#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01892	uniprotkb:P0DTC8	intact:EBI-2839473|uniprotkb:Q9TPY0|uniprotkb:Q29680|uniprotkb:Q29899|uniprotkb:P06338|uniprotkb:P30445|uniprotkb:Q95352|uniprotkb:Q9TQI3|uniprotkb:Q95380|uniprotkb:P30444|uniprotkb:Q9TPX8|uniprotkb:O19619|uniprotkb:P30446|uniprotkb:Q9TQH5|uniprotkb:P10313|uniprotkb:Q9TPX9|uniprotkb:P30514|uniprotkb:Q29837	intact:EBI-25475900	psi-mi:1a02_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A*02(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26995768|imex:IM-29013-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4MNQ|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5HYJ|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4OV5|rcsb pdb:4UQ3|ensembl:ENSG00000227715|ensembl:ENSP00000448077|ensembl:ENST00000547522|rcsb pdb:5SWQ|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5HHM|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E6I|rcsb pdb:5IRO|rcsb pdb:6D7G|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5D2L|rcsb pdb:5D2N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|rcsb pdb:4WJ5|go:"GO:0003723"(RNA binding)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5E00|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4U6Y|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0031901"(early endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050690"(regulation of defense response to virus by virus)|go:"GO:0060337"(type I interferon signaling pathway)|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:1P7Q|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0009986"(cell surface)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0046977"(TAP binding)|go:"GO:2000568"(positive regulation of memory T cell activation)|rcsb pdb:3QFD|rcsb pdb:4K7F|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0030670"(phagocytic vesicle membrane)|rcsb pdb:3QFJ|rcsb pdb:3REW|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:5NMG|rcsb pdb:5NHT|rcsb pdb:5NQK|rcsb pdb:4WUU|rcsb pdb:4E5X|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:4I4W|rcsb pdb:5EOT|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:3TO2|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4EUP|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0042608"(T cell receptor binding)|rcsb pdb:4L3E|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENSP00000447962|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|rcsb pdb:4FTV|rcsb pdb:5E9D|rcsb pdb:5C07|rcsb pdb:5C08|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0050776"(regulation of immune response)|ensembl:ENST00000457879|ensembl:ENST00000547271|go:"GO:0051290"(protein heterotetramerization)|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5N1Y|go:"GO:0002250"(adaptive immune response)|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:5ENW|reactome:R-HSA-8866654|rcsb pdb:5JZI|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5TEZ|rcsb pdb:5WSH|mint:P01892|rcsb pdb:5N6B|rcsb pdb:5W1W|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0062061"(TAP complex binding)|rcsb pdb:6G3J	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	-	no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions.|comment:"Allele =A*02:01:01:01"|comment:"Allele =A*02:01:01:01 according to IPD-IMGT/HLA database"	-	figure legend:1 F/G|comment:"ORF8 overexpression in the HEK293T cells significantly down-regulated MHC-Ι (HLA-A2) expression."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:oTL0BWZeACoxMc++WgT0XDz+sNg9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:d2mEjx62pXyG3kKlBgcLEb+Y8D8	false	-	mutation with no effect:84-84	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01892	uniprotkb:P0DTC8	intact:EBI-2839473|uniprotkb:Q9TPY0|uniprotkb:Q29680|uniprotkb:Q29899|uniprotkb:P06338|uniprotkb:P30445|uniprotkb:Q95352|uniprotkb:Q9TQI3|uniprotkb:Q95380|uniprotkb:P30444|uniprotkb:Q9TPX8|uniprotkb:O19619|uniprotkb:P30446|uniprotkb:Q9TQH5|uniprotkb:P10313|uniprotkb:Q9TPX9|uniprotkb:P30514|uniprotkb:Q29837	intact:EBI-25475900	psi-mi:1a02_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A*02(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996135|imex:IM-29013-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4MNQ|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5HYJ|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4OV5|rcsb pdb:4UQ3|ensembl:ENSG00000227715|ensembl:ENSP00000448077|ensembl:ENST00000547522|rcsb pdb:5SWQ|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5HHM|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E6I|rcsb pdb:5IRO|rcsb pdb:6D7G|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5D2L|rcsb pdb:5D2N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|rcsb pdb:4WJ5|go:"GO:0003723"(RNA