#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34972	uniprotkb:Q7Z6Z7	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P00403	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q8IXI1	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1396563|uniprotkb:Q8NF53|uniprotkb:Q96C13|uniprotkb:Q96S17|uniprotkb:Q9BT60|uniprotkb:Q9H7M8|uniprotkb:A2IDC2|ensembl:ENSP00000321971	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:miro2_human(display_long)|uniprotkb:RHOT2(gene name)|psi-mi:RHOT2(display_short)|uniprotkb:ARHT2(gene name synonym)|uniprotkb:C16orf39(gene name synonym)|uniprotkb:Ras homolog gene family member T2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_620124.1|ensembl:ENSG00000140983(gene)|ensembl:ENST00000315082(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|mint:Q8IXI1|rcsb pdb:5KUT|reactome:R-HSA-9013419	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:E+WoN8aoND+U/YkLBUTecrNbDXg9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P10586	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-7188069|ensembl:ENSP00000353030|uniprotkb:Q5T022|uniprotkb:Q5W9G2|intact:MINT-1189049|uniprotkb:D3DPX7|uniprotkb:Q5T021|uniprotkb:D3DPX6|uniprotkb:Q86WS0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ptprf_human(display_long)|uniprotkb:PTPRF(gene name)|psi-mi:PTPRF(display_short)|uniprotkb:LAR(gene name synonym)|uniprotkb:Leukocyte common antigen related(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000142949(gene)|ensembl:ENST00000359947(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0016477"(cell migration)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900121"(negative regulation of receptor binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|mint:P10586|rcsb pdb:1LAR|rcsb pdb:2DJU|rcsb pdb:2DN7|rcsb pdb:2EDX|rcsb pdb:2EDY|rcsb pdb:2YD5|rcsb pdb:2YD8|rcsb pdb:4N5U|rcsb pdb:6KR4|rcsb pdb:6TPT|rcsb pdb:6TPU|rcsb pdb:6TPV|rcsb pdb:6TPW|reactome:R-HSA-388844|reactome:R-HSA-8849932|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|refseq:NP_002831.2|refseq:NP_569707.2	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	comment:mint|comment:homomint	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:JLPH3tIxOkyVmJ0mZsBZ+TanLVk9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P10321	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q93008	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-302524|intact:EBI-1058656|intact:EBI-28978998|ensembl:ENSP00000367558|uniprotkb:O75550|uniprotkb:Q8WWT3|uniprotkb:Q8WX12	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:usp9x_human(display_long)|uniprotkb:USP9X(gene name)|psi-mi:USP9X(display_short)|uniprotkb:DFFRX(gene name synonym)|uniprotkb:USP9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:FAM(gene name synonym)|uniprotkb:Fat facets in mammals(gene name synonym)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000124486(gene)|ensembl:ENST00000378308(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007292"(female gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-2173795|reactome:R-HSA-5689880|reactome:R-HSA-8866652|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9033241|reactome:R-HSA-977225|go:"GO:0048675"(axon extension)|refseq:NP_001034679.2|refseq:NP_001034680.2|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR031226|interpro:IPR038765|mint:Q93008|rcsb pdb:5VBD|rcsb pdb:5WCH|ensembl:ENST00000324545|ensembl:ENSP00000316357|ensembl:ENSP00000367558|dip:DIP-27562N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:f9AWz8rAV8rMTqcQ46VrYYLTHq89606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q86VU5	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2836030|uniprotkb:Q8TE79|ensembl:ENSP00000361616	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:cmtd1_human(display_long)|uniprotkb:COMTD1(gene name)|psi-mi:COMTD1(display_short)|uniprotkb:UNQ766/PRO1558(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000165644(gene)|ensembl:ENST00000372538(transcript)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032259"(methylation)|interpro:IPR002935(O-methyltransferase, family 3)|interpro:IPR029063|rcsb pdb:2AVD|refseq:NP_653190.2	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:lKfKAJMxvqIw8xqpHBhlZm+8WMs9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P06702	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1055001|uniprotkb:Q6FGA1|uniprotkb:Q9NYM0|uniprotkb:Q9UCJ1|uniprotkb:D3DV36|ensembl:ENSP00000357727	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:s10a9_human(display_long)|uniprotkb:S100 calcium-binding protein A9(gene name synonym)|uniprotkb:Calgranulin-B(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 14(gene name synonym)|uniprotkb:Leukocyte L1 complex heavy chain(gene name synonym)|uniprotkb:Calprotectin L1H subunit(gene name synonym)|uniprotkb:S100A9(gene name)|psi-mi:S100A9(display_short)|uniprotkb:CAGB(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:MRP14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_002956.1|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5I8N|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENSG00000163220(gene)|ensembl:ENST00000368738(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035821"(modulation of process of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045113"(regulation of integrin biosynthetic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|mint:P06702|rcsb pdb:1IRJ|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016209"(antioxidant activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|dip:DIP-1166N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:IGnX4DSnv8xMr5pY4T7X7vYos5A9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O14980	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q00325	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	crc64:78714C85931B22D5	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9P035	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q53GQ0	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2963255|uniprotkb:Q96EA9|ensembl:ENSP00000278353|uniprotkb:A8K9B0|uniprotkb:Q9Y6G8|uniprotkb:Q96JU2|uniprotkb:D3DR23	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:dhb12_human(display_long)|uniprotkb:HSD17B12(gene name)|psi-mi:HSD17B12(display_short)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 12(gene name synonym)|uniprotkb:3-ketoacyl-CoA reductase(gene name synonym)|uniprotkb:SDR12C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 1(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 12(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000149084(gene)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008201"(heparin binding)|go:"GO:0009923"(fatty acid elongase complex)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0050062"(long-chain-fatty-acyl-CoA reductase activity)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|ensembl:ENST00000278353(transcript)|go:"GO:0102339"(3-oxo-arachidoyl-CoA reductase activity)|go:"GO:0102341"(3-oxo-lignoceroyl-CoA reductase activity)|go:"GO:0102342"(3-oxo-cerotoyl-CoA reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q53GQ0|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0102340"(3-oxo-behenoyl-CoA reductase activity)|refseq:NP_057226.