#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NRI5	uniprotkb:P14416	intact:EBI-529989|uniprotkb:O75045|uniprotkb:Q5VT44|uniprotkb:Q5VT45|uniprotkb:Q8IXJ0|uniprotkb:Q8IXJ1|uniprotkb:Q9BX19|uniprotkb:Q9NRI3|uniprotkb:Q9NRI4|uniprotkb:C9J6D0|intact:EBI-28977396|ensembl:ENSP00000403888|uniprotkb:A6NLH2|uniprotkb:C4P095|uniprotkb:C4P0A1|uniprotkb:C4P0A3|uniprotkb:C4P0B3|uniprotkb:C4P091|uniprotkb:C4P0B6|uniprotkb:C4P0C1	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:disc1_human(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Su et al. (2020)	imex:IM-28924|pubmed:32493513	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26968747|imex:IM-28924-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000317586|ensembl:ENSP00000320784|ensembl:ENST00000366633|ensembl:ENSP00000355593|ensembl:ENST00000366636|ensembl:ENSP00000355596|ensembl:ENST00000366637|ensembl:ENSP00000355597|ensembl:ENSP00000403888|ensembl:ENST00000535983|ensembl:ENSP00000443996|ensembl:ENST00000539444|ensembl:ENSP00000440953|ensembl:ENST00000602281|ensembl:ENSP00000473425|ensembl:ENST00000602700|ensembl:ENSP00000473417|ensembl:ENST00000602713|ensembl:ENSP00000473261|ensembl:ENST00000602822|ensembl:ENSP00000473586|ensembl:ENST00000602873|ensembl:ENSP00000473386|ensembl:ENST00000628350|ensembl:ENSP00000487190|ensembl:ENSG00000162946(gene)|ensembl:ENST00000439617(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|mint:Q9NRI5|rcsb pdb:5V4B|refseq:NP_001012975.1|refseq:NP_001012976.1|refseq:NP_001012977.1|refseq:NP_061132.2|refseq:NP_001158011.1|refseq:NP_001158013.1|refseq:NP_001158017.1|refseq:NP_001158018.1|refseq:NP_001158019.1|refseq:NP_001158016.1|refseq:NP_001158027.1|refseq:NP_001158028.1|dip:DIP-33828N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:fig. 1 a-c|comment:"As shown in Fig. 1a, we found that the  human R264Q DISC1 variant, but not the control  A83V variant located outside the binding domain, is  associated with significantly lower DISC1 protein  levels compared to wildtype (WT) DISC1, when transfected into HEK-293 T cells. However, DISC1-  D2R complex levels are significantly increased in  DISC1R264Q (Fig. 1a-c), but not DISC1A83V (Fig. 1d-f)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/04/29	2021/05/03	rogid:m8e3Nji5GtYKa5m5lcFJDAUnh/89606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:nEkleI3nVgsjaY3OBtpr8lx+SD8	false	flag tag:?-?|mutation increasing interaction:264-264	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NRI5	uniprotkb:P14416	intact:EBI-529989|uniprotkb:O75045|uniprotkb:Q5VT44|uniprotkb:Q5VT45|uniprotkb:Q8IXJ0|uniprotkb:Q8IXJ1|uniprotkb:Q9BX19|uniprotkb:Q9NRI3|uniprotkb:Q9NRI4|uniprotkb:C9J6D0|intact:EBI-28977396|ensembl:ENSP00000403888|uniprotkb:A6NLH2|uniprotkb:C4P095|uniprotkb:C4P0A1|uniprotkb:C4P0A3|uniprotkb:C4P0B3|uniprotkb:C4P091|uniprotkb:C4P0B6|uniprotkb:C4P0C1	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:disc1_human(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Su et al. (2020)	imex:IM-28924|pubmed:32493513	