#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96MG7 uniprotkb:Q8WV22 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-26990239|imex:IM-29012-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/10 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rigid:BWVOA3b6pVt7CBe80xnlUzZStPY false cross linker:212-212|cross linker:212-212|cross linker:212-212|cross linker:221-221|cross linker:211-211|cross linker:99-99|cross linker:211-211|cross linker:211-211|cross linker:211-211|cross linker:212-212|cross linker:221-221|cross linker:262-262 cross linker:144-144|cross linker:258-258|cross linker:139-139|cross linker:143-143|cross linker:259-259|cross linker:139-139|cross linker:143-143|cross linker:144-144|cross linker:258-258|cross linker:259-259|cross linker:143-143|cross linker:259-259 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q8WV22 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26990350|imex:IM-29012-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/14 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rigid:aK6fCp/vw0Mj91rXzxanjx+asLU false cross linker:183-183|cross linker:191-191|cross linker:190-190|cross linker:183-183|cross linker:156-156|cross linker:156-156|cross linker:156-156|cross linker:183-183|cross linker:191-191|cross linker:190-190|cross linker:194-194|cross linker:207-207|cross linker:207-207|cross linker:207-207|cross linker:103-103|cross linker:103-103|sufficient binding region:92-212 cross linker:144-144|cross linker:139-139|cross linker:143-143|cross linker:259-259|cross linker:139-139|cross linker:143-143|cross linker:144-144|cross linker:258-258|cross linker:259-259|cross linker:143-143|cross linker:259-259|cross linker:152-152|cross linker:152-152|cross linker:157-157|cross linker:144-144|cross linker:157-157|cross linker:258-258|cross linker:144-144|cross linker:152-152|cross linker:152-152|cross linker:259-259|cross linker:157-157|cross linker:255-255|cross linker:259-259|cross linker:99-99|cross linker:140-140 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q96MG7 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26990350|imex:IM-29012-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 - - - figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/14 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 rigid:aK6fCp/vw0Mj91rXzxanjx+asLU false cross linker:183-183|cross linker:191-191|cross linker:190-190|cross linker:183-183|cross linker:156-156|cross linker:156-156|cross linker:156-156|cross linker:183-183|cross linker:191-191|cross linker:190-190|cross linker:194-194|cross linker:207-207|cross linker:207-207|cross linker:207-207|cross linker:103-103|cross linker:103-103|sufficient binding region:92-212 cross linker:212-212|cross linker:212-212|cross linker:212-212|cross linker:221-221|cross linker:211-211|cross linker:99-99|cross linker:211-211|cross linker:211-211|cross linker:212-212|cross linker:221-221|cross linker:265-265|cross linker:83-83|cross linker:102-102|cross linker:102-102|cross linker:210-210|cross linker:211-211|cross linker:221-221|cross linker:83-83|cross linker:83-83|cross linker:88-88|cross linker:99-99|cross linker:212-212|cross linker:212-212|cross linker:221-221|cross linker:265-265|cross linker:83-83|cross linker:88-88|cross linker:83-83|cross linker:83-83|cross linker:120-120|cross linker:212-212|cross linker:269-269|cross linker:211-211|cross linker:194-194 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SB8 uniprotkb:Q8IY18 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-26995304|imex:IM-29012-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 - - - figure legend:Tables 3, 4, 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/14 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rigid:z8syTS1CeYZ7je02XFLmx6a9Zp0 false cross linker:206-206|cross linker:206-206|cross linker:628-628|cross linker:628-628|cross linker:229-229|cross linker:233-233|cross linker:234-234|cross linker:248-248|cross linker:248-248|cross linker:913-913|cross linker:914-914|cross linker:310-310|cross linker:325-325|cross linker:331-331|cross linker:350-350|cross linker:350-350|cross linker:379-379|cross linker:386-386|cross linker:386-386|cross linker:751-751|cross linker:751-751|cross linker:751-751|cross linker:207-207|cross linker:550-550|cross linker:550-550|cross linker:550-550 cross linker:189-189|his tag:?-?|cross linker:191-191|cross linker:498-498|cross linker:542-542|cross linker:548-548|cross linker:238-238|cross linker:238-238|cross linker:238-238|cross linker:238-238|cross linker:247-247|cross linker:238-238|cross linker:238-238|cross linker:300-300|cross linker:332-332|cross linker:332-332|cross linker:339-339|cross linker:746-746|cross linker:717-717|cross linker:717-717|cross linker:719-719|cross linker:378-378|cross linker:710-710|cross linker:714-714|cross linker:499-499|cross linker:189-189|cross linker:495-495 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q8WV22 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022045|imex:IM-29012-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:Table 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/24 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false sufficient binding region:92-212|cross linker:183-183|cross linker:152-152|cross linker:156-156 cross linker:247-247|cross linker:255-255|cross linker:247-247|cross linker:255-255 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q96MG7 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022045|imex:IM-29012-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 - - - figure legend:Table 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/24 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false sufficient binding region:92-212|cross linker:183-183|cross linker:152-152|cross linker:156-156 cross linker:83-83|cross linker:211-211 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q8IY18 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022045|imex:IM-29012-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 - - - figure legend:Table 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/24 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false sufficient binding region:92-212|cross linker:183-183|cross linker:152-152|cross linker:156-156 his tag:?-?