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:2R2pFY0c9yRuCvLU2J8n2urR+0o9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P24534	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-354334|uniprotkb:Q6IBH9|uniprotkb:A8K795|ensembl:ENSP00000236957|ensembl:ENSP00000376055|ensembl:ENSP00000376056|ensembl:ENSP00000489993|ensembl:ENSP00000490214|ensembl:ENSP00000490326	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ef1b_human(display_long)|uniprotkb:EEF1B(gene name synonym)|uniprotkb:EF1B(gene name synonym)|uniprotkb:EEF1B2(gene name)|psi-mi:EEF1B2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001032752.1|refseq:NP_001950.1|refseq:NP_066944.1|ensembl:ENSG00000114942(gene)|ensembl:ENSG00000283391(gene)|ensembl:ENST00000236957(transcript)|ensembl:ENST00000392221(transcript)|ensembl:ENST00000392222(transcript)|ensembl:ENST00000635728(transcript)|ensembl:ENST00000636275(transcript)|ensembl:ENST00000637253(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0045471"(response to ethanol)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|interpro:IPR036282|mint:P24534|rcsb pdb:1B64|rcsb pdb:5DQS|reactome:R-HSA-156842	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:d4zkwQOMlpr6XBapMfT1sxy2ZPs9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P50402	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P30048	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:+J/zV8u0jGCSzTGXafxgecTv/149606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P61619	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P51571	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1054539|uniprotkb:Q53XY1|uniprotkb:A8K378|ensembl:ENSP00000317331|ensembl:ENSP00000359103|ensembl:ENSP00000359104	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ssrd_human(display_long)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)|uniprotkb:SSR4(gene name)|psi-mi:SSR4(display_short)|uniprotkb:TRAPD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001191455.1|refseq:NP_006271.1|refseq:XP_011529488.1|refseq:XP_011529489.1|ensembl:ENSG00000180879(gene)|ensembl:ENST00000320857(transcript)|ensembl:ENST00000370086(transcript)|ensembl:ENST00000370087(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008855(Translocon-associated)|mint:P51571|reactome:R-HSA-1799339	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:2SNgZQH/jwi61UcuHUf7RYKZH589606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P53618	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P30101	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O75396	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1058865|ensembl:ENSP00000463393|uniprotkb:A8K1G0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sc22b_human(display_long)|uniprotkb:SEC22B(gene name)|psi-mi:SEC22B(display_short)|uniprotkb:SEC22L1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000265808(gene)|ensembl:ENST00000578049(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O75396|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:3EGD|rcsb pdb:3EGX|refseq:NP_004883.3|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6811434|reactome:R-HSA-1236974|dip:DIP-50458N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:DRKtD169T9eYZ2kFufLapidvcKs9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P11586	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O14975	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2801436|uniprotkb:Q53FY6|uniprotkb:A8K2J7|uniprotkb:Q6PF09|ensembl:ENSP00000267842	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:s27a2_human(display_long)|uniprotkb:ACSVL1(gene name synonym)|uniprotkb:FACVL1(gene name synonym)|uniprotkb:FATP2(gene name synonym)|uniprotkb:VLACS(gene name synonym)|uniprotkb:Fatty acid transport protein 2(gene name synonym)|uniprotkb:Fatty-acid-coenzyme A ligase, very long-chain 1(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase(gene name synonym)|uniprotkb:Solute carrier family 27 member 2(gene name synonym)|uniprotkb:THCA-CoA ligase(gene name synonym)|uniprotkb:Very long-chain-fatty-acid-CoA ligase(gene name synonym)|uniprotkb:SLC27A2(gene name)|psi-mi:SLC27A2(display_short)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Phytanate--CoA ligase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001153101.1|refseq:NP_003636.2|ensembl:ENSG00000140284(gene)|ensembl:ENST00000267842(transcript)|go:"GO:0001561"(fatty acid alpha-oxidation)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015245"(fatty acid transmembrane transporter activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031957"(very long-chain fatty acid-CoA ligase activity)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0047747"(cholate-CoA ligase activity)|go:"GO:0050197"(phytanate-CoA ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070251"(pristanate-CoA ligase activity)|go:"GO:0097089"(methyl-branched fatty acid metabolic process)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR030305|interpro:IPR042099|mint:O14975|reactome:R-HSA-193368|reactome:R-HSA-193775|reactome:R-HSA-389599|reactome:R-HSA-6798695|reactome:R-HSA-9033241	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:lOeY1DAlhT5ZfNd5gUhEBBvszws9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P22102	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q12931	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P05109	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-355281|uniprotkb:Q5SY70|uniprotkb:Q9UC92|uniprotkb:Q9UCJ0|uniprotkb:A8K5L3|uniprotkb:Q9UC84|uniprotkb:Q9UCM6|uniprotkb:D3DV37|ensembl:ENSP00000357721|ensembl:ENSP00000357722	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:s10a8_human(display_long)|uniprotkb:S100A8(gene name)|psi-mi:S100A8(display_short)|uniprotkb:CAGA(gene name synonym)|uniprotkb:MRP8(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:S100 calcium-binding protein A8(gene name synonym)|uniprotkb:Calgranulin-A(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 8(gene name synonym)|uniprotkb:Cystic fibrosis antigen(gene name synonym)|uniprotkb:Leukocyte L1 complex light chain(gene name synonym)|uniprotkb:Calprotectin L1L subunit(gene name synonym)|uniprotkb:Urinary stone protein band A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001306126.1|refseq:NP_001306127.1|refseq:NP_001306130.1|refseq:NP_002955.2|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045471"(response to ethanol)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028474|go:"GO:0035662"(Toll-like receptor 4 binding)|mint:P05109|rcsb pdb:1MR8|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5HLO|rcsb pdb:5HLV|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENST00000368732(transcript)|ensembl:ENST00000368733(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|ensembl:ENSG00000143546(gene)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|dip:DIP-1165N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:3Okfhj8fxclZ0Uo/Fa1Z89qC8Ec9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O95831	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O15173	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P61204	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-641535|uniprotkb:P16587|uniprotkb:A8K6G8|ensembl:ENSP00000256682|ensembl:ENSP00000438510|uniprotkb:B7ZB63	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:arf3_human(display_long)|uniprotkb:ARF3(gene name)|psi-mi:ARF3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001650.1|ensembl:ENSG00000134287(gene)|ensembl:ENST00000256682(transcript)|ensembl:ENST00000541959(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61204|rcsb pdb:6II6|reactome:R-HSA-1660514|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_005268913.