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26968759|imex:IM-28924-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000317586|ensembl:ENSP00000320784|ensembl:ENST00000366633|ensembl:ENSP00000355593|ensembl:ENST00000366636|ensembl:ENSP00000355596|ensembl:ENST00000366637|ensembl:ENSP00000355597|ensembl:ENSP00000403888|ensembl:ENST00000535983|ensembl:ENSP00000443996|ensembl:ENST00000539444|ensembl:ENSP00000440953|ensembl:ENST00000602281|ensembl:ENSP00000473425|ensembl:ENST00000602700|ensembl:ENSP00000473417|ensembl:ENST00000602713|ensembl:ENSP00000473261|ensembl:ENST00000602822|ensembl:ENSP00000473586|ensembl:ENST00000602873|ensembl:ENSP00000473386|ensembl:ENST00000628350|ensembl:ENSP00000487190|ensembl:ENSG00000162946(gene)|ensembl:ENST00000439617(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|mint:Q9NRI5|rcsb pdb:5V4B|refseq:NP_001012975.1|refseq:NP_001012976.1|refseq:NP_001012977.1|refseq:NP_061132.2|refseq:NP_001158011.1|refseq:NP_001158013.1|refseq:NP_001158017.1|refseq:NP_001158018.1|refseq:NP_001158019.1|refseq:NP_001158016.1|refseq:NP_001158027.1|refseq:NP_001158028.1|dip:DIP-33828N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:fig. 1 d-f|comment:"As shown in Fig. 1a, we found that the  human R264Q DISC1 variant, but not the control  A83V variant located outside the binding domain, is  associated with significantly lower DISC1 protein  levels compared to wildtype (WT) DISC1, when transfected into HEK-293 T cells. However, DISC1-  D2R complex levels are significantly increased in  DISC1R264Q (Fig. 1a-c), but not DISC1A83V (Fig. 1d-f)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/04/29	2021/05/03	rogid:m8e3Nji5GtYKa5m5lcFJDAUnh/89606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:nEkleI3nVgsjaY3OBtpr8lx+SD8	false	flag tag:?-?|mutation decreasing interaction:83-83	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NRI5	uniprotkb:P14416	intact:EBI-529989|uniprotkb:O75045|uniprotkb:Q5VT44|uniprotkb:Q5VT45|uniprotkb:Q8IXJ0|uniprotkb:Q8IXJ1|uniprotkb:Q9BX19|uniprotkb:Q9NRI3|uniprotkb:Q9NRI4|uniprotkb:C9J6D0|intact:EBI-28977396|ensembl:ENSP00000403888|uniprotkb:A6NLH2|uniprotkb:C4P095|uniprotkb:C4P0A1|uniprotkb:C4P0A3|uniprotkb:C4P0B3|uniprotkb:C4P091|uniprotkb:C4P0B6|uniprotkb:C4P0C1	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:disc1_human(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Su et al. (2020)	imex:IM-28924|pubmed:32493513	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26968803|imex:IM-28924-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000317586|ensembl:ENSP00000320784|ensembl:ENST00000366633|ensembl:ENSP00000355593|ensembl:ENST00000366636|ensembl:ENSP00000355596|ensembl:ENST00000366637|ensembl:ENSP00000355597|ensembl:ENSP00000403888|ensembl:ENST00000535983|ensembl:ENSP00000443996|ensembl:ENST00000539444|ensembl:ENSP00000440953|ensembl:ENST00000602281|ensembl:ENSP00000473425|ensembl:ENST00000602700|ensembl:ENSP00000473417|ensembl:ENST00000602713|ensembl:ENSP00000473261|ensembl:ENST00000602822|ensembl:ENSP00000473586|ensembl:ENST00000602873|ensembl:ENSP00000473386|ensembl:ENST00000628350|ensembl:ENSP00000487190|ensembl:ENSG00000162946(gene)|ensembl:ENST00000439617(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|mint:Q9NRI5|rcsb pdb:5V4B|refseq:NP_001012975.1|refseq:NP_001012976.1|refseq:NP_001012977.1|refseq:NP_061132.2|refseq:NP_001158011.1|refseq:NP_001158013.1|refseq:NP_001158017.1|refseq:NP_001158018.1|refseq:NP_001158019.1|refseq:NP_001158016.1|refseq:NP_001158027.1|refseq:NP_001158028.1|dip:DIP-33828N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:fig. 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:653.0x10^-9 ~6.0(molar)	2021/04/29	2021/05/03	rogid:m8e3Nji5GtYKa5m5lcFJDAUnh/89606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:nEkleI3nVgsjaY3OBtpr8lx+SD8	false	binding-associated region:?