#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60700	uniprotkb:P63098	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-915984|uniprotkb:B5MDU4|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|uniprotkb:Q53SL0|uniprotkb:B2RC10|ensembl:ENSP00000234310	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:canb1_human(display_long)|uniprotkb:PPP3R1(gene name)|psi-mi:PPP3R1(display_short)|uniprotkb:CNA2(gene name synonym)|uniprotkb:CNB(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26922558|imex:IM-28874-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	refseq:NP_000936.1|dip:DIP-6096N|ensembl:ENSG00000221823(gene)|ensembl:ENST00000234310(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:P63098|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2P6B|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4OR9|rcsb pdb:4ORA|rcsb pdb:4ORC|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|reactome:R-HSA-111447|reactome:R-HSA-180024|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3a, 3c|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/13	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|mutation disrupting interaction strength:362-362,364-364|sufficient binding region:140-517|mutation with no effect:362-362|mutation disrupting interaction strength:364-364|mutation with no effect:437-437,466-466	his tag:n-n|sufficient binding region:1-170	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:Q08209	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-352922|uniprotkb:Q8TAW9|uniprotkb:A8K3B7|uniprotkb:B5BUA2|uniprotkb:A1A441|uniprotkb:A8W6Z7|ensembl:ENSP00000378323|uniprotkb:A8W6Z8	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:pp2ba_human(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26922558|imex:IM-28874-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:Q08209|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2JOG|rcsb pdb:2JZI|rcsb pdb:2P6B|rcsb pdb:2R28|rcsb pdb:2W73|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4Q5U|rcsb pdb:5C1V|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6UUQ|reactome:R-HSA-180024|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763|reactome:R-HSA-2025928|refseq:NP_000935.1|refseq:NP_001124163.1|refseq:NP_001124164.1|go:"GO:0043197"(dendritic spine)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042383"(sarcolemma)|dip:DIP-6095N	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3a, 3c|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/13	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|mutation disrupting interaction strength:362-362,364-364|sufficient binding region:140-517|mutation with no effect:362-362|mutation disrupting interaction strength:364-364|mutation with no effect:437-437,466-466	his tag:n-n|sufficient binding region:1-391	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:Q60700	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26947691|imex:IM-28874-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	figure legend:3b|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/13	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	sufficient binding region:140-517|maltose binding protein tag:n-n	mutation disrupting interaction strength:364-364|sufficient binding region:356-370	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:P63098	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-915984|uniprotkb:B5MDU4|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|uniprotkb:Q53SL0|uniprotkb:B2RC10|ensembl:ENSP00000234310	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:canb1_human(display_long)|uniprotkb:PPP3R1(gene name)|psi-mi:PPP3R1(display_short)|uniprotkb:CNA2(gene name synonym)|uniprotkb:CNB(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26947691|imex:IM-28874-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	refseq:NP_000936.1|dip:DIP-6096N|ensembl:ENSG00000221823(gene)|ensembl:ENST00000234310(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:P63098|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2P6B|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4OR9|rcsb pdb:4ORA|rcsb pdb:4ORC|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|reactome:R-HSA-111447|reactome:R-HSA-180024|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3b|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/13	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	sufficient binding region:140-517|maltose binding protein tag:n-n	his tag:n-n|sufficient binding region:1-170	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:Q08209	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-352922|uniprotkb:Q8TAW9|uniprotkb:A8K3B7|uniprotkb:B5BUA2|uniprotkb:A1A441|uniprotkb:A8W6Z7|ensembl:ENSP00000378323|uniprotkb:A8W6Z8	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:pp2ba_human(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26947691|imex:IM-28874-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:Q08209|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2JOG|rcsb pdb:2JZI|rcsb