#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:597326"	uniprotkb:O15269	intact:EBI-8852014	intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26963993|imex:IM-28934-1|wwpdb:7K0I|emdb:EMD-22598	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/05/06	-	rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606	-	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:597326"	uniprotkb:O15270	intact:EBI-8852014	intact:EBI-766136|uniprotkb:Q16685|ensembl:ENSP00000216484	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:sptc2_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2(gene name synonym)|uniprotkb:SPTLC2(gene name)|psi-mi:SPTLC2(display_short)|uniprotkb:KIAA0526(gene name synonym)|uniprotkb:LCB2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2a(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26963993|imex:IM-28934-1|wwpdb:7K0I|emdb:EMD-22598	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004854.1|dip:DIP-34604N|ensembl:ENSG00000100596(gene)|ensembl:ENST00000216484(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0046511"(sphinganine biosynthetic process)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15270|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/05/06	-	rogid:9Y8pOwwEej+jqblWkGS0ixnNHLo9606	-	false	-	sufficient binding region:1-544	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:597326"	uniprotkb:Q969W0	intact:EBI-8852014	intact:EBI-723396|uniprotkb:Q8WTZ7|uniprotkb:B2RD54|ensembl:ENSP00000298130|uniprotkb:D3DS93	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:sptsa_human(display_long)|uniprotkb:SPTSSA(gene name)|psi-mi:SPTSSA(display_short)|uniprotkb:C14orf147(gene name synonym)|uniprotkb:SSSPTA(gene name synonym)|uniprotkb:Small subunit of serine palmitoyltransferase A(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26963993|imex:IM-28934-1|wwpdb:7K0I|emdb:EMD-22598	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_612145.2|ensembl:ENSG00000165389(gene)|ensembl:ENST00000298130(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008104"(protein localization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|interpro:IPR024512|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-60754N	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/05/06	-	rogid:zM1bN9vWtTuEJb4b+C4VybXs+8w9606	-	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:597326"	uniprotkb:O15269	intact:EBI-8852014	intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964005|imex:IM-28934-3|wwpdb:7K0J|emdb:EMD-22599|wwpdb:7K0K|emdb:EMD-22600|wwpdb:7K0L|emdb:EMD-22601	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	-	rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:597326"	uniprotkb:O15270	intact:EBI-8852014	intact:EBI-766136|uniprotkb:Q16685|ensembl:ENSP00000216484	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:sptc2_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2(gene name synonym)|uniprotkb:SPTLC2(gene name)|psi-mi:SPTLC2(display_short)|uniprotkb:KIAA0526(gene name synonym)|uniprotkb:LCB2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2a(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964005|imex:IM-28934-3|wwpdb:7K0J|emdb:EMD-22599|wwpdb:7K0K|emdb:EMD-22600|wwpdb:7K0L|emdb:EMD-22601	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004854.1|dip:DIP-34604N|ensembl:ENSG00000100596(gene)|ensembl:ENST00000216484(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0046511"(sphinganine biosynthetic process)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15270|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	-	rogid:9Y8pOwwEej+jqblWkGS0ixnNHLo9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:597326"	uniprotkb:Q969W0	intact:EBI-8852014	intact:EBI-723396|uniprotkb:Q8WTZ7|uniprotkb:B2RD54|ensembl:ENSP00000298130|uniprotkb:D3DS93	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:sptsa_human(display_long)|uniprotkb:SPTSSA(gene name)|psi-mi:SPTSSA(display_short)|uniprotkb:C14orf147(gene name synonym)|uniprotkb:SSSPTA(gene name synonym)|uniprotkb:Small subunit of serine palmitoyltransferase A(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964005|imex:IM-28934-3|wwpdb:7K0J|emdb:EMD-22599|wwpdb:7K0K|emdb:EMD-22600|wwpdb:7K0L|emdb:EMD-22601	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_612145.2|ensembl:ENSG00000165389(gene)|ensembl:ENST00000298130(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008104"(protein