#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-26597791	uniprotkb:P32366	-	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:53A19450CAF35632	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:Q3E7B6	-	intact:EBI-16210677|ensemblfungi:YCL005W-A|uniprotkb:D6VR05	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:va0e_yeast(display_long)|uniprotkb:VMA9(gene name)|psi-mi:VMA9(display_short)|uniprotkb:CWH36(gene name synonym)|uniprotkb:LDB10(gene name synonym)|uniprotkb:Low dye-binding protein 10(gene name synonym)|uniprotkb:Vacuolar proton pump subunit e(gene name synonym)|uniprotkb:YCL005W-A(locus name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|rcsb pdb:6C6L|ensemblfungi:YCL005W-A(gene)|ensemblfungi:YCL005W-A_mRNA(transcript)|go:"GO:0000032"(cell wall mannoprotein biosynthetic process)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|go:"GO:0042625"(ATPase-coupled ion transmembrane transporter activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0055085"(transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|rcsb pdb:6M0R|rcsb pdb:6M0S|sgd:S000028508|refseq:NP_958835.1|rcsb pdb:5TJ5|interpro:IPR008389(ATPase, V0 complex, subunit E)|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|rcsb pdb:6PE5	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:iIdjg9rxfIsqK3pGjKD5/SR2q4s559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P25515	-	intact:EBI-7739233|ensemblfungi:YEL027W|intact:MINT-1353979|uniprotkb:D3DLM1	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vatl1_yeast(display_long)|uniprotkb:VMA3(gene name)|psi-mi:VMA3(display_short)|uniprotkb:CLS7(gene name synonym)|uniprotkb:CUP5(gene name synonym)|uniprotkb:GEF2(gene name synonym)|uniprotkb:YEL027W(locus name)|uniprotkb:Vacuolar proton pump c subunit(gene name synonym)|uniprotkb:V-ATPase 16 kDa proteolipid subunit 1(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor 2(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YEL027W(gene)|ensemblfungi:YEL027W_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007033"(vacuole organization)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|sgd:S000000753|mint:P25515|refseq:NP_010887.3|dip:DIP-8123N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:FB8A142FFA1FA964|comment:mint|function:Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mv, inside positive and acidic, in the vacuolar membrane vesicles	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:MAXfIOCwZyeV4Vy1T0eKqIbS4ZQ559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P32842	-	intact:EBI-20311|uniprotkb:P32365|uniprotkb:D6W3D6|ensemblfungi:YPL234C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vatl2_yeast(display_long)|uniprotkb:VMA11(gene name)|psi-mi:VMA11(display_short)|uniprotkb:CLS9(gene name synonym)|uniprotkb:TFP3(gene name synonym)|uniprotkb:YPL234C(locus name)|uniprotkb:P1064(orf name)|uniprotkb:Vacuolar proton pump c' subunit(gene name synonym)|uniprotkb:V-ATPase 16 kDa proteolipid subunit 2(gene name synonym)|uniprotkb:Proteolipid protein VMA11(gene name synonym)|uniprotkb:Trifluoperazine resistance protein 3(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	refseq:NP_015090.1|sgd:S000006155|ensemblfungi:YPL234C(gene)|ensemblfungi:YPL234C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0071944"(cell periphery)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|dip:DIP-5394N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:C82D165064EEBBF7	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:dBT3Ck0eQHdf03LiOYP6uUchcYY559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P23968	-	intact:EBI-20293|uniprotkb:D3DKX3|ensemblfungi:YHR026W	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vato_yeast(display_long)|uniprotkb:VMA16(gene name)|psi-mi:VMA16(display_short)|uniprotkb:PPA1(gene name synonym)|uniprotkb:YHR026W(locus name)|uniprotkb:Vacuolar proton pump c'' subunit(gene name synonym)|uniprotkb:V-ATPase 22 kDa proteolipid subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	refseq:NP_011891.1|sgd:S000001068|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YHR026W(gene)|ensemblfungi:YHR026W_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR035921|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|dip:DIP-4054N|mint:P23968	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:033FF5A516B97F8B	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:pQMMMGsUAtBoa6IF8yVU2t+odQQ559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P53262	-	intact:EBI-2061527|uniprotkb:D6VUN8|ensemblfungi:YGR106C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:voa1_yeast(display_long)|uniprotkb:YGR106C(locus name)|uniprotkb:VOA1(gene name)|psi-mi:VOA1(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000003338|refseq:NP_011620.1|mint:P53262|ensemblfungi:YGR106C(gene)|ensemblfungi:YGR106C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:lKLIonttSEX36IQaIKlzxS/Cdxg559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P32563	-	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:77709A914410CD4D	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	calmodulin binding peptide plus protein a tag:c-c	1	8	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P0C5R9	-	intact:EBI-26597773|ensemblfungi:YPR170W-B|uniprotkb:D6W4H1	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:yp17b_yeast(display_long)|uniprotkb:YPR170W-B(locus name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26597798|imex:IM-28991-1|emdb:EMD-20322|wwpdb:6PE4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	