#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-26956485 intact:EBI-26956485 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956383|imex:IM-28888-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2A, Supp. figure 2E|comment:PQSs +3467 and -23,877 CD spectra have the typical pattern of peaks associated with parallel G4 structure.|agonist:K+|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:6011-6027 sufficient binding region:6011-6027 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956558 intact:EBI-26956558 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956556|imex:IM-28888-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2A, Supp. figure 2A|comment:CD spectra also showed peaks associated with parallel G4s, but with a milder increase in the positive peak with increasing [K+]. These G4s are probably less stable or less prone to fold.|agonist:K+|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:644-663 sufficient binding region:644-663 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956583 intact:EBI-26956583 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956570|imex:IM-28888-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2A, Supp. figure 2D|agonist:K+|comment:CD spectra also showed peaks associated with parallel G4s, but with a milder increase in the positive peak with increasing [K+]. These G4s are probably less stable or less prone to fold.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:15924-15941 sufficient binding region:15924-15941 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956647|imex:IM-28888-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2A, Supp. figure 2B|comment:PQSs +3467 and -23,877 CD spectra have the typical pattern of peaks associated with parallel G4 structure.|agonist:"K+ (CHEBI:29103)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:3467-3484 sufficient binding region:3467-3484 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956728|imex:IM-28888-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:3467-3484 sufficient binding region:3467-3484 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 uniprotkb:P62633 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956728|imex:IM-28888-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - false sufficient binding region:3467-3484 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956558 intact:EBI-26956558 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956873|imex:IM-28888-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:644-663 sufficient binding region:644-663 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956558 uniprotkb:P62633 refseq:NC_045512.2 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956873|imex:IM-28888-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - false sufficient binding region:644-663 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956583 intact:EBI-26956583 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956907|imex:IM-28888-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:15924-15941 sufficient binding region:15924-15941 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956583 uniprotkb:P62633 refseq:NC_045512.2 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956907|imex:IM-28888-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - false sufficient binding region:15924-15941 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956485 intact:EBI-26956485 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956919|imex:IM-28888-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:6011-6027 sufficient binding region:6011-6027 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956485 uniprotkb:P62633 refseq:NC_045512.2 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956919|imex:IM-28888-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - figure legend:3B|comment:CNBP caused a distortion and reduction of the characteristic G4 peaks of the spectra of the PQSs +644, +3467, -13,963 and -23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - false sufficient binding region:6011-6027 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956316|imex:IM-28888-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2B|comment:1D 1H NMR showed defined signals around 11-12 ppm, confirming the presence of Hoogsteen bonds and G4 structures.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:3467-3484 sufficient binding region:3467-3484 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956485 intact:EBI-26956485 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956637|imex:IM-28888-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2A|comment:1D 1H NMR showed defined signals around 11–12 ppm, confirming the presence of Hoogsteen bonds and G4 structures.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:6011-6027 sufficient binding region:6011-6027 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956583 intact:EBI-26956583 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956617|imex:IM-28888-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2B|comment:1D 1H NMR also showed G4 signatures but signals were less intense than those for +3467 and −23,877, suggesting that there is a less amount of G4 probably due to lower stabilities and loose global conformation.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:15924-15941 sufficient binding region:15924-15941 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956558 intact:EBI-26956558 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956627|imex:IM-28888-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2B|comment:1D 1H NMR also showed G4 signatures but signals were less intense than those for +3467 and −23,877, suggesting that there is a less amount of G4 probably due to lower stabilities and loose global conformation.