#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N7U6	uniprotkb:Q96D31	intact:EBI-25602059|ensembl:ENSP00000295824|uniprotkb:A6ND25|uniprotkb:A8MPR3|uniprotkb:Q6ZWK9|uniprotkb:Q8IV58|uniprotkb:Q96LQ6	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:efhb_human(display_long)|uniprotkb:EFHB(gene name)|psi-mi:EFHB(display_short)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033543|imex:IM-29086-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163576(gene)|ensembl:ENST00000295824(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040193|refseq:NP_001317617.1|refseq:NP_653316.3	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	-	-	-	figure legend:Fig.2A|agonist:"Thapsigargin  (CHEBI:9516)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/07/14	2021/07/14	rogid:FaekLlgcYmzbBcVucx6SV+RgYMI9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rigid:Knl5hYnOoHObhlnWU0Jm/r3H4y4	false	v5 tag:?-?|sufficient binding region:165-833	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7U6	uniprotkb:Q13586	intact:EBI-25602059|ensembl:ENSP00000295824|uniprotkb:A6ND25|uniprotkb:A8MPR3|uniprotkb:Q6ZWK9|uniprotkb:Q8IV58|uniprotkb:Q96LQ6	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:efhb_human(display_long)|uniprotkb:EFHB(gene name)|psi-mi:EFHB(display_short)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033552|imex:IM-29086-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163576(gene)|ensembl:ENST00000295824(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040193|refseq:NP_001317617.1|refseq:NP_653316.3	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:Fig.2A|agonist:"Thapsigargin  (CHEBI:9516)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/07/14	2021/07/14	rogid:FaekLlgcYmzbBcVucx6SV+RgYMI9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rigid:yX6FxlvaNyfitQ5l44wG365OSjM	false	v5 tag:?-?|sufficient binding region:165-833	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96D31	uniprotkb:Q13586	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033561|imex:IM-29086-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:Fig.3A, 4B|agonist:"Thapsigargin  (CHEBI:9516)"|comment:Effect of Thapsigargin was overcome by depletion of EFHB|comment:"The interaction was  increased in cells expressing EFHB (residues 165-833)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/07/14	2021/07/14	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rigid:vcTi++PINtFYRSz2u8Diz54La3s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96D31	uniprotkb:Q13586	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033578|imex:IM-29086-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:Fig.3B|agonist:"Thapsigargin  (CHEBI:9516)"|comment:"Effect of Thapsigargin was overcome by depletion of EFHB and increased in cells expressing EFHB (residues 165-833)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2021/07/14	2021/07/14	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rigid:vcTi++PINtFYRSz2u8Diz54La3s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7U6	uniprotkb:Q96D31	intact:EBI-25602059|ensembl:ENSP00000295824|uniprotkb:A6ND25|uniprotkb:A8MPR3|uniprotkb:Q6ZWK9|uniprotkb:Q8IV58|uniprotkb:Q96LQ6	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:efhb_human(display_long)|uniprotkb:EFHB(gene name)|psi-mi:EFHB(display_short)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033584|imex:IM-29086-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163576(gene)|ensembl:ENST00000295824(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040193|refseq:NP_001317617.1|refseq:NP_653316.3	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	-	-	-	figure legend:Fig.6C|agonist:"Thapsigargin  (CHEBI:9516)"|comment:dimethyl BAPTA impaired the TG-evoked increase in the EFHB-Orai1 association.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2021/07/14	2021/07/14	rogid:FaekLlgcYmzbBcVucx6SV+RgYMI9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rigid:Knl5hYnOoHObhlnWU0Jm/r3H4y4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13586	uniprotkb:Q96BY9	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	intact:EBI-722561|uniprotkb:Q53HE8|uniprotkb:Q9UNZ3|uniprotkb:Q9Y683|uniprotkb:D3DSU7|uniprotkb:B3KQQ4|uniprotkb:B7Z9J1|uniprotkb:H9MHJ8|uniprotkb:H9MHJ9|ensembl:ENSP00000256255	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:saraf_human(display_long)|uniprotkb:SARAF(gene name)|psi-mi:SARAF(display_short)|uniprotkb:HBV X-transactivated gene 3 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 3(gene name synonym)|uniprotkb:Protein FOAP-7(gene name synonym)|uniprotkb:TMEM66(gene name synonym)|uniprotkb:Transmembrane protein 66(gene name synonym)|uniprotkb:XTP3(gene name synonym)|uniprotkb:HSPC035(orf