#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O70458	uniprotkb:Q9DBL1	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8347166|intact:MINT-1861281|ensembl:ENSMUSP00000015829	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:acdsb_mouse(display_long)|uniprotkb:Acadsb(gene name)|psi-mi:Acadsb(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_080102.1|ensembl:ENSMUSG00000030861(gene)|ensembl:ENSMUST00000015829(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:Q9DBL1|reactome:R-MMU-70895	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	comment:mint|function:"Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent"	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:xAhGO7nAJZdIuw2w6VswY2FS9mw10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P23953	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8347491|intact:MINT-1864941|uniprotkb:Q8K125|uniprotkb:P11374|uniprotkb:E9QQ07|uniprotkb:O54936|ensembl:ENSMUSP00000034189	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:est1c_mouse(display_long)|uniprotkb:Ces1c(gene name)|psi-mi:Ces1c(display_short)|uniprotkb:Es1(gene name synonym)|uniprotkb:Liver carboxylesterase N(gene name synonym)|uniprotkb:Lung surfactant convertase(gene name synonym)|uniprotkb:PES-N(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_031980.2|ensembl:ENSMUSG00000057400(gene)|ensembl:ENSMUST00000034189(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005811"(lipid droplet)|go:"GO:0009617"(response to bacterium)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0080030"(methyl indole-3-acetate esterase activity)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR019826|interpro:IPR029058|mint:P23953	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	comment:mint|function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:WtVaImE24SX5r+UPAefbwDSVQ0w10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P51174	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8345212|uniprotkb:O35302|uniprotkb:Q9CU29|uniprotkb:Q9DB83|uniprotkb:B2KGC6|intact:MINT-1861818|uniprotkb:Q8QZR6	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:acadl_mouse(display_long)|uniprotkb:Acadl(gene name)|psi-mi:Acadl(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|refseq:NP_031407.2|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR034179|interpro:IPR036250|interpro:IPR037069|mint:P51174|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0009409"(response to cold)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042413"(carnitine catabolic process)|go:"GO:0042758"(long-chain fatty acid catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-MMU-77285|reactome:R-MMU-77310|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	comment:mint	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:AhEJczI8Mvr0mAx2w1u+QFZ+fWA10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q8BH95	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8314728|ensembl:ENSMUSP00000026538|uniprotkb:Q3TJK2|intact:MINT-1859826|uniprotkb:Q6GQS2|uniprotkb:Q99LX7|uniprotkb:Q6PEN1	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:echm_mouse(display_long)|uniprotkb:Echs1(gene name)|psi-mi:Echs1(display_short)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|go:"GO:0120092"(crotonyl-CoA hydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:Q8BH95|reactome:R-MMU-70895|reactome:R-MMU-77310|reactome:R-MMU-77346|reactome:R-MMU-77348|reactome:R-MMU-77350|reactome:R-MMU-77352|ensembl:ENSMUSG00000025465(gene)|ensembl:ENSMUST00000026538(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|refseq:NP_444349.1	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	comment:mint|function:Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:SbPqgmn25/Ep+YB4dCqxT3xCxBA10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9CZR8	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8354585|intact:MINT-4094147|uniprotkb:Q3TFF5|ensembl:ENSMUSP00000042134	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:efts_mouse(display_long)|uniprotkb:Tsfm(gene name)|psi-mi:Tsfm(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_079813.1|ensembl:ENSMUSG00000040521(gene)|ensembl:ENSMUST00000040560(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006414"(translational elongation)|go:"GO:0070125"(mitochondrial translational elongation)|go:"GO:0070129"(regulation of mitochondrial translation)|interpro:IPR001816(Translation elongation factor EFTs/EF1B)|interpro:IPR009060(UBA-like)|interpro:IPR014039(Translation elongation factor EFTs/EF1B, dimerisation)|interpro:IPR018101|interpro:IPR036402|mint:Q9CZR8	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	comment:mint|function:Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:jYJw3+6eab4/loyYSaAiWiWQcl010090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q60936	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8347051|uniprotkb:Q8K0M1|uniprotkb:Q9D657|uniprotkb:Q9JHR3|uniprotkb:Q9DBR5|intact:MINT-1859515|ensembl:ENSMUSP00000027766|ensembl:ENSMUSP00000128290	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:coq8a_mouse(display_long)|uniprotkb:Coq8a(gene name)|psi-mi:Coq8a(display_short)|uniprotkb:Adck3(gene name synonym)|uniprotkb:Cabc1(gene name synonym)|uniprotkb:Chaperone activity of bc1 complex-like(gene name synonym)|uniprotkb:Coenzyme Q protein 8A(gene name synonym)|uniprotkb:aarF domain-containing protein kinase 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_075830.2|refseq:NP_001156762.1|refseq:XP_006497024.1|refseq:XP_006497025.1|ensembl:ENSMUSG00000026489(gene)|ensembl:ENSMUST00000027766(transcript)|ensembl:ENSMUST00000170472(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0043531"(ADP binding)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034640|interpro:IPR034646|mint:Q60936	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	function:May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain|comment:mint	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:mBL+f8T49kJm+ryI9VCRcUFyLZM10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q99LC5	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-8334254|uniprotkb:Q8BMD3|intact:MINT-1859759|uniprotkb:Q4V9X5|uniprotkb:Q3THD7|uniprotkb:Q8BMU7|uniprotkb:Q3V000|ensembl:ENSMUSP00000034866	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:etfa_mouse(display_long)|uniprotkb:Etfa(gene name)|psi-mi:Etfa(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_663590.3|ensembl:ENSMUSG00000032314(gene)|ensembl:ENSMUST00000034866(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017133"(mitochondrial electron transfer flavoprotein complex)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001308(Electron transfer flavoprotein, alpha subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR014731(Electron transfer flavoprotein, alpha