pdb:2P6B|rcsb pdb:2R28|rcsb pdb:2W73|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4Q5U|rcsb pdb:5C1V|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6UUQ|reactome:R-HSA-180024|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763|reactome:R-HSA-2025928|refseq:NP_000935.1|refseq:NP_001124163.1|refseq:NP_001124164.1|go:"GO:0043197"(dendritic spine)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042383"(sarcolemma)|dip:DIP-6095N	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3b|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/13	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	sufficient binding region:140-517|maltose binding protein tag:n-n	his tag:n-n|sufficient binding region:1-391	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:P63098	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-915984|uniprotkb:B5MDU4|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|uniprotkb:Q53SL0|uniprotkb:B2RC10|ensembl:ENSP00000234310	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:canb1_human(display_long)|uniprotkb:PPP3R1(gene name)|psi-mi:PPP3R1(display_short)|uniprotkb:CNA2(gene name synonym)|uniprotkb:CNB(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26956080|imex:IM-28874-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	refseq:NP_000936.1|dip:DIP-6096N|ensembl:ENSG00000221823(gene)|ensembl:ENST00000234310(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:P63098|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2P6B|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4OR9|rcsb pdb:4ORA|rcsb pdb:4ORC|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|reactome:R-HSA-111447|reactome:R-HSA-180024|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3D|comment:"A double mutant (with the mutation W352C in CNA as well as a  mutation V119S (V120S) in CNB) also did not bind."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/19	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|sufficient binding region:140-517	mutation disrupting interaction strength:120-120|his tag:n-n|sufficient binding region:1-170	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:Q08209	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-352922|uniprotkb:Q8TAW9|uniprotkb:A8K3B7|uniprotkb:B5BUA2|uniprotkb:A1A441|uniprotkb:A8W6Z7|ensembl:ENSP00000378323|uniprotkb:A8W6Z8	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:pp2ba_human(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26956080|imex:IM-28874-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:Q08209|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2JOG|rcsb pdb:2JZI|rcsb pdb:2P6B|rcsb pdb:2R28|rcsb pdb:2W73|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4Q5U|rcsb pdb:5C1V|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6UUQ|reactome:R-HSA-180024|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763|reactome:R-HSA-2025928|refseq:NP_000935.1|refseq:NP_001124163.1|refseq:NP_001124164.1|go:"GO:0043197"(dendritic spine)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042383"(sarcolemma)|dip:DIP-6095N	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3D|comment:"A double mutant (with the mutation W352C in CNA as well as a  mutation V119S (V120S) in CNB) also did not bind."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/19	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|sufficient binding region:140-517	his tag:n-n|sufficient binding region:1-391	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:P63098	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-915984|uniprotkb:B5MDU4|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|uniprotkb:Q53SL0|uniprotkb:B2RC10|ensembl:ENSP00000234310	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:canb1_human(display_long)|uniprotkb:PPP3R1(gene name)|psi-mi:PPP3R1(display_short)|uniprotkb:CNA2(gene name synonym)|uniprotkb:CNB(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26956112|imex:IM-28874-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	refseq:NP_000936.1|dip:DIP-6096N|ensembl:ENSG00000221823(gene)|ensembl:ENST00000234310(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:P63098|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2P6B|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4OR9|rcsb pdb:4ORA|rcsb pdb:4ORC|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|reactome:R-HSA-111447|reactome:R-HSA-180024|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3D|comment:"A double mutant (with the mutation W352C in CNA as well as a  mutation V119S (V120S) in CNB) also did not bind."