localization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|interpro:IPR024512|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-60754N	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	-	rogid:zM1bN9vWtTuEJb4b+C4VybXs+8w9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:597326"	uniprotkb:Q8N138	intact:EBI-8852014	intact:EBI-721750|uniprotkb:Q6UY83|uniprotkb:B3KS83|ensembl:ENSP00000304858|ensembl:ENSP00000377724|ensembl:ENSP00000464693	psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name)	psi-mi:orml3_human(display_long)|uniprotkb:ORMDL3(gene name)|psi-mi:ORMDL3(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964029|imex:IM-28934-5|wwpdb:7k0m|emdb:EMD-22602	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_644809.1|refseq:NP_001307730.1|refseq:NP_001307731.1|refseq:NP_001307732.1|dip:DIP-48687N|refseq:XP_016880835.1|refseq:XP_016880836.1|refseq:XP_016880837.1|ensembl:ENSG00000172057(gene)|ensembl:ENST00000304046(transcript)|ensembl:ENST00000394169(transcript)|ensembl:ENST00000579695(transcript)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042552"(myelination)|go:"GO:0061744"(motor behavior)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904221"(negative regulation of serine C-palmitoyltransferase activity)|interpro:IPR007203(ORMDL)|interpro:IPR029883|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|reactome:R-HSA-6798695	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	-	rogid:IDP6RMSMs7gmCCqbD9TvidUxFew9606	-	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q8N138	uniprotkb:O15269	intact:EBI-721750|uniprotkb:Q6UY83|uniprotkb:B3KS83|ensembl:ENSP00000304858|ensembl:ENSP00000377724|ensembl:ENSP00000464693	intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554	psi-mi:orml3_human(display_long)|uniprotkb:ORMDL3(gene name)|psi-mi:ORMDL3(display_short)	psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964029|imex:IM-28934-5|wwpdb:7k0m|emdb:EMD-22602	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_644809.1|refseq:NP_001307730.1|refseq:NP_001307731.1|refseq:NP_001307732.1|dip:DIP-48687N|refseq:XP_016880835.1|refseq:XP_016880836.1|refseq:XP_016880837.1|ensembl:ENSG00000172057(gene)|ensembl:ENST00000304046(transcript)|ensembl:ENST00000394169(transcript)|ensembl:ENST00000579695(transcript)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042552"(myelination)|go:"GO:0061744"(motor behavior)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904221"(negative regulation of serine C-palmitoyltransferase activity)|interpro:IPR007203(ORMDL)|interpro:IPR029883|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|reactome:R-HSA-6798695	refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	rogid:IDP6RMSMs7gmCCqbD9TvidUxFew9606	rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606	-	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q8N138	uniprotkb:O15270	intact:EBI-721750|uniprotkb:Q6UY83|uniprotkb:B3KS83|ensembl:ENSP00000304858|ensembl:ENSP00000377724|ensembl:ENSP00000464693	intact:EBI-766136|uniprotkb:Q16685|ensembl:ENSP00000216484	psi-mi:orml3_human(display_long)|uniprotkb:ORMDL3(gene name)|psi-mi:ORMDL3(display_short)	psi-mi:sptc2_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2(gene name synonym)|uniprotkb:SPTLC2(gene name)|psi-mi:SPTLC2(display_short)|uniprotkb:KIAA0526(gene name synonym)|uniprotkb:LCB2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2a(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964029|imex:IM-28934-5|wwpdb:7k0m|emdb:EMD-22602	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_644809.1|refseq:NP_001307730.1|refseq:NP_001307731.1|refseq:NP_001307732.1|dip:DIP-48687N|refseq:XP_016880835.1|refseq:XP_016880836.1|refseq:XP_016880837.1|ensembl:ENSG00000172057(gene)|ensembl:ENST00000304046(transcript)|ensembl:ENST00000394169(transcript)|ensembl:ENST00000579695(transcript)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042552"(myelination)|go:"GO:0061744"(motor behavior)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904221"(negative regulation of serine C-palmitoyltransferase activity)|interpro:IPR007203(ORMDL)|interpro:IPR029883|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|reactome:R-HSA-6798695	refseq:NP_004854.1|dip:DIP-34604N|ensembl:ENSG00000100596(gene)|ensembl:ENST00000216484(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0046511"(sphinganine