#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34896	uniprotkb:P50213	intact:EBI-715117|uniprotkb:Q9UMD1|uniprotkb:Q9UMD2|uniprotkb:Q96HY0|uniprotkb:D3DXD0|uniprotkb:B4DPM9|ensembl:ENSP00000492715|ensembl:ENSP00000495756|ensembl:ENSP00000318868	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	psi-mi:glyc_human(display_long)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:SHMT1(gene name)|psi-mi:SHMT1(display_short)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	May et al. (2019)	imex:IM-28811|pubmed:30613765	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876270|imex:IM-28811-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268715.1|refseq:NP_004160.3|refseq:NP_683718.1|refseq:XP_016880446.1|refseq:XP_016880447.1|refseq:XP_011522294.1|refseq:XP_005256824.1|ensembl:ENSG00000176974(gene)|ensembl:ENSG00000284320(gene)|ensembl:ENST00000316694(transcript)|ensembl:ENST00000640392(transcript)|ensembl:ENST00000644141(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070905"(serine binding)|go:"GO:1904482"(cellular response to tetrahydrofolate)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|rcsb pdb:1BJ4|rcsb pdb:6FL5|rcsb pdb:6M5W|reactome:R-HSA-196757|reactome:R-HSA-71262	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	-	-	-	figure legend:fig. 4f|comment:Interaction identified also in LNZ308 Human glioblastoma cell line|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2021/02/22	2021/03/15	rogid:OoGscelaCrK8ytz7Nyo7Msm8epE9606	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rigid:79jmuh14PSfQ6sT3w82u+xUIscM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34896	uniprotkb:P50213	intact:EBI-715117|uniprotkb:Q9UMD1|uniprotkb:Q9UMD2|uniprotkb:Q96HY0|uniprotkb:D3DXD0|uniprotkb:B4DPM9|ensembl:ENSP00000492715|ensembl:ENSP00000495756|ensembl:ENSP00000318868	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	psi-mi:glyc_human(display_long)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:SHMT1(gene name)|psi-mi:SHMT1(display_short)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	May et al. (2019)	imex:IM-28811|pubmed:30613765	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876328|imex:IM-28811-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268715.1|refseq:NP_004160.3|refseq:NP_683718.1|refseq:XP_016880446.1|refseq:XP_016880447.1|refseq:XP_011522294.1|refseq:XP_005256824.1|ensembl:ENSG00000176974(gene)|ensembl:ENSG00000284320(gene)|ensembl:ENST00000316694(transcript)|ensembl:ENST00000640392(transcript)|ensembl:ENST00000644141(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070905"(serine binding)|go:"GO:1904482"(cellular response to tetrahydrofolate)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|rcsb pdb:1BJ4|rcsb pdb:6FL5|rcsb pdb:6M5W|reactome:R-HSA-196757|reactome:R-HSA-71262	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	-	-	-	figure legend:fig. 4f|comment:Interaction identified also in LNZ308 Human glioblastoma cell line|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-astrocyte)|taxid:9606(Homo sapiens astrocyte)	-	2021/02/22	2021/03/15	rogid:OoGscelaCrK8ytz7Nyo7Msm8epE9606	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rigid:79jmuh14PSfQ6sT3w82u+xUIscM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34896	uniprotkb:P50213	intact:EBI-715117|uniprotkb:Q9UMD1|uniprotkb:Q9UMD2|uniprotkb:Q96HY0|uniprotkb:D3DXD0|uniprotkb:B4DPM9|ensembl:ENSP00000492715|ensembl:ENSP00000495756|ensembl:ENSP00000318868	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	psi-mi:glyc_human(display_long)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:SHMT1(gene name)|psi-mi:SHMT1(display_short)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	May et al. (2019)	imex:IM-28811|pubmed:30613765	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876404|imex:IM-28811-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268715.1|refseq:NP_004160.3|refseq:NP_683718.1|refseq:XP_016880446.1|refseq:XP_016880447.1|refseq:XP_011522294.1|refseq:XP_005256824.1|ensembl:ENSG00000176974(gene)|ensembl:ENSG00000284320(gene)|ensembl:ENST00000316694(transcript)|ensembl:ENST00000640392(transcript)|ensembl:ENST00000644141(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070905"(serine binding)|go:"GO:1904482"(cellular response to tetrahydrofolate)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|rcsb pdb:1BJ4|rcsb pdb:6FL5|rcsb pdb:6M5W|reactome:R-HSA-196757|reactome:R-HSA-71262	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	-	-	-	figure legend:fig. 4f|comment:Interaction identified also in LNZ308 Human glioblastoma cell line|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lnz308)|taxid:9606(Human glioblastoma cell line.)	