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/19	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|sufficient binding region:140-517	mutation disrupting interaction strength:120-120|his tag:n-n|sufficient binding region:1-170	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:Q08209	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-352922|uniprotkb:Q8TAW9|uniprotkb:A8K3B7|uniprotkb:B5BUA2|uniprotkb:A1A441|uniprotkb:A8W6Z7|ensembl:ENSP00000378323|uniprotkb:A8W6Z8	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:pp2ba_human(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26956112|imex:IM-28874-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:Q08209|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2JOG|rcsb pdb:2JZI|rcsb pdb:2P6B|rcsb pdb:2R28|rcsb pdb:2W73|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4Q5U|rcsb pdb:5C1V|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6UUQ|reactome:R-HSA-180024|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763|reactome:R-HSA-2025928|refseq:NP_000935.1|refseq:NP_001124163.1|refseq:NP_001124164.1|go:"GO:0043197"(dendritic spine)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042383"(sarcolemma)|dip:DIP-6095N	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3D|comment:"A double mutant (with the mutation W352C in CNA as well as a  mutation V119S (V120S) in CNB) also did not bind."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/19	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|sufficient binding region:140-517	his tag:n-n|mutation disrupting interaction strength:352-352|sufficient binding region:1-391	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:P63098	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-915984|uniprotkb:B5MDU4|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|uniprotkb:Q53SL0|uniprotkb:B2RC10|ensembl:ENSP00000234310	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:canb1_human(display_long)|uniprotkb:PPP3R1(gene name)|psi-mi:PPP3R1(display_short)|uniprotkb:CNA2(gene name synonym)|uniprotkb:CNB(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26956144|imex:IM-28874-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	refseq:NP_000936.1|dip:DIP-6096N|ensembl:ENSG00000221823(gene)|ensembl:ENST00000234310(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:P63098|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2P6B|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4OR9|rcsb pdb:4ORA|rcsb pdb:4ORC|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|reactome:R-HSA-111447|reactome:R-HSA-180024|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3D|comment:"A double mutant (with the mutation W352C in CNA as well as a  mutation V119S (V120S) in CNB) also did not bind."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/19	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|sufficient binding region:140-517	his tag:n-n|sufficient binding region:1-170	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60700	uniprotkb:Q08209	intact:EBI-7248355|uniprotkb:P70286|uniprotkb:Q8C4N7|intact:MINT-126821|uniprotkb:Q8CDL6|uniprotkb:Q3TLL7|uniprotkb:Q8CBX3|ensembl:ENSMUSP00000023812|ensembl:ENSMUSP00000127629|ensembl:ENSMUSP00000133209	intact:EBI-352922|uniprotkb:Q8TAW9|uniprotkb:A8K3B7|uniprotkb:B5BUA2|uniprotkb:A1A441|uniprotkb:A8W6Z7|ensembl:ENSP00000378323|uniprotkb:A8W6Z8	psi-mi:m3k12_mouse(display_long)|uniprotkb:Map3k12(gene name)|psi-mi:Map3k12(display_short)|uniprotkb:Zpk(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine-zipper protein kinase(gene name synonym)|uniprotkb:Dual leucine zipper bearing kinase(gene name synonym)|uniprotkb:MAPK-upstream kinase(gene name synonym)	psi-mi:pp2ba_human(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duque et al. (2021)	pubmed:33600948|imex:IM-28874	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26956144|imex:IM-28874-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033608.3|refseq:NP_001157115.1|ensembl:ENSMUSG00000023050(gene)|ensembl:ENSMUST00000023812(transcript)|ensembl:ENSMUST00000169377(transcript)|ensembl:ENSMUST00000171565(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027257|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:XP_017172113.1|refseq:XP_017172114.1	go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:Q08209|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2JOG|rcsb pdb:2JZI|rcsb pdb:2P6B|rcsb pdb:2R28|rcsb pdb:2W73|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4Q5U|rcsb pdb:5C1V|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6UUQ|reactome:R-HSA-180024|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763|reactome:R-HSA-2025928|refseq:NP_000935.1|refseq:NP_001124163.1|refseq:NP_001124164.1|go:"GO:0043197"(dendritic spine)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042383"(sarcolemma)|dip:DIP-6095N	-	comment:mint|function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro	-	figure legend:3D|comment:"A double mutant (with the mutation W352C in CNA as well as a  mutation V119S (V120S) in CNB) also did not bind."|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/12	2021/04/19	rogid:fI+BJJCkAZxivJNAIAKTrbdIz/410090	rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606	rigid:0fe82caJdD0Ah0iwSx30b8W4/3Q	false	maltose binding protein tag:n-n|sufficient binding region:140-517	his tag:n-n|mutation disrupting interaction strength:352-352|sufficient binding region:1-391	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)