#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-4399559	intact:EBI-25492388	dip:DIP-24261N	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601109|imex:IM-28669-21	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	chain-seq-start:819|chain-seq-end:2763	no-uniprot-update:	figure legend:Table 1, figure S2|kinetics:"kcat/Km (uM-1 min-1)  10.3"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.16x10^1(second -1)|km:7.9x10^-6(molar)|kcat/km:10.3x10^-8(per mole per second)	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:NFohD3wBuJ6KW1kOz86Uqn562K4	false	sufficient binding region:746-1058	coumarin label:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:P05161	intact:EBI-25492388	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601141|imex:IM-28669-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Table 1, figure S2|kinetics:"kcat/Km (uM-1 min-1)  10.3"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.67x10^1(second -1)|km:3.9x10^-6(molar)|kcat/km:1.7x10^-7(per mole per second)	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:sAbJ18A/aEiem/M8llIq8nKXmD4	false	sufficient binding region:746-1058	coumarin label:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-26601210	intact:EBI-25492388	-	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:rlrgg(display_short)|psi-mi:EBI-26601210(display_long)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601152|imex:IM-28669-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Table 1|kinetics:"kcat/Km (uM-1 min-1)  0.0051"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat/km:8.5x10^-11(per mole per second)	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	-	false	sufficient binding region:746-1058	coumarin label:c-c|modified L-arginine residue:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:167176"	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-26584224	intact:EBI-25492388	psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602365|imex:IM-28669-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:Figure 5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.4x10^-6(molar)|ec50:27.6x10^-6(molar)	2021/01/07	2021/01/25	-	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	false	-	sufficient binding region:746-1058	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:167176"	intact:EBI-26601210	intact:EBI-26584224	-	psi-mi:grl-0617(display_short)|psi-mi:"CHEBI:167176"(display_long)	psi-mi:rlrgg(display_short)|psi-mi:EBI-26601210(display_long)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602365|imex:IM-28669-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Figure 5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.4x10^-6(molar)|ec50:27.6x10^-6(molar)	2021/01/07	2021/01/25	-	-	-	false	-	coumarin label:c-c|modified L-arginine residue:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:167314"	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-26602420	intact:EBI-25492388	psi-mi:compound 6(display_short)|psi-mi:"CHEBI:167314"(display_long)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602407|imex:IM-28669-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:Figure 5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:5.0x10^-6(molar)|ec50:21.0x10^-6(molar)	2021/01/07	2021/01/25	-	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	false	-	sufficient binding region:746-1058	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:167314"	intact:EBI-26601210	intact:EBI-26602420	-	psi-mi:compound 6(display_short)|psi-mi:"CHEBI:167314"(display_long)	psi-mi:rlrgg(display_short)|psi-mi:EBI-26601210(display_long)	psi-mi:"MI:0990"(cleavage assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602407|imex:IM-28669-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Figure 5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:5.0x10^-6(molar)|ec50:21.0x10^-6(molar)	2021/01/07	2021/01/25	-	-	-	false	-	coumarin label:c-c|modified L-arginine residue:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-4399559	intact:EBI-25492388	dip:DIP-24261N	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0998"(deubiquitinase assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601251|imex:IM-28669-23	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	chain-seq-start:819|chain-seq-end:2763	no-uniprot-update:	figure legend:Figure 3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:NFohD3wBuJ6KW1kOz86Uqn562K4	false	sufficient binding region:746-1058	cross linker:48-48|cross linker:76-76	-	4	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
intact:EBI-4399559	uniprotkb:Q6TFZ7	dip:DIP-24261N	intact:EBI-26602468	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:q6tfz7_9viru(display_long)|uniprotkb:Transcriptase(gene name synonym)	psi-mi:"MI:0998"(deubiquitinase assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1980519(Crimean-Congo hemorrhagic fever orthonairovirus)|taxid:1980519(Crimean-Congo hemorrhagic fever orthonairovirus)	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602453|interpro:IPR003323|imex:IM-28669-19	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039694"(viral RNA genome replication)|rcsb pdb:3PRM|rcsb pdb:3PRP|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|interpro:IPR015843(RNA-directed RNA polymerase, Nairovirus type)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR007322(RNA-dependent RNA polymerase, bunyaviral)	-	no-uniprot-update:	-	figure legend:Supp. Figure 3B|comment:positive control|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/25	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:w4PfOjcs8H5wJ2rxQyNxvwcf9kY1980519	rigid:4mZ7i1U21UGEC9Hm4qQNFjr4Svc	false	cross linker:63-63|cross linker:76-76|cross linker:48-48|cross linker:11-11|cross linker:6-6	sufficient binding region:1-169	2	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:P05161	intact:EBI-25492388	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601353|imex:IM-28669-25	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -human|comment:"Moderate enzymatic activity -\"pale green\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:sAbJ18A/aEiem/M8llIq8nKXmD4	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:O02741	intact:EBI-25492388	intact:EBI-26601425|ensembl:ENSBTAP00000019573|uniprotkb:Q3T0N6	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:isg15_bovin(display_long)|uniprotkb:Interferon-stimulated gene product 17(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:ISG17(gene