subunit, C-terminal)|interpro:IPR018206|interpro:IPR029035|interpro:IPR033947|mint:Q99LC5|reactome:R-MMU-611105	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	comment:mint|function:"The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)"	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:J1V6KKCCnRXkfr72ArCLeyh9FLg10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q14CH7	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-26656010|ensembl:ENSMUSP00000024733|uniprotkb:Q68FH3|uniprotkb:Q69ZM9	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:syam_mouse(display_long)|uniprotkb:Aars2(gene name)|psi-mi:Aars2(display_short)|uniprotkb:Aarsl(gene name synonym)|uniprotkb:Gm89(gene name synonym)|uniprotkb:Kiaa1270(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000023938(gene)|ensembl:ENSMUST00000024733(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006400"(tRNA modification)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016597"(amino acid binding)|go:"GO:0070143"(mitochondrial alanyl-tRNA aminoacylation)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|refseq:NP_941010.2	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:MsfDIDc9GeV3o5egprUFqYNAZZM10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9DB77	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773760|uniprotkb:Q8BK11|uniprotkb:Q9CVK7|ensembl:ENSMUSP00000033176	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:qcr2_mouse(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:Uqcrc2(gene name)|psi-mi:Uqcrc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_080175.1|ensembl:ENSMUSG00000030884(gene)|ensembl:ENSMUST00000033176(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006508"(proteolysis)|go:"GO:0042493"|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:Q9DB77|reactome:R-MMU-611105	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:CTpkPoAK0EWa6sxA5LJY0srVn/s10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P70404	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773416|ensembl:ENSMUSP00000056502	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:idhg1_mouse(display_long)|uniprotkb:Isocitric dehydrogenase subunit gamma(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit gamma"(gene name synonym)|uniprotkb:Idh3g(gene name)|psi-mi:Idh3g(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_032349.1|ensembl:ENSMUSG00000002010(gene)|ensembl:ENSMUST00000052761(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:P70404|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:0wCp92dH0hTrNyYmucC9Ob73aBU10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q61941	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-15184302|uniprotkb:Q9JK70	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:nntm_mouse(display_long)|uniprotkb:Nnt(gene name)|psi-mi:Nnt(display_short)|uniprotkb:Nicotinamide nucleotide transhydrogenase(gene name synonym)|uniprotkb:Pyridine nucleotide transhydrogenase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	reactome:R-MMU-71403|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006740"(NADPH regeneration)|go:"GO:0008746"("NAD(P)+ transhydrogenase activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0050661"(NADP binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:0051287"(NAD binding)|interpro:IPR008143(Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2)|interpro:IPR008142(Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-1)|interpro:IPR007886(Alanine dehydrogenase/PNT, N-terminal)|interpro:IPR007698(Alanine dehydrogenase/PNT, C-terminal)|interpro:IPR029035|interpro:IPR026255|interpro:IPR024605|interpro:IPR034300|interpro:IPR036291	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:Seas/Iqob55Q1juwFSGIZt/hqXs10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q91WD5	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772751|uniprotkb:Q3U5Y9|uniprotkb:Q3UJX7|uniprotkb:Q99L23|uniprotkb:Q3TNA8|ensembl:ENSMUSP00000013737	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:ndus2_mouse(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)|uniprotkb:Ndufs2(gene name)|psi-mi:Ndufs2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_694704.1|ensembl:ENSMUSG00000013593(gene)|ensembl:ENSMUST00000013737(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:Q91WD5|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:dk8e26C1hIdTZvDnX5nE1n+juwk10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q91VD9	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772739|uniprotkb:Q3UQ73|uniprotkb:Q8BM16|ensembl:ENSMUSP00000027111|ensembl:ENSMUSP00000126621	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:ndus1_mouse(display_long)|uniprotkb:Complex I-75kD(gene name synonym)|uniprotkb:Ndufs1(gene name)|psi-mi:Ndufs1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_001153510.1|refseq:NP_001153511.1|refseq:NP_001153512.1|refseq:NP_663493.2|refseq:XP_006496015.1|ensembl:ENSMUSG00000025968(gene)|ensembl:ENSMUST00000027111(transcript)|ensembl:ENSMUST00000168099(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043209"(myelin sheath)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:Q91VD9|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:/akd0DjF9D063ihVFyTA0+Q0gJQ10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q8K2B3	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-1219461|uniprotkb:Q0QF19|uniprotkb:Q3UH25|uniprotkb:Q3UKP7|uniprotkb:Q3V4B1|uniprotkb:Q921P5|uniprotkb:Q9Z1Z4|ensembl:ENSMUSP00000022062	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:sdha_mouse(display_long)|uniprotkb:Sdha(gene name)|psi-mi:Sdha(display_short)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_075770.1|ensembl:ENSMUSG00000021577(gene)|ensembl:ENSMUST00000022062(transcript)|go:"GO:0000104"(succinate dehydrogenase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0043209"(myelin sheath)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|mint:Q8K2B3|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:DbI/pBVBwa3ezreOqH3hgGy1qkA10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9CZP5	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-26655978|ensembl:ENSMUSP00000027358|ensembl:ENSMUSP00000109361|ensembl:ENSMUSP00000109362	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:bcs1_mouse(display_long)|uniprotkb:Bcs1l(gene name)|psi-mi:Bcs1l(display_short)|uniprotkb:BCS1-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000026172(gene)|ensembl:ENSMUST00000027358(transcript)|ensembl:ENSMUST00000113732(transcript)|ensembl:ENSMUST00000113733(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR014851(BCS1 N terminal)|interpro:IPR027417|rcsb pdb:6U1Y|rcsb pdb:6UKO|rcsb pdb:6UKP|rcsb pdb:6UKS|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|refseq:NP_001292581.1|refseq:NP_080060.1	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:RE1tc8qtnMLGR3VkEKkh+tnQ6pk10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q8BKZ9	