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:644-663 sufficient binding region:644-663 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956665 intact:EBI-26956665 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+28,903 (n)"(display_short)|psi-mi:EBI-26956665(display_long) psi-mi:"+28,903 (n)"(display_short)|psi-mi:EBI-26956665(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956663|imex:IM-28888-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:2B|comment:"1D 1H NMR did not show G4 signals in the 11-12 ppm region but showed a clear signal around 13.7 ppm, indicating that this sequence does not form Hoogsteen bonds (i.e., G4 structures) but instead contains Watson-Crick base pairs to some extent."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 - - - false sufficient binding region:28903-28917 sufficient binding region:28903-28917 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62633 intact:EBI-26956583 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 refseq:NC_045512.2 psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956681|imex:IM-28888-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - - figure legend:3A|comment:Binding of CNBP to PQS -13,963 was less evident, as only mild shifts were observed at high CNBP concentrations.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - - false - sufficient binding region:15924-15941 - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:P62633 intact:EBI-26956558 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 refseq:NC_045512.2 psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956691|imex:IM-28888-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - - figure legend:3A|comment:PQSs +644, +3467 and -23,877 clearly interacted with CNBP|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - - false - sufficient binding region:644-663 - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:P62633 intact:EBI-26956331 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956701|imex:IM-28888-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - - figure legend:3A|comment:PQSs +644, +3467 and -23,877 clearly interacted with CNBP|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - - false - sufficient binding region:3467-3484 - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) uniprotkb:P62633 intact:EBI-26956485 intact:EBI-1047529|uniprotkb:D3DNB9|uniprotkb:D3DNC0|uniprotkb:D3DNC1|uniprotkb:P20694|uniprotkb:Q5QJR0|uniprotkb:Q6PJI7|uniprotkb:Q96NV3|uniprotkb:B4DP17|uniprotkb:Q4JGY1|uniprotkb:B2RAV9|uniprotkb:Q4JGY0|uniprotkb:Q5U0E9|ensembl:ENSP00000410619|uniprotkb:A8K7V4|uniprotkb:E9PDR7 refseq:NC_045512.2 psi-mi:cnbp_human(display_long)|uniprotkb:Zinc finger protein 9(gene name synonym)|uniprotkb:CNBP(gene name)|psi-mi:CNBP(display_short)|uniprotkb:ZNF9(gene name synonym)|uniprotkb:RNF163(gene name synonym)|uniprotkb:Cellular nucleic acid-binding protein(gene name synonym) psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26956711|imex:IM-28888-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) refseq:NP_001120664.1|refseq:NP_001120668.1|refseq:NP_003409.1|refseq:NP_001120665.1|refseq:NP_001120666.1|ensembl:ENSG00000169714(gene)|ensembl:ENST00000422453(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|mint:P62633|refseq:NP_001120667.1 - - - - figure legend:3A|comment:PQSs +644, +3467 and -23,877 clearly interacted with CNBP|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/19 rogid:x5yqfxy/s3fE/6EmvjrEe7PmanQ9606 - - false - sufficient binding region:6011-6027 - - psi-mi:"MI:0820"(molecular weight estimation by sybr staining) psi-mi:"MI:0820"(molecular weight estimation by sybr staining) intact:EBI-26956558 intact:EBI-26956558 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0966"(ultraviolet-visible spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957074|imex:IM-28888-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S3|comment:TDS spectra showed the typical G4 signatures for the PQS +644.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:644-663 sufficient binding region:644-663 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956583 intact:EBI-26956583 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"-13,963 (nsp12)"(display_short)|psi-mi:EBI-26956583(display_long) psi-mi:"MI:0966"(ultraviolet-visible spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957065|imex:IM-28888-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S3|comment:TDS spectra showed a less well defined spectrum for the −13,963 PQS as compared to +644, +3,467 and -23,877 PQS.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:15924-15941 sufficient binding region:15924-15941 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0966"(ultraviolet-visible spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957047|imex:IM-28888-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S3|comment:TDS spectra showed the typical G4 signature with two positive peaks around 243 and 273 nm and a negative peak at 295 nm.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:3467-3484 sufficient binding region:3467-3484 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956665 intact:EBI-26956665 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+28,903 (n)"(display_short)|psi-mi:EBI-26956665(display_long) psi-mi:"+28,903 (n)"(display_short)|psi-mi:EBI-26956665(display_long) psi-mi:"MI:0966"(ultraviolet-visible spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957083|imex:IM-28888-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S3|comment:A very low signal and poor defined spectrum was seen, which supports the absence of G4 structures and is probably compatible with self-complementary duplex structures.