#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048461|imex:IM-29152-1 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:1C, Supp. figure 1E|comment:Nearly all triubiquitin is cleaved by Nsp3 core after 15 mins whereas a significant portion is still to be cleaved by PLpro.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c|mutation disrupting interaction rate:856-856 cross linker:48-48 - 3 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048537|imex:IM-29152-3 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:1C, Supp. figure 3C.|comment:Nearly all triubiquitin is cleaved by Nsp3 core after 15 mins whereas a significant portion is still to be cleaved by PLpro.|comment:"An \"S1\" PLpro mutant (E912R E948R M953E Y1013K) with an N-terminal Avi-tag did not cleave the Ubiquitin trimer."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:743-1072 cross linker:48-48 - 3 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048640|imex:IM-29152-7 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:1F|comment:Nsp3 retains its specificity for cleaving K48-linked polyubiquitin and does not cleave any of the other polyubiquitin linkages tested.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c cross linker:48-48 - 4 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-26584224 intact:EBI-25492388 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051188|imex:IM-29152-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:3 E/F|comment:GRL-0617 inhibits Nsp3 core with an IC 50 of 3.39 uM; the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:179-1329|strep tag:n-n|his tag:c-c - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" intact:EBI-4399559 intact:EBI-26584224 dip:DIP-24261N psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051188|imex:IM-29152-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - - no-uniprot-update: figure legend:3 E/F|comment:GRL-0617 inhibits Nsp3 core with an IC 50 of 3.39 uM; the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 - false - cross linker:48-48 - 3 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-26584224 intact:EBI-25492388 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051205|imex:IM-29152-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:3 D/F|comment:Only GRL-0617 showed any effects of inhibiting PLpro in cells.|comment:GRL-0617 inhibits SARS-CoV-2 PLpro with an IC 50 of 2.21 uM;the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:743-1072 - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" intact:EBI-4399559 intact:EBI-26584224 dip:DIP-24261N psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051205|imex:IM-29152-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - - no-uniprot-update: figure legend:3 D/F|comment:Only GRL-0617 showed any effects of inhibiting PLpro in cells.|comment:GRL-0617 inhibits SARS-CoV-2 PLpro with an IC 50 of 2.21 uM;the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 - false - cross linker:48-48 - 3 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051284|imex:IM-29152-13 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:Supp. figure 1B|comment:DUB assay showing that the polyubiquitin linkage specificity of PLpro is limited to K48..|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:743-1072 cross linker:48-48 - 4 psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P05161 intact:EBI-25492388 intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048522|imex:IM-29152-21 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N - chain-seq-start:819|chain-seq-end:2763 - figure legend:1C|comment:Nsp3 core cleaves most of the pro-ISG15 by 15 minutes while only ~50% is cleaved by PLpro.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606 rigid:sAbJ18A/aEiem/M8llIq8nKXmD4 false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P05161 intact:EBI-25492388 intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048555|imex:IM-29152-5 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N - chain-seq-start:819|chain-seq-end:2763 - figure legend:1C|comment:Nsp3 core cleaves most of the pro-ISG15 by 15 minutes while only ~50% is cleaved by PLpro.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606 rigid:sAbJ18A/aEiem/M8llIq8nKXmD4 false sufficient binding region:743-1072 - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P0DTD1 intact:EBI-25492388 intact:EBI-25492095 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:r1ab_sars2(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048613|imex:IM-29152-25 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) rcsb pdb:7LZY|rcsb pdb:7LZZ|rcsb pdb:7M00|rcsb pdb:7M01|rcsb pdb:7M02|rcsb pdb:7M03|rcsb pdb:7M04|rcsb pdb:7M8M|rcsb pdb:7M8N|rcsb pdb:7M8O|rcsb pdb:7M8P|rcsb pdb:7M8X|rcsb pdb:7M8Y|rcsb pdb:7M8Z|rcsb pdb:7M90|rcsb pdb:7M91|rcsb pdb:7MBG|rcsb pdb:7MC5|rcsb pdb:7MC6|rcsb pdb:7ME0|rcsb pdb:7MGR|rcsb pdb:7MGS|rcsb pdb:7MHF|rcsb pdb:7MHG|rcsb pdb:7LKD|rcsb pdb:7LKE|rcsb pdb:7LW3|rcsb pdb:7LW4|rcsb pdb:7LYH|rcsb pdb:7LYI|rcsb pdb:7LZT|rcsb pdb:7LZU|rcsb pdb:7LZV|rcsb pdb:7LZW|rcsb pdb:7LZX|rcsb pdb:7MHH|rcsb pdb:7MHI|rcsb pdb:7MHJ|rcsb pdb:7MHK|rcsb pdb:7MHL|rcsb pdb:7MHM|rcsb pdb:7MHN|rcsb pdb:7MHO|rcsb pdb:7MHP|rcsb pdb:7MHQ|rcsb pdb:7MNG|rcsb pdb:7MPB|rcsb pdb:7MRR|rcsb pdb:7MSW|rcsb pdb:7MSX|rcsb pdb:7N06|rcsb pdb:7N33|rcsb pdb:7N5Z|rcsb pdb:7N6N|rcsb pdb:7N89|rcsb pdb:7N8C|rcsb pdb:7NF5|rcsb pdb:7NG3|rcsb pdb:7NG6|rcsb pdb:7NIO|rcsb pdb:7NN0|rcsb pdb:7NNG|rcsb pdb:7O7Y|rcsb pdb:7O7Z|rcsb pdb:7O80|rcsb pdb:7O81|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:5ROB|rcsb pdb:5SA4|rcsb pdb:5SA5|rcsb pdb:5SA6|rcsb pdb:5SA7|rcsb pdb:7BAL|rcsb pdb:7CA8|rcsb pdb:7CAM|rcsb pdb:7CB7|rcsb pdb:7CUT|rcsb pdb:7CUU|rcsb pdb:7D7K|rcsb pdb:7D7L|rcsb pdb:7DIY|rcsb pdb:7E18|rcsb pdb:7E19|rcsb pdb:7EQ4|rcsb pdb:7JSU|rcsb pdb:7JT0|rcsb pdb:7JT7|rcsb pdb:5SA8|rcsb pdb:5SA9|rcsb pdb:5SAA|rcsb pdb:5SAB|rcsb pdb:5SAC|rcsb pdb:5SAD|rcsb pdb:5SAE|rcsb pdb:5SAF|rcsb pdb:5SAG|rcsb pdb:5SAH|rcsb pdb:5SAI|rcsb pdb:7BAJ|rcsb pdb:7BAK|rcsb pdb:7JW8|rcsb pdb:7K0R|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044174"(host cell endosome)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|rcsb pdb:7BQY|rcsb pdb:7BRO|rcsb pdb:7BRP|rcsb pdb:7BTF|rcsb pdb:7BUY|rcsb pdb:7BV1|rcsb pdb:7BV2|refseq:YP_009724389.1|rcsb pdb:6YZ1|rcsb pdb:6WOJ|rcsb pdb:6WNP|rcsb pdb:6WQ3|rcsb pdb:6WQD|rcsb pdb:6WQF|rcsb pdb:6WRH|rcsb pdb:6WRZ|rcsb pdb:6WTC|rcsb pdb:6WTJ|rcsb pdb:6WTK|rcsb pdb:6WTM|rcsb pdb:6WTT|rcsb pdb:6WUU|rcsb pdb:6WVN|rcsb pdb:6WX4|rcsb pdb:6WXC|rcsb pdb:6WXD|rcsb pdb:6YNQ|rcsb pdb:6YVA|rcsb pdb:6YVF|rcsb pdb:6YWK|rcsb pdb:6YWL|rcsb pdb:6YWM|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|rcsb pdb:5R8T|rcsb pdb:5RG1|rcsb pdb:5RG2|rcsb pdb:5RG3|rcsb pdb:5RGG|rcsb pdb:5RGH|rcsb pdb:5RGI|rcsb pdb:5RGJ|rcsb pdb:5RGK|rcsb pdb:5RGL|rcsb pdb:5RGM|rcsb pdb:5RGN|rcsb pdb:5RGO|rcsb pdb:5RGP|rcsb pdb:5RGQ|rcsb pdb:5RGR|rcsb pdb:5RGS|rcsb pdb:6LZE|rcsb pdb:6M0K|rcsb pdb:6M2N|rcsb pdb:6M2Q|rcsb pdb:6M71|rcsb pdb:6VXS|rcsb pdb:6W4B|rcsb pdb:6W4H|rcsb pdb:6W9C|rcsb pdb:6W9Q|rcsb pdb:6WCF|rcsb pdb:6WEN|rcsb pdb:6WEY|rcsb pdb:6WIQ|rcsb pdb:6WJT|rcsb pdb:6WKQ|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|rcsb pdb:6WKS|rcsb pdb:6WLC|rcsb pdb:7AQE|rcsb pdb:7BB2|rcsb pdb:7BE7|rcsb pdb:7BFB|rcsb pdb:7BGP|rcsb pdb:7JST|rcsb pdb:7K0F|rcsb pdb:7KXB|rcsb pdb:7L0D|rcsb pdb:7L10|rcsb pdb:7L11|rcsb pdb:7L12|rcsb pdb:7L13|rcsb pdb:5RV6|rcsb pdb:5RV7|rcsb pdb:5RV8|rcsb pdb:5RV9|rcsb pdb:5RVA|rcsb pdb:5RVB|rcsb pdb:5RVC|rcsb pdb:5RVD|rcsb pdb:5RVE|rcsb pdb:5RVF|rcsb pdb:5RVG|rcsb pdb:5RVH|rcsb pdb:5RVI|rcsb pdb:5RVJ|rcsb pdb:5RVK|rcsb pdb:5RVL|rcsb pdb:5RVM|rcsb pdb:5RVN|rcsb pdb:5RVO|rcsb pdb:5RVP|rcsb pdb:5RVQ|rcsb pdb:5RVR|rcsb pdb:5RVS|rcsb pdb:5RVT|rcsb