#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P19811-PRO_0000036626 - intact:EBI-27070280 - psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) - psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") - psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070208|imex:IM-29173-1 - - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0326"(protein) - intact:EBI-27070211(chain-parent) - go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:1678|chain-seq-end:2370 - figure legend:1A, Supp. figure 12|comment:A weak band only, is visible. Addition of nsp7 resulted in higher levels of radionucleotide incorporation into both Nsp7 and Nsp9.|agonist:Nsp7|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/19 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 - - false mutation with no effect:380-380|strep tag:c-c|guanylated residue:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) - uniprotkb:P19811 uniprotkb:P19811-PRO_0000036626 intact:EBI-27070211|uniprotkb:Q88625|uniprotkb:Q8QZQ5|uniprotkb:Q91DM2 intact:EBI-27070280 psi-mi:rpoa_eavbu(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym) psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070292|imex:IM-29173-3 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_127506.1|refseq:NP_127507.1|rcsb pdb:1MBM|rcsb pdb:2L8K|rcsb pdb:4IUM|rcsb pdb:4N0N|rcsb pdb:4N0O|rcsb pdb:5F17|rcsb pdb:5HBZ|rcsb pdb:5HC1|interpro:IPR027351|interpro:IPR031932|interpro:IPR038451|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR023183|interpro:IPR043502|interpro:IPR022230|interpro:IPR029323|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR037227|interpro:IPR043609|interpro:IPR044348|interpro:IPR027355|interpro:IPR044320|interpro:IPR044314|interpro:IPR032786|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR041053|interpro:IPR043128|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR041361 intact:EBI-27070211(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) - chain-seq-start:1678|chain-seq-end:2370 figure legend:1A, 5 B/C, Supp. figure 12|comment:"In competition experiments GTP outcompeted UTP, whereas adenosine triphosphate (ATP) and cytidine triphosphate (CTP) did not compete."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/19 rogid:uGAR7OOWlmmvx7Rxa6rTMOpItv8299386 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 rigid:xlfxivE9UJ0954nFrYGZ+IavB+I false sufficient binding region:1453-1677..1677|guanylated residue:?-? mutation with no effect:380-380|strep tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475871 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070325|imex:IM-29173-5 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:4393|chain-seq-end:5324 figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/19 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:o1PRCjH4XJrcIhj90TYcVc4o8Qk false guanylated residue:?-? strep tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449626 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475874 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070341|imex:IM-29173-21 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:3943|chain-seq-end:4140 chain-seq-start:4393|chain-seq-end:5324 figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/19 rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:kUYuGjSimMr7yS51yZko2wwLNP4 false guanylated residue:?-? strep tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449626 intact:EBI-25475871 intact:EBI-25475874 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070352|imex:IM-29173-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:3943|chain-seq-end:4140 figure legend:1 B/C, 5 B/C|comment:"In competition experiments GTP outcompeted UTP, whereas adenosine triphosphate (ATP) and cytidine triphosphate (CTP) did not compete."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/19 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049 rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU false guanylated residue:?-? guanylated residue:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475871 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070352|imex:IM-29173-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:4393|chain-seq-end:5324 figure legend:1 B/C, 5 B/C|comment:"In competition experiments GTP outcompeted UTP, whereas adenosine triphosphate (ATP) and cytidine triphosphate (CTP) did not compete."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/19 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU false guanylated residue:?-? strep tag:c-c|mutation disrupting interaction rate:116-116|mutation disrupting interaction rate:116-116 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449626 intact:EBI-25475871 intact:EBI-25475874 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070783|imex:IM-29173-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)|go:"GO:0016779"(nucleotidyltransferase activity) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:3943|chain-seq-end:4140 figure legend:4 A/B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049 rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU false mutation disrupting interaction rate:1-2|mutation disrupting interaction rate:2-2|guanylated residue:?