#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q12879-1	uniprotkb:Q05586-1	intact:EBI-27070593|ensembl:ENSP00000332549|ensembl:ENSP00000379818	intact:EBI-27070564|ensembl:ENSP00000360616	psi-mi:q12879-1(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)	psi-mi:q05586-1(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)|uniprotkb:GRIN1(gene name)|psi-mi:GRIN1(display_short)|uniprotkb:NMDAR1(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:NR1-3(isoform synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Zhang et al. (2021)	imex:IM-29305|pubmed:34321660	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-27070573|wwpdb:7EU7|emdb:EMD-31308|imex:IM-29305-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183454(gene)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|intact:EBI-7249937(isoform-parent)|wwpdb:7EU7(identity)|pubchem:182137(identity)	intact:EBI-998542(isoform-parent)|ensembl:ENSG00000176884(gene)|ensembl:ENST00000371561(transcript)|wwpdb:7EU7(identity)|pubchem:182137(identity)	-	-	-	figure legend:Extended Data Fig. 1A, Extended Data Table 1, Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/08/13	2021/08/21	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	rogid:k5yQuuGoNYzr955sfuumk22eVvM9606	rigid:NzGx6MTTVfJY6ignci5EExjZv6E	false	sufficient binding region:1-841	sufficient binding region:1-847	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q13224	uniprotkb:Q05586-1	intact:EBI-2256942|uniprotkb:Q12919|uniprotkb:Q13220|uniprotkb:Q13225|uniprotkb:Q14CU4|uniprotkb:Q9UM56|intact:EBI-28967100|ensembl:ENSP00000477455	intact:EBI-27070564|ensembl:ENSP00000360616	psi-mi:nmde2_human(display_long)|uniprotkb:GRIN2B(gene name)|psi-mi:GRIN2B(display_short)|uniprotkb:NMDAR2B(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit 3(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)	psi-mi:q05586-1(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)|uniprotkb:GRIN1(gene name)|psi-mi:GRIN1(display_short)|uniprotkb:NMDAR1(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:NR1-3(isoform synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Zhang et al. (2021)	imex:IM-29305|pubmed:34321660	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-27070575|wwpdb:7EU8|emdb:EMD-31309|imex:IM-29305-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000477455|refseq:XP_011518930.1|refseq:XP_011518931.1|refseq:NP_000825.2|dip:DIP-41002N|refseq:XP_016874708.1|ensembl:ENSG00000273079(gene)|ensembl:ENST00000609686(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S11|rcsb pdb:1S2S|rcsb pdb:2IPV|rcsb pdb:5EWJ|rcsb pdb:5EWL|rcsb pdb:5EWM|rcsb pdb:6XBP|rcsb pdb:6XBX|rcsb pdb:6XDL|rcsb pdb:6XDU|rcsb pdb:6XOE|rcsb pdb:7KL0|rcsb pdb:7KL1|rcsb pdb:7KL2|rcsb pdb:7KL4|reactome:R-HSA-3928662|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9032500|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|wwpdb:7EU8(identity)|pubchem:644025(identity)	intact:EBI-998542(isoform-parent)|ensembl:ENSG00000176884(gene)|ensembl:ENST00000371561(transcript)|wwpdb:7EU8(identity)|pubchem:644025(identity)	-	-	-	figure legend:Extended Data Fig. 1A, Extended Data Table 1, Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/08/13	2021/08/21	rogid:7SvBEWjPBe8TLnX0Jlow6fxaMDw9606	rogid:k5yQuuGoNYzr955sfuumk22eVvM9606	rigid:cSuKPs32gphMN60HFzCCAoBBdg0	false	sufficient binding region:1-842	sufficient binding region:1-847	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q13224	uniprotkb:Q05586-1	intact:EBI-2256942|uniprotkb:Q12919|uniprotkb:Q13220|uniprotkb:Q13225|uniprotkb:Q14CU4|uniprotkb:Q9UM56|intact:EBI-28967100|ensembl:ENSP00000477455	intact:EBI-27070564|ensembl:ENSP00000360616	psi-mi:nmde2_human(display_long)|uniprotkb:GRIN2B(gene name)|psi-mi:GRIN2B(display_short)|uniprotkb:NMDAR2B(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit 3(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)	psi-mi:q05586-1(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)|uniprotkb:GRIN1(gene name)|psi-mi:GRIN1(display_short)|uniprotkb:NMDAR1(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:NR1-3(isoform synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhang et al. (2021)	imex:IM-29305|pubmed:34321660	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-27070638|imex:IM-29305-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000477455|refseq:XP_011518930.1|refseq:XP_011518931.1|refseq:NP_000825.2|dip:DIP-41002N|refseq:XP_016874708.1|ensembl:ENSG00000273079(gene)|ensembl:ENST00000609686(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S11|rcsb pdb:1S2S|rcsb pdb:2IPV|rcsb pdb:5EWJ|rcsb pdb:5EWL|rcsb pdb:5EWM|rcsb pdb:6XBP|rcsb pdb:6XBX|rcsb pdb:6XDL|rcsb pdb:6XDU|rcsb pdb:6XOE|rcsb pdb:7KL0|rcsb pdb:7KL1|rcsb pdb:7KL2|rcsb pdb:7KL4|reactome:R-HSA-3928662|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9032500|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|wwpdb:7EU8(identity)|pubchem:644025(identity)	intact:EBI-998542(isoform-parent)|ensembl:ENSG00000176884(gene)|ensembl:ENST00000371561(transcript)|wwpdb:7EU8(identity)|pubchem:644025(identity)	-	-	-	figure legend:Extended Data Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/08/13	2021/08/21	rogid:7SvBEWjPBe8TLnX0Jlow6fxaMDw9606	rogid:k5yQuuGoNYzr955sfuumk22eVvM9606	rigid:cSuKPs32gphMN60HFzCCAoBBdg0	false	sufficient binding region:1-842	sufficient binding region:1-847	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q12879-1	uniprotkb:Q05586-1	intact:EBI-27070593|ensembl:ENSP00000332549|ensembl:ENSP00000379818	intact:EBI-27070564|ensembl:ENSP00000360616	psi-mi:q12879-1(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)	psi-mi:q05586-1(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)|uniprotkb:GRIN1(gene name)|psi-mi:GRIN1(display_short)|uniprotkb:NMDAR1(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:NR1-3(isoform synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhang et al. (2021)	imex:IM-29305|pubmed:34321660	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-27070630|imex:IM-29305-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183454(gene)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|intact:EBI-7249937(isoform-parent)|wwpdb:7EU7|pubchem:182137	intact:EBI-998542(isoform-parent)|ensembl:ENSG00000176884(gene)|ensembl:ENST00000371561(transcript)|wwpdb:7EU7(identity)|pubchem:644025(identity)	-	-	-	figure legend:Extended Data Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/08/13	2021/08/21	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	rogid:k5yQuuGoNYzr955sfuumk22eVvM9606	rigid:NzGx6MTTVfJY6ignci5EExjZv6E	false	sufficient binding region:1-841	sufficient binding region:1-847	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)