name)|uniprotkb:NPD003(orf name)|uniprotkb:PSEC0019(orf name)|uniprotkb:UNQ1967/PRO4499(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033591|imex:IM-29086-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	refseq:NP_001271168.1|refseq:NP_057211.4|ensembl:ENSG00000133872(gene)|ensembl:ENST00000256255(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR009567(Protein of unknown function DUF1183)|rcsb pdb:6O2U|rcsb pdb:6O2V|rcsb pdb:6O2W	-	-	-	figure legend:Fig.6B|comment:"Treatment of the cells with Thapsigargin  (CHEBI:9516) resulted in a significant initial decrease in SARAF-STIM1 interaction. Pretreatment of the cells with dimethy-BAPTA (CHEBI:60889)  impaired the recovery of the SARAF-STIM1 interaction after 30 minutes."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2021/07/14	2021/07/14	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rogid:qxgObw0slMLCKeF+2YAHTxjlkQk9606	rigid:eaUwqk9etr9gXvklmra4iMoK570	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13586	uniprotkb:Q8N7U6	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	intact:EBI-25602059|ensembl:ENSP00000295824|uniprotkb:A6ND25|uniprotkb:A8MPR3|uniprotkb:Q6ZWK9|uniprotkb:Q8IV58|uniprotkb:Q96LQ6	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:efhb_human(display_long)|uniprotkb:EFHB(gene name)|psi-mi:EFHB(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033591|imex:IM-29086-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	ensembl:ENSG00000163576(gene)|ensembl:ENST00000295824(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040193|refseq:NP_001317617.1|refseq:NP_653316.3	-	-	-	figure legend:Fig.6B|comment:"Treatment of the cells with Thapsigargin  (CHEBI:9516) resulted in a significant initial decrease in SARAF-STIM1 interaction. Pretreatment of the cells with dimethy-BAPTA (CHEBI:60889)  impaired the recovery of the SARAF-STIM1 interaction after 30 minutes."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2021/07/14	2021/07/14	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rogid:FaekLlgcYmzbBcVucx6SV+RgYMI9606	rigid:eaUwqk9etr9gXvklmra4iMoK570	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96BY9	uniprotkb:Q13586	intact:EBI-722561|uniprotkb:Q53HE8|uniprotkb:Q9UNZ3|uniprotkb:Q9Y683|uniprotkb:D3DSU7|uniprotkb:B3KQQ4|uniprotkb:B7Z9J1|uniprotkb:H9MHJ8|uniprotkb:H9MHJ9|ensembl:ENSP00000256255	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:saraf_human(display_long)|uniprotkb:SARAF(gene name)|psi-mi:SARAF(display_short)|uniprotkb:HBV X-transactivated gene 3 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 3(gene name synonym)|uniprotkb:Protein FOAP-7(gene name synonym)|uniprotkb:TMEM66(gene name synonym)|uniprotkb:Transmembrane protein 66(gene name synonym)|uniprotkb:XTP3(gene name synonym)|uniprotkb:HSPC035(orf name)|uniprotkb:NPD003(orf name)|uniprotkb:PSEC0019(orf name)|uniprotkb:UNQ1967/PRO4499(orf name)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27033672|imex:IM-29086-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001271168.1|refseq:NP_057211.4|ensembl:ENSG00000133872(gene)|ensembl:ENST00000256255(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR009567(Protein of unknown function DUF1183)|rcsb pdb:6O2U|rcsb pdb:6O2V|rcsb pdb:6O2W	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:Fig.7A|comment:The inhibitory effect of Thapsigargin on this interaction was lost in EFHB depleted cells|antagonist:"Thapsigargin (CHEBI:9516)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2021/07/14	2021/07/14	rogid:qxgObw0slMLCKeF+2YAHTxjlkQk9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rigid:CSVt+o/SjlIyuQsXhNmMUrrA6As	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7U6	uniprotkb:Q13586	intact:EBI-25602059|ensembl:ENSP00000295824|uniprotkb:A6ND25|uniprotkb:A8MPR3|uniprotkb:Q6ZWK9|uniprotkb:Q8IV58|uniprotkb:Q96LQ6	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:efhb_human(display_long)|uniprotkb:EFHB(gene name)|psi-mi:EFHB(display_short)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albarran et al. (2017)	pubmed:30481768|imex:IM-29086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27038902|imex:IM-29086-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163576(gene)|ensembl:ENST00000295824(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040193|refseq:NP_001317617.1|refseq:NP_653316.3	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:Fig.6D|comment:Overexpression of SARAF significantly attenuated the TG-induced EFHB-STIM1 interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2021/07/14	2021/07/20	rogid:FaekLlgcYmzbBcVucx6SV+RgYMI9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rigid:yX6FxlvaNyfitQ5l44wG365OSjM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)