#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16602	uniprotkb:O60894	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-962893|ensembl:ENSP00000254661|uniprotkb:Q6FGS5	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp1_human(display_long)|uniprotkb:RAMP1(gene name)|psi-mi:RAMP1(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Josephs et al. (2021)	imex:IM-29058|pubmed:33602864	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-26968171|imex:IM-29058-1|wwpdb:7KNT|emdb:EMD-22962	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	ensembl:ENSG00000132329(gene)|ensembl:ENST00000254661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0005886"(plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0043235"(receptor complex)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0097643"(amylin receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150056"(amylin receptor complex 1)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990407"(calcitonin gene-related peptide binding)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|interpro:IPR006985(Receptor activity modifying protein)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR038126|rcsb pdb:2YX8|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6ZHO|go:"GO:0009986"(cell surface)|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_005846.1|dip:DIP-37675N	-	-	-	figure legend:Fig. 1, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2021/03/30	2021/05/01	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:AjPlwP60HYwVhzaZc86mkP6XjYQ9606	rigid:AgCEvgVj/m2+VoE6l8B0KBgDplU	false	his tag:c-c|binding-associated region:22-461	flag tag:n-n|binding-associated region:27-148	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P06881	uniprotkb:Q16602	intact:EBI-962928|ensembl:ENSP00000354286|ensembl:ENSP00000417833|uniprotkb:Q93048|uniprotkb:Q9UCP0	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	psi-mi:calca_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Josephs et al. (2021)	imex:IM-29058|pubmed:33602864	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26968213|imex:IM-29058-3|wwpdb:7KNU|emdb:EMD-22963	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000361010(transcript)|ensembl:ENST00000486207(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|ensembl:ENSG00000110680(gene)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031623"(receptor internalization)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0042311"(vasodilation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1LS7|rcsb pdb:6E3Y|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_001029125.1	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	-	-	-	figure legend:Figure 1, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2021/03/30	2021/06/03	rogid:gM1XX8NUOJKraSnqNoX6NO0oH8E9606	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rigid:FwgUJcwuENG42SGxkeKhaAurLv0	false	-	his tag:c-c|binding-associated region:22-461	3	3	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P06881	uniprotkb:O60894	intact:EBI-962928|ensembl:ENSP00000354286|ensembl:ENSP00000417833|uniprotkb:Q93048|uniprotkb:Q9UCP0	intact:EBI-962893|ensembl:ENSP00000254661|uniprotkb:Q6FGS5	psi-mi:calca_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)	psi-mi:ramp1_human(display_long)|uniprotkb:RAMP1(gene name)|psi-mi:RAMP1(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Josephs et al. (2021)	imex:IM-29058|pubmed:33602864	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26968213|imex:IM-29058-3|wwpdb:7KNU|emdb:EMD-22963	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000361010(transcript)|ensembl:ENST00000486207(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|ensembl:ENSG00000110680(gene)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031623"(receptor internalization)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0042311"(vasodilation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1LS7|rcsb pdb:6E3Y|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_001029125.1	ensembl:ENSG00000132329(gene)|ensembl:ENST00000254661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0005886"(plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0043235"(receptor complex)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0097643"(amylin receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150056"(amylin receptor complex 1)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990407"(calcitonin gene-related peptide binding)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|interpro:IPR006985(Receptor activity modifying protein)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR038126|rcsb pdb:2YX8|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6ZHO|go:"GO:0009986"(cell surface)|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_005846.1|dip:DIP-37675N	-	-	-	figure legend:Figure 1, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2021/03/30	2021/06/03	rogid:gM1XX8NUOJKraSnqNoX6NO0oH8E9606	rogid:AjPlwP60HYwVhzaZc86mkP6XjYQ9606	rigid:FwgUJcwuENG42SGxkeKhaAurLv0	false	-	flag tag:n-n|binding-associated region:27-148	3	3	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)