ensemblfungi:YPR170W-B(gene)|ensemblfungi:YPR170W-B_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:6M0R|rcsb pdb:6M0S|sgd:S000028515|refseq:NP_001106949.1|rcsb pdb:6C6L|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|interpro:IPR026770	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 1, Table 1, Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/24	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:gxobHdQTUmDKpO5fyVxrqSug6UU559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P32366	-	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:53A19450CAF35632	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:Q3E7B6	-	intact:EBI-16210677|ensemblfungi:YCL005W-A|uniprotkb:D6VR05	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:va0e_yeast(display_long)|uniprotkb:VMA9(gene name)|psi-mi:VMA9(display_short)|uniprotkb:CWH36(gene name synonym)|uniprotkb:LDB10(gene name synonym)|uniprotkb:Low dye-binding protein 10(gene name synonym)|uniprotkb:Vacuolar proton pump subunit e(gene name synonym)|uniprotkb:YCL005W-A(locus name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|rcsb pdb:6C6L|ensemblfungi:YCL005W-A(gene)|ensemblfungi:YCL005W-A_mRNA(transcript)|go:"GO:0000032"(cell wall mannoprotein biosynthetic process)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|go:"GO:0042625"(ATPase-coupled ion transmembrane transporter activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0055085"(transmembrane transport)|go:"GO:1902600"(proton transmembrane transport)|rcsb pdb:6M0R|rcsb pdb:6M0S|sgd:S000028508|refseq:NP_958835.1|rcsb pdb:5TJ5|interpro:IPR008389(ATPase, V0 complex, subunit E)|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|rcsb pdb:6PE5	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:iIdjg9rxfIsqK3pGjKD5/SR2q4s559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P25515	-	intact:EBI-7739233|ensemblfungi:YEL027W|intact:MINT-1353979|uniprotkb:D3DLM1	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vatl1_yeast(display_long)|uniprotkb:VMA3(gene name)|psi-mi:VMA3(display_short)|uniprotkb:CLS7(gene name synonym)|uniprotkb:CUP5(gene name synonym)|uniprotkb:GEF2(gene name synonym)|uniprotkb:YEL027W(locus name)|uniprotkb:Vacuolar proton pump c subunit(gene name synonym)|uniprotkb:V-ATPase 16 kDa proteolipid subunit 1(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor 2(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YEL027W(gene)|ensemblfungi:YEL027W_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007033"(vacuole organization)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|sgd:S000000753|mint:P25515|refseq:NP_010887.3|dip:DIP-8123N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:FB8A142FFA1FA964|comment:mint|function:Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mv, inside positive and acidic, in the vacuolar membrane vesicles	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:MAXfIOCwZyeV4Vy1T0eKqIbS4ZQ559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P32842	-	intact:EBI-20311|uniprotkb:P32365|uniprotkb:D6W3D6|ensemblfungi:YPL234C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vatl2_yeast(display_long)|uniprotkb:VMA11(gene name)|psi-mi:VMA11(display_short)|uniprotkb:CLS9(gene name synonym)|uniprotkb:TFP3(gene name synonym)|uniprotkb:YPL234C(locus name)|uniprotkb:P1064(orf name)|uniprotkb:Vacuolar proton pump c' subunit(gene name synonym)|uniprotkb:V-ATPase 16 kDa proteolipid subunit 2(gene name synonym)|uniprotkb:Proteolipid protein VMA11(gene name synonym)|uniprotkb:Trifluoperazine resistance protein 3(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	refseq:NP_015090.1|sgd:S000006155|ensemblfungi:YPL234C(gene)|ensemblfungi:YPL234C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0071944"(cell periphery)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|dip:DIP-5394N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:C82D165064EEBBF7	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:dBT3Ck0eQHdf03LiOYP6uUchcYY559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P23968	-	intact:EBI-20293|uniprotkb:D3DKX3|ensemblfungi:YHR026W	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vato_yeast(display_long)|uniprotkb:VMA16(gene name)|psi-mi:VMA16(display_short)|uniprotkb:PPA1(gene name synonym)|uniprotkb:YHR026W(locus name)|uniprotkb:Vacuolar proton pump c'' subunit(gene name synonym)|uniprotkb:V-ATPase 22 kDa proteolipid subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	refseq:NP_011891.1|sgd:S000001068|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YHR026W(gene)|ensemblfungi:YHR026W_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR035921|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|dip:DIP-4054N|mint:P23968	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:033FF5A516B97F8B	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:pQMMMGsUAtBoa6IF8yVU2t+odQQ559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P53262	-	intact:EBI-2061527|uniprotkb:D6VUN8|ensemblfungi:YGR106C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:voa1_yeast(display_long)|uniprotkb:YGR106C(locus name)|uniprotkb:VOA1(gene name)|psi-mi:VOA1(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000003338|refseq:NP_011620.1|mint:P53262|ensemblfungi:YGR106C(gene)|ensemblfungi:YGR106C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034622"|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:lKLIonttSEX36IQaIKlzxS/Cdxg559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P32563	