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-6877565|ensembl:ENSMUSP00000011058	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:odpx_mouse(display_long)|uniprotkb:Pdhx(gene name)|psi-mi:Pdhx(display_short)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000010914(gene)|ensembl:ENSMUST00000011058(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:Q8BKZ9|reactome:R-MMU-204174|reactome:R-MMU-389661|reactome:R-MMU-5362517|reactome:R-MMU-70268|refseq:NP_780303.1	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:5b1n89M4YLpENMk4kqCsO2oQqJ010090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q8QZT1	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773036|uniprotkb:Q3TE92|ensembl:ENSMUSP00000034547	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:thil_mouse(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:Acat1(gene name)|psi-mi:Acat1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_659033.1|ensembl:ENSMUSG00000032047(gene)|ensembl:ENSMUST00000034547(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q8QZT1|reactome:R-MMU-70895|reactome:R-MMU-77108|reactome:R-MMU-77111	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:nnHjpqiL4kor9wZWnMfHtun87EQ10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P26443	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773329|uniprotkb:Q8C273|ensembl:ENSMUSP00000022322	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:dhe3_mouse(display_long)|uniprotkb:Glud1(gene name)|psi-mi:Glud1(display_short)|uniprotkb:Glud(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_032159.1|ensembl:ENSMUSG00000021794(gene)|ensembl:ENSMUST00000022322(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0007616"(long-term memory)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|mint:P26443|reactome:R-MMU-2151201|reactome:R-MMU-8964539	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HbPeUm/tpMD6GrgM/863swTQqGA10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q99JY0	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-299517|ensembl:ENSMUSP00000026841|ensembl:ENSMUSP00000110431|ensembl:ENSMUSP00000110434|uniprotkb:Q3TEH9|uniprotkb:Q8BJI5|uniprotkb:Q8BJM0|uniprotkb:Q8BK52	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:echb_mouse(display_long)|uniprotkb:Hadhb(gene name)|psi-mi:Hadhb(display_short)|uniprotkb:TP-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000059447(gene)|ensembl:ENSMUST00000026841(transcript)|ensembl:ENSMUST00000114783(transcript)|ensembl:ENSMUST00000114786(transcript)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q99JY0|reactome:R-MMU-1482798|reactome:R-MMU-77285|reactome:R-MMU-77305|reactome:R-MMU-77310|reactome:R-MMU-77346|reactome:R-MMU-77348|reactome:R-MMU-77350|interpro:IPR002155(Thiolase)|refseq:NP_663533.1|refseq:NP_001276727.1|refseq:NP_001276728.1|refseq:XP_017176317.1|refseq:XP_017176318.1	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:XpJTZFG2xL1ouAgOyU562mqD64I10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9DC61	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-527530|uniprotkb:Q3TF19|ensembl:ENSMUSP00000075762	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:mppa_mouse(display_long)|uniprotkb:Alpha-MPP(gene name synonym)|uniprotkb:P-55(gene name synonym)|uniprotkb:Pmpca(gene name)|psi-mi:Pmpca(display_short)|uniprotkb:Inpp5e(gene name synonym)|uniprotkb:Inactive zinc metalloprotease alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_775272.1|ensembl:ENSMUSG00000026926(gene)|ensembl:ENSMUST00000076431(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR037715|mint:Q9DC61|reactome:R-MMU-8949664	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:gNx6vEfGhgEGltOqH5c1g62tvjg10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P47738	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-2308120|ensembl:ENSMUSP00000031411	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:aldh2_mouse(display_long)|uniprotkb:Aldh2(gene name)|psi-mi:Aldh2(display_short)|uniprotkb:Ahd-1(gene name synonym)|uniprotkb:Ahd1(gene name synonym)|uniprotkb:ALDH class 2(gene name synonym)|uniprotkb:AHD-M1(gene name synonym)|uniprotkb:ALDHI(gene name synonym)|uniprotkb:ALDH-E2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_033786.1|ensembl:ENSMUSG00000029455(gene)|ensembl:ENSMUST00000031411(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051287"(NAD binding)|go:"GO:0070404"(NADH binding)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P47738|reactome:R-MMU-380612|reactome:R-MMU-71384	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:C4L2qigIlQeaZH4RsNocJovkPMw10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q60930	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-444578|ensembl:ENSMUSP00000022293|uniprotkb:Q78MH6|uniprotkb:Q99L98	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:vdac2_mouse(display_long)|uniprotkb:Voltage-dependent anion-selective channel protein 6(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)|uniprotkb:Vdac6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_035825.1|ensembl:ENSMUSG00000021771(gene)|ensembl:ENSMUST00000022293(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:Q60930|reactome:R-MMU-5689880	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:ApSD4TVlagQ1QHePbOZw7J5rmzQ10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9WUM5	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773740|uniprotkb:Q8C2C3|uniprotkb:Q9DBA3|uniprotkb:Q9DCI8|ensembl:ENSMUSP00000065113	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:suca_mouse(display_long)|uniprotkb:Succinyl-CoA synthetase subunit alpha(gene name synonym)|uniprotkb:Suclg1(gene name)|psi-mi:Suclg1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_063932.2|ensembl:ENSMUSG00000052738(gene)|ensembl:ENSMUST00000064740(transcript)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0009361"("succinate-CoA ligase complex (ADP-forming)")|go:"GO:0019003"(GDP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR003781(CoA-binding)|interpro:IPR005810(Succinyl-CoA ligase, alpha subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|interpro:IPR033847|interpro:IPR036291|mint:Q9WUM5|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:Bb1b4P5dXlGyek/f6p8+X0Dbzt010090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9QYA2	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-2934825|ensembl:ENSMUSP00000032555|ensembl:ENSMUSP00000104090|uniprotkb:Q3TBZ2|uniprotkb:Q3TQA1|uniprotkb:Q8VI26|uniprotkb:Q8VI27|uniprotkb:Q9Z2N1	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:tom40_mouse(display_long)|uniprotkb:Tomm40(gene name)|psi-mi:Tomm40(display_short)|uniprotkb:Mom35(gene name synonym)|uniprotkb:Tom40(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein of 35 kDa(gene name synonym)|uniprotkb:Protein Haymaker(gene name synonym)|uniprotkb:Translocase