pdb:5RVU|rcsb pdb:5RV1|rcsb pdb:5RVV|rcsb pdb:5S18|rcsb pdb:5S1A|rcsb pdb:5S1C|rcsb pdb:5S1E|rcsb pdb:5S1G|rcsb pdb:5RV2|rcsb pdb:5RV3|rcsb pdb:5RV4|rcsb pdb:5S1I|rcsb pdb:5RV5|rcsb pdb:5S1K|rcsb pdb:5S1M|rcsb pdb:5S1O|rcsb pdb:5S1Q|rcsb pdb:7BF6|rcsb pdb:7JPY|rcsb pdb:7JPZ|rcsb pdb:7JQ0|rcsb pdb:7JQ1|rcsb pdb:7JQ2|rcsb pdb:7JQ3|rcsb pdb:7JQ4|rcsb pdb:7JQ5|rcsb pdb:7JQB|rcsb pdb:7BF5|rcsb pdb:7JQC|rcsb pdb:7KEG|rcsb pdb:7KEH|rcsb pdb:7KF4|rcsb pdb:7KOA|rcsb pdb:7KPH|rcsb pdb:7KQO|rcsb pdb:7KQP|rcsb pdb:7KQW|rcsb pdb:7KR0|rcsb pdb:7KR1|rcsb pdb:7KVL|rcsb pdb:7KVR|rcsb pdb:7KX5|rcsb pdb:7KYU|rcsb pdb:7L5D|rcsb pdb:7L6R|rcsb pdb:7L6T|rcsb pdb:7LDX|rcsb pdb:7L14|rcsb pdb:5S1U|rcsb pdb:5S1W|rcsb pdb:5S1Y|rcsb pdb:5S20|rcsb pdb:5S22|rcsb pdb:5S24|rcsb pdb:5S26|rcsb pdb:5S27|rcsb pdb:5S28|rcsb pdb:5S29|rcsb pdb:5S2A|rcsb pdb:5S2B|rcsb pdb:5S2C|rcsb pdb:5S2D|rcsb pdb:5S2E|rcsb pdb:5S2F|rcsb pdb:5S2G|rcsb pdb:5S2H|rcsb pdb:5S2I|rcsb pdb:5S2J|rcsb pdb:5S2K|rcsb pdb:5S2L|rcsb pdb:5S2M|rcsb pdb:5S2N|rcsb pdb:5S1S|rcsb pdb:5S2O|rcsb pdb:5S2P|rcsb pdb:5S2Q|rcsb pdb:5S2R|rcsb pdb:5S2S|rcsb pdb:5S2T|rcsb pdb:5S2U|rcsb pdb:5S2V|rcsb pdb:5S2W|rcsb pdb:5S2X|rcsb pdb:5S2Y|rcsb pdb:5S2Z|rcsb pdb:5S30|rcsb pdb:5S31|rcsb pdb:5S32|rcsb pdb:5S33|rcsb pdb:5S34|rcsb pdb:5S35|rcsb pdb:5S36|rcsb pdb:5S37|rcsb pdb:5S38|rcsb pdb:5S39|rcsb pdb:5S3A|rcsb pdb:5S3B|interpro:IPR027352|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044389|interpro:IPR044401|rcsb pdb:5RL1|rcsb pdb:5RL2|rcsb pdb:5RL3|rcsb pdb:5RL0|rcsb pdb:5RL4|rcsb pdb:5RL5|rcsb pdb:5RS7|rcsb pdb:5RS8|rcsb pdb:5RS9|rcsb pdb:5RSB|rcsb pdb:5RSC|rcsb pdb:5RSD|rcsb pdb:5RSE|rcsb pdb:5RSF|rcsb pdb:5RSG|rcsb pdb:5RSH|rcsb pdb:5RSI|rcsb pdb:5RSJ|rcsb pdb:5RSK|rcsb pdb:5RSL|rcsb pdb:5RSM|rcsb pdb:5RSN|rcsb pdb:5RSO|rcsb pdb:5RSP|rcsb pdb:5RSQ|rcsb pdb:5S3O|rcsb pdb:5S3P|rcsb pdb:5S3Q|rcsb pdb:5S3R|rcsb pdb:5S3S|rcsb pdb:5S3T|rcsb pdb:5S3U|rcsb pdb:5S3V|rcsb pdb:5S3W|rcsb pdb:5S3X|rcsb pdb:5S3Y|rcsb pdb:5S3Z|rcsb pdb:5S40|rcsb pdb:5S3C|rcsb pdb:5S41|rcsb pdb:5S42|rcsb pdb:5S43|rcsb pdb:5S44|rcsb pdb:5S45|rcsb pdb:5S46|rcsb pdb:5S47|rcsb pdb:5S48|rcsb pdb:5S3D|rcsb pdb:5S49|rcsb pdb:5S4A|rcsb pdb:5S3E|rcsb pdb:5S4B|rcsb pdb:5S4C|rcsb pdb:5S3F|rcsb pdb:5S3G|rcsb pdb:5S3H|rcsb pdb:5S3I|rcsb pdb:5S3J|rcsb pdb:5S3K|rcsb pdb:5S3L|rcsb pdb:5S4D|rcsb pdb:5S4E|rcsb pdb:5S4F|rcsb pdb:5S4G|rcsb pdb:5S4H|rcsb pdb:5S4I|rcsb pdb:5S4J|rcsb pdb:5S4K|rcsb pdb:5S6X|rcsb pdb:5S6Y|rcsb pdb:5S6Z|rcsb pdb:5S3M|rcsb pdb:5S3N|rcsb pdb:5S70|rcsb pdb:5S71|rcsb pdb:5RSR|rcsb pdb:5RSS|rcsb pdb:5RST|rcsb pdb:5RSU|rcsb pdb:5RSV|rcsb pdb:5RSW|rcsb pdb:5RSX|rcsb pdb:5RSY|rcsb pdb:5RSZ|rcsb pdb:5RT0|rcsb pdb:5RT1|rcsb pdb:5RT2|rcsb pdb:5RT3|rcsb pdb:5RT4|rcsb pdb:5RT5|rcsb pdb:5RT6|rcsb pdb:5RT7|rcsb pdb:5RT8|rcsb pdb:5RT9|rcsb pdb:5RTA|rcsb pdb:5RTB|rcsb pdb:5RTC|rcsb pdb:5RTD|rcsb pdb:5RTE|rcsb pdb:5RTF|rcsb pdb:5RTG|rcsb pdb:5RTH|rcsb pdb:7ALI|rcsb pdb:7AMJ|rcsb pdb:7ANS|rcsb pdb:7AP6|rcsb pdb:7APH|rcsb pdb:7AQI|rcsb pdb:7AQJ|rcsb pdb:7AR5|rcsb pdb:7AR6|rcsb pdb:5S72|rcsb pdb:5S73|rcsb pdb:5S74|rcsb pdb:6Z5T|rcsb pdb:6Z6I|rcsb pdb:6Z72|rcsb pdb:7A1U|rcsb pdb:7ABU|rcsb pdb:7ADW|rcsb pdb:7AF0|rcsb pdb:7AGA|rcsb pdb:7ARF|rcsb pdb:7AVD|rcsb pdb:7AWR|rcsb pdb:7AWS|rcsb pdb:7AWU|rcsb pdb:7AWW|rcsb pdb:7AX6|rcsb pdb:7AXM|rcsb pdb:7AXO|rcsb pdb:7AY7|rcsb pdb:7AHA|rcsb pdb:7AK4|rcsb pdb:7ALH|rcsb pdb:7B3E|rcsb pdb:7B83|rcsb pdb:7BF3|rcsb pdb:7BF4|rcsb pdb:5RTJ|rcsb pdb:5RTK|rcsb pdb:5RTL|rcsb pdb:5RTM|rcsb pdb:5RTN|rcsb pdb:5RTO|rcsb pdb:5RTP|rcsb pdb:5RTQ|rcsb pdb:5RTR|rcsb pdb:5RTS|rcsb pdb:5RTT|rcsb pdb:5RTI|rcsb pdb:5RTU|rcsb pdb:5RTV|rcsb pdb:5RTW|rcsb pdb:5RTX|rcsb pdb:5RTY|rcsb pdb:5RTZ|rcsb pdb:5RU0|rcsb pdb:5RU1|rcsb pdb:5RU2|rcsb pdb:5RU3|rcsb pdb:5RU4|rcsb pdb:5RU5|rcsb pdb:5RU6|rcsb pdb:5RU7|rcsb pdb:5RU8|rcsb pdb:5RU9|rcsb pdb:5RUA|rcsb pdb:5RUC|rcsb pdb:5RUD|rcsb pdb:5RUE|rcsb pdb:5RUF|rcsb pdb:5RUG|rcsb pdb:5RUH|rcsb pdb:5RUI|rcsb pdb:5RUJ|rcsb pdb:5RUK|rcsb pdb:5RUL|rcsb pdb:5RUM|rcsb pdb:5RUN|rcsb pdb:5RUO|rcsb pdb:5RUP|rcsb pdb:5RUQ|rcsb pdb:5RUR|rcsb pdb:5RUS|rcsb pdb:5RUT|rcsb pdb:5RUU|rcsb pdb:5RUV|rcsb pdb:5RUW|rcsb pdb:5RUX|rcsb pdb:5RUY|rcsb pdb:5RUZ|rcsb pdb:5RV0|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR029063|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR027417|interpro:IPR037227|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042515|interpro:IPR042570|rcsb pdb:6LU7|interpro:IPR037204|rcsb pdb:7LTJ|rcsb pdb:7NBR|rcsb pdb:7NBS|rcsb pdb:7NBY|rcsb pdb:7NEV|rcsb pdb:7NFV|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:5R7Y|rcsb pdb:5R7Z|rcsb pdb:5R80|rcsb pdb:5R81|rcsb pdb:5R82|rcsb pdb:5R83|rcsb pdb:5R84|rcsb pdb:5RE4|rcsb pdb:5RE5|rcsb pdb:5RE6|rcsb pdb:5RE7|rcsb pdb:5RE8|rcsb pdb:5RE9|rcsb pdb:5REA|rcsb pdb:5REB|rcsb pdb:5REC|rcsb pdb:5RED|rcsb pdb:5REE|rcsb pdb:5REF|rcsb pdb:5REG|rcsb pdb:5REH|rcsb pdb:5REI|rcsb pdb:5REJ|rcsb pdb:5REK|rcsb pdb:5REL|rcsb pdb:5REM|rcsb pdb:5REN|rcsb pdb:5REO|rcsb pdb:5REP|rcsb pdb:5RER|rcsb pdb:5RES|rcsb pdb:5RET|rcsb pdb:5REU|rcsb pdb:5REV|rcsb pdb:5REW|rcsb pdb:5REX|rcsb pdb:5REY|rcsb pdb:5REZ|rcsb pdb:5RF0|rcsb pdb:5RF1|rcsb pdb:5RF2|rcsb pdb:5RF3|rcsb pdb:5RF4|rcsb pdb:5RF5|rcsb pdb:5RF6|rcsb pdb:5RF7|rcsb pdb:5RF8|rcsb pdb:5RF9|rcsb pdb:5RFA|rcsb pdb:5RFB|rcsb pdb:5RFC|rcsb pdb:5RFD|rcsb pdb:5RFE|rcsb pdb:5RFF|rcsb pdb:5RFG|rcsb pdb:5RFH|rcsb pdb:5RFI|rcsb pdb:5RFJ|rcsb pdb:5RFK|rcsb pdb:5RFL|rcsb pdb:5RFM|rcsb pdb:5RFN|rcsb pdb:5RFO|rcsb pdb:5RFP|rcsb pdb:5RFQ|rcsb pdb:5RFR|rcsb pdb:5RFS|rcsb pdb:5RFT|rcsb pdb:5RFU|rcsb pdb:5RFV|rcsb pdb:5RFW|rcsb pdb:5RFX|rcsb pdb:5RFY|rcsb pdb:5RFZ|rcsb pdb:5RG0|rcsb pdb:6M03|rcsb pdb:6VWW|rcsb pdb:6W01|rcsb pdb:6W02|rcsb pdb:6W61|rcsb pdb:6W63|rcsb pdb:6W6Y|rcsb pdb:6W75|rcsb pdb:6Y2E|rcsb pdb:6Y2F|rcsb pdb:6Y2G|rcsb pdb:6Y84|rcsb pdb:6YB7|rcsb pdb:7LBS|rcsb pdb:7LFE|rcsb pdb:7L1F|rcsb pdb:7LB7|rcsb pdb:7LBN|rcsb pdb:7LFP|rcsb pdb:7LFZ|rcsb pdb:7LBR|rcsb pdb:7LG2|rcsb pdb:7LG3|rcsb pdb:7LG7|rcsb pdb:7LGO|rcsb pdb:7LKR|rcsb pdb:7LKS|rcsb pdb:7LKT|rcsb pdb:7LKU|rcsb pdb:7LKV|rcsb pdb:7LKW|rcsb pdb:7LKX|rcsb pdb:7LLF|rcsb pdb:7LLZ|rcsb pdb:7LOS|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR027351|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:5RGT|rcsb pdb:5RGU|rcsb pdb:5RGV|rcsb pdb:5RGW|rcsb pdb:5RGX|rcsb pdb:5RGY|rcsb pdb:5RGZ|rcsb pdb:5RH0|rcsb pdb:5RH1|rcsb pdb:5RH2|rcsb pdb:5RH3|rcsb pdb:5RH4|rcsb pdb:5RH5|rcsb pdb:5RH6|rcsb pdb:5RH7|rcsb pdb:5RH8|rcsb pdb:5RH9|rcsb pdb:5RHA|rcsb pdb:5RHB|rcsb pdb:5RHC|rcsb pdb:5RHD|rcsb pdb:5RHE|rcsb pdb:5RHF|rcsb pdb:6WZU|rcsb pdb:6X1B|rcsb pdb:6X4I|rcsb pdb:6XA4|rcsb pdb:6XA9|rcsb pdb:6XAA|rcsb pdb:6XB0|rcsb pdb:6XB1|rcsb pdb:6XB2|rcsb pdb:6XBG|rcsb pdb:6XBH|rcsb pdb:6XBI|rcsb pdb:6XCH|rcsb pdb:6XDH|rcsb pdb:6XFN|rcsb pdb:6XG3|rcsb pdb:6XHM|rcsb pdb:6XHU|rcsb pdb:6XIP|rcsb pdb:6XKF|rcsb pdb:6XKH|rcsb pdb:6XKM|rcsb pdb:6XMK|rcsb pdb:6XOA|rcsb pdb:6XQS|rcsb pdb:6XQT|rcsb pdb:6XQU|rcsb pdb:6YYT|rcsb pdb:6Z2E|rcsb pdb:6ZCT|rcsb pdb:6ZOJ|rcsb pdb:7BQ7|rcsb pdb:7C2I|rcsb pdb:7C2J|rcsb pdb:7C8R|rcsb pdb:7C8T|rcsb pdb:7C8U|rcsb pdb:6WC1|rcsb pdb:6XR3|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZN5|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZRT|rcsb pdb:6ZRU|rcsb pdb:6ZSL|rcsb pdb:7BZF|rcsb pdb:7C2K|rcsb pdb:7C2Q|rcsb pdb:7C2Y|rcsb pdb:7C6S|rcsb pdb:7C6U|rcsb pdb:7C7P|rcsb pdb:7C8B|rcsb pdb:7CBT|rcsb pdb:7CJD|rcsb pdb:7CJM|rcsb pdb:7CMD|rcsb pdb:7COM|rcsb pdb:7JFQ|rcsb pdb:7JHE|rcsb pdb:7JIB|rcsb pdb:7JME|rcsb pdb:7JPE|rcsb pdb:7JR3|rcsb pdb:7JR4|rcsb pdb:7JU7|rcsb pdb:7JUN|rcsb pdb:7JYC|rcsb pdb:5RL6|rcsb pdb:5RL7|rcsb pdb:5RL8|rcsb pdb:5RL9|rcsb pdb:5RLB|rcsb pdb:5RLC|rcsb pdb:5RLD|rcsb pdb:5RLE|rcsb pdb:5RLF|rcsb pdb:5RLG|rcsb pdb:5RLH|rcsb pdb:5RLI|rcsb pdb:5RLJ|rcsb pdb:5RLK|rcsb pdb:5RLL|rcsb pdb:5RLM|rcsb pdb:5RLN|rcsb pdb:5RLO|rcsb pdb:5RLP|rcsb pdb:5RLQ|rcsb pdb:5RLR|rcsb pdb:5RLS|rcsb pdb:5RLT|rcsb pdb:5RLU|rcsb pdb:5RLV|rcsb pdb:5RLW|rcsb pdb:5RLY|rcsb pdb:5RLZ|rcsb pdb:5RM0|rcsb pdb:5RM1|rcsb pdb:5RM2|rcsb pdb:5RM3|rcsb pdb:5RM4|rcsb pdb:5RM5|rcsb pdb:5RM6|rcsb pdb:5RM7|rcsb pdb:5RM8|rcsb pdb:5RM9|rcsb pdb:5RMA|rcsb pdb:5RMB|rcsb pdb:5RMC|rcsb pdb:5RMD|rcsb pdb:5RME|rcsb pdb:5RMF|rcsb pdb:5RMG|rcsb pdb:5RMH|rcsb pdb:5RMI|rcsb pdb:5RMJ|rcsb pdb:5RMK|rcsb pdb:5RML|rcsb pdb:5RMM|rcsb pdb:6ZPE|rcsb pdb:7AKU|rcsb pdb:7CWC|rcsb pdb:7CWB|rcsb pdb:7CX9|rcsb pdb:7D1M|rcsb pdb:7D1O|rcsb pdb:7JKV|rcsb pdb:7JOY|rcsb pdb:7JP1|rcsb pdb:7JVZ|rcsb pdb:7JYY|rcsb pdb:7JZ0|rcsb pdb:7K1L|rcsb pdb:7K1O|rcsb pdb:7K3N|rcsb pdb:7K3T|rcsb pdb:7K40|rcsb pdb:7K5I|rcsb pdb:7K6D|rcsb pdb:7K6E|rcsb pdb:7K7P|rcsb pdb:7K9P|rcsb pdb:7KAG|rcsb pdb:7KFI|rcsb pdb:7KG3|rcsb pdb:7KHP|reactome:R-HSA-9694271|reactome:R-HSA-9694301|reactome:R-HSA-9694676|reactome:R-HSA-9694686|reactome:R-HSA-9694786 - chain-seq-start:819|chain-seq-end:2763 - figure legend:1E, Supp. figure 2D.