#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99PW9	uniprotkb:G3V6K6	intact:EBI-349407	intact:EBI-27088566|ensembl:ENSRNOP00000006087	psi-mi:q99pw9_rat(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)|uniprotkb:rHIP1R(gene name synonym)	psi-mi:g3v6k6_rat(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:rCG_23316(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yang et al. (2017)	pubmed:30574069|imex:IM-29227	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27088564|imex:IM-29227-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621615|refseq:NP_001128235.1|refseq:NP_112513.1|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR002558(I/LWEQ)|go:"GO:0003779"(actin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030425"(dendrite)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR011417(ANTH)|interpro:IPR035964	rgd:2543|ensembl:ENSRNOG00000004332(gene)|ensembl:ENSRNOT00000006087(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033993"(response to lipid)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-RNO-1227986|reactome:R-RNO-1236394|reactome:R-RNO-1250196|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-1963642|reactome:R-RNO-212718|reactome:R-RNO-2179392|reactome:R-RNO-445144|reactome:R-RNO-5673001|reactome:R-RNO-6785631|reactome:R-RNO-6811558|reactome:R-RNO-8847993|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8857538|reactome:R-RNO-8863795|reactome:R-RNO-9009391|reactome:R-RNO-9013507	-	-	-	figure legend:fig. 7a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2021/09/09	2021/09/20	rogid:M5cpwfwf5+Meqyo/EToAG6jpf7810116	rogid:k4Ur6/KTZax5PY+TNWfA3L0JhhI10116	rigid:pP3KcLRS55FmIAXgQP5WB91u254	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:G3V6K6	uniprotkb:Q9JKY5	intact:EBI-27088566|ensembl:ENSRNOP00000006087	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	psi-mi:g3v6k6_rat(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:rCG_23316(orf name)	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2017)	pubmed:30574069|imex:IM-29227	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27088754|imex:IM-29227-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2543|ensembl:ENSRNOG00000004332(gene)|ensembl:ENSRNOT00000006087(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033993"(response to lipid)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-RNO-1227986|reactome:R-RNO-1236394|reactome:R-RNO-1250196|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-1963642|reactome:R-RNO-212718|reactome:R-RNO-2179392|reactome:R-RNO-445144|reactome:R-RNO-5673001|reactome:R-RNO-6785631|reactome:R-RNO-6811558|reactome:R-RNO-8847993|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8857538|reactome:R-RNO-8863795|reactome:R-RNO-9009391|reactome:R-RNO-9013507	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)	-	-	-	figure legend:fig. 7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2021/09/09	2021/09/20	rogid:k4Ur6/KTZax5PY+TNWfA3L0JhhI10116	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	rigid:/04k6oKwafNyiEOk4khAp56MKeM	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JKY5	uniprotkb:Q01279	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	intact:EBI-6296235|ensembl:ENSMUSP00000020329	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:egfr_mouse(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yang et al. (2017)	pubmed:30574069|imex:IM-29227	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27088765|imex:IM-29227-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)	ensembl:ENSMUSG00000020122(gene)|ensembl:ENSMUST00000020329(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:Q01279|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-1963642|reactome:R-MMU-212718|reactome:R-MMU-2179392|reactome:R-MMU-445144|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8857538|reactome:R-MMU-8863795|reactome:R-MMU-9009391|reactome:R-MMU-9013507|dip:DIP-5763N|refseq:NP_997538.1	-	-	-	figure legend:fig. 7c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hippocampus)|taxid:10090(Mouse hippocampal neurons)	-	2021/09/09	2021/09/20	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	rogid:QpcGsHh+dM/fiIe1L/tEfxQTKGY10090	rigid:TDVHrBIMKiyxjmQ+UIrtkmsy+gw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JKY5	uniprotkb:G3V6K6	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	intact:EBI-27088566|ensembl:ENSRNOP00000006087	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:g3v6k6_rat(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:rCG_23316(orf name)	psi-mi:"MI:0096"(pull down)	Yang et al. (2017)	pubmed:30574069|imex:IM-29227	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27088798|imex:IM-29227-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)	rgd:2543|ensembl:ENSRNOG00000004332(gene)|ensembl:ENSRNOT00000006087(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033993"(response to lipid)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-RNO-1227986|reactome:R-RNO-1236394|reactome:R-RNO-1250196|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-1963642|reactome:R-RNO-212718|reactome:R-RNO-2179392|reactome:R-RNO-445144|reactome:R-RNO-5673001|reactome:R-RNO-6785631|reactome:R-RNO-6811558|reactome:R-RNO-8847993|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8857538|reactome:R-RNO-8863795|reactome:R-RNO-9009391|reactome:R-RNO-9013507	-	-	-	figure legend:fig. 7d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/09	2021/10/20	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	rogid:k4Ur6/KTZax5PY+TNWfA3L0JhhI10116	rigid:/04k6oKwafNyiEOk4khAp56MKeM	false	glutathione s tranferase tag:?-?|sufficient binding region:633-822	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)