#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-27058935	intenz:3.1.13	-	intact:EBI-25564924|intact:EBI-25492032|reactome:R-COV-9694688|wwpdb:7diy|wwpdb:7mc6|wwpdb:7mc5|wwpdb:7n0c|emdb:EMD-24103|wwpdb:7n0d|emdb:EMD-24104|wwpdb:7n0b|emdb:EMD-24102	psi-mi:t35p31(display_short)|psi-mi:EBI-27058935(display_long)	psi-mi:nsp10-nsp14_sars2-1(display_short)|psi-mi:3.1.13(display_long)|intact:SARS-CoV-2 3'-5' exoribonuclease proof-reading complex(complex recommended name)|intact:"NSP10:NSP14"(complex systematic name)|intact:SARS-CoV-2 NSP14/NSP10 complex(complex synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058913|imex:IM-29156-1|wwpdb:7N0B|emdb:EMD-24102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:1302"(stable complex)	refseq:NC_045512.2(see-also)	go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:1905354"(exoribonuclease complex)|pubmed:31440227(see-also)|pubmed:29279395(see-also)|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5692(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:33821277(see-also)|intact:EBI-26971334(exp-evidence)	-	comment:"residues 29839-29870 from  NC_045512.2 (3' region minus polyA tail)"	curated-complex:"The SARS-CoV-2 coronavirus 3'-5' exoribonuclease complex which strictly targets double-stranded RNA and can selectively remove a mismatched ribonucleotide at the 3'-end of a dsRNA substrate. Formation of the NSP10-NSP14 complex strongly enhances the exonuclease activity of the bifunctional NSP14 and enhances the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase. May bind to, and act with the nsp7/nsp8/nsp12 polymerase complex (CPX-5742). Proof-reading exonuclease activity may explain why coronaviruses have the largest RNA genomes known to date. Complex formation does not appear to effect the C-terminal N7-methyltransferase activity of NSP14 involved in RNA cap modification."|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation. A flexible N-terminal domain of NSP14 forms the NSP10 docking site and induces conformational changes in the NSP14 that modulate the distance between the catalytic residues.	figure legend:Table S1|comment:"PDBe entries 7n0b and  7n0d  appear to have 4 rather than the stated 3 guanine residues at the 5' terminus of the T-strand RNA;the authors state that \"5'-end non-templated nucleotide addition by T7 RNAP has been observed when there are multiple initiating guanosines in the RNA transcript\"."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	-	-	-	false	RNA chemical modification:1-1|RNA chemical modification:2-3	his tag:n-n	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
intact:EBI-27058935	intenz:3.1.13	-	intact:EBI-25564924|intact:EBI-25492032|reactome:R-COV-9694688|wwpdb:7diy|wwpdb:7mc6|wwpdb:7mc5|wwpdb:7n0c|emdb:EMD-24103|wwpdb:7n0d|emdb:EMD-24104|wwpdb:7n0b|emdb:EMD-24102	psi-mi:t35p31(display_short)|psi-mi:EBI-27058935(display_long)	psi-mi:nsp10-nsp14_sars2-1(display_short)|psi-mi:3.1.13(display_long)|intact:SARS-CoV-2 3'-5' exoribonuclease proof-reading complex(complex recommended name)|intact:"NSP10:NSP14"(complex systematic name)|intact:SARS-CoV-2 NSP14/NSP10 complex(complex synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058964|imex:IM-29156-3|wwpdb:7n0d|emdb:EMD-24104|wwpdb:7n0c|emdb:EMD-24103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:1302"(stable complex)	refseq:NC_045512.2(see-also)	go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:1905354"(exoribonuclease complex)|pubmed:31440227(see-also)|pubmed:29279395(see-also)|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5692(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:33821277(see-also)|intact:EBI-26971334(exp-evidence)	-	comment:"residues 29839-29870 from  NC_045512.2 (3' region minus polyA tail)"	curated-complex:"The SARS-CoV-2 coronavirus 3'-5' exoribonuclease complex which strictly targets double-stranded RNA and can selectively remove a mismatched ribonucleotide at the 3'-end of a dsRNA substrate. Formation of the NSP10-NSP14 complex strongly enhances the exonuclease activity of the bifunctional NSP14 and enhances the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase. May bind to, and act with the nsp7/nsp8/nsp12 polymerase complex (CPX-5742). Proof-reading exonuclease activity may explain why coronaviruses have the largest RNA genomes known to date. Complex formation does not appear to effect the C-terminal N7-methyltransferase activity of NSP14 involved in RNA cap modification."|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation. A flexible N-terminal domain of NSP14 forms the NSP10 docking site and induces conformational changes in the NSP14 that modulate the distance between the catalytic residues.	figure legend:Table S1|comment:"PDBe entries 7n0b and  7n0d  appear to have 4 rather than the stated 3 guanine residues at the 5' terminus of the T-strand RNA;the authors state that \"5'-end non-templated nucleotide addition by T7 RNAP has been observed when there are  multiple initiating guanosines in the RNA transcript\"."|comment:"The \"P\" strand in the 7n0d PDBe entry has a different 5' sequence to that in entry 7n0b and 7n0c. The same sequence as in entries 7n0b and 7n0c has been used here."|comment:Entry 7n0d refers to a higher order oligomer. [Entry 7n0d shows well-resolved densities for five consecutive pyrimidine nucleotides in the substrate-binding pockets of protomers B and D;the exact source and identify of the second RNA substrate molecule are unclear.]|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	-	-	-	false	RNA chemical modification:1-1|RNA chemical modification:2-3	mutation:191-191|his tag:n-n	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