|comment:PLpro is unable to cleave Nsp1-Nsp2 FL substrate, whereas Nsp3 core readily cleaves it.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:wCJ3ZPKZG00c5axKHF8thiOgR6Q2697049 rigid:MeW4B9eUKTAoq3dibSpiCBCKth8 false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c sufficient binding region:1-818 - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P05161 intact:EBI-26584224 intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051221|imex:IM-29152-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N - - - figure legend:3D|comment:GRL-0617 inhibits SARS-CoV-2 PLpro with an IC 50 of 2.21 uM;the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606 - false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-26584224 intact:EBI-25492388 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051221|imex:IM-29152-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:3D|comment:GRL-0617 inhibits SARS-CoV-2 PLpro with an IC 50 of 2.21 uM;the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:743-1072 - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P05161 intact:EBI-26584224 intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051243|imex:IM-29152-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N - - - figure legend:3E|comment:GRL-0617 inhibits Nsp3 core with an IC 50 of 3.39 uM; the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606 - false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-26584224 intact:EBI-25492388 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051243|imex:IM-29152-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:3E|comment:GRL-0617 inhibits Nsp3 core with an IC 50 of 3.39 uM; the substrate is not stated.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:179-1329|strep tag:n-n|his tag:c-c - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-26584224 intact:EBI-25492388 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051840|imex:IM-29152-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Supp. figure 2D.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:179-1329|strep tag:n-n|his tag:c-c - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) chebi:"CHEBI:167176" uniprotkb:P0DTD1 intact:EBI-26584224 intact:EBI-25492095 psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long) psi-mi:r1ab_sars2(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051840|imex:IM-29152-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - rcsb pdb:7LZY|rcsb pdb:7LZZ|rcsb pdb:7M00|rcsb pdb:7M01|rcsb pdb:7M02|rcsb pdb:7M03|rcsb pdb:7M04|rcsb pdb:7M8M|rcsb pdb:7M8N|rcsb pdb:7M8O|rcsb pdb:7M8P|rcsb pdb:7M8X|rcsb pdb:7M8Y|rcsb pdb:7M8Z|rcsb pdb:7M90|rcsb pdb:7M91|rcsb pdb:7MBG|rcsb pdb:7MC5|rcsb pdb:7MC6|rcsb pdb:7ME0|rcsb pdb:7MGR|rcsb pdb:7MGS|rcsb pdb:7MHF|rcsb pdb:7MHG|rcsb pdb:7LKD|rcsb pdb:7LKE|rcsb pdb:7LW3|rcsb pdb:7LW4|rcsb pdb:7LYH|rcsb pdb:7LYI|rcsb pdb:7LZT|rcsb pdb:7LZU|rcsb pdb:7LZV|rcsb pdb:7LZW|rcsb pdb:7LZX|rcsb pdb:7MHH|rcsb pdb:7MHI|rcsb pdb:7MHJ|rcsb pdb:7MHK|rcsb pdb:7MHL|rcsb pdb:7MHM|rcsb pdb:7MHN|rcsb pdb:7MHO|rcsb pdb:7MHP|rcsb pdb:7MHQ|rcsb pdb:7MNG|rcsb pdb:7MPB|rcsb pdb:7MRR|rcsb pdb:7MSW|rcsb pdb:7MSX|rcsb pdb:7N06|rcsb pdb:7N33|rcsb pdb:7N5Z|rcsb pdb:7N6N|rcsb pdb:7N89|rcsb pdb:7N8C|rcsb pdb:7NF5|rcsb pdb:7NG3|rcsb pdb:7NG6|rcsb pdb:7NIO|rcsb pdb:7NN0|rcsb pdb:7NNG|rcsb pdb:7O7Y|rcsb pdb:7O7Z|rcsb pdb:7O80|rcsb pdb:7O81|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:5ROB|rcsb pdb:5SA4|rcsb pdb:5SA5|rcsb pdb:5SA6|rcsb pdb:5SA7|rcsb pdb:7BAL|rcsb pdb:7CA8|rcsb pdb:7CAM|rcsb pdb:7CB7|rcsb pdb:7CUT|rcsb pdb:7CUU|rcsb pdb:7D7K|rcsb pdb:7D7L|rcsb pdb:7DIY|rcsb pdb:7E18|rcsb pdb:7E19|rcsb pdb:7EQ4|rcsb pdb:7JSU|rcsb pdb:7JT0|rcsb pdb:7JT7|rcsb pdb:5SA8|rcsb pdb:5SA9|rcsb pdb:5SAA|rcsb pdb:5SAB|rcsb pdb:5SAC|rcsb pdb:5SAD|rcsb pdb:5SAE|rcsb pdb:5SAF|rcsb pdb:5SAG|rcsb pdb:5SAH|rcsb pdb:5SAI|rcsb pdb:7BAJ|rcsb pdb:7BAK|rcsb pdb:7JW8|rcsb pdb:7K0R|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044174"(host cell endosome)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|rcsb pdb:7BQY|rcsb pdb:7BRO|rcsb pdb:7BRP|rcsb pdb:7BTF|rcsb pdb:7BUY|rcsb pdb:7BV1|rcsb pdb:7BV2|refseq:YP_009724389.1|rcsb pdb:6YZ1|rcsb pdb:6WOJ|rcsb pdb:6WNP|rcsb pdb:6WQ3|rcsb pdb:6WQD|rcsb pdb:6WQF|rcsb pdb:6WRH|rcsb pdb:6WRZ|rcsb pdb:6WTC|rcsb pdb:6WTJ|rcsb pdb:6WTK|rcsb pdb:6WTM|rcsb pdb:6WTT|rcsb pdb:6WUU|rcsb pdb:6WVN|rcsb pdb:6WX4|rcsb pdb:6WXC|rcsb pdb:6WXD|rcsb pdb:6YNQ|rcsb pdb:6YVA|rcsb pdb:6YVF|rcsb pdb:6YWK|rcsb pdb:6YWL|rcsb pdb:6YWM|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|rcsb pdb:5R8T|rcsb pdb:5RG1|rcsb pdb:5RG2|rcsb pdb:5RG3|rcsb pdb:5RGG|rcsb pdb:5RGH|rcsb pdb:5RGI|rcsb pdb:5RGJ|rcsb pdb:5RGK|rcsb pdb:5RGL|rcsb pdb:5RGM|rcsb pdb:5RGN|rcsb pdb:5RGO|rcsb pdb:5RGP|rcsb pdb:5RGQ|rcsb pdb:5RGR|rcsb pdb:5RGS|rcsb pdb:6LZE|rcsb pdb:6M0K|rcsb pdb:6M2N|rcsb pdb:6M2Q|rcsb pdb:6M71|rcsb pdb:6VXS|rcsb pdb:6W4B|rcsb pdb:6W4H|rcsb pdb:6W9C|rcsb pdb:6W9Q|rcsb pdb:6WCF|rcsb pdb:6WEN|rcsb pdb:6WEY|rcsb pdb:6WIQ|rcsb pdb:6WJT|rcsb pdb:6WKQ|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|rcsb pdb:6WKS|rcsb pdb:6WLC|rcsb pdb:7AQE|rcsb pdb:7BB2|rcsb pdb:7BE7|rcsb pdb:7BFB|rcsb pdb:7BGP|rcsb pdb:7JST|rcsb pdb:7K0F|rcsb pdb:7KXB|rcsb pdb:7L0D|rcsb pdb:7L10|rcsb pdb:7L11|rcsb pdb:7L12|rcsb pdb:7L13|rcsb pdb:5RV6|rcsb pdb:5RV7|rcsb pdb:5RV8|rcsb pdb:5RV9|rcsb pdb:5RVA|rcsb pdb:5RVB|rcsb pdb:5RVC|rcsb pdb:5RVD|rcsb pdb:5RVE|rcsb pdb:5RVF|rcsb pdb:5RVG|rcsb pdb:5RVH|rcsb pdb:5RVI|rcsb pdb:5RVJ|rcsb pdb:5RVK|rcsb pdb:5RVL|rcsb pdb:5RVM|rcsb pdb:5RVN|rcsb pdb:5RVO|rcsb pdb:5RVP|rcsb pdb:5RVQ|rcsb pdb:5RVR|rcsb pdb:5RVS|rcsb pdb:5RVT|rcsb pdb:5RVU|rcsb pdb:5RV1|rcsb pdb:5RVV|rcsb pdb:5S18|rcsb pdb:5S1A|rcsb pdb:5S1C|rcsb pdb:5S1E|rcsb pdb:5S1G|rcsb pdb:5RV2|rcsb pdb:5RV3|rcsb pdb:5RV4|rcsb pdb:5S1I|rcsb pdb:5RV5|rcsb pdb:5S1K|rcsb pdb:5S1M|rcsb pdb:5S1O|rcsb pdb:5S1Q|rcsb pdb:7BF6|rcsb pdb:7JPY|rcsb pdb:7JPZ|rcsb pdb:7JQ0|rcsb pdb:7JQ1|rcsb pdb:7JQ2|rcsb pdb:7JQ3|rcsb pdb:7JQ4|rcsb pdb:7JQ5|rcsb pdb:7JQB|rcsb pdb:7BF5|rcsb pdb:7JQC|rcsb pdb:7KEG|rcsb pdb:7KEH|rcsb pdb:7KF4|rcsb pdb:7KOA|rcsb pdb:7KPH|rcsb pdb:7KQO|rcsb pdb:7KQP|rcsb pdb:7KQW|rcsb pdb:7KR0|rcsb pdb:7KR1|rcsb pdb:7KVL|rcsb pdb:7KVR|rcsb pdb:7KX5|rcsb pdb:7KYU|rcsb pdb:7L5D|rcsb pdb:7L6R|rcsb pdb:7L6T|rcsb pdb:7LDX|rcsb pdb:7L14|rcsb pdb:5S1U|rcsb pdb:5S1W|rcsb pdb:5S1Y|rcsb pdb:5S20|rcsb pdb:5S22|rcsb pdb:5S24|rcsb pdb:5S26|rcsb pdb:5S27|rcsb pdb:5S28|rcsb pdb:5S29|rcsb pdb:5S2A|rcsb pdb:5S2B|rcsb pdb:5S2C|rcsb pdb:5S2D|rcsb pdb:5S2E|rcsb pdb:5S2F|rcsb pdb:5S2G|rcsb pdb:5S2H|rcsb pdb:5S2I|rcsb pdb:5S2J|rcsb pdb:5S2K|rcsb pdb:5S2L|rcsb pdb:5S2M|rcsb pdb:5S2N|rcsb pdb:5S1S|rcsb pdb:5S2O|rcsb pdb:5S2P|rcsb pdb:5S2Q|rcsb pdb:5S2R|rcsb pdb:5S2S|rcsb pdb:5S2T|rcsb pdb:5S2U|rcsb