binding)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5E00|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4U6Y|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0031901"(early endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050690"(regulation of defense response to virus by virus)|go:"GO:0060337"(type I interferon signaling pathway)|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:1P7Q|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0009986"(cell surface)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0046977"(TAP binding)|go:"GO:2000568"(positive regulation of memory T cell activation)|rcsb pdb:3QFD|rcsb pdb:4K7F|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0030670"(phagocytic vesicle membrane)|rcsb pdb:3QFJ|rcsb pdb:3REW|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:5NMG|rcsb pdb:5NHT|rcsb pdb:5NQK|rcsb pdb:4WUU|rcsb pdb:4E5X|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:4I4W|rcsb pdb:5EOT|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:3TO2|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4EUP|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0042608"(T cell receptor binding)|rcsb pdb:4L3E|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENSP00000447962|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|rcsb pdb:4FTV|rcsb pdb:5E9D|rcsb pdb:5C07|rcsb pdb:5C08|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0050776"(regulation of immune response)|ensembl:ENST00000457879|ensembl:ENST00000547271|go:"GO:0051290"(protein heterotetramerization)|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5N1Y|go:"GO:0002250"(adaptive immune response)|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:5ENW|reactome:R-HSA-8866654|rcsb pdb:5JZI|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5TEZ|rcsb pdb:5WSH|mint:P01892|rcsb pdb:5N6B|rcsb pdb:5W1W|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0062061"(TAP complex binding)|rcsb pdb:6G3J	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	-	no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions.|comment:"Allele =A*02:01:01:01"|comment:"Allele =A*02:01:01:01 according to IPD-IMGT/HLA database"	-	figure legend:Supp. figure 1  E-F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:oTL0BWZeACoxMc++WgT0XDz+sNg9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:d2mEjx62pXyG3kKlBgcLEb+Y8D8	false	-	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01892	uniprotkb:P0DTC8	intact:EBI-2839473|uniprotkb:Q9TPY0|uniprotkb:Q29680|uniprotkb:Q29899|uniprotkb:P06338|uniprotkb:P30445|uniprotkb:Q95352|uniprotkb:Q9TQI3|uniprotkb:Q95380|uniprotkb:P30444|uniprotkb:Q9TPX8|uniprotkb:O19619|uniprotkb:P30446|uniprotkb:Q9TQH5|uniprotkb:P10313|uniprotkb:Q9TPX9|uniprotkb:P30514|uniprotkb:Q29837	intact:EBI-25475900	psi-mi:1a02_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A*02(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996013|imex:IM-29013-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4MNQ|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5HYJ|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4OV5|rcsb pdb:4UQ3|ensembl:ENSG00000227715|ensembl:ENSP00000448077|ensembl:ENST00000547522|rcsb pdb:5SWQ|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5HHM|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E6I|rcsb pdb:5IRO|rcsb pdb:6D7G|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5D2L|rcsb pdb:5D2N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|rcsb pdb:4WJ5|go:"GO:0003723"(RNA binding)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5E00|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4U6Y|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0031901"(early endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050690"(regulation of defense response to virus by virus)|go:"GO:0060337"(type I interferon signaling pathway)|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:1P7Q|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0009986"(cell surface)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0046977"(TAP binding)|go:"GO:2000568"(positive regulation of memory T cell activation)|rcsb pdb:3QFD|rcsb pdb:4K7F|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0030670"(phagocytic vesicle membrane)|rcsb pdb:3QFJ|rcsb pdb:3REW|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:5NMG|rcsb pdb:5NHT|rcsb pdb:5NQK|rcsb pdb:4WUU|rcsb pdb:4E5X|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:4I4W|rcsb pdb:5EOT|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:3TO2|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4EUP|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0042608"(T cell receptor binding)|rcsb