-	2021/02/22	2021/03/15	rogid:OoGscelaCrK8ytz7Nyo7Msm8epE9606	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rigid:79jmuh14PSfQ6sT3w82u+xUIscM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50213	uniprotkb:P34896	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-715117|uniprotkb:Q9UMD1|uniprotkb:Q9UMD2|uniprotkb:Q96HY0|uniprotkb:D3DXD0|uniprotkb:B4DPM9|ensembl:ENSP00000492715|ensembl:ENSP00000495756|ensembl:ENSP00000318868	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:glyc_human(display_long)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:SHMT1(gene name)|psi-mi:SHMT1(display_short)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	May et al. (2019)	imex:IM-28811|pubmed:30613765	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876409|imex:IM-28811-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	refseq:NP_001268715.1|refseq:NP_004160.3|refseq:NP_683718.1|refseq:XP_016880446.1|refseq:XP_016880447.1|refseq:XP_011522294.1|refseq:XP_005256824.1|ensembl:ENSG00000176974(gene)|ensembl:ENSG00000284320(gene)|ensembl:ENST00000316694(transcript)|ensembl:ENST00000640392(transcript)|ensembl:ENST00000644141(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070905"(serine binding)|go:"GO:1904482"(cellular response to tetrahydrofolate)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|rcsb pdb:1BJ4|rcsb pdb:6FL5|rcsb pdb:6M5W|reactome:R-HSA-196757|reactome:R-HSA-71262	-	-	-	figure legend:fig. 4f|comment:Interaction identified also in LNZ308 Human glioblastoma cell line|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lnz308)|taxid:9606(Human glioblastoma cell line.)	-	2021/02/22	2021/03/15	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:OoGscelaCrK8ytz7Nyo7Msm8epE9606	rigid:79jmuh14PSfQ6sT3w82u+xUIscM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50213	uniprotkb:P34896	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-715117|uniprotkb:Q9UMD1|uniprotkb:Q9UMD2|uniprotkb:Q96HY0|uniprotkb:D3DXD0|uniprotkb:B4DPM9|ensembl:ENSP00000492715|ensembl:ENSP00000495756|ensembl:ENSP00000318868	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:glyc_human(display_long)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:SHMT1(gene name)|psi-mi:SHMT1(display_short)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	May et al. (2019)	imex:IM-28811|pubmed:30613765	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876442|imex:IM-28811-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	refseq:NP_001268715.1|refseq:NP_004160.3|refseq:NP_683718.1|refseq:XP_016880446.1|refseq:XP_016880447.1|refseq:XP_011522294.1|refseq:XP_005256824.1|ensembl:ENSG00000176974(gene)|ensembl:ENSG00000284320(gene)|ensembl:ENST00000316694(transcript)|ensembl:ENST00000640392(transcript)|ensembl:ENST00000644141(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070905"(serine binding)|go:"GO:1904482"(cellular response to tetrahydrofolate)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|rcsb pdb:1BJ4|rcsb pdb:6FL5|rcsb pdb:6M5W|reactome:R-HSA-196757|reactome:R-HSA-71262	-	-	-	comment:"The IDH3a interactome was defined using IP-MS  studies in patient-derived GICs, expressing a scrambled or an IDH3a-  targeting shRNA. Peptides derived from four proteins were reproducibly detected in shScr-expressing GICs upon IDH3a-specific  pulldown, but not in immunoglobulin G (IgG) isotype-matched  control precipitates or in GICs stably expressing shRNA targeted to  IDH3a (Fig. 4, D and E). Among the four candidates, cSHMT was  the only IDH3a interactor that coprecipitated with IDH3a in all  transformed GBM cell lines, patient-derived GICs, and NHAs."|figure legend:fig. 4d|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-gic)|taxid:9606(human glioma-initiating cells)	-	2021/02/22	2021/03/15	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:OoGscelaCrK8ytz7Nyo7Msm8epE9606	rigid:79jmuh14PSfQ6sT3w82u+xUIscM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P50213	uniprotkb:P34896	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-715117|uniprotkb:Q9UMD1|uniprotkb:Q9UMD2|uniprotkb:Q96HY0|uniprotkb:D3DXD0|uniprotkb:B4DPM9|ensembl:ENSP00000492715|ensembl:ENSP00000495756|ensembl:ENSP00000318868	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:glyc_human(display_long)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:SHMT1(gene name)|psi-mi:SHMT1(display_short)|uniprotkb:Serine methylase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	May et al. (2019)	imex:IM-28811|pubmed:30613765	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26876475|imex:IM-28811-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	refseq:NP_001268715.1|refseq:NP_004160.3|refseq:NP_683718.1|refseq:XP_016880446.1|refseq:XP_016880447.1|refseq:XP_011522294.1|refseq:XP_005256824.1|ensembl:ENSG00000176974(gene)|ensembl:ENSG00000284320(gene)|ensembl:ENST00000316694(transcript)|ensembl:ENST00000640392(transcript)|ensembl:ENST00000644141(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070905"(serine binding)|go:"GO:1904482"(cellular response to tetrahydrofolate)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|rcsb pdb:1BJ4|rcsb pdb:6FL5|rcsb pdb:6M5W|reactome:R-HSA-196757|reactome:R-HSA-71262	go:"GO:0051320"(S phase)|go:"GO:0005829"(cytosol)|go:"GO:0005635"(nuclear envelope)	-	-	figure legend:suppl. fig 3a-b,d|comment:"confocal IF microscopy analysis confirmed colocalization of IDH3α and cSHMT in the cytosol (fig. S3A) and at the nuclear envelope in S phase–arrested cells (fig. S3B)."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-astrocyte)|taxid:9606(Homo sapiens astrocyte)	-	2021/02/22	2021/03/15	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:OoGscelaCrK8ytz7Nyo7Msm8epE9606	rigid:79jmuh14PSfQ6sT3w82u+xUIscM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)