#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y6R9 uniprotkb:Q15154 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132242|imex:IM-29364-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N - - - figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rigid:wsT7eFjEE+Mh0BVtowYrHZI/1f0 false myc tag:n-n green fluorescent protein tag:?-?|sufficient binding region:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Y6R9 uniprotkb:Q9UPN4 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-2558372|uniprotkb:B2RN11|uniprotkb:Q96F50|uniprotkb:A6NHI8|ensembl:ENSP00000269392 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:cp131_human(display_long)|uniprotkb:CEP131(gene name)|psi-mi:CEP131(display_short)|uniprotkb:5-azacytidine-induced protein 1(gene name synonym)|uniprotkb:AZI1(gene name synonym)|uniprotkb:KIAA1118(gene name synonym)|uniprotkb:Pre-acrosome localization protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132252|imex:IM-29364-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001009811.2|refseq:NP_055799.2|refseq:NP_001306157.1|ensembl:ENSG00000141577(gene)|ensembl:ENST00000269392(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0120212"(sperm head-tail coupling apparatus)|go:"GO:1905198"(manchette assembly)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990953"(intramanchette transport)|interpro:IPR030465|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005814"(centriole)|dip:DIP-56658N - - - figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:qcnzG6vfogSEappaH9nv7P3kSoQ9606 rigid:oYM/I+iz7YxNLFu1SboU7iOnw9s false myc tag:n-n green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Y6R9 uniprotkb:Q5SW79 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132262|imex:IM-29364-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N - - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/12/01 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 rigid:Z1ckGZlnoooU9JDUbmcvIHwDczM false myc tag:n-n green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Y6R9 uniprotkb:Q9C0C2 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-2104458|uniprotkb:Q6PJ35|uniprotkb:Q6ZV74|uniprotkb:A7E2F8|intact:EBI-28975617|ensembl:ENSP00000350990|ensembl:ENSP00000437271 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:tb182_human(display_long)|uniprotkb:TNKS1BP1(gene name)|psi-mi:TNKS1BP1(display_short)|uniprotkb:KIAA1741(gene name synonym)|uniprotkb:TAB182(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:XP_006718788.1|ensembl:ENSP00000350990|ensembl:ENSP00000437271|refseq:NP_203754.2|ensembl:ENSG00000149115(gene)|ensembl:ENST00000358252(transcript)|ensembl:ENST00000532437(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071532"(ankyrin repeat binding)|interpro:IPR032764|interpro:IPR040006|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:pOIaK7wn7iYvUHbSA0kUZlIgtgw9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q5VW36 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-7411200|uniprotkb:Q6ZME1|uniprotkb:Q9NX87|uniprotkb:Q8IZG0|uniprotkb:D3DRJ9|uniprotkb:Q96MS9|intact:MINT-8247615|uniprotkb:Q9BVF3|uniprotkb:Q96JM8|ensembl:ENSP00000344307|ensembl:ENSP00000369599 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:focad_human(display_long)|uniprotkb:FOCAD(gene name)|psi-mi:FOCAD(display_short)|uniprotkb:KIAA1797(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT ensembl:ENSG00000188352(gene)|ensembl:ENST00000338382(transcript)|ensembl:ENST00000380249(transcript)|go:"GO:0005925"(focal adhesion)|go:"GO:0016021"(integral component of membrane)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021392|interpro:IPR022542|refseq:NP_060264.4|refseq:XP_005251551.2 - - comment:mint|comment:homomint figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:8gruYxc3fF2gtFv6ZF7EVLzURaQ9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q14677 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9BZF9 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-350510|uniprotkb:Q14DD3|uniprotkb:Q8N3B8|uniprotkb:Q9HCL1|uniprotkb:Q9NWC6|uniprotkb:G3XAG2|uniprotkb:Q96NH6|intact:EBI-10977773|ensembl:ENSP00000314556 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:uaca_human(display_long)|uniprotkb:UACA(gene name)|psi-mi:UACA(display_short)|uniprotkb:KIAA1561(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001008225.1|refseq:NP_060473.2|dip:DIP-33117N|ensembl:ENSG00000137831(gene)|ensembl:ENST00000322954(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR030227|interpro:IPR036770|mint:Q9BZF9|reactome:R-HSA-9013407|reactome:R-HSA-9627069 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:F58VkGk2DBsUUrB+wgknUFZhJ+E9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q5M775 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-350473|uniprotkb:Q5IBP1|uniprotkb:Q5IBP2|uniprotkb:Q5IBP3|uniprotkb:Q5IBP4|uniprotkb:Q5M772|uniprotkb:Q5M773|uniprotkb:Q5M774|uniprotkb:Q86XT8|uniprotkb:Q8N4U4|uniprotkb:Q8WU84|uniprotkb:Q9HCQ3|uniprotkb:B4DHH0|ensembl:ENSP00000261503|ensembl:ENSP00000378898|ensembl:ENSP00000502924|ensembl:ENSP00000503971|ensembl:ENSP00000504211|uniprotkb:B7WNS8|intact:EBI-2556892 