of outer membrane 40 kDa subunit homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000002984(gene)|ensembl:ENSMUST00000032555(transcript)|ensembl:ENSMUST00000093552(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0046930"(pore complex)|go:"GO:0051204"(protein insertion into mitochondrial membrane)|go:"GO:0070678"(preprotein binding)|interpro:IPR023614|interpro:IPR027246|interpro:IPR037930|reactome:R-MMU-5205685|refseq:NP_001103218.1|refseq:NP_058567.2	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:uLvvIUNClH260oadgLPk+suS/4U10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9QXX4	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-775952|uniprotkb:Q9CZF6|uniprotkb:Q9DCF5|ensembl:ENSMUSP00000015256|ensembl:ENSMUSP00000139571	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:cmc2_mouse(display_long)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym)|uniprotkb:Slc25a13(gene name)|psi-mi:Slc25a13(display_short)|uniprotkb:Aralar2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_001171043.1|refseq:NP_056644.1|ensembl:ENSMUSG00000015112(gene)|ensembl:ENSMUST00000015256(transcript)|ensembl:ENSMUST00000188414(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9QXX4|reactome:R-MMU-70263|reactome:R-MMU-8963693	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:c7qSgch4lV/J3PGriiqzNknznm010090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P97807	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-1634334|uniprotkb:Q99JL0|uniprotkb:Q9DCX0|intact:EBI-2257633|uniprotkb:Q3UIA9|ensembl:ENSMUSP00000027810	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:fumh_mouse(display_long)|uniprotkb:Fh(gene name)|psi-mi:Fh(display_short)|uniprotkb:Fh1(gene name synonym)|uniprotkb:EF-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_034339.2|ensembl:ENSMUSG00000026526(gene)|ensembl:ENSMUST00000027810(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0000821"(regulation of arginine metabolic process)|go:"GO:0004333"(fumarate hydratase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006106"(fumarate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045239"(tricarboxylic acid cycle enzyme complex)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000362(Fumarate lyase)|interpro:IPR005677(Fumarate hydratase, class II)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR018951|interpro:IPR020557|interpro:IPR022761|interpro:IPR024083|mint:P97807|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:iF/OldWMCxdHfdZo+JtXmx8PbFQ10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:O35857	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-20566939|ensembl:ENSMUSP00000003029|uniprotkb:Q2NLC5	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:tim44_mouse(display_long)|uniprotkb:Timm44(gene name)|psi-mi:Timm44(display_short)|uniprotkb:Mimt44(gene name synonym)|uniprotkb:Tim44(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000002949(gene)|ensembl:ENSMUST00000003029(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|refseq:NP_035722.2	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HqaSsTG5XA4EAHWJyqhBfq1Eyns10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q8BWT1	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-1634016|uniprotkb:Q8JZR8|intact:EBI-4285676|uniprotkb:Q3TIT9|ensembl:ENSMUSP00000037348	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:thim_mouse(display_long)|uniprotkb:Acyl-CoA hydrolase, mitochondrial(gene name synonym)|uniprotkb:Acetyl-CoA acetyltransferase(gene name synonym)|uniprotkb:Acaa2(gene name)|psi-mi:Acaa2(display_short)|uniprotkb:Acetyl-CoA acyltransferase(gene name synonym)|uniprotkb:Beta-ketothiolase(gene name synonym)|uniprotkb:Mitochondrial 3-oxoacyl-CoA thiolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_803421.1|ensembl:ENSMUSG00000036880(gene)|ensembl:ENSMUST00000041053(transcript)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q8BWT1|reactome:R-MMU-77289	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:15aWO97WJBNGYD449bAgjVjkgTY10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:V9GXV0	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-26655939|ensembl:ENSMUSP00000139331	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:v9gxv0_mouse(display_long)|uniprotkb:Idh3b(gene name)|psi-mi:Idh3b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000027406(gene)|ensembl:ENSMUST00000184538(transcript)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006734"(NADH metabolic process)|interpro:IPR024084	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:RZmdCyPQWL2W/0fHpRE9wni8Ogo10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P35486	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773613|ensembl:ENSMUSP00000033662	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:odpa_mouse(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:Pdha1(gene name)|psi-mi:Pdha1(display_short)|uniprotkb:Pdha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_032836.1|ensembl:ENSMUSG00000031299(gene)|ensembl:ENSMUST00000033662(transcript)|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0043209"(myelin sheath)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|mint:P35486|reactome:R-MMU-204174|reactome:R-MMU-389661|reactome:R-MMU-5362517|reactome:R-MMU-70268	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:QIfCMikb5tVYwefUZs3+5ut/nbY10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9CR62	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q8CGK3	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-911958|ensembl:ENSMUSP00000041814|uniprotkb:Q3TSK9|uniprotkb:Q3TVL2|uniprotkb:Q3TXE4|uniprotkb:Q3TZW3|uniprotkb:Q9DBP9	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:lonm_mouse(display_long)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)|uniprotkb:Lonp1(gene name)|psi-mi:Lonp1(display_short)|uniprotkb:Prss15(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:Q8CGK3|interpro:IPR020568|ensembl:ENSMUSG00000041168(gene)|ensembl:ENSMUST00000047226(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034622"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|refseq:NP_083058.2	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:v1wc76SqQNtKne3El7ypY6H1pQI10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q9CZU6	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773122|uniprotkb:Q3UDP3|ensembl:ENSMUSP00000005826	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:cisy_mouse(display_long)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym)|uniprotkb:Cs(gene name)|psi-mi:Cs(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_080720.1|ensembl:ENSMUSG00000005683(gene)|ensembl:ENSMUST00000005826(transcript)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|mint:Q9CZU6|rcsb pdb:3NZI|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:0Ct6UHozD3vl5QxB0YOeKsSEUQw10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:P38647	