|cross linker:192-192 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q96SB8 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022045|imex:IM-29012-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:Table 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/24 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false sufficient binding region:92-212|cross linker:183-183|cross linker:152-152|cross linker:156-156 cross linker:107-107|cross linker:107-107|cross linker:107-107|cross linker:111-111|cross linker:155-155|cross linker:107-107 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N140 uniprotkb:Q8WV22 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0020"(transmission electron microscopy) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995665|imex:IM-29012-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/15 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false strep tag:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N140 uniprotkb:Q96MG7 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0020"(transmission electron microscopy) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995665|imex:IM-29012-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/15 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false strep tag:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N140 uniprotkb:Q8IY18 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995665|imex:IM-29012-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/15 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false strep tag:?-? his tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N140 uniprotkb:Q96SB8 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995665|imex:IM-29012-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/05/26 2021/06/15 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rigid:CjdfUAxcbtJ/+AyJIIbBZJma3C8 false strep tag:?-? flag tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IY18 uniprotkb:Q8N140 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 intact:EBI-744483|ensembl:ENSP00000435619 psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995688|imex:IM-29012-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 - - - figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2021/05/26 2021/06/15 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rigid:BThabHdrsOft+uH44KkEuqeUhzg false sufficient binding region:1-245,884-1101 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IY18 uniprotkb:Q96MF7 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995695|imex:IM-29012-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 - - - figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2021/05/26 2021/06/15 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 rigid:jIVueZvLTogi56w1eDOJwXelO3k false sufficient binding region:1-460,646-1101|sufficient binding region:300-812 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IY18 uniprotkb:Q8IX21 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995702|imex:IM-29012-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 - - - figure legend:Fig. 5A, Supp Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2021/05/26 2021/06/15 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rigid:5fUIsS2SimYRREN/e0b4ln/yHgw false sufficient binding region:1-460,646-1101|sufficient binding region:207-950 sufficient binding region:300-660 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQI6 uniprotkb:Q8IX21 intact:EBI-10975834|ensembl:ENSP00000265140|uniprotkb:Q6NSA5|uniprotkb:Q9Y402|uniprotkb:B4DMG4|uniprotkb:Q3B7K4|uniprotkb:Q6PHW9 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 psi-mi:slf1_human(display_long)|uniprotkb:SLF1(gene name)|psi-mi:SLF1(display_short)|uniprotkb:ANKRD32(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 32(gene name synonym)|uniprotkb:BRCT domain-containing protein 1(gene name synonym)|uniprotkb:BRCTD1(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995715|imex:IM-29012-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115666.2|ensembl:ENSG00000133302(gene)|ensembl:ENST00000265140(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001357(BRCT)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036420|interpro:IPR036770|interpro:IPR042479|mint:Q9BQI6|refseq:XP_016865468.1 refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 - - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2021/05/26 2021/06/15 rogid:qTH92h5XTeqL88TWZA5pSxkLFIg9606 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rigid:u3vfyqNR+JLNWJnLdgC1Rfxg42c false sufficient binding region:199-1058 sufficient binding region:635-1173(IPR044276) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96SB8 uniprotkb:Q8IX21 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995772|imex:IM-29012-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 - - - figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2021/05/26 2021/06/15 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rigid:Ez4+WntcaamcAi1CJryK/hGBujw false sufficient binding region:278-855 sufficient binding region:1-310 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96SB8 uniprotkb:Q8IX21 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995789|imex:IM-29012-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 - - - figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2021/05/26 2021/06/15 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rigid:Ez4+WntcaamcAi1CJryK/hGBujw false sufficient binding region:215-931 sufficient binding region:635-1173 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IX21 uniprotkb:Q8IY18 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0096"(pull down) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995872|imex:IM-29012-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 - - - figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/05/26 2021/06/15 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 rigid:5fUIsS2SimYRREN/e0b4ln/yHgw false sufficient binding region:300-660|radiolabel:?-? his tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8IX21 uniprotkb:Q96SB8 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0096"(pull down) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995899|imex:IM-29012-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:Fig. 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/05/26 2021/06/15 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rigid:Ez4+WntcaamcAi1CJryK/hGBujw false sufficient binding region:215-931|radiolabel:?-? his tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8IX21 uniprotkb:Q96SB8 intact:EBI-2682240|uniprotkb:Q9NPE8|uniprotkb:A8K950|uniprotkb:Q5W0L8|uniprotkb:B1AL17|ensembl:ENSP00000238961|uniprotkb:Q6GMU6 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:slf2_human(display_long)|uniprotkb:SLF2(gene name)|psi-mi:SLF2(display_short)|uniprotkb:C10orf6(gene name synonym)|uniprotkb:FAM178A(gene name synonym)|uniprotkb:Smc5/6 localization factor 1(gene name synonym) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Adamus et al. (2020) imex:IM-29012|pubmed:32389690 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26995918|imex:IM-29012-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060591.3|refseq:NP_001230699.1|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR026161|interpro:IPR044276|mint:Q8IX21|ensembl:ENSG00000119906(gene)|ensembl:ENST00000238961(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990166"(protein localization to site of double-strand break)|refseq:NP_001129595.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/05/26 2021/06/15 rogid:Rf8vnUtDelcFN0qcbmtvHWn2z0c9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rigid:Ez4+WntcaamcAi1CJryK/hGBujw false sufficient binding region:635-1173|radiolabel:?-? flag tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)