-?|mutation with no effect:1-1 guanylated residue:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475871 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070783|imex:IM-29173-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)|go:"GO:0016779"(nucleotidyltransferase activity) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:4393|chain-seq-end:5324 figure legend:4 A/B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU false mutation disrupting interaction rate:1-2|mutation disrupting interaction rate:2-2|guanylated residue:?-?|mutation with no effect:1-1 strep tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P19811 uniprotkb:P19811-PRO_0000036626 intact:EBI-27070211|uniprotkb:Q88625|uniprotkb:Q8QZQ5|uniprotkb:Q91DM2 intact:EBI-27070280 psi-mi:rpoa_eavbu(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym) psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070995|imex:IM-29173-33 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_127506.1|refseq:NP_127507.1|rcsb pdb:1MBM|rcsb pdb:2L8K|rcsb pdb:4IUM|rcsb pdb:4N0N|rcsb pdb:4N0O|rcsb pdb:5F17|rcsb pdb:5HBZ|rcsb pdb:5HC1|interpro:IPR027351|interpro:IPR031932|interpro:IPR038451|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR023183|interpro:IPR043502|interpro:IPR022230|interpro:IPR029323|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR037227|interpro:IPR043609|interpro:IPR044348|interpro:IPR027355|interpro:IPR044320|interpro:IPR044314|interpro:IPR032786|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR041053|interpro:IPR043128|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR041361 intact:EBI-27070211(chain-parent) go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation)|go:"GO:0016779"(nucleotidyltransferase activity) - chain-seq-start:1678|chain-seq-end:2370 figure legend:Supp. figure 12|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:uGAR7OOWlmmvx7Rxa6rTMOpItv8299386 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 rigid:xlfxivE9UJ0954nFrYGZ+IavB+I false mutation with no effect:1595-1595|sufficient binding region:1453-1677..1677|guanylated residue:?-?|mutation with no effect:1455-1455|mutation with no effect:1608-1608|mutation with no effect:1624-1624 strep tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475871 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070431|imex:IM-29173-7 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:4393|chain-seq-end:5324 figure legend:Table 1, Figure 4C, Supp. figure 6/7/8|comment:"The data indicates that lysine-2 is the preferred acceptor site for GMP. The modification site (Ser1) was not confirmed by Alanine mutation."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/20 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:o1PRCjH4XJrcIhj90TYcVc4o8Qk false guanylated residue:2-2|mutation with no effect:1-1|mutation disrupting interaction rate:1-2|guanylated residue:1-1|mutation disrupting interaction rate:2-2 strep tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P19811 uniprotkb:P19811-PRO_0000036626 intact:EBI-27070211|uniprotkb:Q88625|uniprotkb:Q8QZQ5|uniprotkb:Q91DM2 intact:EBI-27070280 psi-mi:rpoa_eavbu(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym) psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070442|imex:IM-29173-9 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_127506.1|refseq:NP_127507.1|rcsb pdb:1MBM|rcsb pdb:2L8K|rcsb pdb:4IUM|rcsb pdb:4N0N|rcsb pdb:4N0O|rcsb pdb:5F17|rcsb pdb:5HBZ|rcsb pdb:5HC1|interpro:IPR027351|interpro:IPR031932|interpro:IPR038451|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR023183|interpro:IPR043502|interpro:IPR022230|interpro:IPR029323|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR037227|interpro:IPR043609|interpro:IPR044348|interpro:IPR027355|interpro:IPR044320|interpro:IPR044314|interpro:IPR032786|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR041053|interpro:IPR043128|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR041361 intact:EBI-27070211(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) - chain-seq-start:1678|chain-seq-end:2370 figure legend:Table 1, Supp. figure 11|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/20 rogid:uGAR7OOWlmmvx7Rxa6rTMOpItv8299386 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 rigid:xlfxivE9UJ0954nFrYGZ+IavB+I false mutation with no effect:1455-1455|guanylated residue:1595-1595|mutation disrupting interaction rate:1595-1595|mutation disrupting interaction rate:1608-1608|guanylated residue:1608-1608|guanylated residue:1624-1624|mutation disrupting interaction rate:1624-1624|sufficient binding region:1453-1677..1677|guanylated residue:1455-1455 strep tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P19811-PRO_0000036626 - intact:EBI-27070280 - psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) - psi-mi:"MI:0415"(enzymatic study) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") - psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070731|imex:IM-29173-11 - - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0326"(protein) - intact:EBI-27070211(chain-parent) - go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0044600"(protein