biosynthetic process)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15270|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	rogid:IDP6RMSMs7gmCCqbD9TvidUxFew9606	rogid:9Y8pOwwEej+jqblWkGS0ixnNHLo9606	-	false	-	sufficient binding region:1-544	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q8N138	uniprotkb:Q969W0	intact:EBI-721750|uniprotkb:Q6UY83|uniprotkb:B3KS83|ensembl:ENSP00000304858|ensembl:ENSP00000377724|ensembl:ENSP00000464693	intact:EBI-723396|uniprotkb:Q8WTZ7|uniprotkb:B2RD54|ensembl:ENSP00000298130|uniprotkb:D3DS93	psi-mi:orml3_human(display_long)|uniprotkb:ORMDL3(gene name)|psi-mi:ORMDL3(display_short)	psi-mi:sptsa_human(display_long)|uniprotkb:SPTSSA(gene name)|psi-mi:SPTSSA(display_short)|uniprotkb:C14orf147(gene name synonym)|uniprotkb:SSSPTA(gene name synonym)|uniprotkb:Small subunit of serine palmitoyltransferase A(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26964029|imex:IM-28934-5|wwpdb:7k0m|emdb:EMD-22602	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_644809.1|refseq:NP_001307730.1|refseq:NP_001307731.1|refseq:NP_001307732.1|dip:DIP-48687N|refseq:XP_016880835.1|refseq:XP_016880836.1|refseq:XP_016880837.1|ensembl:ENSG00000172057(gene)|ensembl:ENST00000304046(transcript)|ensembl:ENST00000394169(transcript)|ensembl:ENST00000579695(transcript)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035339"(SPOTS complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042552"(myelination)|go:"GO:0061744"(motor behavior)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:1900060"(negative regulation of ceramide biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904221"(negative regulation of serine C-palmitoyltransferase activity)|interpro:IPR007203(ORMDL)|interpro:IPR029883|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|reactome:R-HSA-6798695	refseq:NP_612145.2|ensembl:ENSG00000165389(gene)|ensembl:ENST00000298130(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008104"(protein localization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|interpro:IPR024512|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-60754N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2021/04/27	2021/04/27	rogid:IDP6RMSMs7gmCCqbD9TvidUxFew9606	rogid:zM1bN9vWtTuEJb4b+C4VybXs+8w9606	-	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17115"	chebi:"CHEBI:15525"	intact:EBI-26965207|chebi:"CHEBI:45440"|chebi:"CHEBI:45451"|chebi:"CHEBI:45677"|chebi:"CHEBI:45590"|chebi:"CHEBI:45597"|chebi:"CHEBI:13167"|chebi:"CHEBI:21387"|chebi:"CHEBI:6301"	intact:EBI-2008688	psi-mi:l-serine(display_short)|psi-mi:"CHEBI:17115"(display_long)|intact:"(2S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-(-)-serine"(synonym)|intact:"(S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-hydroxypropionic acid"(synonym)|intact:"(S)-serine"(synonym)|intact:beta-Hydroxy-L-alanine(synonym)|intact:beta-Hydroxyalanine(synonym)|intact:"L-(-)-serine"(synonym)|intact:L-2-Amino-3-hydroxypropionic acid(synonym)|intact:L-3-Hydroxy-2-aminopropionic acid(synonym)|intact:L-3-Hydroxy-alanine(synonym)|intact:L-Ser(synonym)|intact:L-Serin(synonym)|intact:L-Serine(synonym)|intact:S(synonym)|intact:Ser(synonym)|intact:SERINE(synonym)|intact:Serine(synonym)|intact:L-serine(iupac name)	psi-mi:palmitoyl-coa(display_short)|psi-mi:"CHEBI:15525"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26965205|imex:IM-28934-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004758"(serine C-palmitoyltransferase activity)	-	-	figure legend:Fig. 1B|kinetics:Km for serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:2.6x10^-4(molar)	2021/04/27	2021/04/28	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17115"	rhea:"RHEA:14761"	intact:EBI-26965207|chebi:"CHEBI:45440"|chebi:"CHEBI:45451"|chebi:"CHEBI:45677"|chebi:"CHEBI:45590"|chebi:"CHEBI:45597"|chebi:"CHEBI:13167"|chebi:"CHEBI:21387"|chebi:"CHEBI:6301"	intact:EBI-26964783|wwpdb:7K0I|emdb:EMD-22598|intenz:2.3.1.50	psi-mi:l-serine(display_short)|psi-mi:"CHEBI:17115"(display_long)|intact:"(2S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-(-)-serine"(synonym)|intact:"(S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-hydroxypropionic acid"(synonym)|intact:"(S)-serine"(synonym)|intact:beta-Hydroxy-L-alanine(synonym)|intact:beta-Hydroxyalanine(synonym)|intact:"L-(-)-serine"(synonym)|intact:L-2-Amino-3-hydroxypropionic