#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63211 uniprotkb:P20789 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:"MI:2340"(electron microscopy 3D helical reconstruction) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-26982362|wwpdb:7L0P|wwpdb:7L0Q|wwpdb:7L0R|wwpdb:7L0S|emdb:EMD-23099|emdb:EMD-23100|emdb:EMD-23101|emdb:EMD-23102|imex:IM-29150-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N - - - figure legend:Table 1, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n mutation:273-290|sufficient binding region:50-390|mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362 5 5 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) uniprotkb:P63211 uniprotkb:P20068-PRO_0000019532 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-25406762 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:2340"(electron microscopy 3D helical reconstruction) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-26982362|wwpdb:7L0P|wwpdb:7L0Q|wwpdb:7L0R|wwpdb:7L0S|emdb:EMD-23099|emdb:EMD-23100|emdb:EMD-23101|emdb:EMD-23102|imex:IM-29150-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Table 1, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - 5 5 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:2340"(electron microscopy 3D helical reconstruction) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-26982362|wwpdb:7L0P|wwpdb:7L0Q|wwpdb:7L0R|wwpdb:7L0S|emdb:EMD-23099|emdb:EMD-23100|emdb:EMD-23101|emdb:EMD-23102|imex:IM-29150-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Table 1, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n his tag:n-n 5 5 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:2340"(electron microscopy 3D helical reconstruction) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-26982362|wwpdb:7L0P|wwpdb:7L0Q|wwpdb:7L0R|wwpdb:7L0S|emdb:EMD-23099|emdb:EMD-23100|emdb:EMD-23101|emdb:EMD-23102|imex:IM-29150-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Table 1, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - 5 5 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) uniprotkb:P63211 uniprotkb:P20789 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27031992|imex:IM-29150-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N - - - figure legend:Ext. Fig. 1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n mutation:273-290|binding-associated region:50-390|mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362 5 5 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20068-PRO_0000019532 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-25406762 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27031992|imex:IM-29150-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Ext. Fig. 1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - 5 5 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27031992|imex:IM-29150-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Ext. Fig. 1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n L-histidine residue:n-n 5 5 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27031992|imex:IM-29150-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Ext. Fig. 1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - 5 5 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27052964|imex:IM-29150-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Ext. Fig. 1c, 1d|comment:"Structure stabilized using circularized nanodiscs (cNDs) prepared with covalently circularized membrane scaffold proteins"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:akfZ/+MIkaH7yJgzUElF6PU2sh0 false ha tag:n-n L-histidine residue:n-n 5 5 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:0016"(circular dichroism) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27052964|imex:IM-29150-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Ext. Fig. 1c, 1d|comment:"Structure stabilized using circularized nanodiscs (cNDs) prepared with covalently circularized membrane scaffold proteins"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:akfZ/+MIkaH7yJgzUElF6PU2sh0 false ha tag:n-n - 5 5 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20789 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27052993|imex:IM-29150-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N - - - figure legend:Fig. 1b, Extd Fig. 1g, 1h|comment:"Structure shown to be stabilized using circularized nanodiscs (cNDs) prepared with covalently circularized membrane scaffold proteins"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n binding-associated region:50-390|mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362|mutation:273-290 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20068-PRO_0000019532 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-25406762 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:0016"(circular dichroism) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27052993|imex:IM-29150-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Fig. 1b, Extd Fig. 1g, 1h|comment:"Structure shown to be stabilized using circularized nanodiscs (cNDs) prepared with covalently circularized membrane scaffold proteins"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27052993|imex:IM-29150-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Fig. 1b, Extd Fig. 1g, 1h|comment:"Structure shown to be stabilized using circularized nanodiscs (cNDs) prepared with covalently circularized membrane scaffold proteins"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n L-histidine residue:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:0016"(circular dichroism) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27052993|imex:IM-29150-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Fig. 1b, Extd Fig. 1g, 1h|comment:"Structure shown to be stabilized using circularized nanodiscs (cNDs) prepared with covalently circularized membrane scaffold proteins"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20789 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:"MI:1247"(microscale thermophoresis) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053034|imex:IM-29150-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N - - - figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n binding-associated region:50-390|mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362|mutation:273-290 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20068-PRO_0000019532 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-25406762 