pdb:5S2V|rcsb pdb:5S2W|rcsb pdb:5S2X|rcsb pdb:5S2Y|rcsb pdb:5S2Z|rcsb pdb:5S30|rcsb pdb:5S31|rcsb pdb:5S32|rcsb pdb:5S33|rcsb pdb:5S34|rcsb pdb:5S35|rcsb pdb:5S36|rcsb pdb:5S37|rcsb pdb:5S38|rcsb pdb:5S39|rcsb pdb:5S3A|rcsb pdb:5S3B|interpro:IPR027352|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044389|interpro:IPR044401|rcsb pdb:5RL1|rcsb pdb:5RL2|rcsb pdb:5RL3|rcsb pdb:5RL0|rcsb pdb:5RL4|rcsb pdb:5RL5|rcsb pdb:5RS7|rcsb pdb:5RS8|rcsb pdb:5RS9|rcsb pdb:5RSB|rcsb pdb:5RSC|rcsb pdb:5RSD|rcsb pdb:5RSE|rcsb pdb:5RSF|rcsb pdb:5RSG|rcsb pdb:5RSH|rcsb pdb:5RSI|rcsb pdb:5RSJ|rcsb pdb:5RSK|rcsb pdb:5RSL|rcsb pdb:5RSM|rcsb pdb:5RSN|rcsb pdb:5RSO|rcsb pdb:5RSP|rcsb pdb:5RSQ|rcsb pdb:5S3O|rcsb pdb:5S3P|rcsb pdb:5S3Q|rcsb pdb:5S3R|rcsb pdb:5S3S|rcsb pdb:5S3T|rcsb pdb:5S3U|rcsb pdb:5S3V|rcsb pdb:5S3W|rcsb pdb:5S3X|rcsb pdb:5S3Y|rcsb pdb:5S3Z|rcsb pdb:5S40|rcsb pdb:5S3C|rcsb pdb:5S41|rcsb pdb:5S42|rcsb pdb:5S43|rcsb pdb:5S44|rcsb pdb:5S45|rcsb pdb:5S46|rcsb pdb:5S47|rcsb pdb:5S48|rcsb pdb:5S3D|rcsb pdb:5S49|rcsb pdb:5S4A|rcsb pdb:5S3E|rcsb pdb:5S4B|rcsb pdb:5S4C|rcsb pdb:5S3F|rcsb pdb:5S3G|rcsb pdb:5S3H|rcsb pdb:5S3I|rcsb pdb:5S3J|rcsb pdb:5S3K|rcsb pdb:5S3L|rcsb pdb:5S4D|rcsb pdb:5S4E|rcsb pdb:5S4F|rcsb pdb:5S4G|rcsb pdb:5S4H|rcsb pdb:5S4I|rcsb pdb:5S4J|rcsb pdb:5S4K|rcsb pdb:5S6X|rcsb pdb:5S6Y|rcsb pdb:5S6Z|rcsb pdb:5S3M|rcsb pdb:5S3N|rcsb pdb:5S70|rcsb pdb:5S71|rcsb pdb:5RSR|rcsb pdb:5RSS|rcsb pdb:5RST|rcsb pdb:5RSU|rcsb pdb:5RSV|rcsb pdb:5RSW|rcsb pdb:5RSX|rcsb pdb:5RSY|rcsb pdb:5RSZ|rcsb pdb:5RT0|rcsb pdb:5RT1|rcsb pdb:5RT2|rcsb pdb:5RT3|rcsb pdb:5RT4|rcsb pdb:5RT5|rcsb pdb:5RT6|rcsb pdb:5RT7|rcsb pdb:5RT8|rcsb pdb:5RT9|rcsb pdb:5RTA|rcsb pdb:5RTB|rcsb pdb:5RTC|rcsb pdb:5RTD|rcsb pdb:5RTE|rcsb pdb:5RTF|rcsb pdb:5RTG|rcsb pdb:5RTH|rcsb pdb:7ALI|rcsb pdb:7AMJ|rcsb pdb:7ANS|rcsb pdb:7AP6|rcsb pdb:7APH|rcsb pdb:7AQI|rcsb pdb:7AQJ|rcsb pdb:7AR5|rcsb pdb:7AR6|rcsb pdb:5S72|rcsb pdb:5S73|rcsb pdb:5S74|rcsb pdb:6Z5T|rcsb pdb:6Z6I|rcsb pdb:6Z72|rcsb pdb:7A1U|rcsb pdb:7ABU|rcsb pdb:7ADW|rcsb pdb:7AF0|rcsb pdb:7AGA|rcsb pdb:7ARF|rcsb pdb:7AVD|rcsb pdb:7AWR|rcsb pdb:7AWS|rcsb pdb:7AWU|rcsb pdb:7AWW|rcsb pdb:7AX6|rcsb pdb:7AXM|rcsb pdb:7AXO|rcsb pdb:7AY7|rcsb pdb:7AHA|rcsb pdb:7AK4|rcsb pdb:7ALH|rcsb pdb:7B3E|rcsb pdb:7B83|rcsb pdb:7BF3|rcsb pdb:7BF4|rcsb pdb:5RTJ|rcsb pdb:5RTK|rcsb pdb:5RTL|rcsb pdb:5RTM|rcsb pdb:5RTN|rcsb pdb:5RTO|rcsb pdb:5RTP|rcsb pdb:5RTQ|rcsb pdb:5RTR|rcsb pdb:5RTS|rcsb pdb:5RTT|rcsb pdb:5RTI|rcsb pdb:5RTU|rcsb pdb:5RTV|rcsb pdb:5RTW|rcsb pdb:5RTX|rcsb pdb:5RTY|rcsb pdb:5RTZ|rcsb pdb:5RU0|rcsb pdb:5RU1|rcsb pdb:5RU2|rcsb pdb:5RU3|rcsb pdb:5RU4|rcsb pdb:5RU5|rcsb pdb:5RU6|rcsb pdb:5RU7|rcsb pdb:5RU8|rcsb pdb:5RU9|rcsb pdb:5RUA|rcsb pdb:5RUC|rcsb pdb:5RUD|rcsb pdb:5RUE|rcsb pdb:5RUF|rcsb pdb:5RUG|rcsb pdb:5RUH|rcsb pdb:5RUI|rcsb pdb:5RUJ|rcsb pdb:5RUK|rcsb pdb:5RUL|rcsb pdb:5RUM|rcsb pdb:5RUN|rcsb pdb:5RUO|rcsb pdb:5RUP|rcsb pdb:5RUQ|rcsb pdb:5RUR|rcsb pdb:5RUS|rcsb pdb:5RUT|rcsb pdb:5RUU|rcsb pdb:5RUV|rcsb pdb:5RUW|rcsb pdb:5RUX|rcsb pdb:5RUY|rcsb pdb:5RUZ|rcsb pdb:5RV0|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR029063|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR027417|interpro:IPR037227|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042515|interpro:IPR042570|rcsb pdb:6LU7|interpro:IPR037204|rcsb pdb:7LTJ|rcsb pdb:7NBR|rcsb pdb:7NBS|rcsb pdb:7NBY|rcsb pdb:7NEV|rcsb pdb:7NFV|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:5R7Y|rcsb pdb:5R7Z|rcsb pdb:5R80|rcsb pdb:5R81|rcsb pdb:5R82|rcsb pdb:5R83|rcsb pdb:5R84|rcsb pdb:5RE4|rcsb pdb:5RE5|rcsb pdb:5RE6|rcsb pdb:5RE7|rcsb pdb:5RE8|rcsb pdb:5RE9|rcsb pdb:5REA|rcsb pdb:5REB|rcsb pdb:5REC|rcsb pdb:5RED|rcsb pdb:5REE|rcsb pdb:5REF|rcsb pdb:5REG|rcsb pdb:5REH|rcsb pdb:5REI|rcsb pdb:5REJ|rcsb pdb:5REK|rcsb pdb:5REL|rcsb pdb:5REM|rcsb pdb:5REN|rcsb pdb:5REO|rcsb pdb:5REP|rcsb pdb:5RER|rcsb pdb:5RES|rcsb pdb:5RET|rcsb pdb:5REU|rcsb pdb:5REV|rcsb pdb:5REW|rcsb pdb:5REX|rcsb pdb:5REY|rcsb pdb:5REZ|rcsb pdb:5RF0|rcsb pdb:5RF1|rcsb pdb:5RF2|rcsb pdb:5RF3|rcsb pdb:5RF4|rcsb pdb:5RF5|rcsb pdb:5RF6|rcsb pdb:5RF7|rcsb pdb:5RF8|rcsb pdb:5RF9|rcsb pdb:5RFA|rcsb pdb:5RFB|rcsb pdb:5RFC|rcsb pdb:5RFD|rcsb pdb:5RFE|rcsb pdb:5RFF|rcsb pdb:5RFG|rcsb pdb:5RFH|rcsb pdb:5RFI|rcsb pdb:5RFJ|rcsb pdb:5RFK|rcsb pdb:5RFL|rcsb pdb:5RFM|rcsb pdb:5RFN|rcsb pdb:5RFO|rcsb pdb:5RFP|rcsb pdb:5RFQ|rcsb pdb:5RFR|rcsb pdb:5RFS|rcsb pdb:5RFT|rcsb pdb:5RFU|rcsb pdb:5RFV|rcsb pdb:5RFW|rcsb pdb:5RFX|rcsb pdb:5RFY|rcsb pdb:5RFZ|rcsb pdb:5RG0|rcsb pdb:6M03|rcsb pdb:6VWW|rcsb pdb:6W01|rcsb pdb:6W02|rcsb pdb:6W61|rcsb pdb:6W63|rcsb pdb:6W6Y|rcsb pdb:6W75|rcsb pdb:6Y2E|rcsb pdb:6Y2F|rcsb pdb:6Y2G|rcsb pdb:6Y84|rcsb pdb:6YB7|rcsb pdb:7LBS|rcsb pdb:7LFE|rcsb pdb:7L1F|rcsb pdb:7LB7|rcsb pdb:7LBN|rcsb pdb:7LFP|rcsb pdb:7LFZ|rcsb pdb:7LBR|rcsb pdb:7LG2|rcsb pdb:7LG3|rcsb pdb:7LG7|rcsb pdb:7LGO|rcsb pdb:7LKR|rcsb pdb:7LKS|rcsb pdb:7LKT|rcsb pdb:7LKU|rcsb pdb:7LKV|rcsb pdb:7LKW|rcsb pdb:7LKX|rcsb pdb:7LLF|rcsb pdb:7LLZ|rcsb pdb:7LOS|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR027351|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:5RGT|rcsb pdb:5RGU|rcsb pdb:5RGV|rcsb pdb:5RGW|rcsb pdb:5RGX|rcsb pdb:5RGY|rcsb pdb:5RGZ|rcsb pdb:5RH0|rcsb pdb:5RH1|rcsb pdb:5RH2|rcsb pdb:5RH3|rcsb pdb:5RH4|rcsb pdb:5RH5|rcsb pdb:5RH6|rcsb pdb:5RH7|rcsb pdb:5RH8|rcsb pdb:5RH9|rcsb pdb:5RHA|rcsb pdb:5RHB|rcsb pdb:5RHC|rcsb pdb:5RHD|rcsb pdb:5RHE|rcsb pdb:5RHF|rcsb pdb:6WZU|rcsb pdb:6X1B|rcsb pdb:6X4I|rcsb pdb:6XA4|rcsb pdb:6XA9|rcsb pdb:6XAA|rcsb pdb:6XB0|rcsb pdb:6XB1|rcsb pdb:6XB2|rcsb pdb:6XBG|rcsb pdb:6XBH|rcsb pdb:6XBI|rcsb pdb:6XCH|rcsb pdb:6XDH|rcsb pdb:6XFN|rcsb pdb:6XG3|rcsb pdb:6XHM|rcsb pdb:6XHU|rcsb pdb:6XIP|rcsb pdb:6XKF|rcsb pdb:6XKH|rcsb pdb:6XKM|rcsb pdb:6XMK|rcsb pdb:6XOA|rcsb pdb:6XQS|rcsb pdb:6XQT|rcsb pdb:6XQU|rcsb pdb:6YYT|rcsb pdb:6Z2E|rcsb pdb:6ZCT|rcsb pdb:6ZOJ|rcsb pdb:7BQ7|rcsb pdb:7C2I|rcsb pdb:7C2J|rcsb pdb:7C8R|rcsb pdb:7C8T|rcsb pdb:7C8U|rcsb pdb:6WC1|rcsb pdb:6XR3|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZN5|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZRT|rcsb pdb:6ZRU|rcsb pdb:6ZSL|rcsb pdb:7BZF|rcsb pdb:7C2K|rcsb pdb:7C2Q|rcsb pdb:7C2Y|rcsb pdb:7C6S|rcsb pdb:7C6U|rcsb pdb:7C7P|rcsb pdb:7C8B|rcsb pdb:7CBT|rcsb pdb:7CJD|rcsb pdb:7CJM|rcsb pdb:7CMD|rcsb pdb:7COM|rcsb pdb:7JFQ|rcsb pdb:7JHE|rcsb pdb:7JIB|rcsb pdb:7JME|rcsb pdb:7JPE|rcsb pdb:7JR3|rcsb pdb:7JR4|rcsb pdb:7JU7|rcsb pdb:7JUN|rcsb pdb:7JYC|rcsb pdb:5RL6|rcsb pdb:5RL7|rcsb pdb:5RL8|rcsb pdb:5RL9|rcsb pdb:5RLB|rcsb pdb:5RLC|rcsb pdb:5RLD|rcsb pdb:5RLE|rcsb pdb:5RLF|rcsb pdb:5RLG|rcsb pdb:5RLH|rcsb pdb:5RLI|rcsb pdb:5RLJ|rcsb pdb:5RLK|rcsb pdb:5RLL|rcsb pdb:5RLM|rcsb pdb:5RLN|rcsb pdb:5RLO|rcsb pdb:5RLP|rcsb pdb:5RLQ|rcsb pdb:5RLR|rcsb pdb:5RLS|rcsb pdb:5RLT|rcsb pdb:5RLU|rcsb pdb:5RLV|rcsb pdb:5RLW|rcsb pdb:5RLY|rcsb pdb:5RLZ|rcsb pdb:5RM0|rcsb pdb:5RM1|rcsb pdb:5RM2|rcsb pdb:5RM3|rcsb pdb:5RM4|rcsb pdb:5RM5|rcsb pdb:5RM6|rcsb pdb:5RM7|rcsb pdb:5RM8|rcsb pdb:5RM9|rcsb pdb:5RMA|rcsb pdb:5RMB|rcsb pdb:5RMC|rcsb pdb:5RMD|rcsb pdb:5RME|rcsb pdb:5RMF|rcsb pdb:5RMG|rcsb pdb:5RMH|rcsb pdb:5RMI|rcsb pdb:5RMJ|rcsb pdb:5RMK|rcsb pdb:5RML|rcsb pdb:5RMM|rcsb pdb:6ZPE|rcsb pdb:7AKU|rcsb pdb:7CWC|rcsb pdb:7CWB|rcsb pdb:7CX9|rcsb pdb:7D1M|rcsb pdb:7D1O|rcsb pdb:7JKV|rcsb pdb:7JOY|rcsb pdb:7JP1|rcsb pdb:7JVZ|rcsb pdb:7JYY|rcsb pdb:7JZ0|rcsb pdb:7K1L|rcsb pdb:7K1O|rcsb pdb:7K3N|rcsb pdb:7K3T|rcsb pdb:7K40|rcsb pdb:7K5I|rcsb pdb:7K6D|rcsb pdb:7K6E|rcsb pdb:7K7P|rcsb pdb:7K9P|rcsb pdb:7KAG|rcsb pdb:7KFI|rcsb pdb:7KG3|rcsb pdb:7KHP|reactome:R-HSA-9694271|reactome:R-HSA-9694301|reactome:R-HSA-9694676|reactome:R-HSA-9694686|reactome:R-HSA-9694786 - - - figure legend:Supp. figure 2D.