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q5SWU9	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773043|uniprotkb:A2A6H4|uniprotkb:Q5SWU6|uniprotkb:Q5SWU7|uniprotkb:Q5SWU8|uniprotkb:Q6JIZ1|uniprotkb:Q6PHL9|uniprotkb:Q705X8|uniprotkb:Q705X9|uniprotkb:Q91VC8|uniprotkb:Q925C4|uniprotkb:Q925C5|ensembl:ENSMUSP00000020843|ensembl:ENSMUSP00000099490	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:acaca_mouse(display_long)|uniprotkb:ACC-alpha(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase 265(gene name synonym)|uniprotkb:Acaca(gene name)|psi-mi:Acaca(display_short)|uniprotkb:Acac(gene name synonym)|uniprotkb:Gm738(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:XP_011246969.1|refseq:NP_579938.2|refseq:XP_006532016.1|refseq:XP_006532017.1|refseq:XP_006532018.1|refseq:XP_006532019.1|refseq:XP_006532020.1|dip:DIP-32276N|ensembl:ENSMUSG00000020532(gene)|ensembl:ENSMUST00000020843(transcript)|ensembl:ENSMUST00000103201(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0009374"(biotin binding)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:Q5SWU9|reactome:R-MMU-163765|reactome:R-MMU-196780|reactome:R-MMU-200425|reactome:R-MMU-75105	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:VfXewZAby/B32mkiYMpokapdv1k10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q91ZA3	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773582|uniprotkb:Q80VU5|uniprotkb:Q922N3|ensembl:ENSMUSP00000038763	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:pcca_mouse(display_long)|uniprotkb:"Propanoyl-CoA:carbon dioxide ligase subunit alpha"(gene name synonym)|uniprotkb:Pcca(gene name)|psi-mi:Pcca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_659093.2|ensembl:ENSMUSG00000041650(gene)|ensembl:ENSMUST00000038374(transcript)|go:"GO:0004658"(propionyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016421"(CoA carboxylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR041265|mint:Q91ZA3|reactome:R-MMU-196780|reactome:R-MMU-71032	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:eqI9nLLrOV7h0emfhPMR6sdbZ2A10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q05920	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773565	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:pyc_mouse(display_long)|uniprotkb:Pyruvic carboxylase(gene name synonym)|uniprotkb:Pc(gene name)|psi-mi:Pc(display_short)|uniprotkb:Pcx(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR001882(Biotin-binding site)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR003379(Conserved carboxylase region)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR005930(Pyruvate carboxylase)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011053(Single hybrid motif)|mint:Q05920|go:"GO:0004736"(pyruvate carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0046872"(metal ion binding)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|reactome:R-MMU-196780|reactome:R-MMU-70263	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:lsSatV0UMI9POKETZcn4gD/gp1Q10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70458	uniprotkb:Q99MR8	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-773469|uniprotkb:Q3TGU0|uniprotkb:Q9D8R2|ensembl:ENSMUSP00000029259	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:mcca_mouse(display_long)|uniprotkb:3-methylcrotonyl-CoA carboxylase 1(gene name synonym)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase biotin-containing subunit(gene name synonym)|uniprotkb:Mccc1(gene name)|psi-mi:Mccc1(display_short)|uniprotkb:Mcca(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26655934|imex:IM-28737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_076133.3|ensembl:ENSMUSG00000027709(gene)|ensembl:ENSMUST00000029259(transcript)|go:"GO:0002169"(3-methylcrotonyl-CoA carboxylase complex, mitochondrial)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0016421"(CoA carboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR016185(PreATP-grasp-like fold)|mint:Q99MR8|reactome:R-MMU-196780|reactome:R-MMU-70895	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. table 1|comment:"we employed EGFRvIII-expressing mouse astrocytes in order to identify potential OSMR binding partners endogenously using a specific antibody to OSMR. IP-LC-MS/MS analysis revealed a large cohort of mitochondrial proteins that are known to regulate electron transport chain (ETC) as well as mitochondrial respiration (Supplementary Table 1)"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:SziuYdcOx+maKy71pNxoKql1HGI10090	rigid:VABxqq94YDkcajZ8MtsCsv5h314	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99650	uniprotkb:O43615	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-861737|uniprotkb:Q8N193|uniprotkb:A8K0R9|uniprotkb:D6W664|ensembl:ENSP00000270538	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:tim44_human(display_long)|uniprotkb:TIMM44(gene name)|psi-mi:TIMM44(display_short)|uniprotkb:MIMT44(gene name synonym)|uniprotkb:TIM44(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656096|imex:IM-28737-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	refseq:NP_006342.2|ensembl:ENSG00000104980(gene)|ensembl:ENST00000270538(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|mint:O43615|rcsb pdb:2CW9|reactome:R-HSA-1268020	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2c-d|comment:"We performed co-immunoprecipitation (co-IP) followed by Western blot (WB) analysis, on either whole cell lysates (WCL) or purified mitochondrial fractions, and found that OSMR physically interacted with both mtHSP70 and TIM44 endogenously in multiple patient-derived BTSCs (Fig. 2c–f)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/02/15	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:Hwln5XuF3a9IMwVhP63Ud+LM5M09606	rigid:HqyalGinxSO/gpoMs7x5Zi6EoyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:P38646	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656096|imex:IM-28737-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2c-d|comment:"We performed co-immunoprecipitation (co-IP) followed by Western blot (WB) analysis, on either whole cell lysates (WCL) or purified mitochondrial fractions, and found that OSMR physically interacted with both mtHSP70 and TIM44 endogenously in multiple patient-derived BTSCs (Fig. 2c–f)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/02/15	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rigid:HqyalGinxSO/gpoMs7x5Zi6EoyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:P28331	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656120|imex:IM-28737-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2 l-o|comment:"Via co-IP of either WCL or purified mitochondrial fractions, we found that OSMR interacted endogenously with both NDUFS1 and NDUFS2 in multiple patient-derived BTSCs (Fig. 2l–o)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/02/15	