-	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:77709A914410CD4D	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	calmodulin binding peptide plus protein a tag:c-c	1	8	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P0C5R9	-	intact:EBI-26597773|ensemblfungi:YPR170W-B|uniprotkb:D6W4H1	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:yp17b_yeast(display_long)|uniprotkb:YPR170W-B(locus name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26612658|imex:IM-28991-3|wwpdb:6PE5|emdb:EMD-20323	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	ensemblfungi:YPR170W-B(gene)|ensemblfungi:YPR170W-B_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:6M0R|rcsb pdb:6M0S|sgd:S000028515|refseq:NP_001106949.1|rcsb pdb:6C6L|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|interpro:IPR026770	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Fig 1, Table 1|note:Two copies of VopQ molecule|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:gxobHdQTUmDKpO5fyVxrqSug6UU559292	rigid:OxyWuoysP4Uxoe6sv7xX8FSHaEs	false	his tag:n-n|mutation:283-283,308-308	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32563	intact:EBI-26597791	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	-	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:"MI:0096"(pull down)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26954668|imex:IM-28991-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	-	crc64:77709A914410CD4D	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Edxt Data Fig 6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/16	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rigid:sCZHbWgSjCX1COpVO03bNTGlb1k	false	calmodulin binding peptide plus protein a tag:c-c	his tag:n-n|mutation with no effect:200-200|mutation with no effect:204-204,206-206	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32563	uniprotkb:P32366	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:"MI:0096"(pull down)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26954668|imex:IM-28991-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	-	crc64:77709A914410CD4D	crc64:53A19450CAF35632	figure legend:Edxt Data Fig 6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/16	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rigid:sCZHbWgSjCX1COpVO03bNTGlb1k	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32563	intact:EBI-26597791	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	-	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:"MI:0096"(pull down)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26954681|imex:IM-28991-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	-	crc64:77709A914410CD4D	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Extended Fig.6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/16	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rigid:sCZHbWgSjCX1COpVO03bNTGlb1k	false	calmodulin binding peptide plus protein a tag:c-c	his tag:n-n|necessary binding region:155-316|necessary binding region:404-492	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32563	uniprotkb:P32366	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:"MI:0096"(pull down)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26954681|imex:IM-28991-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	-	crc64:77709A914410CD4D	crc64:53A19450CAF35632	figure legend:Extended Fig.6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/04/16	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rigid:sCZHbWgSjCX1COpVO03bNTGlb1k	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32366	uniprotkb:P32563	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:"MI:0096"(pull down)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26954699|imex:IM-28991-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	-	crc64:53A19450CAF35632	crc64:77709A914410CD4D	figure legend:Edxt Data Fig 6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2021/01/19	2021/05/18	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rigid:09YDVLEiuSJ7h6po9FyS9scqtqY	false	-	calmodulin binding peptide plus protein a tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
intact:EBI-26597791	uniprotkb:P32366	-	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26968700|imex:IM-28991-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:53A19450CAF35632	figure legend:Extended Data Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/05/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rigid:sCZHbWgSjCX1COpVO03bNTGlb1k	false	mutation:283-283,308-308|his tag:n-n	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26597791	uniprotkb:P32563	-	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	psi-mi:a0a4z7tvw3_vibph(display_short)|psi-mi:EBI-26597791(display_long)|uniprotkb:CGH73_02470(orf name)	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2020)	pubmed:32424347|imex:IM-28991	taxid:670(Vibrio parahaemolyticus)|taxid:670(Vibrio parahaemolyticus)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26968700|imex:IM-28991-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A4Z7TVW3(uniprot-removed-ac)	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	crc64:77709A914410CD4D	figure legend:Extended Data Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/19	2021/05/25	rogid:aHnKkOU/nAQIYXIkqVXlxY5yQGU670	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rigid:sCZHbWgSjCX1COpVO03bNTGlb1k	false	mutation:283-283,308-308|his tag:n-n	-	1	8	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)