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 - rogid:wCJ3ZPKZG00c5axKHF8thiOgR6Q2697049 - false - sufficient binding region:1-818 - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:Q9HAQ2 intact:EBI-25492388 intact:EBI-8472129|intact:MINT-8417679|uniprotkb:Q9H8A4|uniprotkb:Q86Z28|ensembl:ENSP00000265529|ensembl:ENSP00000391100|ensembl:ENSP00000507186 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:kif9_human(display_long)|uniprotkb:KIF9(gene name)|psi-mi:KIF9(display_short) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:XP_011532306.1|refseq:NP_071737.1|refseq:NP_001128350.1|refseq:NP_878905.2|refseq:XP_016862518.1|ensembl:ENSG00000088727(gene)|ensembl:ENST00000265529(transcript)|ensembl:ENST00000452770(transcript)|ensembl:ENST00000684063(transcript)|go:"GO:0002102"(podosome)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:1903008"(organelle disassembly)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q9HAQ2|rcsb pdb:3NWN|reactome:R-HSA-6811434|reactome:R-HSA-983189 - chain-seq-start:819|chain-seq-end:2763 comment:mint|comment:homomint figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:53+NnzzIaB0e+FlgTdFXGvetKtg9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:O00571 intact:EBI-25492388 intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P42336 intact:EBI-25492388 intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648 - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P23193 intact:EBI-25492388 intact:EBI-2608271|uniprotkb:A6NF25|uniprotkb:A8K339|uniprotkb:Q15563|uniprotkb:Q6FG87|ensembl:ENSP00000428426 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:tcea1_human(display_long)|uniprotkb:TCEA1(gene name)|psi-mi:TCEA1(display_short)|uniprotkb:GTF2S(gene name synonym)|uniprotkb:TFIIS(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein 1(gene name synonym)|uniprotkb:Transcription elongation factor TFIIS.o(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_006747.1|refseq:NP_958845.1|ensembl:ENSG00000187735(gene)|ensembl:ENST00000521604(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901919"(positive regulation of exoribonuclease activity)|interpro:IPR001222(Zinc finger, TFIIS-type)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR003618(Transcription elongation factor S-II, central region)|interpro:IPR006289(Transcription elongation factor, TFIIS)|interpro:IPR017923|interpro:IPR035100|interpro:IPR035441|interpro:IPR036575|mint:P23193|reactome:R-HSA-167243|reactome:R-HSA-167246|rcsb pdb:1TFI|reactome:R-HSA-167287|rcsb pdb:3NDQ|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:6O9L|reactome:R-HSA-112382|reactome:R-HSA-167290|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-75955|dip:DIP-48480N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:88QvzePEd32tHYxrij2EoOYkaLk9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:Q14103 intact:EBI-25492388 intact:EBI-299674|ensembl:ENSP00000313199|uniprotkb:P07029|uniprotkb:Q01858|uniprotkb:Q14100|uniprotkb:Q14101|uniprotkb:Q14102|uniprotkb:Q4W5A1|uniprotkb:A8K9J2|uniprotkb:Q9UCE8|uniprotkb:Q9UCE9 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:hnrpd_human(display_long)|uniprotkb:HNRNPD(gene name)|psi-mi:HNRNPD(display_short)|uniprotkb:AUF1(gene name synonym)|uniprotkb:HNRPD(gene name synonym)|uniprotkb:AU-rich element RNA-binding protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) ensembl:ENSG00000138668(gene)|ensembl:ENST00000313899(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1901355"(response to rapamycin)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1904586"(cellular response to putrescine)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990828"(hepatocyte dedifferentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR035979|mint:Q14103|rcsb pdb:1HD0|rcsb pdb:1HD1|rcsb pdb:1IQT|rcsb pdb:1WTB|rcsb pdb:1X0F|rcsb pdb:2Z5N|rcsb pdb:5IM0|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|reactome:R-HSA-450408|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:NP_001003810.1|refseq:NP_002129.2|refseq:NP_112737.1|refseq:NP_112738.1|dip:DIP-31163N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:LrC0nOpN6jGn3WELs5NEOccNPnw9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P23528 intact:EBI-25492388 intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:O14657 intact:EBI-25492388 intact:EBI-2564400|ensembl:ENSP00000259339 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:tor1b_human(display_long)|uniprotkb:TOR1B(gene name)|psi-mi:TOR1B(display_short)|uniprotkb:DQ1(gene name synonym)|uniprotkb:Torsin family 1 member B(gene name synonym)|uniprotkb:FKSG18(orf name)|uniprotkb:Torsin ATPase-1B(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_055321.1|refseq:NP_001304822.1|refseq:NP_001304823.1|ensembl:ENSG00000136816(gene)|ensembl:ENST00000259339(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0019894"(kinesin binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR010448(Torsin)|interpro:IPR017378(Torsin, subgroup)|interpro:IPR027417|interpro:IPR030550|reactome:R-HSA-8856825|dip:DIP-56930N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:fndSvHSKjI77izB7z7LdCyhmdbk9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P20742 intact:EBI-25492388 intact:EBI-11083133|uniprotkb:Q2NKL2|uniprotkb:A6ND27|uniprotkb:Q7M4N7|uniprotkb:Q15273|ensembl:ENSP00000261336 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:pzp_human(display_long)|uniprotkb:PZP(gene name)|psi-mi:PZP(display_short)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6(gene name synonym)|uniprotkb:CPAMD6(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) ensembl:ENSG00000126838(gene)|ensembl:ENST00000261336(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813 - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:1viNiqZApOWM5KvhoWk6KY0i0jI9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P47929 intact:EBI-25492388 intact:EBI-357504|ensembl:ENSP00000313571|ensembl:ENSP00000367891|ensembl:ENSP00000489395|ensembl:ENSP00000489582|uniprotkb:Q6IB87 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:leg7_human(display_long)|uniprotkb:LGALS7(gene name)|psi-mi:LGALS7(display_short)|uniprotkb:PIG1(gene name synonym)|uniprotkb:HKL-14(gene name synonym)|uniprotkb:PI7(gene name synonym)|uniprotkb:p53-induced gene 1 protein(gene name synonym)|uniprotkb:LGALS7B(gene name)|psi-mi:LGALS7B(display_short) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) ensembl:ENSG00000178934(gene)|ensembl:ENSG00000205076(gene)|ensembl:ENSG00000282902(gene)|ensembl:ENSG00000283082(gene)|ensembl:ENST00000314980(transcript)|ensembl:ENST00000378626(transcript)|ensembl:ENST00000634448(transcript)|ensembl:ENST00000634800(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016936"(galactoside binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030640|interpro:IPR044156|mint:P47929|rcsb pdb:1BKZ|rcsb pdb:2GAL|rcsb pdb:3GAL|rcsb pdb:3ZXE|rcsb pdb:3ZXF|rcsb pdb:4GAL|rcsb pdb:4UW3|rcsb pdb:4UW4|rcsb pdb:4UW5|rcsb pdb:4UW6|rcsb pdb:4XBQ|rcsb pdb:4Y26|rcsb pdb:5GAL|rcsb pdb:5H9Q|rcsb pdb:5H9S|refseq:NP_001035972.1|refseq:NP_002298.1 - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:TIAlvVZ7rOYqTAGrYAFbJY231gc9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P12829 intact:EBI-25492388 intact:EBI-1222789|uniprotkb:P11783|uniprotkb:D3DXJ7|ensembl:ENSP00000347055|ensembl:ENSP00000377096|ensembl:ENSP00000461570 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:myl4_human(display_long)|uniprotkb:MYL4(gene name)|psi-mi:MYL4(display_short)|uniprotkb:MLC1(gene name synonym)|uniprotkb:PRO1957(orf name)|uniprotkb:Myosin light chain 1, embryonic muscle/atrial isoform(gene name synonym)|uniprotkb:Myosin light chain alkali GT-1 