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606	rigid:EbRIhcTGvONH86dZt93yZU+b/50	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:O75306	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656120|imex:IM-28737-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2 l-o|comment:"Via co-IP of either WCL or purified mitochondrial fractions, we found that OSMR interacted endogenously with both NDUFS1 and NDUFS2 in multiple patient-derived BTSCs (Fig. 2l–o)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/02/15	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606	rigid:EbRIhcTGvONH86dZt93yZU+b/50	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38646	uniprotkb:Q99650	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656114|imex:IM-28737-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.2 g,i|comment:"Next, we performed PLA analysis using antibodies to OSMR and mtHSP70. Significant PLA signal was detected in BTSC73 and 147 (Fig. 2g, h), and the PLA interaction signal was found in puncti with the mitochondria as revealed by co-staining of the BTSC73 with MitoTracker (Fig. 2i)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:iQbqcROdJSC/TqnLo3dmGfVJ4xA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P28331	uniprotkb:Q99650	intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656128|imex:IM-28737-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.2 p,r,s.|comment:"the interactions of OSMR with either NDUFS1 or NDUFS2 were validated by PLA in different patient-derived BTSCs (Fig. 2p, q). Furthermore, we confirmed that the mitochondria is the site of interaction of OSMR/NDUFS1 and OSMR/NDUFS2 as revealed by double labeling of the PLA signal with the MitoTracker (Fig. 2r, s)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/02/15	rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:kTLF08GQTFKPa7bEDbWUI+OUAWQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75306	uniprotkb:Q99650	intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656134|imex:IM-28737-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.2 p,r,s.|comment:"the interactions of OSMR with either NDUFS1 or NDUFS2 were validated by PLA in different patient-derived BTSCs (Fig. 2p, q). Furthermore, we confirmed that the mitochondria is the site of interaction of OSMR/NDUFS1 and OSMR/NDUFS2 as revealed by double labeling of the PLA signal with the MitoTracker (Fig. 2r, s)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/02/15	rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:v8Te0zcmVbbGg2ezir7Sk8YdUdg	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9UII2	uniprotkb:Q99650	intact:EBI-718459|uniprotkb:Q5JXL8|uniprotkb:Q6IAQ7|uniprotkb:Q9BSL9|ensembl:ENSP00000335203|ensembl:ENSP00000494248	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:atif1_human(display_long)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATPI(gene name synonym)|uniprotkb:ATPIF1(gene name synonym)|uniprotkb:"Inhibitor of F(1)F(o)-ATPase"(gene name synonym)|uniprotkb:ATP5IF1(gene name)|psi-mi:ATP5IF1(display_short)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26875835|imex:IM-28737-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057395.1|refseq:NP_835497.1|refseq:NP_835498.1|ensembl:ENSG00000130770(gene)|ensembl:ENSG00000285390(gene)|ensembl:ENST00000335514(transcript)|ensembl:ENST00000647074(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043532"(angiostatin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140260"(mitochondrial proton-transporting ATP synthase complex binding)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|interpro:IPR007648(Mitochondrial ATPase inhibitor, IATP)|mint:Q9UII2|go:"GO:0051346"(negative regulation of hydrolase activity)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.1 g-i|comment:"Next, we performed PLA analysis using antibodies to OSMR and mtHSP70. Significant PLA signal was detected in BTSC73 and 147 (Fig. 2g, h), and the PLA interaction signal was found in puncti with the mitochondria as revealed by co-staining of the BTSC73 with MitoTracker (Fig. 2i)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:KLbFWln/ZxNq87OFWJRU6OzkHtc9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:KWuItfI0i+pJTxGH/FNG/zDD1vY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O70458	uniprotkb:Q91WD5	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772751|uniprotkb:Q3U5Y9|uniprotkb:Q3UJX7|uniprotkb:Q99L23|uniprotkb:Q3TNA8|ensembl:ENSMUSP00000013737	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:ndus2_mouse(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)|uniprotkb:Ndufs2(gene name)|psi-mi:Ndufs2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656149|imex:IM-28737-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_694704.1|ensembl:ENSMUSG00000013593(gene)|ensembl:ENSMUST00000013737(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:Q91WD5|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 1c|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:dk8e26C1hIdTZvDnX5nE1n+juwk10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:Q91VD9	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772739|uniprotkb:Q3UQ73|uniprotkb:Q8BM16|ensembl:ENSMUSP00000027111|ensembl:ENSMUSP00000126621	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:ndus1_mouse(display_long)|uniprotkb:Complex I-75kD(gene name synonym)|uniprotkb:Ndufs1(gene name)|psi-mi:Ndufs1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656149|imex:IM-28737-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_001153510.1|refseq:NP_001153511.1|refseq:NP_001153512.1|refseq:NP_663493.2|refseq:XP_006496015.1|ensembl:ENSMUSG00000025968(gene)|ensembl:ENSMUST00000027111(transcript)|ensembl:ENSMUST00000168099(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043209"(myelin sheath)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:Q91VD9|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 1c|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:/akd0DjF9D063ihVFyTA0+Q0gJQ10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:O35857	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-20566939|ensembl:ENSMUSP00000003029|uniprotkb:Q2NLC5	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:tim44_mouse(display_long)|uniprotkb:Timm44(gene name)|psi-mi:Timm44(display_short)|uniprotkb:Mimt44(gene name synonym)|uniprotkb:Tim44(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656149|imex:IM-28737-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000002949(gene)|ensembl:ENSMUST00000003029(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|refseq:NP_035722.2	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 1c|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HqaSsTG5XA4EAHWJyqhBfq1Eyns10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:P38647	