#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13533	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-1048066|uniprotkb:Q13943|uniprotkb:Q14906|uniprotkb:Q14907|uniprotkb:A2RTX1|ensembl:ENSP00000386041|uniprotkb:D9YZU2	intact:EBI-25492388	psi-mi:myh6_human(display_long)|uniprotkb:Myosin heavy chain 6(gene name synonym)|uniprotkb:Myosin heavy chain, cardiac muscle alpha isoform(gene name synonym)|uniprotkb:MYH6(gene name)|psi-mi:MYH6(display_short)|uniprotkb:MYHCA(gene name synonym)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996222|imex:IM-29014-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002462.2|ensembl:ENSG00000197616(gene)|ensembl:ENST00000405093(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007512"(adult heart development)|go:"GO:0007522"(visceral muscle development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016459"(myosin complex)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030239"(myofibril assembly)|go:"GO:0032982"(myosin filament)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060420"(regulation of heart growth)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|reactome:R-HSA-390522	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"5 A/D, (Supp. figure 7 and 3D)"|comment:A longer MYH6/7 substrate, CFP-HRLDEAEQIALKGG↓KKQLQK-YFP, was also tested and found to be cleavable.  MERS PLpro produced only very weak bands after 24 h at room temperature.|antagonist:Zinc Acetate|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/16	rogid:W+Z6SSSLWzCGPSaXQFr+rNuOaB09606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:fYuWTacf6IpT7SWZHBWoF/PmyCI	false	sufficient binding region:1801-1816|cyan fluorescent protein tag:n-n|biological feature:1810-1810|his tag:n-n|yellow fluorescent protein tag:c-c	sufficient binding region:746-1060(IPR013016)|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P07225	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-2803380|uniprotkb:Q7Z715|uniprotkb:Q9UCZ8|uniprotkb:Q15518|uniprotkb:A8KAC9|uniprotkb:D3DN28|ensembl:ENSP00000330021|ensembl:ENSP00000377783	intact:EBI-25492388	psi-mi:pros_human(display_long)|uniprotkb:PROS(gene name synonym)|uniprotkb:PROS1(gene name)|psi-mi:PROS1(display_short)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996294|imex:IM-29014-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001301006.1|refseq:NP_000304.2|ensembl:ENSG00000184500(gene)|ensembl:ENST00000348974(transcript)|ensembl:ENST00000394236(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR033189|interpro:IPR035972|rcsb pdb:1Z6C|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-977606	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"6, (Supp. figure 7 and 3D)"|comment:"PROS1 sequence:It is stated that:- \"the variant IDHSAWLLIALRGG has also been found in humans.\"; however this sequence (D345) is the one listed in the only reviewed Uniprot entry - P07225."|comment:Cleavage was slow;cleavage products were visible in SDS-PAGE gels after 1-3 days of room-temperature incubation.|antagonist:Zinc Acetate|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/16	rogid:Dzwsl0PAf4lRj25V/jOlfPQzvRU9606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:ADij1p8s4yJahvoEDLbFCbnWh+w	false	sufficient binding region:344-363|cyan fluorescent protein tag:n-n|biological feature:357-357|his tag:n-n|yellow fluorescent protein tag:c-c|variant:345-345	sufficient binding region:746-1060(IPR013016)|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9BZS1	uniprotkb:K9N7C7-PRO_0000422441	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	intact:EBI-25592237	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:k9n7c7-pro_0000422441(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996646|imex:IM-29014-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:"7A, (Supp. figure 7 and 3D)"|antagonist:Zinc Acetate|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/16	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:gU+QZy5LwJHJ1ht/aSXd8wRLQN8	false	sufficient binding region:35-59|cyan fluorescent protein tag:n-n|his tag:n-n|yellow fluorescent protein tag:c-c	sufficient binding region:629..629-950..950(IPR013016)|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:K9N7C7-PRO_0000422441	uniprotkb:P07225	intact:EBI-25592237	intact:EBI-2803380|uniprotkb:Q7Z715|uniprotkb:Q9UCZ8|uniprotkb:Q15518|uniprotkb:A8KAC9|uniprotkb:D3DN28|ensembl:ENSP00000330021|ensembl:ENSP00000377783	psi-mi:k9n7c7-pro_0000422441(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:pros_human(display_long)|uniprotkb:PROS(gene name synonym)|uniprotkb:PROS1(gene name)|psi-mi:PROS1(display_short)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996673|imex:IM-29014-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25591996(chain-parent)	refseq:NP_001301006.1|refseq:NP_000304.2|ensembl:ENSG00000184500(gene)|ensembl:ENST00000348974(transcript)|ensembl:ENST00000394236(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR033189|interpro:IPR035972|rcsb pdb:1Z6C|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-977606	-	chain-seq-start:854|chain-seq-end:2740	-	figure legend:"6, (Supp. figure 7 and 3D)"|antagonist:Zinc Acetate|comment:"PROS1 sequence:It is stated that:- \"the variant IDHSAWLLIALRGG has also been found in humans.