isoform(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050247|imex:IM-29152-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001002841.1|refseq:NP_002467.1|refseq:XP_005257448.1|ensembl:ENSG00000198336(gene)|ensembl:ENST00000354968(transcript)|ensembl:ENST00000393450(transcript)|ensembl:ENST00000572316(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0016459"(myosin complex)|go:"GO:0031672"(A band)|go:"GO:0032038"(myosin II heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|reactome:R-HSA-390522 - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in PLpro pull downs are highlighted with Blue balls. (as shown here plus DDX3X)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:uoEY8vvAP2xDNz2TaBNrnxKFSGI9606 rigid:ebWADjj1Fa+PkLRCvBrkZmd1zZY false sufficient binding region:743-1072|strep tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:O00571 intact:EBI-25492388 intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:Q9Y6K5 intact:EBI-25492388 intact:EBI-6115729|uniprotkb:Q2HJ14|uniprotkb:Q9H3P5|ensembl:ENSP00000228928 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:oas3_human(display_long)|uniprotkb:OAS3(gene name)|psi-mi:OAS3(display_short)|uniprotkb:p100 OAS(gene name synonym)|uniprotkb:P/OKcl.4(orf name) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_006178.2|ensembl:ENSG00000111331(gene)|ensembl:ENST00000228928(transcript)|go:"GO:0001730"(2'-5'-oligoadenylate synthetase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035395"("negative regulation of chemokine (C-X-C motif) ligand 9 production")|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0060700"(regulation of ribonuclease activity)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR006116(2-5-oligoadenylate synthetase, ubiquitin-like region)|interpro:IPR006117(2-5-oligoadenylate synthetase, conserved site)|interpro:IPR018952|interpro:IPR026774|interpro:IPR043518|interpro:IPR043519|rcsb pdb:4S3N|reactome:R-HSA-877300|reactome:R-HSA-8983711|reactome:R-HSA-909733 - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:7/yDwZr/Wibns/WevqiaT7bCskY9606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:Q9Y3Z3 intact:EBI-25492388 intact:EBI-1054601|uniprotkb:Q5JXG8|uniprotkb:Q9H004|uniprotkb:Q9H005|uniprotkb:Q9H3U9|uniprotkb:B4E2A5|uniprotkb:Q8N491|uniprotkb:E1P5V2|ensembl:ENSP00000493536|ensembl:ENSP00000495667|ensembl:ENSP00000506877|ensembl:ENSP00000507178 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:samh1_human(display_long)|uniprotkb:Dendritic cell-derived IFNG-induced protein(gene name synonym)|uniprotkb:Monocyte protein 5(gene name synonym)|uniprotkb:SAMHD1(gene name)|psi-mi:SAMHD1(display_short)|uniprotkb:MOP5(gene name synonym)|uniprotkb:SAM domain and HD domain-containing protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_056289.2|refseq:XP_005260441.1|ensembl:ENSG00000101347(gene)|ensembl:ENST00000646673(transcript)|ensembl:ENST00000646869(transcript)|ensembl:ENST00000683766(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003676"(nucleic acid binding)|ensembl:ENST00000682773(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006203"(dGTP catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008832"(dGTPase activity)|go:"GO:0009264"(deoxyribonucleotide catabolic process)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016793"(triphosphoric monoester hydrolase activity)|go:"GO:0032567"(dGTP binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046061"(dATP catabolic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:0106375"(deoxynucleoside triphosphate hydrolase activity)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013761(Sterile alpha motif-type)|mint:Q9Y3Z3|rcsb pdb:2E8O|rcsb pdb:3U1N|rcsb pdb:4BZB|rcsb pdb:4BZC|rcsb pdb:4CC9|rcsb pdb:4MZ7|rcsb pdb:4Q7H|rcsb pdb:4QFX|rcsb pdb:4QFY|rcsb pdb:4QFZ|rcsb pdb:4QG0|rcsb pdb:4QG1|rcsb pdb:4QG2|rcsb pdb:4QG4|rcsb pdb:4RXO|rcsb pdb:4RXP|rcsb pdb:4RXQ|rcsb pdb:4RXR|rcsb pdb:4RXS|rcsb pdb:4TNP|rcsb pdb:4TNQ|rcsb pdb:4TNR|rcsb pdb:4TNX|rcsb pdb:4TNY|rcsb pdb:4TNZ|rcsb pdb:4TO0|rcsb pdb:4TO1|rcsb pdb:4TO2|rcsb pdb:4TO3|rcsb pdb:4TO4|rcsb pdb:4TO5|rcsb pdb:6DW4|rcsb pdb:6DW5|rcsb pdb:6DW7|rcsb pdb:6DWD|rcsb pdb:6DWJ|rcsb pdb:6DWK|rcsb pdb:6TX0|rcsb pdb:6TXA|rcsb pdb:6TXC|rcsb pdb:6TXE|rcsb pdb:6TXF|rcsb pdb:6U6X|rcsb pdb:6U6Y|rcsb pdb:6U6Z|rcsb pdb:6XU1|rcsb pdb:6YOM|rcsb pdb:7A5Y|reactome:R-HSA-8956319|rcsb pdb:4TO6|rcsb pdb:4ZWE|reactome:R-HSA-909733|rcsb pdb:4ZWG|rcsb pdb:5AO0|rcsb pdb:5AO1|rcsb pdb:5AO2|rcsb pdb:5AO3|rcsb pdb:5AO4|rcsb pdb:6CM2|rcsb pdb:6DW3|dip:DIP-50704N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:cxoMHFueO9JuBg2d0PoGCYoOwY09606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P51114 intact:EBI-25492388 intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P09913 intact:EBI-25492388 intact:EBI-3507167|uniprotkb:Q5T767|ensembl:ENSP00000360891|ensembl:ENSP00000490935|ensembl:ENSP00000505033|ensembl:ENSP00000506255 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ifit2_human(display_long)|uniprotkb:IFIT2(gene name)|psi-mi:IFIT2(display_short)|uniprotkb:G10P2(gene name synonym)|uniprotkb:IFI54(gene name synonym)|uniprotkb:ISG-54 K(gene name synonym)|uniprotkb:Interferon-induced 54 kDa protein(gene name synonym)|uniprotkb:CIG-42(gene name synonym)|uniprotkb:ISG54(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001538.4|ensembl:ENSG00000119922(gene)|ensembl:ENST00000371826(transcript)|ensembl:ENST00000638108(transcript)|ensembl:ENST00000680809(transcript)|ensembl:ENST00000680954(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009615"(response to virus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024124|rcsb pdb:4G1T|reactome:R-HSA-909733|dip:DIP-48848N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:uF6j55sUpUNfNPuLW2cq2vw9XHI9606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P09914 intact:EBI-25492388 intact:EBI-745117|uniprotkb:Q96QM5|intact:EBI-11024988|uniprotkb:B3KS50|uniprotkb:D3DR31|ensembl:ENSP00000360869|uniprotkb:Q5T7J1 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ifit1_human(display_long)|uniprotkb:Interferon-induced 56 kDa protein(gene name synonym)|uniprotkb:IFIT1(gene name)|psi-mi:IFIT1(display_short)|uniprotkb:G10P1(gene name synonym)|uniprotkb:IFI56(gene name synonym)|uniprotkb:IFNAI1(gene name synonym)|uniprotkb:ISG56(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001539.3|refseq:NP_001257857.1|refseq:NP_001257858.1|refseq:NP_001257859.1|ensembl:ENSG00000185745(gene)|ensembl:ENST00000371804(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009615"(response to virus)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043657"(host cell)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071357"(cellular response to type I interferon)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024121|mint:P09914|rcsb pdb:4HOU|rcsb pdb:5UDI|rcsb pdb:5UDJ|rcsb pdb:5UDK|rcsb pdb:5UDL|rcsb pdb:5W5H|rcsb pdb:5W5I|rcsb pdb:6C6K|reactome:R-HSA-1169408|reactome:R-HSA-909733|dip:DIP-37898N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:ANeil+D2pneKAoDFS4Vy97BHu8A9606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P33993 intact:EBI-25492388 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P05161 intact:EBI-25492388 intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym) psi-mi:"MI:0096"(pull down) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-27050631|imex:IM-29152-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N - chain-seq-start:819|chain-seq-end:2763 - figure legend:Figure 2 and text|comment:"Nsp3 DeltaTM and PLpro had a largely overlapping interactome, however most interactors cannot be identified from the figure 2. Interactors enriched in NSP3DeltaTM pull downs are highlighted with Red balls. (as shown here plus some from extra proteins from the text )."