#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTC2	uniprotkb:P01130	intact:EBI-25474821	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592776|imex:IM-28670-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	-	-	-	figure legend:2|comment:Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD  with reasonable affinity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2021/01/11	2021/01/15	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rigid:kfAhlWsVMvbMh76r44RNUGMT8ug	false	s tag:n-n|flag tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTC2	uniprotkb:P00533	intact:EBI-25474821	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592776|imex:IM-28670-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	-	-	-	figure legend:2|comment:Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD  with reasonable affinity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2021/01/11	2021/01/15	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rigid:kfAhlWsVMvbMh76r44RNUGMT8ug	false	s tag:n-n|flag tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTC2	uniprotkb:P30530	intact:EBI-25474821	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592776|imex:IM-28670-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	-	-	-	figure legend:2|comment:Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD  with reasonable affinity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2021/01/11	2021/01/15	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rigid:kfAhlWsVMvbMh76r44RNUGMT8ug	false	s tag:n-n|flag tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTC2	uniprotkb:P01130	intact:EBI-25474821	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592797|imex:IM-28670-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	-	-	-	figure legend:2|comment:Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD  with reasonable affinity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-beas_2b)|taxid:9606(Human bronchial epithelial cell line BEAS-2B)	-	2021/01/11	2021/01/15	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rigid:kfAhlWsVMvbMh76r44RNUGMT8ug	false	s tag:n-n|flag tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTC2	uniprotkb:P00533	intact:EBI-25474821	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592797|imex:IM-28670-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	-	-	-	figure legend:2|comment:Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD  with reasonable affinity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-beas_2b)|taxid:9606(Human bronchial epithelial cell line BEAS-2B)	-	2021/01/11	2021/01/15	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rigid:kfAhlWsVMvbMh76r44RNUGMT8ug	false	s tag:n-n|flag tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTC2	uniprotkb:P30530	intact:EBI-25474821	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592797|imex:IM-28670-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	-	-	-	figure legend:2|comment:Three human receptor proteins, AXL, LDLR and EGFR, bound the SARS-CoV-2-S NTD or RBD  with reasonable affinity.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-beas_2b)|taxid:9606(Human bronchial epithelial cell line BEAS-2B)	-	2021/01/11	2021/01/15	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rigid:kfAhlWsVMvbMh76r44RNUGMT8ug	false	s tag:n-n|flag tag:n-n|sbp:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592818|imex:IM-28670-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00533	uniprotkb:P0DTC2	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-25474821	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592826|imex:IM-28670-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:ody3TEiVNL/yoVeBnuVg0mGf82s	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P01130	uniprotkb:P0DTC2	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	intact:EBI-25474821	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592834|imex:IM-28670-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:QQdeGqNGOHPHwq/vmIpp2vCD0pY	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYF1	uniprotkb:P0DTC2	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25474821	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592842|imex:IM-28670-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:3A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:HsUltcKq/ARrTkmVPSSTEFwwdk8	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26595684|imex:IM-28670-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:4I|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/18	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	myc tag:n-n|sufficient binding region:1-449	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P01130	uniprotkb:P0DTC2	intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7	intact:EBI-25474821	psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592857|imex:IM-28670-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3B|comment:LDLR and EGFR did not co-localize to the cell membrane.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:QQdeGqNGOHPHwq/vmIpp2vCD0pY	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592865|imex:IM-28670-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	go:"GO:0005886"(plasma membrane)	-	-	figure legend:3B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P00533	uniprotkb:P0DTC2	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-25474821	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592881|imex:IM-28670-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3B|comment:LDLR and EGFR did not co-localize to the cell membrane.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:ody3TEiVNL/yoVeBnuVg0mGf82s	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q9BYF1	uniprotkb:P0DTC2	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25474821	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26592873|imex:IM-28670-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	go:"GO:0005886"(plasma membrane)	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:3B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/15	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:HsUltcKq/ARrTkmVPSSTEFwwdk8	false	myc tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26593609|imex:IM-28670-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/11	2021/01/15	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	his tag:?-?|sufficient binding region:1-449	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26595344|imex:IM-28670-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:882.0x10^-9(molar)	2021/01/11	2021/01/18	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	flag tag:?-?	his tag:?-?|sufficient binding region:13-303	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26595327|imex:IM-28670-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:3D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.82x10^-7(molar)	2021/01/11	2021/01/18	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	flag tag:?-?	his tag:?-?|sufficient binding region:13-303	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30530	uniprotkb:P0DTC2	intact:EBI-2850927|uniprotkb:Q9UD27|uniprotkb:Q8N5L2|ensembl:ENSP00000301178	intact:EBI-25474821	psi-mi:ufo_human(display_long)|uniprotkb:UFO(gene name synonym)|uniprotkb:AXL oncogene(gene name synonym)|uniprotkb:AXL(gene name)|psi-mi:AXL(display_short)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26595492|imex:IM-28670-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001690.2|refseq:NP_068713.2|ensembl:ENSG00000167601(gene)|ensembl:ENST00000301178(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021885"(forebrain cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032940"(secretion by cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044228"(host cell surface)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051250"(negative regulation of lymphocyte activation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P30530|rcsb pdb:2C5D|rcsb pdb:4RA0|rcsb pdb:5U6B|rcsb pdb:5VXZ|reactome:R-HSA-4420097	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	go:"GO:0009986"(cell surface)	-	-	figure legend:4F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/18	rogid:GMGuoyV5CkwYx9zsEx4NTCkPezA9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:TNoZ+tKkrcehhoLdM6cW0RULa/k	false	myc tag:?-?	-	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q9BYF1	uniprotkb:P0DTC2	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25474821	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Wang et al. (2021)	pubmed:33420426|imex:IM-28670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26595510|imex:IM-28670-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	go:"GO:0009986"(cell surface)	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:4F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/01/11	2021/01/18	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:HsUltcKq/ARrTkmVPSSTEFwwdk8	false	myc tag:?-?	-	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)