acid(synonym)|intact:L-3-Hydroxy-2-aminopropionic acid(synonym)|intact:L-3-Hydroxy-alanine(synonym)|intact:L-Ser(synonym)|intact:L-Serin(synonym)|intact:L-Serine(synonym)|intact:S(synonym)|intact:Ser(synonym)|intact:SERINE(synonym)|intact:Serine(synonym)|intact:L-serine(iupac name)	psi-mi:spt-c2-sa_human(display_short)|psi-mi:"RHEA:14761"(display_long)|intact:Serine palmitoyltransferase complex, SPTLC1-SPTLC2-SPTSSA variant(complex recommended name)|intact:SPT complex(complex synonym)|intact:Serine C-palmitoyltransferase complex(complex synonym)|intact:"2xSPTLC1:2xSPTLC2:2xSPTSSA"(complex systematic name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26965205|imex:IM-28934-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|intact:EBI-26963993(exp-evidence)|complex portal:CPX-6663(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:33558761(see-also)|reactome:R-HSA-428140(see-also)|pubmed:19416851(see-also)|efo:"Orphanet:36386"(see-also)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)	go:"GO:0004758"(serine C-palmitoyltransferase activity)	-	curated-complex:"Catalyzes the first, rate-limiting step of the sphingolipid synthesis pathway, driving the condensation of L-serine and acyl-CoA thioester substrates to form 3-dehydrosphinganinium (CHEBI:58299). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for a C16-CoA substrate, typically palmitoyl-CoA."|complex-properties:"The cytosolic regions of SPTLC1 and SPTLC2 interact to form a heterodimer which further assembles into a dimer-of-dimers. SPTSSA then interacts with SPTLC2 via its cytosolic interfacial helix and appears to promote the catalytic activity of the complex by stabilizing SPTLC2. The side chain of SPTSSA Met-28 protrudes into and seals the substrate-binding tunnel formed mainly by SPTLC2. Binding of any substrates longer than a C16-CoA would be energetically disfavoured due to steric clashes with Met-28. The pyridoxal 5'-phosphate (PLP) molecules bind primarily to SPTLC2 residues, where the amine group of L-serine attacks and displaces the lysine bound to PLP indicating that SPTLC2 is the catalytic subunit of the enzyme complex."|disease:"Hereditary sensory neuropathy type I (HSN I) [Orphanet:36386]: a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset."|complex-assembly:Heterohexamer	figure legend:Fig. 1B|kinetics:Km for serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:2.6x10^-4(molar)	2021/04/27	2021/04/28	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17115"	chebi:"CHEBI:582124"	intact:EBI-26965207|chebi:"CHEBI:45440"|chebi:"CHEBI:45451"|chebi:"CHEBI:45677"|chebi:"CHEBI:45590"|chebi:"CHEBI:45597"|chebi:"CHEBI:13167"|chebi:"CHEBI:21387"|chebi:"CHEBI:6301"	intact:EBI-26965289	psi-mi:l-serine(display_short)|psi-mi:"CHEBI:17115"(display_long)|intact:"(2S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-(-)-serine"(synonym)|intact:"(S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-hydroxypropionic acid"(synonym)|intact:"(S)-serine"(synonym)|intact:beta-Hydroxy-L-alanine(synonym)|intact:beta-Hydroxyalanine(synonym)|intact:"L-(-)-serine"(synonym)|intact:L-2-Amino-3-hydroxypropionic acid(synonym)|intact:L-3-Hydroxy-2-aminopropionic acid(synonym)|intact:L-3-Hydroxy-alanine(synonym)|intact:L-Ser(synonym)|intact:L-Serin(synonym)|intact:L-Serine(synonym)|intact:S(synonym)|intact:Ser(synonym)|intact:SERINE(synonym)|intact:Serine(synonym)|intact:L-serine(iupac name)	psi-mi:myriocin(display_short)|psi-mi:"CHEBI:582124"(display_long)|intact:antibiotic ISP-I(synonym)|intact:Thermozymocidin(synonym)|intact:"(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid"(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26965297|imex:IM-28934-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004758"(serine C-palmitoyltransferase activity)	-	-	figure legend:Fig. 1B|kinetics:Km for serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:3.0x10^-4(molar)	2021/04/27	2021/04/28	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17115"	chebi:"CHEBI:15525"	intact:EBI-26965207|chebi:"CHEBI:45440"|chebi:"CHEBI:45451"|chebi:"CHEBI:45677"|chebi:"CHEBI:45590"|chebi:"CHEBI:45597"|chebi:"CHEBI:13167"|chebi:"CHEBI:21387"|chebi:"CHEBI:6301"	intact:EBI-2008688	