pdb:4L3E|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENSP00000447962|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|rcsb pdb:4FTV|rcsb pdb:5E9D|rcsb pdb:5C07|rcsb pdb:5C08|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0050776"(regulation of immune response)|ensembl:ENST00000457879|ensembl:ENST00000547271|go:"GO:0051290"(protein heterotetramerization)|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5N1Y|go:"GO:0002250"(adaptive immune response)|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:5ENW|reactome:R-HSA-8866654|rcsb pdb:5JZI|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5TEZ|rcsb pdb:5WSH|mint:P01892|rcsb pdb:5N6B|rcsb pdb:5W1W|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0062061"(TAP complex binding)|rcsb pdb:6G3J	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	go:"GO:0005737"(cytoplasm)	no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions.|comment:"Allele =A*02:01:01:01"|comment:"Allele =A*02:01:01:01 according to IPD-IMGT/HLA database"	-	figure legend:4E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:oTL0BWZeACoxMc++WgT0XDz+sNg9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:d2mEjx62pXyG3kKlBgcLEb+Y8D8	false	-	ha tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q14457	uniprotkb:P0DTC8	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-25475900	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996126|imex:IM-29013-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	go:"GO:0005737"(cytoplasm)	-	-	figure legend:5H|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:mNiFD1Yls6gv1idS8wWcQ0viMII	false	green fluorescent protein tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P01892	uniprotkb:P0DTC8	intact:EBI-2839473|uniprotkb:Q9TPY0|uniprotkb:Q29680|uniprotkb:Q29899|uniprotkb:P06338|uniprotkb:P30445|uniprotkb:Q95352|uniprotkb:Q9TQI3|uniprotkb:Q95380|uniprotkb:P30444|uniprotkb:Q9TPX8|uniprotkb:O19619|uniprotkb:P30446|uniprotkb:Q9TQH5|uniprotkb:P10313|uniprotkb:Q9TPX9|uniprotkb:P30514|uniprotkb:Q29837	intact:EBI-25475900	psi-mi:1a02_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A*02(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0030"(cross-linking study)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996029|imex:IM-29013-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4MNQ|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5HYJ|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4OV5|rcsb pdb:4UQ3|ensembl:ENSG00000227715|ensembl:ENSP00000448077|ensembl:ENST00000547522|rcsb pdb:5SWQ|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5HHM|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E6I|rcsb pdb:5IRO|rcsb pdb:6D7G|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5D2L|rcsb pdb:5D2N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|rcsb pdb:4WJ5|go:"GO:0003723"(RNA binding)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5E00|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4U6Y|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0031901"(early endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050690"(regulation of defense response to virus by virus)|go:"GO:0060337"(type I interferon signaling pathway)|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:1P7Q|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0009986"(cell surface)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0046977"(TAP binding)|go:"GO:2000568"(positive regulation of memory T cell activation)|rcsb pdb:3QFD|rcsb pdb:4K7F|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0030670"(phagocytic vesicle membrane)|rcsb pdb:3QFJ|rcsb pdb:3REW|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:5NMG|rcsb pdb:5NHT|rcsb pdb:5NQK|rcsb pdb:4WUU|rcsb pdb:4E5X|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:4I4W|rcsb pdb:5EOT|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:3TO2|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4EUP|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0042608"(T cell receptor binding)|rcsb pdb:4L3E|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENSP00000447962|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|rcsb pdb:4FTV|rcsb pdb:5E9D|rcsb pdb:5C07|rcsb pdb:5C08|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0050776"(regulation of immune response)|ensembl:ENST00000457879|ensembl:ENST00000547271|go:"GO:0051290"(protein heterotetramerization)|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5N1Y|go:"GO:0002250"(adaptive immune response)|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:5ENW|reactome:R-HSA-8866654|rcsb pdb:5JZI|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5TEZ|rcsb pdb:5WSH|mint:P01892|rcsb pdb:5N6B|rcsb pdb:5W1W|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0062061"(TAP complex binding)|rcsb pdb:6G3J	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	go:"GO:0005737"(cytoplasm)	no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions.|comment:"Allele =A*02:01:01:01"|comment:"Allele =A*02:01:01:01 according to IPD-IMGT/HLA database"	-	figure legend:4F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:oTL0BWZeACoxMc++WgT0XDz+sNg9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:d2mEjx62pXyG3kKlBgcLEb+Y8D8	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14457	uniprotkb:P0DTC8	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-25475900	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0030"(cross-linking study)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996115|imex:IM-29013-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	go:"GO:0005737"(cytoplasm)	-	-	figure legend:5I|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:mNiFD1Yls6gv1idS8wWcQ0viMII	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01892	uniprotkb:P0DTC8	intact:EBI-2839473|uniprotkb:Q9TPY0|uniprotkb:Q29680|uniprotkb:Q29899|uniprotkb:P06338|uniprotkb:P30445|uniprotkb:Q95352|uniprotkb:Q9TQI3|uniprotkb:Q95380|uniprotkb:P30444|uniprotkb:Q9TPX8|uniprotkb:O19619|uniprotkb:P30446|uniprotkb:Q9TQH5|uniprotkb:P10313|uniprotkb:Q9TPX9|uniprotkb:P30514|uniprotkb:Q29837	intact:EBI-25475900	psi-mi:1a02_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A*02(gene name synonym)	psi-mi:ns8_sars2(display_long)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2021)	pubmed:34021074|imex:IM-29013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996093|imex:IM-29013-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4MNQ|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5HYJ|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4OV5|rcsb pdb:4UQ3|ensembl:ENSG00000227715|ensembl:ENSP00000448077|ensembl:ENST00000547522|rcsb pdb:5SWQ|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5HHM|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E6I|rcsb pdb:5IRO|rcsb pdb:6D7G|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5D2L|rcsb pdb:5D2N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|rcsb pdb:4WJ5|go:"GO:0003723"(RNA binding)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5E00|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4U6Y|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0031901"(early endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050690"(regulation of defense response to virus by virus)|go:"GO:0060337"(type I interferon signaling pathway)|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:1P7Q|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0009986"(cell surface)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0046977"(TAP binding)|go:"GO:2000568"(positive regulation of memory T cell activation)|rcsb pdb:3QFD|rcsb pdb:4K7F|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0030670"(phagocytic vesicle membrane)|rcsb pdb:3QFJ|rcsb pdb:3REW|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:5NMG|rcsb pdb:5NHT|rcsb pdb:5NQK|rcsb pdb:4WUU|rcsb pdb:4E5X|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:4I4W|rcsb pdb:5EOT|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:3TO2|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4EUP|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0042608"(T cell receptor binding)|rcsb pdb:4L3E|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENSP00000447962|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|rcsb pdb:4FTV|rcsb pdb:5E9D|rcsb pdb:5C07|rcsb pdb:5C08|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0050776"(regulation of immune response)|ensembl:ENST00000457879|ensembl:ENST00000547271|go:"GO:0051290"(protein heterotetramerization)|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5N1Y|go:"GO:0002250"(adaptive immune response)|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:5ENW|reactome:R-HSA-8866654|rcsb pdb:5JZI|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5TEZ|rcsb pdb:5WSH|mint:P01892|rcsb pdb:5N6B|rcsb pdb:5W1W|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0062061"(TAP complex binding)|rcsb pdb:6G3J	go:"GO:0042802"(identical protein binding)|go:"GO:0044174"(host cell endosome)|interpro:IPR044391|interpro:IPR022722|refseq:YP_009724396.1|rcsb pdb:7JTL|rcsb pdb:7JX6	go:"GO:0005737"(cytoplasm)	no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions.|comment:"Allele =A*02:01:01:01"|comment:"Allele =A*02:01:01:01 according to IPD-IMGT/HLA database"	-	figure legend:4G|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/05/28	2022/01/11	rogid:oTL0BWZeACoxMc++WgT0XDz+sNg9606	rogid:ewwYrFNyPZ3iELR/bcvfB2DfU3Q2697049	rigid:d2mEjx62pXyG3kKlBgcLEb+Y8D8	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)