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q15363	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-998485|ensembl:ENSP00000262225	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P08195	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-702356|uniprotkb:Q13543|ensembl:ENSP00000367122	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:4f2_human(display_long)|uniprotkb:Lymphocyte activation antigen 4F2 large subunit(gene name synonym)|uniprotkb:4F2 heavy chain antigen(gene name synonym)|uniprotkb:SLC3A2(gene name)|psi-mi:SLC3A2(display_short)|uniprotkb:MDU1(gene name synonym)|uniprotkb:Solute carrier family 3 member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001012680.1|refseq:NP_001012682.1|refseq:NP_001013269.1|refseq:NP_002385.3|ensembl:ENSG00000168003(gene)|ensembl:ENST00000377890(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003824"(catalytic activity)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015173"(aromatic amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0015820"(leucine transport)|go:"GO:0015823"(phenylalanine transport)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044225"(apical pole of neuron)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098713"(leucine import across plasma membrane)|go:"GO:1903801"(L-leucine import across plasma membrane)|go:"GO:1904273"(L-alanine import across plasma membrane)|go:"GO:1990184"(amino acid transport complex)|interpro:IPR006047(Glycosyl hydrolase, family 13, catalytic region)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR031984|interpro:IPR042280|mint:P08195|rcsb pdb:2DH2|rcsb pdb:2DH3|rcsb pdb:6IRS|rcsb pdb:6IRT|rcsb pdb:6JMQ|rcsb pdb:6JMR|rcsb pdb:6S8V|rcsb pdb:7CCS|reactome:R-HSA-210991|reactome:R-HSA-352230|reactome:R-HSA-5660862|reactome:R-HSA-71240	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:+7lJ/35nXzIs8SLCor0Vh5fAZYQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P13073	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P51648	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1391128|uniprotkb:Q93011|uniprotkb:Q96J37|uniprotkb:Q6I9T3|ensembl:ENSP00000176643|ensembl:ENSP00000461916|ensembl:ENSP00000463637|ensembl:ENSP00000500092	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:al3a2_human(display_long)|uniprotkb:Aldehyde dehydrogenase 10(gene name synonym)|uniprotkb:Microsomal aldehyde dehydrogenase(gene name synonym)|uniprotkb:ALDH3A2(gene name)|psi-mi:ALDH3A2(display_short)|uniprotkb:ALDH10(gene name synonym)|uniprotkb:FALDH(gene name synonym)|uniprotkb:Fatty aldehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_000373.1|refseq:NP_001026976.1|refseq:XP_011522034.1|refseq:XP_011522035.1|refseq:XP_016879845.1|refseq:XP_016879846.1|ensembl:ENST00000672357(transcript)|go:"GO:0004028"(3-chloroallyl aldehyde dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006714"(sesquiterpenoid metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008544"(epidermis development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033306"(phytol metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0046458"(hexadecanal metabolic process)|go:"GO:0046577"(long-chain-alcohol oxidase activity)|go:"GO:0050061"(long-chain-aldehyde dehydrogenase activity)|go:"GO:0052814"(medium-chain-aldehyde dehydrogenase activity)|interpro:IPR012394("Aldehyde dehydrogenase NAD(P)-dependent")|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P51648|rcsb pdb:4QGK|reactome:R-HSA-1660661|reactome:R-HSA-389599|reactome:R-HSA-9603798|reactome:R-HSA-9609523|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENSG00000072210(gene)|ensembl:ENST00000176643(transcript)|ensembl:ENST00000579855(transcript)|ensembl:ENST00000581518(transcript)	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:ADi5/NMf5JsjzaonzFIbHZebIlQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P07237	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9HCU5	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2553896|uniprotkb:Q9UH94|ensembl:ENSP00000260643|uniprotkb:Q53SZ8	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:preb_human(display_long)|uniprotkb:SEC12(gene name synonym)|uniprotkb:Mammalian guanine nucleotide exchange factor mSec12(gene name synonym)|uniprotkb:PREB(gene name)|psi-mi:PREB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_037520.1|ensembl:ENSG00000138073(gene)|ensembl:ENST00000260643(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051020"(GTPase binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|rcsb pdb:5TF2|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|refseq:NP_001317414.1|refseq:NP_001317415.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:3xjABrP1KtfZUMb/BSbe8ZN6dJ49606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P13797	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-698052|uniprotkb:B1AQ09|uniprotkb:Q86YI6|uniprotkb:A8K579|uniprotkb:B4DGB4|uniprotkb:B7Z6M1|ensembl:ENSP00000348163|ensembl:ENSP00000445339	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:plst_human(display_long)|uniprotkb:T-plastin(gene name synonym)|uniprotkb:PLS3(gene name)|psi-mi:PLS3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001129497.1|refseq:NP_005023.2|refseq:XP_011535836.1|refseq:NP_001165806.1|refseq:NP_001269266.1|refseq:NP_001269267.1|ensembl:ENSG00000102024(gene)|ensembl:ENST00000355899(transcript)|ensembl:ENST00000539310(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0032432"(actin filament bundle)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051639"(actin filament network formation)|go:"GO:0060348"(bone development)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:P13797|rcsb pdb:1AOA|rcsb pdb:1WJO	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:RWAS8uhDHEtqdDd1gfsqDDyvvsE9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9BQB6	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-6256462|ensembl:ENSP00000378426|uniprotkb:A6NIQ6|uniprotkb:B2R4Z6|uniprotkb:Q6UX90|uniprotkb:Q7Z2R4	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:vkor1_human(display_long)|uniprotkb:VKORC1(gene name)|psi-mi:VKORC1(display_short)|uniprotkb:VKOR(gene name synonym)|uniprotkb:Vitamin K1 2,3-epoxide reductase subunit 1(gene name synonym)|uniprotkb:MSTP134(orf name)|uniprotkb:MSTP576(orf name)|uniprotkb:UNQ308/PRO351(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000167397(gene)|ensembl:ENST00000394975(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017144"|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047057"("vitamin-K-epoxide reductase (warfarin-sensitive) activity")|go:"GO:0048038"(quinone binding)|go:"GO:0060348"(bone development)|interpro:IPR012932(Vitamin K epoxide reductase)|interpro:IPR038354|interpro:IPR042406|mint:Q9BQB6|rcsb pdb:6WV3|rcsb pdb:6WV4|rcsb pdb:6WV5|rcsb pdb:6WV6|rcsb pdb:6WV7|rcsb pdb:6WVH|reactome:R-HSA-6806664|refseq:NP_001298240.1|refseq:NP_076869.1|refseq:NP_996560.