psi-mi:l-serine(display_short)|psi-mi:"CHEBI:17115"(display_long)|intact:"(2S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-(-)-serine"(synonym)|intact:"(S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-hydroxypropionic acid"(synonym)|intact:"(S)-serine"(synonym)|intact:beta-Hydroxy-L-alanine(synonym)|intact:beta-Hydroxyalanine(synonym)|intact:"L-(-)-serine"(synonym)|intact:L-2-Amino-3-hydroxypropionic acid(synonym)|intact:L-3-Hydroxy-2-aminopropionic acid(synonym)|intact:L-3-Hydroxy-alanine(synonym)|intact:L-Ser(synonym)|intact:L-Serin(synonym)|intact:L-Serine(synonym)|intact:S(synonym)|intact:Ser(synonym)|intact:SERINE(synonym)|intact:Serine(synonym)|intact:L-serine(iupac name)	psi-mi:palmitoyl-coa(display_short)|psi-mi:"CHEBI:15525"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26965297|imex:IM-28934-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004758"(serine C-palmitoyltransferase activity)	-	-	figure legend:Fig. 1B|kinetics:Km for serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:3.0x10^-4(molar)	2021/04/27	2021/04/28	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17115"	rhea:"RHEA:14761"	intact:EBI-26965207|chebi:"CHEBI:45440"|chebi:"CHEBI:45451"|chebi:"CHEBI:45677"|chebi:"CHEBI:45590"|chebi:"CHEBI:45597"|chebi:"CHEBI:13167"|chebi:"CHEBI:21387"|chebi:"CHEBI:6301"	intact:EBI-26964783|wwpdb:7K0I|emdb:EMD-22598|intenz:2.3.1.50	psi-mi:l-serine(display_short)|psi-mi:"CHEBI:17115"(display_long)|intact:"(2S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-(-)-serine"(synonym)|intact:"(S)-2-amino-3-hydroxypropanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-hydroxypropionic acid"(synonym)|intact:"(S)-serine"(synonym)|intact:beta-Hydroxy-L-alanine(synonym)|intact:beta-Hydroxyalanine(synonym)|intact:"L-(-)-serine"(synonym)|intact:L-2-Amino-3-hydroxypropionic acid(synonym)|intact:L-3-Hydroxy-2-aminopropionic acid(synonym)|intact:L-3-Hydroxy-alanine(synonym)|intact:L-Ser(synonym)|intact:L-Serin(synonym)|intact:L-Serine(synonym)|intact:S(synonym)|intact:Ser(synonym)|intact:SERINE(synonym)|intact:Serine(synonym)|intact:L-serine(iupac name)	psi-mi:spt-c2-sa_human(display_short)|psi-mi:"RHEA:14761"(display_long)|intact:Serine palmitoyltransferase complex, SPTLC1-SPTLC2-SPTSSA variant(complex recommended name)|intact:SPT complex(complex synonym)|intact:Serine C-palmitoyltransferase complex(complex synonym)|intact:"2xSPTLC1:2xSPTLC2:2xSPTSSA"(complex systematic name)	psi-mi:"MI:0415"(enzymatic study)	Wang et al. (2021)	imex:IM-28934|pubmed:33558761	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26965297|imex:IM-28934-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|intact:EBI-26963993(exp-evidence)|complex portal:CPX-6663(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:33558761(see-also)|reactome:R-HSA-428140(see-also)|pubmed:19416851(see-also)|efo:"Orphanet:36386"(see-also)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)	go:"GO:0004758"(serine C-palmitoyltransferase activity)	-	curated-complex:"Catalyzes the first, rate-limiting step of the sphingolipid synthesis pathway, driving the condensation of L-serine and acyl-CoA thioester substrates to form 3-dehydrosphinganinium (CHEBI:58299). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for a C16-CoA substrate, typically palmitoyl-CoA."|complex-properties:"The cytosolic regions of SPTLC1 and SPTLC2 interact to form a heterodimer which further assembles into a dimer-of-dimers. SPTSSA then interacts with SPTLC2 via its cytosolic interfacial helix and appears to promote the catalytic activity of the complex by stabilizing SPTLC2. The side chain of SPTSSA Met-28 protrudes into and seals the substrate-binding tunnel formed mainly by SPTLC2. Binding of any substrates longer than a C16-CoA would be energetically disfavoured due to steric clashes with Met-28. The pyridoxal 5'-phosphate (PLP) molecules bind primarily to SPTLC2 residues, where the amine group of L-serine attacks and displaces the lysine bound to PLP indicating that SPTLC2 is the catalytic subunit of the enzyme complex."|disease:"Hereditary sensory neuropathy type I (HSN I) [Orphanet:36386]: a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset."|complex-assembly:Heterohexamer	figure legend:Fig. 1B|kinetics:Km for serine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:3.0x10^-4(molar)	2021/04/27	2021/04/28	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)