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:cytsb_human(display_long)|uniprotkb:Nuclear structure protein 5(gene name synonym)|uniprotkb:Sperm antigen HCMOGT-1(gene name synonym)|uniprotkb:SPECC1(gene name)|psi-mi:SPECC1(display_short)|uniprotkb:CYTSB(gene name synonym)|uniprotkb:Sperm antigen with calponin homology and coiled-coil domains 1(gene name synonym)|uniprotkb:NSP5(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001028725.1|refseq:NP_001028726.1|refseq:NP_001028727.1|refseq:NP_001230367.1|refseq:NP_001230368.1|refseq:NP_690868.3|ensembl:ENSG00000128487(gene)|ensembl:ENST00000261503(transcript)|ensembl:ENST00000395527(transcript)|ensembl:ENST00000677914(transcript)|ensembl:ENST00000679058(transcript)|ensembl:ENST00000679255(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR036872|mint:Q5M775|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_016880814.1 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:iF+19RpfJDyn5whTFnPmDxxECz09606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9UEY8 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-2838698|uniprotkb:Q9UEY7|uniprotkb:O43243|uniprotkb:Q92773|uniprotkb:Q5VU09|uniprotkb:D3DRA8|intact:EBI-28975834|ensembl:ENSP00000348381 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:addg_human(display_long)|uniprotkb:ADD3(gene name)|psi-mi:ADD3(display_short)|uniprotkb:ADDL(gene name synonym)|uniprotkb:Adducin-like protein 70(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT ensembl:ENST00000277900|ensembl:ENSP00000277900|ensembl:ENSP00000348381|ensembl:ENST00000360162|ensembl:ENSP00000353286|refseq:NP_001307520.1|refseq:NP_001307521.1|refseq:NP_001307522.1|refseq:NP_001307523.1|refseq:NP_001112.2|refseq:NP_058432.1|refseq:NP_063968.1|interpro:IPR036409|mint:Q9UEY8|reactome:R-HSA-5223345|reactome:R-HSA-9013405|reactome:R-HSA-9035034|ensembl:ENSG00000148700(gene)|ensembl:ENST00000356080(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR001303(Class II aldolase/adducin, N-terminal)|interpro:IPR027772 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:10ZAHAI90VaVf/xUxFcNVX5cIts9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9Y3D0 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-744045|ensembl:ENSP00000387471 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:cia2b_human(display_long)|uniprotkb:CIAO2B(gene name)|psi-mi:CIAO2B(display_short)|uniprotkb:CIAB(gene name synonym)|uniprotkb:FAM96B(gene name synonym)|uniprotkb:MIP18(gene name synonym)|uniprotkb:MSS19-interacting protein of 18 kDa(gene name synonym)|uniprotkb:Mitotic spindle-associated MMXD complex subunit MIP18(gene name synonym)|uniprotkb:Protein FAM96B(gene name synonym)|uniprotkb:CGI-128(orf name)|uniprotkb:HSPC118(orf name) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_057146.1|ensembl:ENSG00000166595(gene)|ensembl:ENST00000422424(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030496"(midbody)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002744(Protein of unknown function DUF59)|interpro:IPR034904|interpro:IPR039796|mint:Q9Y3D0|reactome:R-HSA-2564830 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:6LfOUjTAKuEjop3XVyyxx6c4Wl09606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9H2D6 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-715619|uniprotkb:B1AHD4|uniprotkb:B1AHD7|uniprotkb:O94797|uniprotkb:Q2PZW8|uniprotkb:Q2Q3Z9|uniprotkb:Q2Q400|uniprotkb:Q5R3M6|uniprotkb:Q96DW1|uniprotkb:Q9BT77|uniprotkb:Q9BTL7|uniprotkb:Q9BY98|uniprotkb:Q9Y3L4|ensembl:ENSP00000496394|intact:EBI-2560917|uniprotkb:F2Z2W0|uniprotkb:F8W6V6 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:tara_human(display_long)|uniprotkb:Protein Tara(gene name synonym)|uniprotkb:Trio-associated repeat on actin(gene name synonym)|uniprotkb:TRIOBP(gene name)|psi-mi:TRIOBP(display_short)|uniprotkb:KIAA1662(gene name synonym)|uniprotkb:TARA(gene name synonym)|uniprotkb:HRIHFB2122(orf name) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001034230.1|refseq:NP_008963.3|refseq:NP_619538.2|ensembl:ENSG00000100106(gene)|ensembl:ENST00000644935(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030047"(actin modification)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045159"(myosin II binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051301"(cell division)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q9H2D6|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading) - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:2evioSQxAnH1x5VPGsZyK+fJTY09606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9NR28 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-517508|uniprotkb:Q96LV0|uniprotkb:Q9BT11|uniprotkb:Q9HAV6|uniprotkb:B2RDQ0|ensembl:ENSP00000442360|ensembl:ENSP00000499058|uniprotkb:Q6W3F3 