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:C3RrQ+y7Huai7PExa9LOvfqni+U9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9BVA1	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-355665|uniprotkb:A8K068|ensembl:ENSP00000259818	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tbb2b_human(display_long)|uniprotkb:TUBB2B(gene name)|psi-mi:TUBB2B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_821080.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BVA1|rcsb pdb:6E7C|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|ensembl:ENST00000259818(transcript)|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-5663220|ensembl:ENSG00000137285(gene)	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:sluQMryNuOvp6xlV558+agiRwvE9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P39656	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P40939	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P04843	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P04844	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-719731|uniprotkb:Q5JYR6|uniprotkb:Q9UBE1|uniprotkb:Q6IBA5|uniprotkb:Q96E21|uniprotkb:Q9BUQ3|ensembl:ENSP00000237530	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:rpn2_human(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:RIBIIR(gene name synonym)|uniprotkb:RPN2(gene name)|psi-mi:RPN2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001129243.1|refseq:NP_002942.2|ensembl:ENSG00000118705(gene)|ensembl:ENST00000237530(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:P04844|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|refseq:NP_001311234.1|refseq:NP_001311235.1|refseq:NP_001311228.1|refseq:NP_001311230.1|refseq:NP_001311231.1|refseq:NP_001311232.1|refseq:NP_001311233.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:7bTuuEb3ykWQvkI/5DKpga48s/w9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9BXW9	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:9szrKioB24vbUy47a30DPUQhqkA9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9BQE3	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1103245|ensembl:ENSP00000301072	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tba1c_human(display_long)|uniprotkb:TUBA1C(gene name)|psi-mi:TUBA1C(display_short)|uniprotkb:TUBA6(gene name synonym)|uniprotkb:Tubulin alpha-6 chain(gene name synonym)|uniprotkb:Alpha-tubulin 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|ensembl:ENSG00000167553(gene)|ensembl:ENST00000301072(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031982"(vesicle)|go:"GO:0051301"(cell division)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BQE3|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_116093.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:53r1CNUJNgCreVCw4riUsTPh+yw9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q14257	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P49411	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P50395	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1049143|uniprotkb:O43928|uniprotkb:Q9UQM6|ensembl:ENSP00000369538|uniprotkb:Q5SX88	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:gdib_human(display_long)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)|uniprotkb:GDI2(gene name)|psi-mi:GDI2(display_short)|uniprotkb:RABGDIB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000057608(gene)|ensembl:ENST00000380191(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0034774"(secretory granule lumen)|refseq:NP_001108628.1|refseq:NP_001485.2|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50395|reactome:R-HSA-6798695|reactome:R-HSA-8876198|dip:DIP-50593N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:KTUS915xP+QA9QFU2aZSyS+Hkgc9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P62341	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-720342|ensembl:ENSP00000418910|uniprotkb:O95904|uniprotkb:Q8IY80|uniprotkb:Q9CZ45|uniprotkb:Q9NZJ3	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:selt_human(display_long)|uniprotkb:UNQ150/PRO176(orf name)|uniprotkb:SELENOT(gene name)|psi-mi:SELENOT(display_short)|uniprotkb:SELT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000471696(transcript)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008430"(selenium binding)|go:"GO:0009749"(response to glucose)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031016"(pancreas development)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0098869"(cellular oxidant detoxification)|ensembl:ENSG00000198843(gene)|interpro:IPR011893(SelT/selW/selH selenoprotein)|interpro:IPR019389|interpro:IPR036249|refseq:NP_057359.2	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:qQidic3+BjplpLqlzjeVDL+28Hk9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P49755	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-998422|uniprotkb:Q15602|uniprotkb:Q16536|uniprotkb:Q86TC2|uniprotkb:Q86TS5|uniprotkb:B2R605|intact:EBI-1058680|ensembl:ENSP00000303145	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tmeda_human(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmp-21-I(gene name synonym)|uniprotkb:p24delta(gene name synonym)|uniprotkb:S31III125(gene name synonym)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)|uniprotkb:S31I125(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:P49755|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811434|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|ensembl:ENSG00000170348(gene)|ensembl:ENST00000303575(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|refseq:NP_006818.3	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:Sj4B0x1qf0VJmI1aDFaw2/PiTxM9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P20020	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:kCpUNLYDF38hciXj32D8rXbXULg9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O60884	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9Y4P3	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2513719|ensembl:ENSP00000307260|uniprotkb:Q9UQE2	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tbl2_human(display_long)|uniprotkb:TBL2(gene name)|psi-mi:TBL2(display_short)|uniprotkb:WBSCR13(gene name synonym)|uniprotkb:WS beta-transducin repeats protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 13 protein(gene name synonym)|uniprotkb:UNQ563/PRO1125(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000106638(gene)|ensembl:ENST00000305632(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR042410|mint:Q9Y4P3|refseq:NP_036585.