guanylyltransferase activity)|go:"GO:0018260"(protein guanylylation) chain-seq-start:1678|chain-seq-end:2370 - figure legend:Table 1, Supp. figure 11|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 - - false strep tag:c-c|guanylated residue:380-380|mutation disrupting interaction rate:380-380 - - - psi-mi:"MI:0102"(sequence tag identification) - uniprotkb:P19811-PRO_0000036626 - intact:EBI-27070280 - psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) - psi-mi:"MI:1229"(uridylation assay) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") - psi-mi:"MI:1230"(uridylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070822|imex:IM-29173-13 - - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0326"(protein) - intact:EBI-27070211(chain-parent) - go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0018177"(protein uridylylation)|go:"GO:0070569"(uridylyltransferase activity) chain-seq-start:1678|chain-seq-end:2370 - figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 - - false strep tag:c-c|uridylated residue:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) - uniprotkb:P19811 uniprotkb:P19811-PRO_0000036626 intact:EBI-27070211|uniprotkb:Q88625|uniprotkb:Q8QZQ5|uniprotkb:Q91DM2 intact:EBI-27070280 psi-mi:rpoa_eavbu(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym) psi-mi:p19811-pro_0000036626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:1229"(uridylation assay) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") taxid:299386(EAV)|taxid:299386("Equine arteritis virus (strain Bucyrus)") psi-mi:"MI:1230"(uridylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070834|imex:IM-29173-15 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_127506.1|refseq:NP_127507.1|rcsb pdb:1MBM|rcsb pdb:2L8K|rcsb pdb:4IUM|rcsb pdb:4N0N|rcsb pdb:4N0O|rcsb pdb:5F17|rcsb pdb:5HBZ|rcsb pdb:5HC1|interpro:IPR027351|interpro:IPR031932|interpro:IPR038451|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR023183|interpro:IPR043502|interpro:IPR022230|interpro:IPR029323|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR037227|interpro:IPR043609|interpro:IPR044348|interpro:IPR027355|interpro:IPR044320|interpro:IPR044314|interpro:IPR032786|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR041053|interpro:IPR043128|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR041361 intact:EBI-27070211(chain-parent) go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0018177"(protein uridylylation)|go:"GO:0070569"(uridylyltransferase activity) - chain-seq-start:1678|chain-seq-end:2370 figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:uGAR7OOWlmmvx7Rxa6rTMOpItv8299386 rogid:4KLL8Z/FjwSPjlUbJbiLXzXmPR8299386 rigid:xlfxivE9UJ0954nFrYGZ+IavB+I false sufficient binding region:1453-1677..1677|uridylated residue:?-? strep tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449626 intact:EBI-25475871 intact:EBI-25475874 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:1229"(uridylation assay) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:1230"(uridylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070847|imex:IM-29173-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0018177"(protein uridylylation)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0070569"(uridylyltransferase activity) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:3943|chain-seq-end:4140 figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049 rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU false uridylated residue:?-? uridylated residue:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475871 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:1229"(uridylation assay) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:1230"(uridylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070847|imex:IM-29173-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0018177"(protein uridylylation)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0070569"(uridylyltransferase activity) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:4393|chain-seq-end:5324 figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU false uridylated residue:?-? strep tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P0DTD1-PRO_0000449625 uniprotkb:P0DTD1-PRO_0000449629 intact:EBI-25475871 intact:EBI-25475885 psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:1229"(uridylation assay) Conti et al. (2020) pubmed:34189273|imex:IM-29173 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:1230"(uridylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27070959|imex:IM-29173-31 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0018177"(protein uridylylation)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0070569"(uridylyltransferase activity) chain-seq-start:3860|chain-seq-end:3942 chain-seq-start:4393|chain-seq-end:5324 figure legend:5 D/E, Supp. Table 6|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/08/12 2021/08/23 rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049 rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049 rigid:o1PRCjH4XJrcIhj90TYcVc4o8Qk false uridylated residue:1-1 strep tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)