065502	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:sodium diphosphate(display_short)|psi-mi:"CHEBI:71240"(display_long)|intact:Diphosphoric acid, tetrasodium salt(synonym)|intact:Natrium pyrophosphat(synonym)|intact:Pyrophosphoric acid tetrasodium salt(synonym)|intact:Sodium pyrophosphate(synonym)|intact:Tetrasodium pyrophosphate(synonym)|intact:TSPP(synonym)|intact:sodium diphosphate(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066026|imex:IM-29165-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:1343"(enzyme regulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	-	figure legend:Supp. figure 7|comment:GMP is removed from Nsp9.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	-	-	false	32p radiolabel:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:17345"	uniprotkb:P0DTD1-PRO_0000449627	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-25475877	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:p0dtd1-pro_0000449627(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066108|imex:IM-29165-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	chain-seq-start:4141|chain-seq-end:4253	figure legend:Supp. figure 8, Lane 6|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	rogid:4/ohQhJXTSeDo5Sge6OUGfwU6zo2697049	-	false	32p radiolabel:?-?|sufficient binding region:?-?	sufficient binding region:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17345"	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-25475885	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066108|imex:IM-29165-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	chain-seq-start:4393|chain-seq-end:5324	figure legend:Supp. figure 8, Lane 6|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	-	false	32p radiolabel:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17345"	chebi:"CHEBI:71240"	intact:EBI-9007299|chebi:"CHEBI:13341"|chebi:"CHEBI:14381"|chebi:"CHEBI:129502"|chebi:"CHEBI:24449"|chebi:"CHEBI:24450"|chebi:"CHEBI:29058"|chebi:"CHEBI:40119"|chebi:"CHEBI:42979"|chebi:"CHEBI:42615"|chebi:"CHEBI:42647"|chebi:"CHEBI:42831"|chebi:"CHEBI:42887"|chebi:"CHEBI:42892"|chebi:"CHEBI:47450"|chebi:"CHEBI:5228"	intact:EBI-27065502	psi-mi:gmp(display_short)|psi-mi:"CHEBI:17345"(display_long)|intact:5'-GMP(synonym)|intact:GMP(synonym)|intact:Guanosine 5'-monophosphate(synonym)|intact:Guanosine 5'-phosphate(synonym)|intact:Guanosine monophosphate(synonym)|intact:guanosine-5'-monophosphate(synonym)|intact:Guanylic acid(synonym)|intact:pG(synonym)|intact:5'-guanylic acid(iupac name)|intact:"[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate"(iupac name)	psi-mi:sodium diphosphate(display_short)|psi-mi:"CHEBI:71240"(display_long)|intact:Diphosphoric acid, tetrasodium salt(synonym)|intact:Natrium pyrophosphat(synonym)|intact:Pyrophosphoric acid tetrasodium salt(synonym)|intact:Sodium pyrophosphate(synonym)|intact:Tetrasodium pyrophosphate(synonym)|intact:TSPP(synonym)|intact:sodium diphosphate(iupac name)	psi-mi:"MI:0990"(cleavage assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066108|imex:IM-29165-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	inchi key:RQFCJASXJCIDSX-UUOKFMHZSA-N	-	figure legend:Supp. figure 8, Lane 6|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	-	-	false	32p radiolabel:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-25475885	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0419"(gtpase assay)	Wang et al. (2021)	imex:IM-29165|pubmed:34352100	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27066219|imex:IM-29165-23	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	chain-seq-start:4393|chain-seq-end:5324	figure legend:Supp. figure 8, Lane 7|comment:nsp12 shows unusual intrinsic nucleotide hydrolytic activity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/11	2021/08/16	-	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)