#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16891	uniprotkb:P54252	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	intact:EBI-946046|uniprotkb:O15284|uniprotkb:O15285|uniprotkb:O15286|uniprotkb:Q8N189|uniprotkb:Q96TC3|uniprotkb:Q96TC4|uniprotkb:Q9H3N0|uniprotkb:A7LFZ5|uniprotkb:D6RDL9|uniprotkb:E9PB63|ensembl:ENSP00000496695	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:atx3_human(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chapman et al. (2018)	pubmed:31379806|imex:IM-28816	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26877640|imex:IM-28816-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	refseq:NP_001121168.1|refseq:NP_004984.2|refseq:NP_109376.1|refseq:NP_001158252.1|ensembl:ENSG00000066427(gene)|ensembl:ENST00000644486(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045202"(synapse)|go:"GO:0051117"(ATPase binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR033865|mint:P54252|rcsb pdb:1YZB|rcsb pdb:2AGA|rcsb pdb:2DOS|rcsb pdb:2JRI|rcsb pdb:2KLZ|rcsb pdb:4WTH|rcsb pdb:4YS9|reactome:R-HSA-5689877|reactome:R-HSA-9615017	-	-	-	figure legend:f2c|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-moDCs)|taxid:9606(human monocyte-derived dendritic cell)	-	2021/02/12	2021/03/16	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	rogid:p8Ck3OVZVARmRC06N+KSX09/x0c9606	rigid:GVwmxGzL0GW0Oi0pwDXhYroYlwc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16891	uniprotkb:P54252	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	intact:EBI-946046|uniprotkb:O15284|uniprotkb:O15285|uniprotkb:O15286|uniprotkb:Q8N189|uniprotkb:Q96TC3|uniprotkb:Q96TC4|uniprotkb:Q9H3N0|uniprotkb:A7LFZ5|uniprotkb:D6RDL9|uniprotkb:E9PB63|ensembl:ENSP00000496695	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:atx3_human(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chapman et al. (2018)	pubmed:31379806|imex:IM-28816	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26877644|imex:IM-28816-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	refseq:NP_001121168.1|refseq:NP_004984.2|refseq:NP_109376.1|refseq:NP_001158252.1|ensembl:ENSG00000066427(gene)|ensembl:ENST00000644486(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045202"(synapse)|go:"GO:0051117"(ATPase binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR033865|mint:P54252|rcsb pdb:1YZB|rcsb pdb:2AGA|rcsb pdb:2DOS|rcsb pdb:2JRI|rcsb pdb:2KLZ|rcsb pdb:4WTH|rcsb pdb:4YS9|reactome:R-HSA-5689877|reactome:R-HSA-9615017	-	-	-	figure legend:f2d|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-moDCs)|taxid:9606(human monocyte-derived dendritic cell)	-	2021/02/12	2021/03/16	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	rogid:p8Ck3OVZVARmRC06N+KSX09/x0c9606	rigid:GVwmxGzL0GW0Oi0pwDXhYroYlwc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16891	uniprotkb:P54252	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	intact:EBI-946046|uniprotkb:O15284|uniprotkb:O15285|uniprotkb:O15286|uniprotkb:Q8N189|uniprotkb:Q96TC3|uniprotkb:Q96TC4|uniprotkb:Q9H3N0|uniprotkb:A7LFZ5|uniprotkb:D6RDL9|uniprotkb:E9PB63|ensembl:ENSP00000496695	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:atx3_human(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chapman et al. (2018)	pubmed:31379806|imex:IM-28816	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26877636|imex:IM-28816-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	refseq:NP_001121168.1|refseq:NP_004984.2|refseq:NP_109376.1|refseq:NP_001158252.1|ensembl:ENSG00000066427(gene)|ensembl:ENST00000644486(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045202"(synapse)|go:"GO:0051117"(ATPase binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR033865|mint:P54252|rcsb pdb:1YZB|rcsb pdb:2AGA|rcsb pdb:2DOS|rcsb pdb:2JRI|rcsb pdb:2KLZ|rcsb pdb:4WTH|rcsb pdb:4YS9|reactome:R-HSA-5689877|reactome:R-HSA-9615017	-	-	-	figure legend:f2a nfa|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-moDCs)|taxid:9606(human monocyte-derived dendritic cell)	-	2021/02/12	2021/03/16	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	rogid:p8Ck3OVZVARmRC06N+KSX09/x0c9606	rigid:GVwmxGzL0GW0Oi0pwDXhYroYlwc	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q16891	uniprotkb:P54252	intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262	intact:EBI-946046|uniprotkb:O15284|uniprotkb:O15285|uniprotkb:O15286|uniprotkb:Q8N189|uniprotkb:Q96TC3|uniprotkb:Q96TC4|uniprotkb:Q9H3N0|uniprotkb:A7LFZ5|uniprotkb:D6RDL9|uniprotkb:E9PB63|ensembl:ENSP00000496695	psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name)	psi-mi:atx3_human(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chapman et al. (2018)	pubmed:31379806|imex:IM-28816	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26877656|imex:IM-28816-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N	refseq:NP_001121168.1|refseq:NP_004984.2|refseq:NP_109376.1|refseq:NP_001158252.1|ensembl:ENSG00000066427(gene)|ensembl:ENST00000644486(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045202"(synapse)|go:"GO:0051117"(ATPase binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR033865|mint:P54252|rcsb pdb:1YZB|rcsb pdb:2AGA|rcsb pdb:2DOS|rcsb pdb:2JRI|rcsb pdb:2KLZ|rcsb pdb:4WTH|rcsb pdb:4YS9|reactome:R-HSA-5689877|reactome:R-HSA-9615017	-	-	-	figure legend:f2e|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-moDCs)|taxid:9606(human monocyte-derived dendritic cell)	-	2021/02/12	2021/03/16	rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606	rogid:p8Ck3OVZVARmRC06N+KSX09/x0c9606	rigid:GVwmxGzL0GW0Oi0pwDXhYroYlwc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P54252	uniprotkb:Q6IAA8	intact:EBI-946046|uniprotkb:O15284|uniprotkb:O15285|uniprotkb:O15286|uniprotkb:Q8N189|uniprotkb:Q96TC3|uniprotkb:Q96TC4|uniprotkb:Q9H3N0|uniprotkb:A7LFZ5|uniprotkb:D6RDL9|uniprotkb:E9PB63|ensembl:ENSP00000496695	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:atx3_human(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chapman et al. (2018)	pubmed:31379806|imex:IM-28816	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26877668|imex:IM-28816-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121168.1|refseq:NP_004984.2|refseq:NP_109376.1|refseq:NP_001158252.1|ensembl:ENSG00000066427(gene)|ensembl:ENST00000644486(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045202"(synapse)|go:"GO:0051117"(ATPase binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR033865|mint:P54252|rcsb pdb:1YZB|rcsb pdb:2AGA|rcsb pdb:2DOS|rcsb pdb:2JRI|rcsb pdb:2KLZ|rcsb pdb:4WTH|rcsb pdb:4YS9|reactome:R-HSA-5689877|reactome:R-HSA-9615017	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:f6d|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/12	2021/03/16	rogid:p8Ck3OVZVARmRC06N+KSX09/x0c9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rigid:86ZWtBySyl9/qMJjsv+GoTVIn+Q	false	ha tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)