#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01097	uniprotkb:P35438	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fan et al. (2020)	pubmed:32033586|imex:IM-28643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26595707|imex:IM-28643-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	figure legend:fig. 4i|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hippocampus)|taxid:10090(Mouse hippocampal neurons)	-	2021/01/18	2021/01/18	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:sv+Q6toV1+82fdGTWMIm1MhP9zk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01097	uniprotkb:P35438	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fan et al. (2020)	pubmed:32033586|imex:IM-28643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26595739|imex:IM-28643-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	figure legend:fig. 4i|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hippocampus)|taxid:10090(Mouse hippocampal neurons)	-	2021/01/18	2021/01/18	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:sv+Q6toV1+82fdGTWMIm1MhP9zk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49769	uniprotkb:P35438	intact:EBI-990067|uniprotkb:Q91WK6|uniprotkb:Q9JLP9|ensembl:ENSMUSP00000048363|ensembl:ENSMUSP00000098786	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:psn1_mouse(display_long)|uniprotkb:Protein S182(gene name synonym)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Ad3h(gene name synonym)|uniprotkb:Psnl1(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fan et al. (2020)	pubmed:32033586|imex:IM-28643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26595747|imex:IM-28643-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49769|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|ensembl:ENSMUSG00000019969(gene)|ensembl:ENSMUST00000041806(transcript)|ensembl:ENSMUST00000101225(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010467"(gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0015031"(protein transport)|go:"GO:0015871"(choline transport)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040011"(locomotion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0016485"(protein processing)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051604"(protein maturation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:0048143"(astrocyte activation)|refseq:NP_032969.1|refseq:XP_006515668.1|dip:DIP-36237N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	figure legend:fig. 4i|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hippocampus)|taxid:10090(Mouse hippocampal neurons)	-	2021/01/18	2021/01/18	rogid:o/Am8u42WLTycj02WRXHancU9Ek10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:6JGl5kGCvspDDpTqBfmabV5wBD0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49769	uniprotkb:P35438	intact:EBI-990067|uniprotkb:Q91WK6|uniprotkb:Q9JLP9|ensembl:ENSMUSP00000048363|ensembl:ENSMUSP00000098786	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:psn1_mouse(display_long)|uniprotkb:Protein S182(gene name synonym)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Ad3h(gene name synonym)|uniprotkb:Psnl1(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fan et al. (2020)	pubmed:32033586|imex:IM-28643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26595751|imex:IM-28643-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49769|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|ensembl:ENSMUSG00000019969(gene)|ensembl:ENSMUST00000041806(transcript)|ensembl:ENSMUST00000101225(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010467"(gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0015031"(protein transport)|go:"GO:0015871"(choline transport)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040011"(locomotion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0016485"(protein processing)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051604"(protein maturation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:0048143"(astrocyte activation)|refseq:NP_032969.1|refseq:XP_006515668.1|dip:DIP-36237N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	figure legend:fig. 4i|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hippocampus)|taxid:10090(Mouse hippocampal neurons)	-	2021/01/18	2021/01/18	rogid:o/Am8u42WLTycj02WRXHancU9Ek10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rigid:6JGl5kGCvspDDpTqBfmabV5wBD0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)