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:dbloh_human(display_long)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_620308.1|refseq:NP_063940.1|ensembl:ENST00000464942(transcript)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000650715(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|rcsb pdb:1FEW|dip:DIP-27627N|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1OXQ|rcsb pdb:1TW6|rcsb pdb:1XB0|rcsb pdb:1XB1|rcsb pdb:3D9U|rcsb pdb:3UIH|rcsb pdb:3UIJ|rcsb pdb:4TX5|rcsb pdb:6JX6|reactome:R-HSA-111457|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-9627069 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:P36873 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-356283|ensembl:ENSP00000335084 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:P50552 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:P31946 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9Y613 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-348433|ensembl:ENSP00000258201|uniprotkb:Q59F76|uniprotkb:Q6Y1F2|uniprotkb:Q76MS8|uniprotkb:Q8N521 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:fhod1_human(display_long)|uniprotkb:FHOD1(gene name)|psi-mi:FHOD1(display_short)|uniprotkb:FHOS(gene name synonym)|uniprotkb:FHOS1(gene name synonym)|uniprotkb:Formin homolog overexpressed in spleen 1(gene name synonym)|uniprotkb:Formin homology 2 domain-containing protein 1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_037373.2|ensembl:ENSG00000135723(gene)|ensembl:ENST00000258201(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007097"(nuclear migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051015"(actin filament binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051639"(actin filament network formation)|go:"GO:0051660"(establishment of centrosome localization)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027647|interpro:IPR041387|interpro:IPR042201|rcsb pdb:3DAD|rcsb pdb:6XF1|rcsb pdb:6XF2|mint:Q9Y613|dip:DIP-31134N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:8zGurHJ5FL9gvqZazyRAHElMAdI9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q96SB3 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-351275|uniprotkb:Q8TCR9|intact:EBI-28984643|ensembl:ENSP00000478767|intact:EBI-4401886|uniprotkb:D3DTX6 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:neb2_human(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:PPP1R9B(gene name)|psi-mi:PPP1R9B(display_short)|uniprotkb:PPP1R6(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT ensembl:ENSG00000108819(gene)|ensembl:ENST00000612501(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q96SB3|ensembl:ENSP00000478767|refseq:NP_115984.3 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:X6fQLpaYhXCqzRlQNEoX67P/HbU9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9P206 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-3939668|uniprotkb:B5MDY0|uniprotkb:Q8TCQ0|ensembl:ENSP00000362579|uniprotkb:B4DQU8|uniprotkb:C9JH84 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:k1522_human(display_long)|uniprotkb:KIAA1522(gene name)|psi-mi:KIAA1522(display_short) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT ensembl:ENST00000294521|ensembl:ENSP00000294521|ensembl:ENSP00000362579|ensembl:ENST00000373481|ensembl:ENSP00000362580|ensembl:ENST00000401073|ensembl:ENSP00000383851|ensembl:ENSG00000162522(gene)|ensembl:ENST00000373480(transcript)|go:"GO:0030154"(cell differentiation)|mint:Q9P206|refseq:NP_001185901.1|refseq:NP_001185902.1|refseq:NP_065939.2|refseq:XP_006710854.1 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:RbEPBXAGgG4Icbw8i4pFoIKU1LM9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9P0K7 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1023749|uniprotkb:Q6V1W9|uniprotkb:Q7Z5I4|uniprotkb:Q7Z733|uniprotkb:Q9P2L2|uniprotkb:Q9Y3T5|uniprotkb:E9PED3|intact:EBI-2555698|ensembl:ENSP00000265109|ensembl:ENSP00000388725|ensembl:ENSP00000422942 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:rai14_human(display_long)|uniprotkb:Ankyrin repeat and coiled-coil structure-containing protein(gene name synonym)|uniprotkb:Retinoic acid-induced protein 14(gene name synonym)|uniprotkb:Novel retinal pigment epithelial cell protein(gene name synonym)|uniprotkb:RAI14(gene name)|psi-mi:RAI14(display_short)|uniprotkb:KIAA1334(gene name synonym)|uniprotkb:NORPEG(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001138992.1|refseq:NP_001138993.1|refseq:NP_001138994.1|refseq:NP_001138995.1|refseq:NP_001138997.1|refseq:NP_056392.2|refseq:XP_011512319.1|refseq:XP_011512320.1|refseq:XP_011512321.1|refseq:XP_011512322.1|refseq:XP_011512323.1|refseq:XP_011512324.1|ensembl:ENSG00000039560(gene)|ensembl:ENST00000265109(transcript)|ensembl:ENST00000428746(transcript)|ensembl:ENST00000503673(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR042420|mint:Q9P0K7|refseq:XP_006714532.1|refseq:XP_016864824.1 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:m5hQYx6HEi9QEAey1UiNpeAp6tw9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:P61981 