#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15762	uniprotkb:Q15762	intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947	intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947	psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym)	psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2019)	imex:IM-29356|pubmed:30591568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27124628|wwpdb:6isb|imex:IM-29356-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane)	refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane)	-	-	-	figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/11/12	2021/11/16	rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606	rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606	rigid:BVkgoDnpUNWgIXO0jVliiG/3028	false	sufficient binding region:19-250	sufficient binding region:19-250	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15151	uniprotkb:Q8K4F0	intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9	intact:EBI-27124659|ensembl:ENSMUSP00000043551|ensembl:ENSMUSP00000158324	psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym)	psi-mi:cd226_mouse(display_long)|uniprotkb:Cd226(gene name)|psi-mi:Cd226(display_short)|uniprotkb:Pta1(gene name synonym)|uniprotkb:Platelet and T-cell activation antigen 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2019)	imex:IM-29356|pubmed:30591568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27124647|wwpdb:6isc|imex:IM-29356-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597	refseq:NP_848802.2|refseq:XP_006526525.1|ensembl:ENSMUSG00000034028(gene)|ensembl:ENSMUST00000037142(transcript)|ensembl:ENSMUST00000236828(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISA|rcsb pdb:6ISC|reactome:R-MMU-198933	-	-	-	figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/16	rogid:PsTFmeD+9vG6ieNef6MupXts60g9606	rogid:Sw4QFg3z0FxGBLdXcqJTLJ2a7P010090	rigid:2noT27SBqKyXI8pNK/3Bt98LDqw	false	sufficient binding region:1-143|his tag:c-c	sufficient binding region:21-243	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15151	uniprotkb:Q8K4F0	intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9	intact:EBI-27124659|ensembl:ENSMUSP00000043551|ensembl:ENSMUSP00000158324	psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym)	psi-mi:cd226_mouse(display_long)|uniprotkb:Cd226(gene name)|psi-mi:Cd226(display_short)|uniprotkb:Pta1(gene name synonym)|uniprotkb:Platelet and T-cell activation antigen 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2019)	imex:IM-29356|pubmed:30591568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27124718|imex:IM-29356-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597	refseq:NP_848802.2|refseq:XP_006526525.1|ensembl:ENSMUSG00000034028(gene)|ensembl:ENSMUST00000037142(transcript)|ensembl:ENSMUST00000236828(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISA|rcsb pdb:6ISC|reactome:R-MMU-198933	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/16	rogid:PsTFmeD+9vG6ieNef6MupXts60g9606	rogid:Sw4QFg3z0FxGBLdXcqJTLJ2a7P010090	rigid:2noT27SBqKyXI8pNK/3Bt98LDqw	false	sufficient binding region:1-143|his tag:c-c	sufficient binding region:21-243	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15762	uniprotkb:P15151	intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947	intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9	psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym)	psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2019)	imex:IM-29356|pubmed:30591568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27124728|imex:IM-29356-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane)	go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/16	rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606	rogid:PsTFmeD+9vG6ieNef6MupXts60g9606	rigid:lHpaVMYVq+DrIgYv/0zBKn4xsdY	false	sufficient binding region:19-250	sufficient binding region:1-143|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15151	uniprotkb:Q15762	intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9	intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947	psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym)	psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Wang et al. (2019)	imex:IM-29356|pubmed:30591568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27124808|imex:IM-29356-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597	refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane)	-	-	-	figure legend:3 C/E, 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.4x10^-6(molar)	2021/11/12	2021/11/17	rogid:PsTFmeD+9vG6ieNef6MupXts60g9606	rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606	rigid:lHpaVMYVq+DrIgYv/0zBKn4xsdY	false	sufficient binding region:1-143|his tag:c-c|mutation disrupting interaction strength:63-63,128-128	sufficient binding region:19-250	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15151	uniprotkb:Q8K4F0	intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9	intact:EBI-27124659|ensembl:ENSMUSP00000043551|ensembl:ENSMUSP00000158324	psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym)	psi-mi:cd226_mouse(display_long)|uniprotkb:Cd226(gene name)|psi-mi:Cd226(display_short)|uniprotkb:Pta1(gene name synonym)|uniprotkb:Platelet and T-cell activation antigen 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Wang et al. (2019)	imex:IM-29356|pubmed:30591568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27124819|imex:IM-29356-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597	refseq:NP_848802.2|refseq:XP_006526525.1|ensembl:ENSMUSG00000034028(gene)|ensembl:ENSMUST00000037142(transcript)|ensembl:ENSMUST00000236828(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISA|rcsb pdb:6ISC|reactome:R-MMU-198933	-	-	-	figure legend:3 D/F, 5A, Supp. figure 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.4x10^-6(molar)	2021/11/12	2021/11/17	rogid:PsTFmeD+9vG6ieNef6MupXts60g9606	rogid:Sw4QFg3z0FxGBLdXcqJTLJ2a7P010090	rigid:2noT27SBqKyXI8pNK/3Bt98LDqw	false	sufficient binding region:1-143|his tag:c-c|mutation disrupting interaction strength:63-63,128-128	sufficient binding region:21-243|mutation disrupting interaction strength:114-114,47-47,49-49,68-68|mutation decreasing interaction strength:68-68|mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:114-114	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)