#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7L1W4	uniprotkb:Q7L1W4	intact:EBI-861997|uniprotkb:Q6UWB2|uniprotkb:Q9NVW3|uniprotkb:D3DT29|ensembl:ENSP00000338887|ensembl:ENSP00000378093	intact:EBI-861997|uniprotkb:Q6UWB2|uniprotkb:Q9NVW3|uniprotkb:D3DT29|ensembl:ENSP00000338887|ensembl:ENSP00000378093	psi-mi:lrc8d_human(display_long)|uniprotkb:Leucine-rich repeat-containing protein 8D(gene name synonym)|uniprotkb:UNQ213/PRO239(orf name)|uniprotkb:LRRC8D(gene name)|psi-mi:LRRC8D(display_short)|uniprotkb:LRRC5(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 5(gene name synonym)	psi-mi:lrc8d_human(display_long)|uniprotkb:Leucine-rich repeat-containing protein 8D(gene name synonym)|uniprotkb:UNQ213/PRO239(orf name)|uniprotkb:LRRC8D(gene name)|psi-mi:LRRC8D(display_short)|uniprotkb:LRRC5(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 5(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Nakamura et al. (2020)	imex:IM-29275|pubmed:32415200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27096647|wwpdb:6M04|emdb:EMD-30029|imex:IM-29275-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127951.1|refseq:NP_060573.2|refseq:XP_016857088.1|refseq:XP_016857089.1|refseq:XP_016857090.1|refseq:XP_016857091.1|refseq:XP_011539991.1|dip:DIP-31280N|ensembl:ENSG00000171492(gene)|ensembl:ENST00000337338(transcript)|ensembl:ENST00000394593(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|rcsb pdb:6M04|reactome:R-HSA-5223345	refseq:NP_001127951.1|refseq:NP_060573.2|refseq:XP_016857088.1|refseq:XP_016857089.1|refseq:XP_016857090.1|refseq:XP_016857091.1|refseq:XP_011539991.1|dip:DIP-31280N|ensembl:ENSG00000171492(gene)|ensembl:ENST00000337338(transcript)|ensembl:ENST00000394593(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|rcsb pdb:6M04|reactome:R-HSA-5223345	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2021/09/29	2021/09/30	rogid:ufVPVQVTeiRGQwGw/VFY2BlXRvk9606	rogid:ufVPVQVTeiRGQwGw/VFY2BlXRvk9606	rigid:RCndJu6f7qNmzezXZUh1lkEVGQY	false	-	-	6	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q7L1W4	uniprotkb:Q7L1W4	intact:EBI-861997|uniprotkb:Q6UWB2|uniprotkb:Q9NVW3|uniprotkb:D3DT29|ensembl:ENSP00000338887|ensembl:ENSP00000378093	intact:EBI-861997|uniprotkb:Q6UWB2|uniprotkb:Q9NVW3|uniprotkb:D3DT29|ensembl:ENSP00000338887|ensembl:ENSP00000378093	psi-mi:lrc8d_human(display_long)|uniprotkb:Leucine-rich repeat-containing protein 8D(gene name synonym)|uniprotkb:UNQ213/PRO239(orf name)|uniprotkb:LRRC8D(gene name)|psi-mi:LRRC8D(display_short)|uniprotkb:LRRC5(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 5(gene name synonym)	psi-mi:lrc8d_human(display_long)|uniprotkb:Leucine-rich repeat-containing protein 8D(gene name synonym)|uniprotkb:UNQ213/PRO239(orf name)|uniprotkb:LRRC8D(gene name)|psi-mi:LRRC8D(display_short)|uniprotkb:LRRC5(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 5(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Nakamura et al. (2020)	imex:IM-29275|pubmed:32415200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27096764|imex:IM-29275-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127951.1|refseq:NP_060573.2|refseq:XP_016857088.1|refseq:XP_016857089.1|refseq:XP_016857090.1|refseq:XP_016857091.1|refseq:XP_011539991.1|dip:DIP-31280N|ensembl:ENSG00000171492(gene)|ensembl:ENST00000337338(transcript)|ensembl:ENST00000394593(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|rcsb pdb:6M04|reactome:R-HSA-5223345	refseq:NP_001127951.1|refseq:NP_060573.2|refseq:XP_016857088.1|refseq:XP_016857089.1|refseq:XP_016857090.1|refseq:XP_016857091.1|refseq:XP_011539991.1|dip:DIP-31280N|ensembl:ENSG00000171492(gene)|ensembl:ENST00000337338(transcript)|ensembl:ENST00000394593(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|rcsb pdb:6M04|reactome:R-HSA-5223345	-	-	-	figure legend:Supplementary Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2021/09/29	2021/09/30	rogid:ufVPVQVTeiRGQwGw/VFY2BlXRvk9606	rogid:ufVPVQVTeiRGQwGw/VFY2BlXRvk9606	rigid:RCndJu6f7qNmzezXZUh1lkEVGQY	false	-	-	6	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)