#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTC3	uniprotkb:P0DTC3	intact:EBI-25475894	intact:EBI-25475894	psi-mi:ap3a_sars2(display_long)|uniprotkb:Accessory protein 3a(gene name synonym)|uniprotkb:Protein U274(gene name synonym)|uniprotkb:Protein X1(gene name synonym)|uniprotkb:3a(orf name)|uniprotkb:Protein 3a(gene name synonym)	psi-mi:ap3a_sars2(display_long)|uniprotkb:Accessory protein 3a(gene name synonym)|uniprotkb:Protein U274(gene name synonym)|uniprotkb:Protein X1(gene name synonym)|uniprotkb:3a(orf name)|uniprotkb:Protein 3a(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kern et al. (2021)	imex:IM-29073|pubmed:34158638	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27029423|imex:IM-29073-1|wwpdb:6XDC|emdb:EMD-22136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005216"(ion channel activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044174"(host cell endosome)|go:"GO:0044187"(host cell lysosome)|go:"GO:0055036"(virion membrane)|interpro:IPR024407|rcsb pdb:7KJR|refseq:YP_009724391.1|rcsb pdb:6XDC|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694635|reactome:R-HSA-9694719	go:"GO:0005216"(ion channel activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044174"(host cell endosome)|go:"GO:0044187"(host cell lysosome)|go:"GO:0055036"(virion membrane)|interpro:IPR024407|rcsb pdb:7KJR|refseq:YP_009724391.1|rcsb pdb:6XDC|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694635|reactome:R-HSA-9694719	-	-	-	figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2021/07/05	2021/07/06	rogid:+XLMj0dW09li5IMSmd2O00ETMCo2697049	rogid:+XLMj0dW09li5IMSmd2O00ETMCo2697049	rigid:J5azPdNc5judutp6MNMOBdbPbAA	false	-	-	2	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P02647	uniprotkb:P0DTC3	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	intact:EBI-25475894	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:ap3a_sars2(display_long)|uniprotkb:Accessory protein 3a(gene name synonym)|uniprotkb:Protein U274(gene name synonym)|uniprotkb:Protein X1(gene name synonym)|uniprotkb:3a(orf name)|uniprotkb:Protein 3a(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kern et al. (2021)	imex:IM-29073|pubmed:34158638	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27029439|imex:IM-29073-3|wwpdb:7kjr|emdb:EMD-22898	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	go:"GO:0005216"(ion channel activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044174"(host cell endosome)|go:"GO:0044187"(host cell lysosome)|go:"GO:0055036"(virion membrane)|interpro:IPR024407|rcsb pdb:7KJR|refseq:YP_009724391.1|rcsb pdb:6XDC|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694635|reactome:R-HSA-9694719	-	-	-	figure legend:Table 1|comment:ORF3a in Nanodiscs|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/05	2021/07/06	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	rogid:+XLMj0dW09li5IMSmd2O00ETMCo2697049	rigid:RUfhVY43pZnuENwnStE6VLlRByc	false	his tag:n-n|sufficient binding region:79-267	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)