intact:EBI-27058935	intenz:3.1.13	-	intact:EBI-25564924|intact:EBI-25492032|reactome:R-COV-9694688|wwpdb:7diy|wwpdb:7mc6|wwpdb:7mc5|wwpdb:7n0c|emdb:EMD-24103|wwpdb:7n0d|emdb:EMD-24104|wwpdb:7n0b|emdb:EMD-24102	psi-mi:t35p31(display_short)|psi-mi:EBI-27058935(display_long)	psi-mi:nsp10-nsp14_sars2-1(display_short)|psi-mi:3.1.13(display_long)|intact:SARS-CoV-2 3'-5' exoribonuclease proof-reading complex(complex recommended name)|intact:"NSP10:NSP14"(complex systematic name)|intact:SARS-CoV-2 NSP14/NSP10 complex(complex synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059022|imex:IM-29156-7|wwpdb:7n0c|emdb:EMD-24103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2359"(ds rna)	psi-mi:"MI:1302"(stable complex)	refseq:NC_045512.2(see-also)	go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:1905354"(exoribonuclease complex)|pubmed:31440227(see-also)|pubmed:29279395(see-also)|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5692(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:33821277(see-also)|intact:EBI-26971334(exp-evidence)	-	comment:"residues 29839-29870 from  NC_045512.2 (3' region minus polyA tail)"	curated-complex:"The SARS-CoV-2 coronavirus 3'-5' exoribonuclease complex which strictly targets double-stranded RNA and can selectively remove a mismatched ribonucleotide at the 3'-end of a dsRNA substrate. Formation of the NSP10-NSP14 complex strongly enhances the exonuclease activity of the bifunctional NSP14 and enhances the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase. May bind to, and act with the nsp7/nsp8/nsp12 polymerase complex (CPX-5742). Proof-reading exonuclease activity may explain why coronaviruses have the largest RNA genomes known to date. Complex formation does not appear to effect the C-terminal N7-methyltransferase activity of NSP14 involved in RNA cap modification."|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation. A flexible N-terminal domain of NSP14 forms the NSP10 docking site and induces conformational changes in the NSP14 that modulate the distance between the catalytic residues.	figure legend:Table S1|comment:"The \"P\" strand in the 7n0d PDBe entry has a different 5' sequence to that in entry 7n0b and 7n0c. The same sequence as in entries 7n0b and 7n0c has been used here."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	-	-	-	false	RNA chemical modification:2-3	mutation:191-191|his tag:n-n	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P0DTD1-PRO_0000449628	uniprotkb:P0DTD1-PRO_0000449631	intact:EBI-25475880	intact:EBI-25475920	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059005|imex:IM-29156-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:4254|chain-seq-end:4392	chain-seq-start:5926|chain-seq-end:6452	figure legend:1B|agonist:"MgCl2 (CHEBI:6636 )"|antagonist:"CaCl2 (CHEBI:3312)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049	-	false	-	mutation disrupting interaction rate:191-191|his tag:n-n	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449628	intact:EBI-27058935	intact:EBI-25475880	-	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:t35p31(display_short)|psi-mi:EBI-27058935(display_long)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059005|imex:IM-29156-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	refseq:NC_045512.2(see-also)	-	chain-seq-start:4254|chain-seq-end:4392	comment:"residues 29839-29870 from  NC_045512.2 (3' region minus polyA tail)"	figure legend:1B|agonist:"MgCl2 (CHEBI:6636 )"|antagonist:"CaCl2 (CHEBI:3312)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	-	-	false	-	RNA chemical modification:2-3	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449628	uniprotkb:P0DTD1-PRO_0000449631	intact:EBI-25475880	intact:EBI-25475920	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059052|imex:IM-29156-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:4254|chain-seq-end:4392	chain-seq-start:5926|chain-seq-end:6452	figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049	-	false	-	mutation disrupting interaction rate:191-191|his tag:n-n	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449628	intact:EBI-27059066	intact:EBI-25475880	-	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p32-1(display_short)|psi-mi:EBI-27059066(display_long)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059052|imex:IM-29156-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:4254|chain-seq-end:4392	-	figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	-	-	false	-	mutation with no effect:32-32|mutation decreasing interaction rate:32-32|mutation decreasing interaction rate:32-32	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449628	intact:EBI-25475874	intact:EBI-25475880	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059092|imex:IM-29156-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:4254|chain-seq-end:4392	figure legend:S5B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	-	false	-	-	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449631	intact:EBI-25475874	intact:EBI-25475920	