#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:E9PYH6	uniprotkb:Q8CFN5	intact:EBI-17172269|ensembl:ENSMUSP00000037600|ensembl:ENSMUSP00000047672	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	psi-mi:set1a_mouse(display_long)|uniprotkb:SET domain-containing protein 1A(gene name synonym)|uniprotkb:Setd1a(gene name)|psi-mi:Setd1a(display_short)	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mukai et al. (2019)	pubmed:31606247|imex:IM-28940	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26970050|imex:IM-28940-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000042308(gene)|ensembl:ENSMUST00000047075(transcript)|ensembl:ENSMUST00000047157(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024657|interpro:IPR034467|interpro:IPR035979|interpro:IPR037841|interpro:IPR044570|reactome:R-MMU-3214841|reactome:R-MMU-8936459|go:"GO:0035097"(histone methyltransferase complex)|refseq:NP_821172.2|refseq:XP_017177700.1|refseq:XP_017177701.1|refseq:XP_017177702.1|refseq:XP_017177703.1	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. 3f|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2021/05/04	2021/05/04	rogid:vNh5u0JJkgYRFxgpRqRYG4AMxFE10090	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rigid:WhzALgkN5TeXjevYCkOCxkQg6lM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:E9PYH6	uniprotkb:Q60929	intact:EBI-17172269|ensembl:ENSMUSP00000037600|ensembl:ENSMUSP00000047672	intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566	psi-mi:set1a_mouse(display_long)|uniprotkb:SET domain-containing protein 1A(gene name synonym)|uniprotkb:Setd1a(gene name)|psi-mi:Setd1a(display_short)	psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mukai et al. (2019)	pubmed:31606247|imex:IM-28940	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26970050|imex:IM-28940-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000042308(gene)|ensembl:ENSMUST00000047075(transcript)|ensembl:ENSMUST00000047157(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024657|interpro:IPR034467|interpro:IPR035979|interpro:IPR037841|interpro:IPR044570|reactome:R-MMU-3214841|reactome:R-MMU-8936459|go:"GO:0035097"(histone methyltransferase complex)|refseq:NP_821172.2|refseq:XP_017177700.1|refseq:XP_017177701.1|refseq:XP_017177702.1|refseq:XP_017177703.1	refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. 3f|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2021/05/04	2021/05/04	rogid:vNh5u0JJkgYRFxgpRqRYG4AMxFE10090	rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090	rigid:WhzALgkN5TeXjevYCkOCxkQg6lM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)