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656149|imex:IM-28737-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	go:"GO:0005739"(mitochondrion)	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 1c|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-astrocyte)|taxid:10090(Mus musculus astrocyte [Brain astrocytes; Astroglia])	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:P38647	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656169|imex:IM-28737-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	-	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 5d|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:O35857	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-20566939|ensembl:ENSMUSP00000003029|uniprotkb:Q2NLC5	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:tim44_mouse(display_long)|uniprotkb:Timm44(gene name)|psi-mi:Timm44(display_short)|uniprotkb:Mimt44(gene name synonym)|uniprotkb:Tim44(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656169|imex:IM-28737-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	ensembl:ENSMUSG00000002949(gene)|ensembl:ENSMUST00000003029(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|refseq:NP_035722.2	-	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 5d|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:HqaSsTG5XA4EAHWJyqhBfq1Eyns10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:Q91VD9	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772739|uniprotkb:Q3UQ73|uniprotkb:Q8BM16|ensembl:ENSMUSP00000027111|ensembl:ENSMUSP00000126621	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:ndus1_mouse(display_long)|uniprotkb:Complex I-75kD(gene name synonym)|uniprotkb:Ndufs1(gene name)|psi-mi:Ndufs1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656169|imex:IM-28737-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_001153510.1|refseq:NP_001153511.1|refseq:NP_001153512.1|refseq:NP_663493.2|refseq:XP_006496015.1|ensembl:ENSMUSG00000025968(gene)|ensembl:ENSMUST00000027111(transcript)|ensembl:ENSMUST00000168099(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043209"(myelin sheath)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:Q91VD9|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198	-	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 5d|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:/akd0DjF9D063ihVFyTA0+Q0gJQ10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70458	uniprotkb:Q91WD5	intact:EBI-8418211|intact:MINT-4105360|uniprotkb:O88821	intact:EBI-772751|uniprotkb:Q3U5Y9|uniprotkb:Q3UJX7|uniprotkb:Q99L23|uniprotkb:Q3TNA8|ensembl:ENSMUSP00000013737	psi-mi:osmr_mouse(display_long)|uniprotkb:Osmr(gene name)|psi-mi:Osmr(display_short)|uniprotkb:Osmrb(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)	psi-mi:ndus2_mouse(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)|uniprotkb:Ndufs2(gene name)|psi-mi:Ndufs2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26656169|imex:IM-28737-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297398.1|refseq:NP_035149.2|dip:DIP-5787N|mint:O70458|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-MMU-6788467	refseq:NP_694704.1|ensembl:ENSMUSG00000013593(gene)|ensembl:ENSMUST00000013737(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:Q91WD5|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198	-	comment:mint|function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	-	figure legend:suppl. fig. 5d|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cgns)|taxid:10090(Mus musculus)	-	2021/02/15	2021/02/15	rogid:N4imxCTKIbCUV5V2UG6efnnDa2A10090	rogid:dk8e26C1hIdTZvDnX5nE1n+juwk10090	rigid:yxuwchp3YOApXTxAxYzhzD6vwws	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:O43615	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-861737|uniprotkb:Q8N193|uniprotkb:A8K0R9|uniprotkb:D6W664|ensembl:ENSP00000270538	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:tim44_human(display_long)|uniprotkb:TIMM44(gene name)|psi-mi:TIMM44(display_short)|uniprotkb:MIMT44(gene name synonym)|uniprotkb:TIM44(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26874738|imex:IM-28737-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	refseq:NP_006342.2|ensembl:ENSG00000104980(gene)|ensembl:ENST00000270538(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|mint:O43615|rcsb pdb:2CW9|reactome:R-HSA-1268020	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2e-f|comment:"We performed co-immunoprecipitation (co-IP) followed by Western blot (WB) analysis, on either whole cell lysates (WCL) or purified mitochondrial fractions, and found that OSMR physically interacted with both mtHSP70 and TIM44 endogenously in multiple patient-derived BTSCs (Fig. 2c–f)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:Hwln5XuF3a9IMwVhP63Ud+LM5M09606	rigid:HqyalGinxSO/gpoMs7x5Zi6EoyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:P38646	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26874738|imex:IM-28737-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2e-f|comment:"We performed co-immunoprecipitation (co-IP) followed by Western blot (WB) analysis, on either whole cell lysates (WCL) or purified mitochondrial fractions, and found that OSMR physically interacted with both mtHSP70 and TIM44 endogenously in multiple patient-derived BTSCs (Fig. 2c–f)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rigid:HqyalGinxSO/gpoMs7x5Zi6EoyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:P28331	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26874746|imex:IM-28737-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2 l-o|comment:"Via co-IP of either WCL or purified mitochondrial fractions, we found that OSMR interacted endogenously with both NDUFS1 and NDUFS2 in multiple patient-derived BTSCs (Fig. 2l–o)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606	rigid:EbRIhcTGvONH86dZt93yZU+b/50	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99650	uniprotkb:O75306	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26874746|imex:IM-28737-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig. 2 l-o|comment:"Via co-IP of either WCL or purified mitochondrial fractions, we found that OSMR interacted endogenously with both NDUFS1 and NDUFS2 in multiple patient-derived BTSCs (Fig. 2l–o)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606	rigid:EbRIhcTGvONH86dZt93yZU+b/50	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UII2	uniprotkb:Q99650	intact:EBI-718459|uniprotkb:Q5JXL8|uniprotkb:Q6IAQ7|uniprotkb:Q9BSL9|ensembl:ENSP00000335203|ensembl:ENSP00000494248	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:atif1_human(display_long)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATPI(gene name synonym)|uniprotkb:ATPIF1(gene name synonym)|uniprotkb:"Inhibitor of F(1)F(o)-ATPase"(gene name synonym)|uniprotkb:ATP5IF1(gene