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:28903-28917 sufficient binding region:28903-28917 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956485 intact:EBI-26956485 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"-23,877 (nsp3)"(display_short)|psi-mi:EBI-26956485(display_long) psi-mi:"MI:0966"(ultraviolet-visible spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957056|imex:IM-28888-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S3|comment:TDS spectra showed the typical G4 signature with two positive peaks around 243 and 273 nm and a negative peak at 295 nm.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:6011-6027 sufficient binding region:6011-6027 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26957764 intact:EBI-26957764 ensembl:ENST00000369535.5 ensembl:ENST00000369535.5 psi-mi:promoter/pre-5'utr nras(display_short)|psi-mi:EBI-26957764(display_long) psi-mi:promoter/pre-5'utr nras(display_short)|psi-mi:EBI-26957764(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957388|imex:IM-28888-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - genomic coord:"chr1:114716863-114716883" genomic coord:"chr1:114716863-114716883" figure legend:Figure S4|comment:"NRAS Human RNA oligo -Positive control:> X400 fluorescence"|caution:"Reference 90 (PMID: 17322877) is given for the NRAS Human RNA oligo as a positive control here. The sequence for the only oligo found in that publication has been used here, however the sequence does not lie in the 5' UTR as stated, but in a flanking region ~100 residues upstream of Exon 1 (Transcript: NRAS-201 ENST00000369535.5)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:76023" intact:EBI-26957764 intact:EBI-8805500 ensembl:ENST00000369535.5 psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long) psi-mi:promoter/pre-5'utr nras(display_short)|psi-mi:EBI-26957764(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957388|imex:IM-28888-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - genomic coord:"chr1:114716863-114716883" figure legend:Figure S4|comment:"NRAS Human RNA oligo -Positive control:> X400 fluorescence"|caution:"Reference 90 (PMID: 17322877) is given for the NRAS Human RNA oligo as a positive control here. The sequence for the only oligo found in that publication has been used here, however the sequence does not lie in the 5' UTR as stated, but in a flanking region ~100 residues upstream of Exon 1 (Transcript: NRAS-201 ENST00000369535.5)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957399|imex:IM-28888-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was enhanced above 30-fold for +3467.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:3467-3484 sufficient binding region:3467-3484 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:76023" intact:EBI-26956331 intact:EBI-8805500 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957399|imex:IM-28888-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was enhanced above 30-fold for +3467.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false - sufficient binding region:3467-3484 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956558 intact:EBI-26956558 refseq:NC_045512.2 refseq:NC_045512.2 psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957408|imex:IM-28888-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was increased barely above 10-fold.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:644-663 sufficient binding region:644-663 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:76023" intact:EBI-26956558 intact:EBI-8805500 refseq:NC_045512.2 psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long) psi-mi:"+644 (nsp1)"(display_short)|psi-mi:EBI-26956558(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957408|imex:IM-28888-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was increased barely above 10-fold.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false - sufficient binding region:644-663 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957426|imex:IM-28888-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was increased barely above 10-fold.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:15924-15941 sufficient binding region:15924-15941 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:76023" intact:EBI-26956331 intact:EBI-8805500 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957426|imex:IM-28888-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was increased barely above 10-fold.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false - sufficient binding region:15924-15941 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26956331 intact:EBI-26956331 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957476|imex:IM-28888-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was enhanced above 50-fold for −23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false sufficient binding region:6011-6027 sufficient binding region:6011-6027 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:76023" intact:EBI-26956331 intact:EBI-8805500 refseq:NC_045512.2|intact:EBI-26956583|intact:EBI-26956485 psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long) psi-mi:"+3467 (nsp3)"(display_short)|psi-mi:EBI-26956331(display_long) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Bezzi et al. (2021) imex:IM-28888|pubmed:33807682 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26957476|imex:IM-28888-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:Figure S4|comment:ThT fluorescence was enhanced above 50-fold for −23,877.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/04/08 2021/04/20 - - - false - sufficient binding region:6011-6027 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)