#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26657494|imex:IM-28770-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 3A, 3B, Supp Data 1, Supp Tables 1 and 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/02/17 2021/02/17 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false - flag tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26657521|imex:IM-28770-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/17 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26665668|imex:IM-28770-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/23 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false - necessary binding region:30-54|flag tag:c-c|green fluorescent protein tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26686224|imex:IM-28770-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Supp. Figs. 6C, 15A|comment:Endoplasmic reticulum stress, induced by treatment with tunicamycin or thapsigargin has no effect on the PIGBOS-CLCC1 interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/23 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false - sufficient binding region:30-54|flag tag:c-c|mutation disrupting interaction strength:30-32|mutation decreasing interaction strength:34-36|mutation with no effect:37-39|mutation with no effect:40-42|mutation with no effect:43-45|mutation with no effect:46-48|mutation with no effect:49-51|mutation with no effect:52-54 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0486"(UniProt) intact:EBI-26657606|imex:IM-28770-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 3C, 3D, Supp. figure 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/17 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false - flag tag:n-n|tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0809"(bimolecular fluorescence complementation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26665684|imex:IM-28770-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 go:"GO:0031966"(mitochondrial membrane) - - figure legend:Figs. 4A, Supp. Fig. 10C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2021/02/17 2021/02/23 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false nGFP:?-? cGFP:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0809"(bimolecular fluorescence complementation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26665706|imex:IM-28770-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2021/02/17 2021/02/23 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false nGFP:?-?|ha tag:?-? cGFP:c-c|flag tag:c-c|necessary binding region:30-54 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-26665732|imex:IM-28770-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2021/02/17 2021/02/23 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false nGFP:?-?|ha tag:c-c necessary binding region:30-54|cGFP:c-c|flag tag:c-c - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26674663|imex:IM-28770-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Figs. 4C, 4E.|comment:Overexpression of VAPB and PTPIP51 ER-mitochondria contact site proteins significantly increased interactions between PIGBOS and CLCC1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2021/02/17 2021/02/25 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false nGFP:?-?|ha tag:c-c cGFP:c-c|flag tag:c-c|necessary binding region:30-54 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26686254|imex:IM-28770-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Supp. Figs. 12A, 15B|comment:Overexpression of VAPB and PTPIP51 ER-mitochondria contact site proteins significantly increased interactions between PIGBOS and CLCC1 Endoplasmic reticulum stress, induced by treatment with tunicamycin or thapsigargin has no effect on the PIGBOS-CLCC1 interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/25 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false nGFP:?-?|ha tag:c-c cGFP:c-c|flag tag:c-c|necessary binding region:30-54 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:A0A0B4J2F0 uniprotkb:A0A0B4J2F0 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26686277|imex:IM-28770-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Supp. Figs. 19B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/23 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:notWBet6vEzESJ1VczOwgtkwaaI false ha tag:c-c flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:C0HLN0 uniprotkb:A0A0B4J2F0 intact:EBI-26686303 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:pios1_rat(display_long)|uniprotkb:PIGB opposite strand protein 1 homolog(gene name synonym)|uniprotkb:Pigbos1(gene name)|psi-mi:Pigbos1(display_short) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26686311|imex:IM-28770-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295361.1|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|rgd:6502569 ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Supp. Figs. 19C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/23 rogid:b30OFnJqK9MdknZu5jlFuzKUgQs10116 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:A5l4mYKCMFXyYYP3lHXgjxXlBv8 false ha tag:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96S66 uniprotkb:A0A0B4J2F0 intact:EBI-2836109|uniprotkb:Q8WYP9|uniprotkb:Q8WYP8|uniprotkb:O94861|uniprotkb:Q9BU25|ensembl:ENSP00000349456|ensembl:ENSP00000358986|ensembl:ENSP00000502251|ensembl:ENSP00000502457|ensembl:ENSP00000502648|ensembl:ENSP00000502836 intact:EBI-26657479|ensembl:ENSP00000482636|ensembl:ENSP00000484893 psi-mi:clcc1_human(display_long)|uniprotkb:CLCC1(gene name)|psi-mi:CLCC1(display_short)|uniprotkb:KIAA0761(gene name synonym)|uniprotkb:MCLC(gene name synonym)|uniprotkb:Mid-1-related chloride channel protein 1(gene name synonym) psi-mi:pios1_human(display_long)|uniprotkb:PIGBOS1(gene name)|psi-mi:PIGBOS1(display_short)|uniprotkb:PIGB opposite strand protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chu et al. (2019) imex:IM-28770|pubmed:31653868 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26687328|imex:IM-28770-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041675.1|refseq:NP_055942.1|refseq:NP_001265131.1|refseq:NP_001265132.1|ensembl:ENSG00000121940(gene)|ensembl:ENST00000356970(transcript)|ensembl:ENST00000369969(transcript)|ensembl:ENST00000674849(transcript)|ensembl:ENST00000675508(transcript)|ensembl:ENST00000675654(transcript)|ensembl:ENST00000675956(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|interpro:IPR009231(Mid-1-related chloride channel) ensembl:ENSG00000225973(gene)|ensembl:ENST00000436697(transcript)|ensembl:ENST00000567948(transcript)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|refseq:NP_001295350.1|refseq:NP_001295351.1|refseq:NP_001295352.1 - - - figure legend:Supp. Fig 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/17 2021/02/25 rogid:l1dx06MXJa4s4kcVIvr1rRm9Wu09606 rogid:XiIflioCy0tuDsnRlakuv/SvYnU9606 rigid:WYJTCgETbGouJ/+phy9zPv3tnvs false ha tag:c-c flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)