#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-4399559	uniprotkb:P0C6V0-PRO_0000338281	dip:DIP-24261N	intact:EBI-25821269	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:p0c6v0-pro_0000338281(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0990"(cleavage assay)	Deng et al. (2020)	pubmed:32188728|imex:IM-28676	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26603761|imex:IM-28676-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	intact:EBI-25821214(chain-parent)	-	no-uniprot-update:	chain-seq-start:833|chain-seq-end:2837	figure legend:Figure 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:6.7x10^-5(molar)|kcat:0.71x10^1(second -1)|kcat/km:1.05x10^-6(per mole per second)	2021/01/22	2021/01/27	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:/X+hmk/7yCyCykKykcDQ4x7OBSs11142	rigid:aHIixhoeliDO1JscIYbl2R1maFA	false	coumarin label:c-c	sufficient binding region:777-1077|mutation decreasing interaction rate:940-940|mutation decreasing interaction rate:980-980|mutation increasing interaction rate:971-971	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26601210	uniprotkb:P0C6V0-PRO_0000338281	-	intact:EBI-25821269	psi-mi:rlrgg(display_short)|psi-mi:EBI-26601210(display_long)	psi-mi:p0c6v0-pro_0000338281(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0990"(cleavage assay)	Deng et al. (2020)	pubmed:32188728|imex:IM-28676	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26603812|imex:IM-28676-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25821214(chain-parent)	-	-	chain-seq-start:833|chain-seq-end:2837	figure legend:Figure 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat/km:4.0x10^-11(per mole per second)	2021/01/22	2021/01/27	-	rogid:/X+hmk/7yCyCykKykcDQ4x7OBSs11142	-	false	coumarin label:c-c|modified L-arginine residue:n-n	sufficient binding region:777-1077|mutation increasing interaction rate:940-940|mutation with no effect:980-980|mutation with no effect:971-971	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05161	uniprotkb:P0C6V0-PRO_0000338281	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-25821269	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6v0-pro_0000338281(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0990"(cleavage assay)	Deng et al. (2020)	pubmed:32188728|imex:IM-28676	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26603848|imex:IM-28676-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	intact:EBI-25821214(chain-parent)	-	-	chain-seq-start:833|chain-seq-end:2837	figure legend:Figure 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat/km:4.0x10^-8(per mole per second)	2021/01/22	2021/01/27	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:/X+hmk/7yCyCykKykcDQ4x7OBSs11142	rigid:9Gx8izT/Fw5VQR7H1UilxF5eI2o	false	coumarin label:c-c	sufficient binding region:777-1077|mutation increasing interaction rate:940-940|mutation decreasing interaction rate:980-980|mutation disrupting interaction rate:971-971	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)