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:1247"(microscale thermophoresis) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053034|imex:IM-29150-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:1247"(microscale thermophoresis) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053034|imex:IM-29150-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n L-histidine residue:n-n|fluorescent dye label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:1247"(microscale thermophoresis) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053034|imex:IM-29150-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20789 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053162|imex:IM-29150-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N - - - figure legend:Extd. Fig. 3b, Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n binding-associated region:50-390|mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362|mutation:273-290|15n label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20068-PRO_0000019532 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-25406762 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053162|imex:IM-29150-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Extd. Fig. 3b, Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n 15n label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053162|imex:IM-29150-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Extd. Fig. 3b, Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n L-histidine residue:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053162|imex:IM-29150-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Extd. Fig. 3b, Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20789 uniprotkb:P20068-PRO_0000019532 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 intact:EBI-25406762 psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-27053215|imex:IM-29150-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Extd. Fig. 3a, Supp. Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:whUUO3Gmy4PgC4MEuSOJKJP1NYg false binding-associated region:50-390|mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362|mutation:273-290|15n label:?-? 15n label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20789 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-11511610|ensembl:ENSRNOP00000035997|ensembl:ENSRNOP00000072865 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:ntr1_rat(display_long)|uniprotkb:Ntsr1(gene name)|psi-mi:Ntsr1(display_short)|uniprotkb:Ntsr(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053252|imex:IM-29150-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N rgd:1306076|refseq:NP_001102437.1|refseq:XP_006235850.1|ensembl:ENSRNOG00000028708(gene)|ensembl:ENSRNOT00000039780(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0043679"(axon terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|ensembl:ENSRNOT00000082073(transcript)|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-RNO-375276|reactome:R-RNO-416476|rcsb pdb:7L0P|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3ZEV|rcsb pdb:4BUO|rcsb pdb:4BV0|rcsb pdb:4BWB|rcsb pdb:4GRV|rcsb pdb:4XEE|rcsb pdb:4XES|rcsb pdb:5T04|rcsb pdb:6YVR|rcsb pdb:6Z4Q|rcsb pdb:6Z4S|rcsb pdb:6Z4V|rcsb pdb:6Z66|rcsb pdb:6Z8N|rcsb pdb:6ZA8|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|rcsb pdb:6ZIN|dip:DIP-59956N - - - figure legend:Extd Fig. 4a-d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:pAtnxIvKrIIDQFaLaGgH9AKWL2g10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n mutation:86-86,103-103,105-105,161-161,213-213,234-234,253-253,305-305,358-358,362-362|mutation:273-290|binding-associated region:50-390 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P20068-PRO_0000019532 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-25406762 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p20068-pro_0000019532(display_long)|uniprotkb:Nts(gene name)|psi-mi:Nts(display_short) psi-mi:"MI:0969"(bio-layer interferometry) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053252|imex:IM-29150-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N intact:EBI-25406725(chain-parent) - - chain-seq-start:150|chain-seq-end:162 figure legend:Extd Fig. 4a-d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ10116 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P62873-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20716555|ensembl:ENSP00000367872|ensembl:ENSP00000481878 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p62873-1(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0969"(bio-layer interferometry) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053252|imex:IM-29150-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENST00000378609(transcript)|ensembl:ENST00000610897(transcript)|ensembl:ENSG00000078369(gene)|intact:EBI-357130(isoform-parent) - - - figure legend:Extd Fig. 4a-d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n L-histidine residue:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63211 uniprotkb:P63096-1 intact:EBI-10220715|ensembl:ENSP00000248572|ensembl:ENSP00000388777|uniprotkb:Q6LCP6|uniprotkb:O43835|uniprotkb:A4D1H2|uniprotkb:Q16026|uniprotkb:Q08447 intact:EBI-20719902|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091 psi-mi:gbg1_human(display_long)|uniprotkb:GNGT1(gene name)|psi-mi:GNGT1(display_short)|uniprotkb:Transducin gamma chain(gene name synonym) psi-mi:p63096-1(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short) psi-mi:"MI:0969"(bio-layer interferometry) Zhang et al. (2021) imex:IM-29150|pubmed:33633398 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-27053252|imex:IM-29150-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127928(gene)|ensembl:ENST00000248572(transcript)|ensembl:ENST00000429473(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008104"(protein localization)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|refseq:NP_001316355.1|refseq:NP_068774.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-416476|dip:DIP-471N ensembl:ENSG00000127955(gene)|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|intact:EBI-618639(isoform-parent) - - - figure legend:Extd Fig. 4a-d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/30 2021/08/02 rogid:NxlxAriCsR/704Ox3CWukcrK4BU9606 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606 rigid:Nsy+KLUXDMQCru41R5UUV7Set00 false ha tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)