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:K0mFwM08LEIAWO/zg4Irplaq9oM9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:A1L0T0	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-720553|uniprotkb:O43341|uniprotkb:Q99651|uniprotkb:Q9BWN5|uniprotkb:Q9UEB2|intact:EBI-3184145|intact:EBI-1236857|uniprotkb:Q96F08|ensembl:ENSP00000263383	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:hacl2_human(display_long)|uniprotkb:Acetolactate synthase-like protein(gene name synonym)|uniprotkb:HACL2(gene name synonym)|uniprotkb:ILVBL(gene name)|psi-mi:ILVBL(display_short)|uniprotkb:AHAS(gene name synonym)|uniprotkb:IlvB-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_006835.2|refseq:XP_005259774.1|ensembl:ENSG00000105135(gene)|ensembl:ENST00000263383(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001561"(fatty acid alpha-oxidation)|go:"GO:0003984"(acetolactate synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005948"(acetolactate synthase complex)|go:"GO:0009097"(isoleucine biosynthetic process)|go:"GO:0009099"(valine biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016829"(lyase activity)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR000399(TPP-binding enzymes, conserved site)|interpro:IPR011766(Thiamine pyrophosphate enzyme, C-terminal TPP-binding)|interpro:IPR012000(Thiamine pyrophosphate enzyme, central region)|interpro:IPR012001(Thiamine pyrophosphate enzyme, N-terminal TPP binding region)|interpro:IPR029035|interpro:IPR029061	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:WDj/FsULgscGSIgcTe8+1+vKhS09606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O75915	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2860752|uniprotkb:B2R6V5|uniprotkb:Q53ES3|uniprotkb:Q5KU08|ensembl:ENSP00000273258	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:praf3_human(display_long)|uniprotkb:ARL6IP5(gene name)|psi-mi:ARL6IP5(display_short)|uniprotkb:DERP11(gene name synonym)|uniprotkb:JWA(gene name synonym)|uniprotkb:PRA2(gene name synonym)|uniprotkb:PRAF3(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 6-interacting protein 5(gene name synonym)|uniprotkb:Cytoskeleton-related vitamin A-responsive protein(gene name synonym)|uniprotkb:Dermal papilla-derived protein 11(gene name synonym)|uniprotkb:GTRAP3-18(gene name synonym)|uniprotkb:Glutamate transporter EAAC1-interacting protein(gene name synonym)|uniprotkb:JM5(gene name synonym)|uniprotkb:Prenylated Rab acceptor protein 2(gene name synonym)|uniprotkb:Protein JWa(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM27(gene name synonym)|uniprotkb:HSPC127(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_006398.1|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051051"(negative regulation of transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098712"(L-glutamate import across plasma membrane)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:O75915|reactome:R-HSA-210500|ensembl:ENSG00000144746(gene)|ensembl:ENST00000273258(transcript)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007611"(learning or memory)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015031"(protein transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:TG2yH1gqzVhFgxBtuZqsE1dLAvQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P42356	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P55084	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q8NI60	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-745535|uniprotkb:Q8NCJ6|intact:EBI-1384330|uniprotkb:Q5T7A5|uniprotkb:Q63HK0|uniprotkb:Q9HBQ1|uniprotkb:Q9NQ67|ensembl:ENSP00000355739	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:coq8a_human(display_long)|uniprotkb:COQ8A(gene name)|psi-mi:COQ8A(display_short)|uniprotkb:ADCK3(gene name synonym)|uniprotkb:CABC1(gene name synonym)|uniprotkb:Chaperone activity of bc1 complex-like(gene name synonym)|uniprotkb:Coenzyme Q protein 8A(gene name synonym)|uniprotkb:aarF domain-containing protein kinase 3(gene name synonym)|uniprotkb:PP265(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_064632.2|refseq:XP_011542540.1|refseq:XP_011542541.1|refseq:XP_011542542.1|refseq:XP_011542543.1|refseq:XP_005273258.1|refseq:XP_016857341.1|ensembl:ENSG00000163050(gene)|ensembl:ENST00000366777(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0043531"(ADP binding)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034640|interpro:IPR034646|rcsb pdb:4PED|rcsb pdb:5I35	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:mR2b+x/tnfsqK1fAzS0qYPijtvw9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q15043	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-6116466|uniprotkb:A6NH98|uniprotkb:B4DIW3|uniprotkb:B6EU88|uniprotkb:D3DSR4|uniprotkb:Q6ZME8|uniprotkb:Q96BB3|ensembl:ENSP00000289952|ensembl:ENSP00000370635	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:s39ae_human(display_long)|uniprotkb:SLC39A14(gene name)|psi-mi:SLC39A14(display_short)|uniprotkb:KIAA0062(gene name synonym)|uniprotkb:ZIP14(gene name synonym)|uniprotkb:LIV-1 subfamily of ZIP zinc transporter 4(gene name synonym)|uniprotkb:Solute carrier family 39 member 14(gene name synonym)|uniprotkb:Zrt- and Irt-like protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:XP_011542780.1|refseq:NP_001121903.1|refseq:NP_001128625.1|refseq:NP_056174.2|refseq:XP_005273522.1|refseq:XP_005273523.1|refseq:XP_006716387.1|refseq:XP_016868783.1|refseq:XP_016868784.1|ensembl:ENSG00000104635(gene)|ensembl:ENST00000289952(transcript)|ensembl:ENST00000381237(transcript)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0015086"(cadmium ion transmembrane transporter activity)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0015296"("anion:cation symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033212"(iron import into cell)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055071"(manganese ion homeostasis)|go:"GO:0070574"(cadmium ion transmembrane transport)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071578"(zinc ion import across plasma membrane)|go:"GO:0098739"(import across plasma membrane)|interpro:IPR003689(Zinc/iron permease)|mint:Q15043|reactome:R-HSA-442380	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:tpJl2FORU2if7SOPN8ZDwPvF+HM9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O00264	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9H3N1	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1051115|uniprotkb:Q8N487|uniprotkb:Q8NBN5|uniprotkb:Q9Y4T6|uniprotkb:B2R7A4|ensembl:ENSP00000393316	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tmx1_human(display_long)|uniprotkb:Transmembrane Trx-related protein(gene name synonym)|uniprotkb:TMX1(gene name)|psi-mi:TMX1(display_short)|uniprotkb:TXNDC1(gene name synonym)|uniprotkb:TMX(gene name synonym)|uniprotkb:TXNDC(gene name synonym)|uniprotkb:PSEC0085(orf name)|uniprotkb:UNQ235/PRO268(orf name)|uniprotkb:Thioredoxin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_110382.3|ensembl:ENSG00000139921(gene)|ensembl:ENST00000457354(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:Q9H3N1|rcsb pdb:1X5E	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:ZJH5N22Dnrk+SXa3Ysqqfu1md/I9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O15258	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-716910|uniprotkb:O95322|ensembl:ENSP00000464222|ensembl:ENSP00000475168	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:rer1_human(display_long)|uniprotkb:RER1(gene name)|psi-mi:RER1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_008964.3|refseq:XP_011538844.1|refseq:XP_011538845.1|refseq:XP_006710369.1|ensembl:ENSG00000157916(gene)|ensembl:ENST00000488353(transcript)|ensembl:ENST00000605895(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009986"(cell surface)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR004932(Retrieval of early ER protein Rer1)|mint:O15258|refseq:XP_016855622.1|refseq:XP_016855623.1|refseq:XP_016855624.