\"; however this sequence (D345) is the one listed in the only reviewed Uniprot entry - P07225. Cleavage was slow;cleavage products were visible in SDS-PAGE gels after 1-3 days of room-temperature incubation."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/16	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rogid:Dzwsl0PAf4lRj25V/jOlfPQzvRU9606	rigid:eUMxoiyW8c5JPcDw5v2c5oM5YBA	false	mutation disrupting interaction rate:739-739|sufficient binding region:629..629-950..950(IPR013016)|his tag:n-n	sufficient binding region:344-363|cyan fluorescent protein tag:n-n|biological feature:357-357|his tag:n-n|yellow fluorescent protein tag:c-c|variant:345-345	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0102"(sequence tag identification)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BZS1	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	intact:EBI-25492388	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996969|imex:IM-29014-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"7A, (Supp. figure 7 and 3D)"|antagonist:Zinc Acetate|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/17	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:YYOysCWz7xTHn6V5OeXxtSuvh6A	false	sufficient binding region:35-59|cyan fluorescent protein tag:n-n|his tag:n-n|yellow fluorescent protein tag:c-c	sufficient binding region:746-1060|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9BZS1	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	intact:EBI-25492388	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26996996|imex:IM-29014-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"7B, (Supp. figure 7 and 3D)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/17	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:YYOysCWz7xTHn6V5OeXxtSuvh6A	false	sufficient binding region:42-59|cyan fluorescent protein tag:n-n|his tag:n-n|yellow fluorescent protein tag:c-c|biological feature:53-53	sufficient binding region:746-1060|his tag:n-n	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9BZS1	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	intact:EBI-25492388	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26997029|imex:IM-29014-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"7 C/D, (Supp. figure 7 and 3D)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/17	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:YYOysCWz7xTHn6V5OeXxtSuvh6A	false	sufficient binding region:1-260|biological feature:53-53|his tag:n-n	sufficient binding region:746-1060|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9BZS1	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80	intact:EBI-25492388	psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26997094|imex:IM-29014-15	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"7 C, (Supp. figure 7 and 3D)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/17	rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:YYOysCWz7xTHn6V5OeXxtSuvh6A	false	sufficient binding region:1-260|biological feature:53-53|his tag:n-n	sufficient binding region:746-1060|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q15303	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	intact:EBI-25492388	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Reynolds et al. (maybe nowt curatable - all In Vivo enz, assay?)	imex:IM-29014|pubmed:34019767	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26997123|imex:IM-29014-17	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:"7F, (Supp. figure 7 and 3D)"|comment:No significant cleavage was observed with the MERS PLpro.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/28	2021/06/17	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:FaSk4YU4ibkpUGe4kOvcYum6bZI	false	sufficient binding region:136-151|cyan fluorescent protein tag:n-n|his tag:n-n|yellow fluorescent protein tag:c-c|biological feature:146-146	sufficient binding region:746-1060|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)