-?|mutation increasing interaction:264-264|glutathione s tranferase tag:?-?	transactivating tag:?-?|binding-associated region:211-225	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q811T9	uniprotkb:P14416	intact:EBI-2298259|uniprotkb:Q7TQ21|uniprotkb:Q8CF87|uniprotkb:Q8CF88|uniprotkb:Q8CHP1|uniprotkb:Q8CHP2|ensembl:ENSMUSP00000095914|ensembl:ENSMUSP00000112410	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:disc1_mouse(display_long)|uniprotkb:Disc1(gene name)|psi-mi:Disc1(display_short)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Su et al. (2020)	imex:IM-28924|pubmed:32493513	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26968853|imex:IM-28924-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246690.1|refseq:NP_777278.2|refseq:NP_777279.2|dip:DIP-54914N|ensembl:ENSMUSG00000043051(gene)|ensembl:ENSMUST00000098311(transcript)|ensembl:ENSMUST00000118942(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007399"(nervous system development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|rcsb pdb:5YI4|rcsb pdb:6IRR	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:fig. 4 c-d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/29	2021/05/03	rogid:UfsMePjEeOVJHilw8WbAmeBkQ3g10090	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:6OWQ1kmn8ZVxkG/NVL5ttNa/hwo	false	binding-associated region:?-?|mutation increasing interaction:100-100|glutathione s tranferase tag:?-?	transactivating tag:?-?|binding-associated region:211-225	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61168	uniprotkb:Q811T9	intact:EBI-8019871|uniprotkb:P13953|intact:MINT-5313868|uniprotkb:Q0VGH9|ensembl:ENSMUSP00000075170	intact:EBI-2298259|uniprotkb:Q7TQ21|uniprotkb:Q8CF87|uniprotkb:Q8CF88|uniprotkb:Q8CHP1|uniprotkb:Q8CHP2|ensembl:ENSMUSP00000095914|ensembl:ENSMUSP00000112410	psi-mi:drd2_mouse(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:Drd2(gene name)|psi-mi:Drd2(display_short)	psi-mi:disc1_mouse(display_long)|uniprotkb:Disc1(gene name)|psi-mi:Disc1(display_short)	psi-mi:"MI:0096"(pull down)	Su et al. (2020)	imex:IM-28924|pubmed:32493513	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26968884|imex:IM-28924-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034207.2|refseq:XP_006510059.1|ensembl:ENSMUSG00000032259(gene)|ensembl:ENSMUST00000075764(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006914"(autophagy)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030534"(adult behavior)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031223"(auditory behavior)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390651	refseq:XP_011246690.1|refseq:NP_777278.2|refseq:NP_777279.2|dip:DIP-54914N|ensembl:ENSMUSG00000043051(gene)|ensembl:ENSMUST00000098311(transcript)|ensembl:ENSMUST00000118942(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007399"(nervous system development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|rcsb pdb:5YI4|rcsb pdb:6IRR	-	comment:mint|function:"This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase"	-	figure legend:fig. 4a-b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/29	2021/06/09	rogid:b5aAA6i4aqki/+7Ardtrfizn/OY10090	rogid:UfsMePjEeOVJHilw8WbAmeBkQ3g10090	rigid:VU43W5L3kWIDdOClCvHWUYkqu4g	false	-	glutathione s tranferase tag:?-?|binding-associated region:?-?|mutation increasing interaction:100-100	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)