name synonym)|uniprotkb:UCRP(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601418|imex:IM-28669-27	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	ensembl:ENSBTAG00000014707(gene)|ensembl:ENSBTAT00000019573(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|rcsb pdb:2BX0|rcsb pdb:6JH1|reactome:R-BTA-1169408|reactome:R-BTA-5656169|reactome:R-BTA-936440|refseq:NP_776791.1	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -cow|comment:"Moderate enzymatic activity -\"pale green\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:NWMn7EFZ/T0yyu1wgssv2zQWZiQ9913	rigid:YGFV/1l/7D76DTEphod9aob4Z9U	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q64339	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25492388	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601466|imex:IM-28669-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:819|chain-seq-end:2763	figure legend:Figure 4 -mouse|comment:"Moderate enzymatic activity -\"pale green\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/22	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:mfpKiuCaISm+UZ69yteAmRckTBo	false	-	sufficient binding region:746-1058	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:B2LUG8	intact:EBI-25492388	intact:EBI-26601480	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:b2lug8_pig(display_long)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601473|imex:IM-28669-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -pig|comment:"Moderate enzymatic activity -\"pale green\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:SyKA1g+jldVuOJjyNAVs3ePt9rw9823	rigid:siCELuhe65wL5uLcHYmb4+jdS54	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:A0A5N4DAX7	intact:EBI-25492388	intact:EBI-25821387	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:a0a5n4dax7_camdr(display_long)|uniprotkb:Cadr_000013024(orf name)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9838(camdr)|taxid:9838(Camelus dromedarius)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26601486|imex:IM-28669-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -camel|comment:"Moderate enzymatic activity -\"pale green\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/22	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:24f6q1f4RIYXMOoR/0vzbssOCWE9838	rigid:L4wuqQJ5R+vAiQC2lgxGBI9y5TE	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:Q9GKP4	intact:EBI-25492388	intact:EBI-25821151	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:q9gkp4_sheep(display_long)|uniprotkb:ISG17(gene name)|psi-mi:ISG17(display_short)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602287|imex:IM-28669-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	refseq:NP_001009735.1|rcsb pdb:6OAR|rcsb pdb:6OAT|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -sheep|comment:"High enzymatic activity -\"dark green\" result"|comment:"The stated accession number  is for sheep ISG17 (AF152103.1), rather than ISG15: the sequence of the AF152103.1 (Uniprot Q9GKP4)  protein  has  100%  homology to  Sheep ISG15- Uniprot A0A6P9FNA5,  and 99.4% with the longer protein W5PBE1."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/25	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:gyvyyeTX8t3mhHFK8aPQD9a7fFI9940	rigid:e3s/KLEqF/Pk30ECvYN3A0z6/WA	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:L5LC70	intact:EBI-25492388	intact:EBI-25760965	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:l5lc70_myods(display_long)|uniprotkb:MDA_GLEAN10007532(orf name)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:225400(David's myotis)|taxid:225400(Myotis davidii)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602296|imex:IM-28669-13	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	rcsb pdb:6MDH|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -vesper bat|comment:"High enzymatic activity -\"dark green\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/25	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:lRy7vrf4hv09cNqGxRAtdpwts/Q225400	rigid:Y3JE0PlAxrSuYJXVPmfFKabLMQI	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	refseq:XP_015999857.2	intact:EBI-25492388	intact:EBI-26602316	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:isg15_rouae(display_short)|psi-mi:XP_015999857.2(display_long)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9407(rouae)|taxid:9407(Rousettus aegyptiacus)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602304|imex:IM-28669-29	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniparc:UPI00168D4095(see-also)|uniparc:UPI00078978EA(see-also)	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -Egyptian fruit bat|comment:"Low enzymatic activity -\"orange\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/25	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	-	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:A0A1S2ZWT3	intact:EBI-25492388	intact:EBI-26602350	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:a0a1s2zwt3_erieu(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9365(Western European hedgehog)|taxid:9365(Erinaceus europaeus)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602342|imex:IM-28669-31	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	refseq:XP_007525810.2|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -Hedgehog|comment:"Low enzymatic activity -\"orange\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/25	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:m6aXscW6tmt0l17ogit0H41sIGE9365	rigid:FoxZD0WP8+j9h1+Ufnn0k0fjpG8	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P0DTD1-PRO_0000449621	uniprotkb:R9QB93	intact:EBI-25492388	intact:EBI-25568326	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:r9qb93_tupbe(display_long)	psi-mi:"MI:0435"(protease assay)	Freitas et al. (2020)	pubmed:32428392|imex:IM-28669	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:37347(Common tree shrew)|taxid:37347(Tupaia belangeri)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26602358|imex:IM-28669-15	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:819|chain-seq-end:2763	-	figure legend:Figure 4 -Northern tree Shrew|comment:"Low enzymatic activity -\"orange\" result"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/07	2021/01/25	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rogid:EtUQOE+B8D5/kQdqp2eNr/ctlek37347	rigid:s2jN3domJwMnFjnbsgAcLbZpujQ	false	sufficient binding region:746-1058	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)