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606 rigid:i+7jdVxFjauSNWGlMk2e4F/2OzE false sufficient binding region:1-1329,1584-1944|strep tag:n-n|his tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P0DTD1 intact:EBI-25492388 intact:EBI-25492095 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:r1ab_sars2(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27048574|imex:IM-29152-23 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) rcsb pdb:7LZY|rcsb pdb:7LZZ|rcsb pdb:7M00|rcsb pdb:7M01|rcsb pdb:7M02|rcsb pdb:7M03|rcsb pdb:7M04|rcsb pdb:7M8M|rcsb pdb:7M8N|rcsb pdb:7M8O|rcsb pdb:7M8P|rcsb pdb:7M8X|rcsb pdb:7M8Y|rcsb pdb:7M8Z|rcsb pdb:7M90|rcsb pdb:7M91|rcsb pdb:7MBG|rcsb pdb:7MC5|rcsb pdb:7MC6|rcsb pdb:7ME0|rcsb pdb:7MGR|rcsb pdb:7MGS|rcsb pdb:7MHF|rcsb pdb:7MHG|rcsb pdb:7LKD|rcsb pdb:7LKE|rcsb pdb:7LW3|rcsb pdb:7LW4|rcsb pdb:7LYH|rcsb pdb:7LYI|rcsb pdb:7LZT|rcsb pdb:7LZU|rcsb pdb:7LZV|rcsb pdb:7LZW|rcsb pdb:7LZX|rcsb pdb:7MHH|rcsb pdb:7MHI|rcsb pdb:7MHJ|rcsb pdb:7MHK|rcsb pdb:7MHL|rcsb pdb:7MHM|rcsb pdb:7MHN|rcsb pdb:7MHO|rcsb pdb:7MHP|rcsb pdb:7MHQ|rcsb pdb:7MNG|rcsb pdb:7MPB|rcsb pdb:7MRR|rcsb pdb:7MSW|rcsb pdb:7MSX|rcsb pdb:7N06|rcsb pdb:7N33|rcsb pdb:7N5Z|rcsb pdb:7N6N|rcsb pdb:7N89|rcsb pdb:7N8C|rcsb pdb:7NF5|rcsb pdb:7NG3|rcsb pdb:7NG6|rcsb pdb:7NIO|rcsb pdb:7NN0|rcsb pdb:7NNG|rcsb pdb:7O7Y|rcsb pdb:7O7Z|rcsb pdb:7O80|rcsb pdb:7O81|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:5ROB|rcsb pdb:5SA4|rcsb pdb:5SA5|rcsb pdb:5SA6|rcsb pdb:5SA7|rcsb pdb:7BAL|rcsb pdb:7CA8|rcsb pdb:7CAM|rcsb pdb:7CB7|rcsb pdb:7CUT|rcsb pdb:7CUU|rcsb pdb:7D7K|rcsb pdb:7D7L|rcsb pdb:7DIY|rcsb pdb:7E18|rcsb pdb:7E19|rcsb pdb:7EQ4|rcsb pdb:7JSU|rcsb pdb:7JT0|rcsb pdb:7JT7|rcsb pdb:5SA8|rcsb pdb:5SA9|rcsb pdb:5SAA|rcsb pdb:5SAB|rcsb pdb:5SAC|rcsb pdb:5SAD|rcsb pdb:5SAE|rcsb pdb:5SAF|rcsb pdb:5SAG|rcsb pdb:5SAH|rcsb pdb:5SAI|rcsb pdb:7BAJ|rcsb pdb:7BAK|rcsb pdb:7JW8|rcsb pdb:7K0R|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044174"(host cell endosome)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|rcsb pdb:7BQY|rcsb pdb:7BRO|rcsb pdb:7BRP|rcsb pdb:7BTF|rcsb pdb:7BUY|rcsb pdb:7BV1|rcsb pdb:7BV2|refseq:YP_009724389.1|rcsb pdb:6YZ1|rcsb pdb:6WOJ|rcsb pdb:6WNP|rcsb pdb:6WQ3|rcsb pdb:6WQD|rcsb pdb:6WQF|rcsb pdb:6WRH|rcsb pdb:6WRZ|rcsb pdb:6WTC|rcsb pdb:6WTJ|rcsb pdb:6WTK|rcsb pdb:6WTM|rcsb pdb:6WTT|rcsb pdb:6WUU|rcsb pdb:6WVN|rcsb pdb:6WX4|rcsb pdb:6WXC|rcsb pdb:6WXD|rcsb pdb:6YNQ|rcsb pdb:6YVA|rcsb pdb:6YVF|rcsb pdb:6YWK|rcsb pdb:6YWL|rcsb pdb:6YWM|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|rcsb pdb:5R8T|rcsb pdb:5RG1|rcsb pdb:5RG2|rcsb pdb:5RG3|rcsb pdb:5RGG|rcsb pdb:5RGH|rcsb pdb:5RGI|rcsb pdb:5RGJ|rcsb pdb:5RGK|rcsb pdb:5RGL|rcsb pdb:5RGM|rcsb pdb:5RGN|rcsb pdb:5RGO|rcsb pdb:5RGP|rcsb pdb:5RGQ|rcsb pdb:5RGR|rcsb pdb:5RGS|rcsb pdb:6LZE|rcsb pdb:6M0K|rcsb pdb:6M2N|rcsb pdb:6M2Q|rcsb pdb:6M71|rcsb pdb:6VXS|rcsb pdb:6W4B|rcsb pdb:6W4H|rcsb pdb:6W9C|rcsb pdb:6W9Q|rcsb pdb:6WCF|rcsb pdb:6WEN|rcsb pdb:6WEY|rcsb pdb:6WIQ|rcsb pdb:6WJT|rcsb pdb:6WKQ|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|rcsb pdb:6WKS|rcsb pdb:6WLC|rcsb pdb:7AQE|rcsb pdb:7BB2|rcsb pdb:7BE7|rcsb pdb:7BFB|rcsb pdb:7BGP|rcsb pdb:7JST|rcsb pdb:7K0F|rcsb pdb:7KXB|rcsb pdb:7L0D|rcsb pdb:7L10|rcsb pdb:7L11|rcsb pdb:7L12|rcsb pdb:7L13|rcsb pdb:5RV6|rcsb pdb:5RV7|rcsb pdb:5RV8|rcsb pdb:5RV9|rcsb pdb:5RVA|rcsb pdb:5RVB|rcsb pdb:5RVC|rcsb pdb:5RVD|rcsb pdb:5RVE|rcsb pdb:5RVF|rcsb pdb:5RVG|rcsb pdb:5RVH|rcsb pdb:5RVI|rcsb pdb:5RVJ|rcsb pdb:5RVK|rcsb pdb:5RVL|rcsb pdb:5RVM|rcsb pdb:5RVN|rcsb pdb:5RVO|rcsb pdb:5RVP|rcsb pdb:5RVQ|rcsb pdb:5RVR|rcsb pdb:5RVS|rcsb pdb:5RVT|rcsb pdb:5RVU|rcsb pdb:5RV1|rcsb pdb:5RVV|rcsb pdb:5S18|rcsb pdb:5S1A|rcsb pdb:5S1C|rcsb pdb:5S1E|rcsb pdb:5S1G|rcsb pdb:5RV2|rcsb pdb:5RV3|rcsb pdb:5RV4|rcsb pdb:5S1I|rcsb pdb:5RV5|rcsb pdb:5S1K|rcsb pdb:5S1M|rcsb pdb:5S1O|rcsb pdb:5S1Q|rcsb pdb:7BF6|rcsb pdb:7JPY|rcsb pdb:7JPZ|rcsb pdb:7JQ0|rcsb pdb:7JQ1|rcsb pdb:7JQ2|rcsb pdb:7JQ3|rcsb pdb:7JQ4|rcsb pdb:7JQ5|rcsb pdb:7JQB|rcsb pdb:7BF5|rcsb pdb:7JQC|rcsb pdb:7KEG|rcsb pdb:7KEH|rcsb pdb:7KF4|rcsb pdb:7KOA|rcsb pdb:7KPH|rcsb pdb:7KQO|rcsb pdb:7KQP|rcsb pdb:7KQW|rcsb pdb:7KR0|rcsb pdb:7KR1|rcsb pdb:7KVL|rcsb pdb:7KVR|rcsb pdb:7KX5|rcsb pdb:7KYU|rcsb pdb:7L5D|rcsb pdb:7L6R|rcsb pdb:7L6T|rcsb pdb:7LDX|rcsb pdb:7L14|rcsb pdb:5S1U|rcsb pdb:5S1W|rcsb pdb:5S1Y|rcsb pdb:5S20|rcsb pdb:5S22|rcsb pdb:5S24|rcsb pdb:5S26|rcsb pdb:5S27|rcsb pdb:5S28|rcsb pdb:5S29|rcsb pdb:5S2A|rcsb pdb:5S2B|rcsb pdb:5S2C|rcsb pdb:5S2D|rcsb pdb:5S2E|rcsb pdb:5S2F|rcsb pdb:5S2G|rcsb pdb:5S2H|rcsb pdb:5S2I|rcsb pdb:5S2J|rcsb pdb:5S2K|rcsb pdb:5S2L|rcsb pdb:5S2M|rcsb pdb:5S2N|rcsb pdb:5S1S|rcsb pdb:5S2O|rcsb pdb:5S2P|rcsb pdb:5S2Q|rcsb pdb:5S2R|rcsb pdb:5S2S|rcsb pdb:5S2T|rcsb pdb:5S2U|rcsb pdb:5S2V|rcsb pdb:5S2W|rcsb pdb:5S2X|rcsb pdb:5S2Y|rcsb pdb:5S2Z|rcsb pdb:5S30|rcsb pdb:5S31|rcsb pdb:5S32|rcsb pdb:5S33|rcsb pdb:5S34|rcsb pdb:5S35|rcsb pdb:5S36|rcsb pdb:5S37|rcsb pdb:5S38|rcsb pdb:5S39|rcsb pdb:5S3A|rcsb pdb:5S3B|interpro:IPR027352|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044389|interpro:IPR044401|rcsb pdb:5RL1|rcsb pdb:5RL2|rcsb pdb:5RL3|rcsb pdb:5RL0|rcsb pdb:5RL4|rcsb pdb:5RL5|rcsb pdb:5RS7|rcsb pdb:5RS8|rcsb pdb:5RS9|rcsb pdb:5RSB|rcsb pdb:5RSC|rcsb pdb:5RSD|rcsb pdb:5RSE|rcsb pdb:5RSF|rcsb pdb:5RSG|rcsb pdb:5RSH|rcsb pdb:5RSI|rcsb pdb:5RSJ|rcsb pdb:5RSK|rcsb pdb:5RSL|rcsb pdb:5RSM|rcsb pdb:5RSN|rcsb pdb:5RSO|rcsb pdb:5RSP|rcsb pdb:5RSQ|rcsb pdb:5S3O|rcsb pdb:5S3P|rcsb pdb:5S3Q|rcsb pdb:5S3R|rcsb pdb:5S3S|rcsb pdb:5S3T|rcsb pdb:5S3U|rcsb pdb:5S3V|rcsb pdb:5S3W|rcsb pdb:5S3X|rcsb pdb:5S3Y|rcsb pdb:5S3Z|rcsb pdb:5S40|rcsb pdb:5S3C|rcsb pdb:5S41|rcsb pdb:5S42|rcsb pdb:5S43|rcsb pdb:5S44|rcsb pdb:5S45|rcsb pdb:5S46|rcsb pdb:5S47|rcsb pdb:5S48|rcsb pdb:5S3D|rcsb pdb:5S49|rcsb pdb:5S4A|rcsb pdb:5S3E|rcsb pdb:5S4B|rcsb pdb:5S4C|rcsb pdb:5S3F|rcsb pdb:5S3G|rcsb pdb:5S3H|rcsb pdb:5S3I|rcsb pdb:5S3J|rcsb pdb:5S3K|rcsb pdb:5S3L|rcsb pdb:5S4D|rcsb pdb:5S4E|rcsb pdb:5S4F|rcsb pdb:5S4G|rcsb pdb:5S4H|rcsb pdb:5S4I|rcsb pdb:5S4J|rcsb pdb:5S4K|rcsb pdb:5S6X|rcsb pdb:5S6Y|rcsb pdb:5S6Z|rcsb pdb:5S3M|rcsb pdb:5S3N|rcsb pdb:5S70|rcsb pdb:5S71|rcsb pdb:5RSR|rcsb pdb:5RSS|rcsb pdb:5RST|rcsb pdb:5RSU|rcsb pdb:5RSV|rcsb pdb:5RSW|rcsb pdb:5RSX|rcsb pdb:5RSY|rcsb pdb:5RSZ|rcsb pdb:5RT0|rcsb pdb:5RT1|rcsb pdb:5RT2|rcsb pdb:5RT3|rcsb pdb:5RT4|rcsb pdb:5RT5|rcsb pdb:5RT6|rcsb pdb:5RT7|rcsb pdb:5RT8|rcsb pdb:5RT9|rcsb pdb:5RTA|rcsb pdb:5RTB|rcsb pdb:5RTC|rcsb pdb:5RTD|rcsb pdb:5RTE|rcsb pdb:5RTF|rcsb pdb:5RTG|rcsb pdb:5RTH|rcsb pdb:7ALI|rcsb pdb:7AMJ|rcsb pdb:7ANS|rcsb pdb:7AP6|rcsb pdb:7APH|rcsb pdb:7AQI|rcsb pdb:7AQJ|rcsb pdb:7AR5|rcsb pdb:7AR6|rcsb pdb:5S72|rcsb pdb:5S73|rcsb pdb:5S74|rcsb pdb:6Z5T|rcsb pdb:6Z6I|rcsb pdb:6Z72|rcsb pdb:7A1U|rcsb pdb:7ABU|rcsb pdb:7ADW|rcsb pdb:7AF0|rcsb pdb:7AGA|rcsb pdb:7ARF|rcsb pdb:7AVD|rcsb pdb:7AWR|rcsb pdb:7AWS|rcsb pdb:7AWU|rcsb pdb:7AWW|rcsb pdb:7AX6|rcsb pdb:7AXM|rcsb pdb:7AXO|rcsb pdb:7AY7|rcsb pdb:7AHA|rcsb pdb:7AK4|rcsb pdb:7ALH|rcsb pdb:7B3E|rcsb pdb:7B83|rcsb pdb:7BF3|rcsb pdb:7BF4|rcsb pdb:5RTJ|rcsb pdb:5RTK|rcsb pdb:5RTL|rcsb pdb:5RTM|rcsb pdb:5RTN|rcsb pdb:5RTO|rcsb pdb:5RTP|rcsb pdb:5RTQ|rcsb pdb:5RTR|rcsb pdb:5RTS|rcsb pdb:5RTT|rcsb pdb:5RTI|rcsb pdb:5RTU|rcsb pdb:5RTV|rcsb pdb:5RTW|rcsb pdb:5RTX|rcsb pdb:5RTY|rcsb pdb:5RTZ|rcsb pdb:5RU0|rcsb pdb:5RU1|rcsb pdb:5RU2|rcsb pdb:5RU3|rcsb pdb:5RU4|rcsb pdb:5RU5|rcsb pdb:5RU6|rcsb pdb:5RU7|rcsb pdb:5RU8|rcsb pdb:5RU9|rcsb pdb:5RUA|rcsb pdb:5RUC|rcsb pdb:5RUD|rcsb pdb:5RUE|rcsb pdb:5RUF|rcsb pdb:5RUG|rcsb pdb:5RUH|rcsb pdb:5RUI|rcsb pdb:5RUJ|rcsb pdb:5RUK|rcsb pdb:5RUL|rcsb pdb:5RUM|rcsb pdb:5RUN|rcsb pdb:5RUO|rcsb pdb:5RUP|rcsb pdb:5RUQ|rcsb pdb:5RUR|rcsb pdb:5RUS|rcsb pdb:5RUT|rcsb pdb:5RUU|rcsb pdb:5RUV|rcsb pdb:5RUW|rcsb pdb:5RUX|rcsb pdb:5RUY|rcsb pdb:5RUZ|rcsb pdb:5RV0|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR029063|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR027417|interpro:IPR037227|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042515|interpro:IPR042570|rcsb