name)|psi-mi:ATP5IF1(display_short)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26875857|imex:IM-28737-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057395.1|refseq:NP_835497.1|refseq:NP_835498.1|ensembl:ENSG00000130770(gene)|ensembl:ENSG00000285390(gene)|ensembl:ENST00000335514(transcript)|ensembl:ENST00000647074(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043532"(angiostatin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140260"(mitochondrial proton-transporting ATP synthase complex binding)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|interpro:IPR007648(Mitochondrial ATPase inhibitor, IATP)|mint:Q9UII2|go:"GO:0051346"(negative regulation of hydrolase activity)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.1h|comment:"Next, we performed PLA analysis using antibodies to OSMR and mtHSP70. Significant PLA signal was detected in BTSC73 and 147 (Fig. 2g, h), and the PLA interaction signal was found in puncti with the mitochondria as revealed by co-staining of the BTSC73 with MitoTracker (Fig. 2i)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:KLbFWln/ZxNq87OFWJRU6OzkHtc9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:KWuItfI0i+pJTxGH/FNG/zDD1vY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P38646	uniprotkb:Q99650	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26875863|imex:IM-28737-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.2 h|comment:"Next, we performed PLA analysis using antibodies to OSMR and mtHSP70. Significant PLA signal was detected in BTSC73 and 147 (Fig. 2g, h), and the PLA interaction signal was found in puncti with the mitochondria as revealed by co-staining of the BTSC73 with MitoTracker (Fig. 2i)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:iQbqcROdJSC/TqnLo3dmGfVJ4xA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P28331	uniprotkb:Q99650	intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26875869|imex:IM-28737-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.2 q|comment:"the interactions of OSMR with either NDUFS1 or NDUFS2 were validated by PLA in different patient-derived BTSCs (Fig. 2p, q). Furthermore, we confirmed that the mitochondria is the site of interaction of OSMR/NDUFS1 and OSMR/NDUFS2 as revealed by double labeling of the PLA signal with the MitoTracker (Fig. 2r, s)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/24	rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:kTLF08GQTFKPa7bEDbWUI+OUAWQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75306	uniprotkb:Q99650	intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym)	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26875875|imex:IM-28737-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.2 q|comment:"the interactions of OSMR with either NDUFS1 or NDUFS2 were validated by PLA in different patient-derived BTSCs (Fig. 2p, q). Furthermore, we confirmed that the mitochondria is the site of interaction of OSMR/NDUFS1 and OSMR/NDUFS2 as revealed by double labeling of the PLA signal with the MitoTracker (Fig. 2r, s)."|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/12	rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rigid:v8Te0zcmVbbGg2ezir7Sk8YdUdg	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q99650	uniprotkb:Q9UII2	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-718459|uniprotkb:Q5JXL8|uniprotkb:Q6IAQ7|uniprotkb:Q9BSL9|ensembl:ENSP00000335203|ensembl:ENSP00000494248	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:atif1_human(display_long)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATPI(gene name synonym)|uniprotkb:ATPIF1(gene name synonym)|uniprotkb:"Inhibitor of F(1)F(o)-ATPase"(gene name synonym)|uniprotkb:ATP5IF1(gene name)|psi-mi:ATP5IF1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876215|imex:IM-28737-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	refseq:NP_057395.1|refseq:NP_835497.1|refseq:NP_835498.1|ensembl:ENSG00000130770(gene)|ensembl:ENSG00000285390(gene)|ensembl:ENST00000335514(transcript)|ensembl:ENST00000647074(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043532"(angiostatin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140260"(mitochondrial proton-transporting ATP synthase complex binding)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|interpro:IPR007648(Mitochondrial ATPase inhibitor, IATP)|mint:Q9UII2|go:"GO:0051346"(negative regulation of hydrolase activity)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.1e|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc73)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/15	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:KLbFWln/ZxNq87OFWJRU6OzkHtc9606	rigid:KWuItfI0i+pJTxGH/FNG/zDD1vY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q99650	uniprotkb:Q9UII2	intact:EBI-2804080|uniprotkb:Q96QJ6|uniprotkb:Q6P4E8|ensembl:ENSP00000274276	intact:EBI-718459|uniprotkb:Q5JXL8|uniprotkb:Q6IAQ7|uniprotkb:Q9BSL9|ensembl:ENSP00000335203|ensembl:ENSP00000494248	psi-mi:osmr_human(display_long)|uniprotkb:OSMRB(gene name synonym)|uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)|uniprotkb:OSMR(gene name)|psi-mi:OSMR(display_short)	psi-mi:atif1_human(display_long)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATPI(gene name synonym)|uniprotkb:ATPIF1(gene name synonym)|uniprotkb:"Inhibitor of F(1)F(o)-ATPase"(gene name synonym)|uniprotkb:ATP5IF1(gene name)|psi-mi:ATP5IF1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Sharanek et al. (2020)	pubmed:32807793|imex:IM-28737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876231|imex:IM-28737-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001310433.1|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|reactome:R-HSA-6788467|ensembl:ENSG00000145623(gene)|ensembl:ENST00000274276(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005900"(oncostatin-M receptor complex)|refseq:NP_001161827.1|refseq:NP_003990.1|refseq:NP_001310434.1|refseq:NP_001310435.1|refseq:NP_001310436.1	refseq:NP_057395.1|refseq:NP_835497.1|refseq:NP_835498.1|ensembl:ENSG00000130770(gene)|ensembl:ENSG00000285390(gene)|ensembl:ENST00000335514(transcript)|ensembl:ENST00000647074(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043532"(angiostatin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140260"(mitochondrial proton-transporting ATP synthase complex binding)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|interpro:IPR007648(Mitochondrial ATPase inhibitor, IATP)|mint:Q9UII2|go:"GO:0051346"(negative regulation of hydrolase activity)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:fig.1f|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-btsc147)|taxid:9606(patient-derived EGFRvIII-expressing human BTSC)	-	2021/02/15	2021/03/15	rogid:9mJAsXVJf+fRZtw21BPg0eDUHZY9606	rogid:KLbFWln/ZxNq87OFWJRU6OzkHtc9606	rigid:KWuItfI0i+pJTxGH/FNG/zDD1vY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)