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:rLTZIWGawmaVck0uemR5/E9bFRk9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q13501	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O43149	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-715672|uniprotkb:Q6NXG0|uniprotkb:Q6ZRA1|uniprotkb:Q6ZSF4|uniprotkb:Q9NVB9|uniprotkb:A7MBM5|ensembl:ENSP00000371051	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:zzef1_human(display_long)|uniprotkb:ZZEF1(gene name)|psi-mi:ZZEF1(display_short)|uniprotkb:KIAA0399(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_055928.3|go:"GO:0005509"(calcium ion binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011992(EF-Hand type)|interpro:IPR040099|interpro:IPR041986|interpro:IPR043145|mint:O43149|ensembl:ENST00000381638(transcript)|ensembl:ENSG00000074755(gene)	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:LpYXMInET7VBZ/ZLV23wuQksKTA9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q4ZIN3	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-718159|uniprotkb:O60392|uniprotkb:Q8NF79|uniprotkb:Q96H30|ensembl:ENSP00000349087	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:mbrl_human(display_long)|uniprotkb:TMEM259(gene name)|psi-mi:TMEM259(display_short)|uniprotkb:C19orf6(gene name synonym)|uniprotkb:Transmembrane protein 259(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001028198.1|refseq:NP_219488.1|ensembl:ENSG00000182087(gene)|ensembl:ENST00000356663(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904294"(positive regulation of ERAD pathway)|interpro:IPR019144|mint:Q4ZIN3	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:9pOT/zZF8drU1qnANZaZaMgVmUo9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O15269	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q96A33	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-720151|uniprotkb:Q96D00|uniprotkb:Q96JZ7|uniprotkb:Q9H3E4|uniprotkb:Q9NRG3|uniprotkb:B2RAS8|uniprotkb:D3DU20|ensembl:ENSP00000225726|ensembl:ENSP00000384888	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ccd47_human(display_long)|uniprotkb:CCDC47(gene name)|psi-mi:CCDC47(display_short)|uniprotkb:Calumin(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 47(gene name synonym)|uniprotkb:GK001(orf name)|uniprotkb:MSTP041(orf name)|uniprotkb:PSEC0077(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_064583.2|ensembl:ENSG00000108588(gene)|ensembl:ENST00000225726(transcript)|ensembl:ENST00000403162(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006983"(ER overload response)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043022"(ribosome binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045048"(protein insertion into ER membrane)|interpro:IPR012879(Protein of unknown function DUF1682)|mint:Q96A33|rcsb pdb:6W6L|go:"GO:0030867"(rough endoplasmic reticulum membrane)|refseq:XP_005257584.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:DdZFzZrrc4culfYoex0Czf/X6SQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O95260	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1043378|uniprotkb:O95261|uniprotkb:Q8WW04|ensembl:ENSP00000224652|uniprotkb:Q5SQQ3	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ate1_human(display_long)|uniprotkb:Arginine-tRNA--protein transferase 1(gene name synonym)|uniprotkb:ATE1(gene name)|psi-mi:ATE1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000107669(gene)|ensembl:ENST00000224652(transcript)|interpro:IPR007471(Arginine-tRNA-protein transferase, N-terminal)|interpro:IPR007472(Arginine-tRNA-protein transferase, C-terminal)|go:"GO:0004057"(arginyltransferase activity)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017137(Arginine-tRNA--protein transferase 1, eukaryotic)|go:"GO:0005634"(nucleus)|interpro:IPR030700|mint:O95260|go:"GO:0005737"(cytoplasm)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016598"(protein arginylation)|refseq:NP_001001976.1|refseq:NP_008972.2|refseq:NP_001275663.1|refseq:NP_001275664.1|refseq:NP_001275665.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:vK21nNxx2fa9ct7O5WG0LqtD9u09606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9UBV2	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O43505	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-6138697|uniprotkb:Q4TTN0|ensembl:ENSP00000309096	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:b4ga1_human(display_long)|uniprotkb:B4GAT1(gene name)|psi-mi:B4GAT1(display_short)|uniprotkb:B3GNT1(gene name synonym)|uniprotkb:B3GNT6(gene name synonym)|uniprotkb:I-beta-1,3-N-acetylglucosaminyltransferase(gene name synonym)|uniprotkb:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase(gene name synonym)|uniprotkb:Poly-N-acetyllactosamine extension enzyme(gene name synonym)|uniprotkb:"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_006867.1|dip:DIP-48921N|ensembl:ENSG00000174684(gene)|ensembl:ENST00000311181(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008532"(N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity)|go:"GO:0015020"(glucuronosyltransferase activity)|go:"GO:0018146"(keratan sulfate biosynthetic process)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR043189|reactome:R-HSA-2022854|reactome:R-HSA-5083627|reactome:R-HSA-5173105	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:385SVje+9APXIP/uy7JT3ybCqpA9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q99442	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-949221|ensembl:ENSP00000337688|ensembl:ENSP00000420331|uniprotkb:O00682|uniprotkb:O00729|intact:EBI-2689278|uniprotkb:D3DNQ0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sec62_human(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short)|uniprotkb:TLOC1(gene name synonym)|uniprotkb:Translocation protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000008952(gene)|ensembl:ENST00000337002(transcript)|ensembl:ENST00000480708(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR004728(Translocation protein Sec62)|rcsb pdb:7BRT|refseq:NP_003253.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:u7na6TjTcixVS+ZK2ygkFA1QDKY9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P37268	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-714550|intact:EBI-1058542|uniprotkb:Q96GT0|ensembl:ENSP00000220584|ensembl:ENSP00000480828|ensembl:ENSP00000481481|uniprotkb:B3KQ95|uniprotkb:B4DJE5|uniprotkb:B4DT56|uniprotkb:B7Z1J3	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:fdft_human(display_long)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:FDFT1(gene name)|psi-mi:FDFT1(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000618539(transcript)|refseq:NP_004453.3|ensembl:ENSG00000079459(gene)|ensembl:ENST00000220584(transcript)|ensembl:ENST00000615631(transcript)|rcsb pdb:3LEE|rcsb pdb:3Q2Z|rcsb pdb:3Q30|rcsb pdb:3V66|rcsb pdb:3VJ8|rcsb pdb:3VJ9|rcsb pdb:3VJA|rcsb pdb:3VJB|rcsb pdb:3VJC|rcsb pdb:3WC9|rcsb pdb:3WCD|rcsb pdb:3WCF|rcsb pdb:3WCH|rcsb pdb:3WCI|rcsb pdb:3WCJ|rcsb pdb:3WCL|rcsb pdb:3WCM|rcsb pdb:3WEF|rcsb pdb:3WEG|rcsb pdb:3WEH|rcsb pdb:3WEI|rcsb pdb:3WEJ|rcsb pdb:3WEK|rcsb pdb:3WSA|rcsb pdb:6PYJ|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|reactome:R-HSA-191273|reactome:R-HSA-1989781|reactome:R-HSA-2426168|rcsb pdb:3ASX|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|mint:P37268|rcsb pdb:1EZF|refseq:NP_001274671.1|refseq:NP_001274672.1|refseq:NP_001274673.1|refseq:NP_001274674.1|refseq:NP_001274676.1|refseq:NP_001274677.1|refseq:NP_001274678.1|refseq:NP_001274679.1|refseq:NP_001274680.1|refseq:NP_001274685.1|refseq:XP_016868706.