pdb:6LU7|interpro:IPR037204|rcsb pdb:7LTJ|rcsb pdb:7NBR|rcsb pdb:7NBS|rcsb pdb:7NBY|rcsb pdb:7NEV|rcsb pdb:7NFV|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:5R7Y|rcsb pdb:5R7Z|rcsb pdb:5R80|rcsb pdb:5R81|rcsb pdb:5R82|rcsb pdb:5R83|rcsb pdb:5R84|rcsb pdb:5RE4|rcsb pdb:5RE5|rcsb pdb:5RE6|rcsb pdb:5RE7|rcsb pdb:5RE8|rcsb pdb:5RE9|rcsb pdb:5REA|rcsb pdb:5REB|rcsb pdb:5REC|rcsb pdb:5RED|rcsb pdb:5REE|rcsb pdb:5REF|rcsb pdb:5REG|rcsb pdb:5REH|rcsb pdb:5REI|rcsb pdb:5REJ|rcsb pdb:5REK|rcsb pdb:5REL|rcsb pdb:5REM|rcsb pdb:5REN|rcsb pdb:5REO|rcsb pdb:5REP|rcsb pdb:5RER|rcsb pdb:5RES|rcsb pdb:5RET|rcsb pdb:5REU|rcsb pdb:5REV|rcsb pdb:5REW|rcsb pdb:5REX|rcsb pdb:5REY|rcsb pdb:5REZ|rcsb pdb:5RF0|rcsb pdb:5RF1|rcsb pdb:5RF2|rcsb pdb:5RF3|rcsb pdb:5RF4|rcsb pdb:5RF5|rcsb pdb:5RF6|rcsb pdb:5RF7|rcsb pdb:5RF8|rcsb pdb:5RF9|rcsb pdb:5RFA|rcsb pdb:5RFB|rcsb pdb:5RFC|rcsb pdb:5RFD|rcsb pdb:5RFE|rcsb pdb:5RFF|rcsb pdb:5RFG|rcsb pdb:5RFH|rcsb pdb:5RFI|rcsb pdb:5RFJ|rcsb pdb:5RFK|rcsb pdb:5RFL|rcsb pdb:5RFM|rcsb pdb:5RFN|rcsb pdb:5RFO|rcsb pdb:5RFP|rcsb pdb:5RFQ|rcsb pdb:5RFR|rcsb pdb:5RFS|rcsb pdb:5RFT|rcsb pdb:5RFU|rcsb pdb:5RFV|rcsb pdb:5RFW|rcsb pdb:5RFX|rcsb pdb:5RFY|rcsb pdb:5RFZ|rcsb pdb:5RG0|rcsb pdb:6M03|rcsb pdb:6VWW|rcsb pdb:6W01|rcsb pdb:6W02|rcsb pdb:6W61|rcsb pdb:6W63|rcsb pdb:6W6Y|rcsb pdb:6W75|rcsb pdb:6Y2E|rcsb pdb:6Y2F|rcsb pdb:6Y2G|rcsb pdb:6Y84|rcsb pdb:6YB7|rcsb pdb:7LBS|rcsb pdb:7LFE|rcsb pdb:7L1F|rcsb pdb:7LB7|rcsb pdb:7LBN|rcsb pdb:7LFP|rcsb pdb:7LFZ|rcsb pdb:7LBR|rcsb pdb:7LG2|rcsb pdb:7LG3|rcsb pdb:7LG7|rcsb pdb:7LGO|rcsb pdb:7LKR|rcsb pdb:7LKS|rcsb pdb:7LKT|rcsb pdb:7LKU|rcsb pdb:7LKV|rcsb pdb:7LKW|rcsb pdb:7LKX|rcsb pdb:7LLF|rcsb pdb:7LLZ|rcsb pdb:7LOS|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR027351|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:5RGT|rcsb pdb:5RGU|rcsb pdb:5RGV|rcsb pdb:5RGW|rcsb pdb:5RGX|rcsb pdb:5RGY|rcsb pdb:5RGZ|rcsb pdb:5RH0|rcsb pdb:5RH1|rcsb pdb:5RH2|rcsb pdb:5RH3|rcsb pdb:5RH4|rcsb pdb:5RH5|rcsb pdb:5RH6|rcsb pdb:5RH7|rcsb pdb:5RH8|rcsb pdb:5RH9|rcsb pdb:5RHA|rcsb pdb:5RHB|rcsb pdb:5RHC|rcsb pdb:5RHD|rcsb pdb:5RHE|rcsb pdb:5RHF|rcsb pdb:6WZU|rcsb pdb:6X1B|rcsb pdb:6X4I|rcsb pdb:6XA4|rcsb pdb:6XA9|rcsb pdb:6XAA|rcsb pdb:6XB0|rcsb pdb:6XB1|rcsb pdb:6XB2|rcsb pdb:6XBG|rcsb pdb:6XBH|rcsb pdb:6XBI|rcsb pdb:6XCH|rcsb pdb:6XDH|rcsb pdb:6XFN|rcsb pdb:6XG3|rcsb pdb:6XHM|rcsb pdb:6XHU|rcsb pdb:6XIP|rcsb pdb:6XKF|rcsb pdb:6XKH|rcsb pdb:6XKM|rcsb pdb:6XMK|rcsb pdb:6XOA|rcsb pdb:6XQS|rcsb pdb:6XQT|rcsb pdb:6XQU|rcsb pdb:6YYT|rcsb pdb:6Z2E|rcsb pdb:6ZCT|rcsb pdb:6ZOJ|rcsb pdb:7BQ7|rcsb pdb:7C2I|rcsb pdb:7C2J|rcsb pdb:7C8R|rcsb pdb:7C8T|rcsb pdb:7C8U|rcsb pdb:6WC1|rcsb pdb:6XR3|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZN5|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZRT|rcsb pdb:6ZRU|rcsb pdb:6ZSL|rcsb pdb:7BZF|rcsb pdb:7C2K|rcsb pdb:7C2Q|rcsb pdb:7C2Y|rcsb pdb:7C6S|rcsb pdb:7C6U|rcsb pdb:7C7P|rcsb pdb:7C8B|rcsb pdb:7CBT|rcsb pdb:7CJD|rcsb pdb:7CJM|rcsb pdb:7CMD|rcsb pdb:7COM|rcsb pdb:7JFQ|rcsb pdb:7JHE|rcsb pdb:7JIB|rcsb pdb:7JME|rcsb pdb:7JPE|rcsb pdb:7JR3|rcsb pdb:7JR4|rcsb pdb:7JU7|rcsb pdb:7JUN|rcsb pdb:7JYC|rcsb pdb:5RL6|rcsb pdb:5RL7|rcsb pdb:5RL8|rcsb pdb:5RL9|rcsb pdb:5RLB|rcsb pdb:5RLC|rcsb pdb:5RLD|rcsb pdb:5RLE|rcsb pdb:5RLF|rcsb pdb:5RLG|rcsb pdb:5RLH|rcsb pdb:5RLI|rcsb pdb:5RLJ|rcsb pdb:5RLK|rcsb pdb:5RLL|rcsb pdb:5RLM|rcsb pdb:5RLN|rcsb pdb:5RLO|rcsb pdb:5RLP|rcsb pdb:5RLQ|rcsb pdb:5RLR|rcsb pdb:5RLS|rcsb pdb:5RLT|rcsb pdb:5RLU|rcsb pdb:5RLV|rcsb pdb:5RLW|rcsb pdb:5RLY|rcsb pdb:5RLZ|rcsb pdb:5RM0|rcsb pdb:5RM1|rcsb pdb:5RM2|rcsb pdb:5RM3|rcsb pdb:5RM4|rcsb pdb:5RM5|rcsb pdb:5RM6|rcsb pdb:5RM7|rcsb pdb:5RM8|rcsb pdb:5RM9|rcsb pdb:5RMA|rcsb pdb:5RMB|rcsb pdb:5RMC|rcsb pdb:5RMD|rcsb pdb:5RME|rcsb pdb:5RMF|rcsb pdb:5RMG|rcsb pdb:5RMH|rcsb pdb:5RMI|rcsb pdb:5RMJ|rcsb pdb:5RMK|rcsb pdb:5RML|rcsb pdb:5RMM|rcsb pdb:6ZPE|rcsb pdb:7AKU|rcsb pdb:7CWC|rcsb pdb:7CWB|rcsb pdb:7CX9|rcsb pdb:7D1M|rcsb pdb:7D1O|rcsb pdb:7JKV|rcsb pdb:7JOY|rcsb pdb:7JP1|rcsb pdb:7JVZ|rcsb pdb:7JYY|rcsb pdb:7JZ0|rcsb pdb:7K1L|rcsb pdb:7K1O|rcsb pdb:7K3N|rcsb pdb:7K3T|rcsb pdb:7K40|rcsb pdb:7K5I|rcsb pdb:7K6D|rcsb pdb:7K6E|rcsb pdb:7K7P|rcsb pdb:7K9P|rcsb pdb:7KAG|rcsb pdb:7KFI|rcsb pdb:7KG3|rcsb pdb:7KHP|reactome:R-HSA-9694271|reactome:R-HSA-9694301|reactome:R-HSA-9694676|reactome:R-HSA-9694686|reactome:R-HSA-9694786 - chain-seq-start:819|chain-seq-end:2763 - figure legend:"1G, Supp. figure 1A (lanes 2-5)"|comment:Nsp3 core is able to cleave the Nsp1-2Delta substrate, whilst PLpro is not.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/28 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:wCJ3ZPKZG00c5axKHF8thiOgR6Q2697049 rigid:MeW4B9eUKTAoq3dibSpiCBCKth8 false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c mutation disrupting interaction rate:180-180|his tag:?-?|sufficient binding region:1-199 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P0DTD1-PRO_0000449621 uniprotkb:P0DTD1-PRO_0000449619 intact:EBI-25492388 intact:EBI-25475847 psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449619(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:2197"(probe interaction assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0469"(IntAct) intact:EBI-27051391|imex:IM-29152-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - chain-seq-start:819|chain-seq-end:2763 chain-seq-start:1|chain-seq-end:180 figure legend:Supp. figure 1F|comment:While Nsp3-Core was efficiently modified by Nsp1Prg, barely any conversion was observed for PLpro.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:SaSNaqNfTqsYEpmhXnBT8bJZczM2697049 rigid:4eQmHiCkX2QU3ugNCqpczneWszQ false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c|modified L-cysteine residue:856-856 sufficient binding region:1-179|modified glycine residue:179-179|tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:2197"(probe interaction assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0469"(IntAct) intact:EBI-27051919|imex:IM-29152-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:Supp. figure 3B|comment:"An \"S1\" PLpro mutant (E912R E948R M953E Y1013K) with an N-terminal Avi-tag did not bind Ubiquitin."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/19 2021/07/29 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:743-1072 modified glycine residue:76-76 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051641|imex:IM-29152-17 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:Supp. figure 1G|kinetics:Vmax=0.66 mM min-1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) km:29.39x10^-6(molar)|kcat:0.37x10^1(second -1) 2021/07/19 2021/07/29 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:743-1072 cross linker:48-48 - 3 psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449621 intact:EBI-4399559 intact:EBI-25492388 dip:DIP-24261N psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0998"(deubiquitinase assay) Armstrong et al. (2020) pubmed:34270554|imex:IM-29152 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0204"(deubiquitination reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27051666|imex:IM-29152-35 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 - chain-seq-start:819|chain-seq-end:2763 no-uniprot-update: figure legend:Supp. figure 1G|kinetics:Vmax of 0.62 mM min-1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kcat:0.34(second -1)|km:17.79x10^-6(molar) 2021/07/19 2021/07/29 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:NFohD3wBuJ6KW1kOz86Uqn562K4 false sufficient binding region:179-1329|strep tag:n-n|his tag:c-c|mutation disrupting interaction rate:856-856 cross linker:48-48 - 3 psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)