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059092|imex:IM-29156-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:5926|chain-seq-end:6452	figure legend:S5B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-27058935	intact:EBI-25475874	-	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:t35p31(display_short)|psi-mi:EBI-27058935(display_long)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059092|imex:IM-29156-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	refseq:NC_045512.2(see-also)	-	chain-seq-start:3943|chain-seq-end:4140	comment:"residues 29839-29870 from  NC_045512.2 (3' region minus polyA tail)"	figure legend:S5B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	-	-	false	-	RNA chemical modification:2-3	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449628	uniprotkb:P0DTD1-PRO_0000449631	intact:EBI-25475880	intact:EBI-25475920	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059107|imex:IM-29156-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:4254|chain-seq-end:4392	chain-seq-start:5926|chain-seq-end:6452	figure legend:Supp. figure 9|comment:"It is stated that \"T45 corresponds to the 3'-end 44 nt of SARS-CoV-2 genome followed by a CMP\";however even after removing several residues from both 3' and 5' sequences, no match to any SARS2  sequence was found on Blasting."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049	-	false	-	mutation disrupting interaction rate:191-191|his tag:n-n	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449628	intact:EBI-27059066	intact:EBI-25475880	-	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p32-1(display_short)|psi-mi:EBI-27059066(display_long)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059107|imex:IM-29156-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:4254|chain-seq-end:4392	-	figure legend:Supp. figure 9|comment:"It is stated that \"T45 corresponds to the 3'-end 44 nt of SARS-CoV-2 genome followed by a CMP\";however even after removing several residues from both 3' and 5' sequences, no match to any SARS2  sequence was found on Blasting."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	-	-	false	-	sufficient binding region:1-32	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449628	intact:EBI-27059122	intact:EBI-25475880	-	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:t45(display_short)|psi-mi:EBI-27059122(display_long)	psi-mi:"MI:0990"(cleavage assay)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059107|imex:IM-29156-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:4254|chain-seq-end:4392	-	figure legend:Supp. figure 9|comment:"It is stated that \"T45 corresponds to the 3'-end 44 nt of SARS-CoV-2 genome followed by a CMP\";however even after removing several residues from both 3' and 5' sequences, no match to any SARS2  sequence was found on Blasting."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	-	-	false	-	sufficient binding region:1-45|biotin tag:1-1	-	-	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)	psi-mi:"MI:0820"(molecular weight estimation by sybr staining)
uniprotkb:P0DTD1-PRO_0000449626	intenz:3.1.13	intact:EBI-25475874	intact:EBI-25564924|intact:EBI-25492032|reactome:R-COV-9694688|wwpdb:7diy|wwpdb:7mc6|wwpdb:7mc5|wwpdb:7n0c|emdb:EMD-24103|wwpdb:7n0d|emdb:EMD-24104|wwpdb:7n0b|emdb:EMD-24102	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:nsp10-nsp14_sars2-1(display_short)|psi-mi:3.1.13(display_long)|intact:SARS-CoV-2 3'-5' exoribonuclease proof-reading complex(complex recommended name)|intact:"NSP10:NSP14"(complex systematic name)|intact:SARS-CoV-2 NSP14/NSP10 complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2021)	imex:IM-29156|pubmed:34315827	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27059072|imex:IM-29156-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:1905354"(exoribonuclease complex)|pubmed:31440227(see-also)|pubmed:29279395(see-also)|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5692(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:33821277(see-also)|intact:EBI-26971334(exp-evidence)	-	chain-seq-start:3943|chain-seq-end:4140	curated-complex:"The SARS-CoV-2 coronavirus 3'-5' exoribonuclease complex which strictly targets double-stranded RNA and can selectively remove a mismatched ribonucleotide at the 3'-end of a dsRNA substrate. Formation of the NSP10-NSP14 complex strongly enhances the exonuclease activity of the bifunctional NSP14 and enhances the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase. May bind to, and act with the nsp7/nsp8/nsp12 polymerase complex (CPX-5742). Proof-reading exonuclease activity may explain why coronaviruses have the largest RNA genomes known to date. Complex formation does not appear to effect the C-terminal N7-methyltransferase activity of NSP14 involved in RNA cap modification."|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation. A flexible N-terminal domain of NSP14 forms the NSP10 docking site and induces conformational changes in the NSP14 that modulate the distance between the catalytic residues.	figure legend:Supp. figure  1A,2A|comment:"nsp8 co-eluted with the nsp10-nsp14-RNA complex on the SEC column:association of nsp8 with the nsp10-nsp14-RNA complex is weak."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/01	2021/08/10	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	-	-	false	his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)