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:3TjanjXw3X58/ZOEsB1xczV0/qQ9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q8IWV7	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-711736|uniprotkb:O60708|uniprotkb:O75492|uniprotkb:Q14D45|uniprotkb:Q68DN9|uniprotkb:Q8IWY6|uniprotkb:Q96JY4|ensembl:ENSP00000290650	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ubr1_human(display_long)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-I(gene name synonym)|uniprotkb:UBR1(gene name)|psi-mi:UBR1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase UBR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_777576.1|dip:DIP-47033N|ensembl:ENSG00000159459(gene)|ensembl:ENST00000290650(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV7|rcsb pdb:3NY1|rcsb pdb:5TDC|reactome:R-HSA-983168	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:BcTsfaVfIa+WpIb8EPaPca2UZN89606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P27824	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:P16615	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q99720	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q96JJ7	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2514069|intact:EBI-28973673|uniprotkb:B3KV75|uniprotkb:Q52LT7|uniprotkb:Q8N5J0|uniprotkb:Q9NWJ9|ensembl:ENSP00000299608	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:tmx3_human(display_long)|uniprotkb:TMX3(gene name)|psi-mi:TMX3(display_short)|uniprotkb:KIAA1830(gene name synonym)|uniprotkb:TXNDC10(gene name synonym)|uniprotkb:Thioredoxin-related transmembrane protein 3(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSP00000299608|ensembl:ENST00000562706|ensembl:ENSP00000457262|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0031092"(platelet alpha granule membrane)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|reactome:R-HSA-114608|ensembl:ENST00000299608(transcript)|ensembl:ENSG00000166479(gene)|refseq:NP_061895.3	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:Qber8pA1sCprlKl8Yoc5XtVEd5s9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q06136	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-3909166|uniprotkb:B2R5Y1|ensembl:ENSP00000494352|uniprotkb:B4DMX0	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:kdsr_human(display_long)|uniprotkb:KDSR(gene name)|psi-mi:KDSR(display_short)|uniprotkb:FVT1(gene name synonym)|uniprotkb:3-dehydrosphinganine reductase(gene name synonym)|uniprotkb:Follicular variant translocation protein 1(gene name synonym)|uniprotkb:SDR35C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 35C member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_002026.1|ensembl:ENST00000645214(transcript)|ensembl:ENSG00000119537(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006666"(3-keto-sphinganine metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0047560"(3-dehydrosphinganine reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q06136|reactome:R-HSA-1660661	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:Qeo5s672s/qK8CE52sS1Pr01kFY9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O14967	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-3907005|uniprotkb:D3DNY8|uniprotkb:B3KS90|uniprotkb:B4DXV8|ensembl:ENSP00000326699|ensembl:ENSP00000392782	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:clgn_human(display_long)|uniprotkb:CLGN(gene name)|psi-mi:CLGN(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_001124147.1|refseq:NP_004353.1|ensembl:ENSG00000153132(gene)|ensembl:ENST00000325617(transcript)|ensembl:ENST00000414773(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:O14967	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:Akb2XoiNjob34njC2erE11yg80w9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:O15162	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-740019|ensembl:ENSP00000345494|uniprotkb:B2R8H8|uniprotkb:B4DTE8	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:pls1_human(display_long)|uniprotkb:PLSCR1(gene name)|psi-mi:PLSCR1(display_short)|uniprotkb:"Ca(2+)-dependent phospholipid scramblase 1"(gene name synonym)|uniprotkb:Erythrocyte phospholipid scramblase(gene name synonym)|uniprotkb:MmTRA1b(gene name synonym)|uniprotkb:"Mg(2+)-dependent nuclease"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000188313(gene)|ensembl:ENST00000342435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001618"(virus receptor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006659"(phosphatidylserine biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0017124"(SH3 domain binding)|ensembl:ENSP00000345494|ensembl:ENST00000448787|ensembl:ENSP00000411675|refseq:NP_066928.1|go:"GO:0017128"(phospholipid scramblase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0032791"(lead ion binding)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051607"(defense response to virus)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070782"(phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR005552(Scramblase)|mint:O15162|rcsb pdb:1Y2A|refseq:XP_011511209.1|refseq:XP_011511206.1|refseq:XP_005247595.1|refseq:XP_011511208.1|refseq:XP_016862118.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:XudfvUkrZbB28t9tpFkokgnDFGc9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q8IYS2	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2866116|uniprotkb:Q8IVF8|uniprotkb:Q8NDI7|uniprotkb:Q5JXC1|uniprotkb:Q9BSY1|ensembl:ENSP00000365756|ensembl:ENSP00000480577	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:k2013_human(display_long)|uniprotkb:KIAA2013(gene name)|psi-mi:KIAA2013(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_612355.1|refseq:XP_005263588.1|ensembl:ENSG00000116685(gene)|ensembl:ENST00000376572(transcript)|ensembl:ENST00000616327(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|mint:Q8IYS2|interpro:IPR018795	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:c98fgl75bIy0X3/+3fN4cVTgDY09606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q5T447	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-2691157|uniprotkb:B3KPV7|uniprotkb:B3KRH4|uniprotkb:Q5T448|uniprotkb:Q9H783|ensembl:ENSP00000361245	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:hecd3_human(display_long)|uniprotkb:HECT domain-containing protein 3(gene name synonym)|uniprotkb:HECTD3(gene name)|psi-mi:HECTD3(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase HECTD3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_078878.3|ensembl:ENSG00000126107(gene)|ensembl:ENST00000372172(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000569(HECT)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR035983|interpro:IPR042469|mint:Q5T447|reactome:R-HSA-983168|go:"GO:0019905"(syntaxin binding)	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:laodrF8CReKmM4d6n3sHGBmQB6Q9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9UJ14	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1058791|ensembl:ENSP00000338964|uniprotkb:Q8N899|uniprotkb:Q8NF66|uniprotkb:Q9BYP5|uniprotkb:Q9BYP6	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:ggt7_human(display_long)|uniprotkb:GGT7(gene name)|psi-mi:GGT7(display_short)|uniprotkb:GGTL3(gene name synonym)|uniprotkb:GGTL5(gene name synonym)|uniprotkb:Gamma-glutamyltranspeptidase 7(gene name synonym)|uniprotkb:Gamma-glutamyltransferase-like 3(gene name synonym)|uniprotkb:Gamma-glutamyltransferase-like 5(gene name synonym)|uniprotkb:Gamma-glutamyltransferase 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_821158.2|ensembl:ENSG00000131067(gene)|ensembl:ENST00000336431(transcript)|go:"GO:0000048"(peptidyltransferase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036374"(glutathione hydrolase activity)|go:"GO:0102953"(hypoglycin A gamma-glutamyl transpeptidase activity)|go:"GO:0103068"(leukotriene C4 gamma-glutamyl transferase activity)|go:"GO:1901750"(leukotriene D4 biosynthetic process)|go:"GO:1902883"(negative regulation of response to oxidative stress)|interpro:IPR000101(Gamma-glutamyltranspeptidase)|interpro:IPR029055|interpro:IPR043137|interpro:IPR043138|reactome:R-HSA-174403|reactome:R-HSA-5423646	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:gAPBdehRHCbx1QWo/NmujxXx9hc9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q9Y394	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-1387800|uniprotkb:Q9UKU2|uniprotkb:B2R896|ensembl:ENSP00000216500|ensembl:ENSP00000451882	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:dhrs7_human(display_long)|uniprotkb:DHRS7(gene name)|psi-mi:DHRS7(display_short)|uniprotkb:RETSDR4(gene name synonym)|uniprotkb:SDR34C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 34C member 1(gene name synonym)|uniprotkb:CGI-86(orf name)|uniprotkb:UNQ285/PRO3448(orf name)|uniprotkb:DHRS7A(gene name synonym)|uniprotkb:Retinal short-chain dehydrogenase/reductase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	refseq:NP_057113.1|refseq:NP_001309209.1|ensembl:ENSG00000100612(gene)|ensembl:ENST00000216500(transcript)|ensembl:ENST00000557185(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:OcTvozRJMb/lmA0bzcIcNpWIbYE9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q15392	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-5457558|uniprotkb:B7Z817|ensembl:ENSP00000360316|ensembl:ENSP00000416585|uniprotkb:D3DQ51|uniprotkb:Q9HBA8|intact:EBI-10964490	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:dhc24_human(display_long)|uniprotkb:DHCR24(gene name)|psi-mi:DHCR24(display_short)|uniprotkb:KIAA0018(gene name synonym)|uniprotkb:24-dehydrocholesterol reductase(gene name synonym)|uniprotkb:Diminuto/dwarf1 homolog(gene name synonym)|uniprotkb:Seladin-1(gene name synonym)|uniprotkb:3-beta-hydroxysterol Delta-24-reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880846|imex:IM-28819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENSG00000116133(gene)|ensembl:ENST00000371269(transcript)|ensembl:ENST00000436604(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016628"(oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0050614"(delta24-sterol reductase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061024"(membrane organization)|go:"GO:0071949"(FAD binding)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016166(FAD-binding, type 2)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR040165|go:"GO:0005737"(cytoplasm)|mint:Q15392|reactome:R-HSA-6807047|reactome:R-HSA-6807062|refseq:NP_055577.1	-	comment:"Indeed, a total of 39.2% of the CB2 protein sequence was covered by mass spectrometric data. In total 698 proteins were identified. As expected for a GPCR guanine-nucleotide-binding protein G subunits alpha GNAI3 and GNAS1 have each been identified by one unique peptide. After subtraction of background interactions (Figure 1B) and protein frequency library assessment (Glatter et al., 2009) we could identify 83 putative interactors that were classified by the identification of minimally two unique peptides as highly probable interactors"	-	figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/03/18	2021/11/30	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:kg8bxZHxFFTUmvP9UQMeVFRNWQM9606	rigid:RCfQNeVUEr1u+yV9Vqasq6VW6AM	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P34972	uniprotkb:Q13501	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880942|imex:IM-28819-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/18	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:R9GbsgRqm6bPOsKU0xbGwk7AIt4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34972	uniprotkb:Q13501	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880948|imex:IM-28819-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:f5b|comment:"We designed expression constructs deleting the three intracellular loops and the C-terminus of the CB2 receptor (Figure 5A). Surprisingly none of these deletion constructs altered the interaction of CB2 with p62 in co-IP studies if correlated to the different expression levels in the input and the IPs (Figure 5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/18	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:R9GbsgRqm6bPOsKU0xbGwk7AIt4	false	sufficient binding region:1-300|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34972	uniprotkb:Q13501	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880955|imex:IM-28819-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:F4D|comment:"Our 3D reconstruction images indicated that those p62 vesicles were surrounded by CB2 positive areas that were adjacent to the surface membrane (Figure 4D). These results demonstrate that about half of the p62 positive areas co-expressed CB2 and that these p62-CB2 vesicles are at the cell membrane."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/18	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:R9GbsgRqm6bPOsKU0xbGwk7AIt4	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P34972	uniprotkb:Q13501	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sharaf et al. (2018)	imex:IM-28819|pubmed:31616248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26900288|imex:IM-28819-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:f6b|comment:"We designed expression constructs deleting the three intracellular loops and the C-terminus of the CB2 receptor (Figure 5A). Surprisingly none of these deletion constructs altered the interaction of CB2 with p62 in co-IP studies if correlated to the different expression levels in the input and the IPs (Figure 5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/31	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:R9GbsgRqm6bPOsKU0xbGwk7AIt4	false	ha tag:?-?	necessary binding region:122-168|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)