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:P27348 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:O43491 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1052044|uniprotkb:Q5T4F0|uniprotkb:B4DHI8|uniprotkb:Q68DV2|uniprotkb:E9PPD9|ensembl:ENSP00000338481|ensembl:ENSP00000357110 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:e41l2_human(display_long)|uniprotkb:Generally expressed protein 4.1(gene name synonym)|uniprotkb:EPB41L2(gene name)|psi-mi:EPB41L2(display_short)|uniprotkb:Erythrocyte membrane protein band 4.1-like 2(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001422.1|refseq:NP_001129026.1|refseq:NP_001129027.1|refseq:NP_001239589.1|refseq:XP_011533832.1|refseq:XP_011533836.1|ensembl:ENSG00000079819(gene)|ensembl:ENST00000337057(transcript)|ensembl:ENST00000368128(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0008091"(spectrin)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030546|interpro:IPR035963|mint:O43491|reactome:R-HSA-6794361|refseq:XP_016865844.1|refseq:XP_016865848.1|refseq:XP_016865849.1|refseq:XP_016865850.1|refseq:XP_016865851.1|dip:DIP-17034N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:QvhY6g+bBqTBR8oHl/php27Wb7Y9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:P62258 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q9NR09 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:/EZap+9dFkEnO5fRsbzriORwllk9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q5SW79 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27132749|imex:IM-29364-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N - - - figure legend:Supp Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/25 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 rigid:V4RFVkMarBQo5zc7mlNdYolT6TE false lap tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9Y6R9 uniprotkb:Q5SW79 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-27133472|imex:IM-29364-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N go:"GO:0005813"(centrosome) - - figure legend:Fig. 3A|comment:Cells were treated with nocodazole to disperse the satellites and better visualise centrosomal VFL3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/11/29 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 rigid:Z1ckGZlnoooU9JDUbmcvIHwDczM false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9Y6R9 uniprotkb:Q9UPN4 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-2558372|uniprotkb:B2RN11|uniprotkb:Q96F50|uniprotkb:A6NHI8|ensembl:ENSP00000269392 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:cp131_human(display_long)|uniprotkb:CEP131(gene name)|psi-mi:CEP131(display_short)|uniprotkb:5-azacytidine-induced protein 1(gene name synonym)|uniprotkb:AZI1(gene name synonym)|uniprotkb:KIAA1118(gene name synonym)|uniprotkb:Pre-acrosome localization protein 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-28929725|imex:IM-29364-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_001009811.2|refseq:NP_055799.2|refseq:NP_001306157.1|ensembl:ENSG00000141577(gene)|ensembl:ENST00000269392(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0120212"(sperm head-tail coupling apparatus)|go:"GO:1905198"(manchette assembly)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990953"(intramanchette transport)|interpro:IPR030465|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005814"(centriole)|dip:DIP-56658N go:"GO:0034451"(centriolar satellite) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/12/01 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:qcnzG6vfogSEappaH9nv7P3kSoQ9606 rigid:IZ2d2nWVtDKsMLnLccwecTCzAso false myc tag:n-n - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9Y6R9 uniprotkb:Q15154 intact:EBI-10961230|uniprotkb:C8CAP4|uniprotkb:Q9HDB6|ensembl:ENSP00000471454 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 psi-mi:ccd61_human(display_long)|uniprotkb:CCDC61(gene name)|psi-mi:CCDC61(display_short)|uniprotkb:Coiled-coil domain-containing protein 61(gene name synonym)|uniprotkb:VFL3 homolog(gene name synonym) psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Pizon et al. (2020) pubmed:31789463|imex:IM-29364 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-28929725|imex:IM-29364-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001254652.1|refseq:XP_005259249.1|refseq:XP_011525559.1|ensembl:ENSG00000104983(gene)|ensembl:ENST00000595358(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008017"(microtubule binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0098534"(centriole assembly)|go:"GO:0120103"(centriolar subdistal appendage)|rcsb pdb:6HXT refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N go:"GO:0034451"(centriolar satellite) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2021/11/15 2021/12/01 rogid:+/yRx3Uy7HdhvYlZXf8+lld9FNE9606 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rigid:IZ2d2nWVtDKsMLnLccwecTCzAso false myc tag:n-n - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)