#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P00846 uniprotkb:Q96LL9 intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym) psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27023768|imex:IM-29041-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 - - comment:mint figure legend:Fig. 2G|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/26 2021/06/26 rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rigid:UbMW7i3XkTEZicZXquelK7d7kVw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9HD23 uniprotkb:Q96LL9 intact:EBI-6164303|ensembl:ENSP00000367637|uniprotkb:B4DQL2|uniprotkb:A8K4U3|uniprotkb:B3KNN2|uniprotkb:Q5T3Y1|uniprotkb:Q6NTG4|uniprotkb:Q96KF8|uniprotkb:Q9BVP1 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 psi-mi:mrs2_human(display_long)|uniprotkb:MRS2(gene name)|psi-mi:MRS2(display_short)|uniprotkb:HPT(gene name synonym)|uniprotkb:MRS2-like protein(gene name synonym)|uniprotkb:MRS2L(gene name synonym) psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27023772|imex:IM-29041-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000124532(gene)|ensembl:ENST00000378386(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045016"(mitochondrial magnesium ion transmembrane transport)|go:"GO:0055085"(transmembrane transport)|interpro:IPR039204|reactome:R-HSA-5223345|refseq:NP_001273193.1|refseq:NP_001273194.1|refseq:NP_001273195.1|refseq:NP_065713.1 ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 - - comment:mint figure legend:Fig. 2G|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/26 2021/06/26 rogid:qvKwgSW3lcwro4mQsW0ex2yN6IM9606 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rigid:keJu2U4p6gD92VM90xPyJBQy1B4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96LL9 uniprotkb:P27824 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3 psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27023776|imex:IM-29041-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N - comment:mint - figure legend:Fig. 2G|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/26 2021/06/26 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606 rigid:U+7426SRZDRDt2CYpvbQL2dRNXs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96LL9 uniprotkb:Q06055 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 intact:EBI-3912136|uniprotkb:B3KQQ6|ensembl:ENSP00000340315|ensembl:ENSP00000377878|ensembl:ENSP00000447317|ensembl:ENSP00000448801 psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:at5g2_human(display_long)|uniprotkb:ATP5MC2(gene name)|psi-mi:ATP5MC2(display_short)|uniprotkb:ATP synthase lipid-binding protein(gene name synonym)|uniprotkb:ATP synthase membrane subunit c locus 2(gene name synonym)|uniprotkb:ATP synthase proteolipid P2(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit C2"(gene name synonym)|uniprotkb:ATP5G2(gene name synonym)|uniprotkb:ATPase protein 9(gene name synonym)|uniprotkb:ATPase subunit c(gene name synonym)|uniprotkb:PSEC0033(orf name) psi-mi:"MI:0018"(two hybrid) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27023780|imex:IM-29041-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 refseq:NP_001002031.1|refseq:NP_005167.2|ensembl:ENSG00000135390(gene)|ensembl:ENST00000338662(transcript)|ensembl:ENST00000394349(transcript)|ensembl:ENST00000552242(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|interpro:IPR000454(ATPase, F0 complex, subunit C)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR020537|interpro:IPR035921|interpro:IPR038662|mint:Q06055|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENST00000549164(transcript)|refseq:NP_001317198.1|refseq:XP_016874949.1|refseq:XP_016874950.1 - comment:mint - figure legend:Fig. 2G|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/26 2021/06/26 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rogid:4ZhP9IXjOV0f7aZYk2/ReIVZsDk9606 rigid:++V07rndbObhNnqL0pA/jDrNaYc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y3A6 uniprotkb:Q96LL9 intact:EBI-7560959|intact:MINT-3085589|uniprotkb:B2R703|uniprotkb:D3DT38|uniprotkb:Q96AX8|uniprotkb:B1AKT4|ensembl:ENSP00000359305 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 psi-mi:tmed5_human(display_long)|uniprotkb:TMED5(gene name)|psi-mi:TMED5(display_short)|uniprotkb:p24 family protein gamma-2(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:CGI-100(orf name)|uniprotkb:UNQ397/PRO733(orf name) psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27023784|imex:IM-29041-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161302.1|refseq:NP_057124.3|ensembl:ENSG00000117500(gene)|ensembl:ENST00000370282(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR009038(GOLD)|interpro:IPR015717(ST2 receptor binding protein related)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|mint:Q9Y3A6|reactome:R-HSA-3238698 ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 - comment:mint|comment:homomint comment:mint figure legend:Fig. 2G|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/26 2021/06/26 rogid:3XAcqSucHNP4F3ilaBFRMSQ1B8Q9606 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rigid:TZ0sA25WMvgMOr8bq5Aopk8KRJA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) rhea:"RHEA:57720" uniprotkb:Q96LL9 intact:EBI-25825251|intenz:7.1.2.2 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 psi-mi:mito_f1f0_atp_synthase_human(display_short)|psi-mi:"RHEA:57720"(display_long)|intact:Mitochondrial respiratory chain complex V(complex synonym)|intact:Mitochondrial proton-transporting ATP synthase complex(complex recommended name)|intact:"3xATP5F1A:3xATP5F1B:ATP5F1C:ATP5F1D:ATP5F1E:ATP5F1EP2:ATP5MC1:ATP5MC2:ATP5MC3:ATP5MD:ATP5ME:ATP5MF:ATP5MG:ATP5MGL:ATP5MPL:ATP5PB:ATP5PD:ATP5PF:ATP5PO:MT-ATP6:MT-ATP8:"(complex systematic name)|intact:F1-F0 ATP synthase complex(synonym)|intact:F1-Fo ATP synthase complex(synonym) psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27023797|imex:IM-29041-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1302"(stable complex) psi-mi:"MI:0326"(protein) efo:"Orphanet:254913"(see-also)|efo:"Orphanet:320360"(see-also)|efo:"Orphanet:480"(see-also)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0005743"(mitochondrial inner membrane)|evidence ontology:"ECO:0005547"|pubmed:25938092(see-also)|pubmed:26297831(see-also)|complex portal:CPX-6151(complex-primary)|efo:"Orphanet:644"(see-also)|efo:"Orphanet:104"(see-also)|efo:"Orphanet:255210"(see-also)|efo:"Orphanet:225154"(see-also)|efo:"Orphanet:397750"(see-also) ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 go:"GO:0005739"(mitochondrion) complex-properties:"Multimeric enzyme complex with an overall molecular weight of about 600,000 Da, consisting of an extra-membranous F1 catalytic domain linked by a central stalk to an intrinsic Fo membrane domain. ATP5F1A and ATP5F1B subunits (the stator) are arranged alternately around a coiled coil of two anti-parallel alpha helices in the ATP5F1C subunit. The catalytic sites are in the ATP5F1B subunits at the ATP5F1A/B subunit interface. The proton pore of the ATP synthase consists of a ring of membrane-integrated c subunits (ATP5F1G1/2/3), which rotates, driven by downhill proton diffusion across the membrane. An essential carboxylate side chain in each subunit provides a proton-binding site. The entire central rotor shaft, made of the c-ring and ATP5F1C/D/E subunits, rotates and induces cyclic conformational changes in the ATP5F1A/B-heterohexamer necessary for the synthesis of ATP. To prevent dragged rotation, the peripheral stator stalk, consisting of ATP5PO/OSCP, /ATP5PFF6,ATP5PB/b- and ATP5PD/d-subunits, connects the stator casing in F1 and that in Fo (a-subunit)."|curated-complex:"Acts to convert the energy of oxidation-reduction reactions of the electron transport chain (respiration) to the phosphorylation of ADP. The synthesis of ATP is coupled to the respiratory chain via the proton potential. The ATP synthase is a molecular motor composed of two separable parts: F1 and Fo. The F1 portion contains the catalytic sites for ATP synthesis and protrudes into the mitochondrial matrix. Fo forms a proton turbine that is embedded in the inner membrane and connected to the rotor of F1. The flux of protons flowing down a potential gradient powers the rotation of the rotor driving the synthesis of ATP. Thus, the flow of protons though Fo is coupled to the synthesis of ATP."|rapid curation: comment:mint figure legend:Fig. 2K|comment:To further confirm the interaction between DNAJC30 and ATP synthase, we isolated mitochondria from human STC and immunoprecipitated the intact ATP synthase.|comment:"We captured proteins of both F0 and F1 subunits as well as DNAJC30 (Figure 2K) and were able to confirm another interacting protein from the Y2H screen, the magnesium transporter MRS2."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex) - 2021/06/26 2021/06/26 - rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) rhea:"RHEA:57720" uniprotkb:Q9HD23 intact:EBI-25825251|intenz:7.1.2.2 intact:EBI-6164303|ensembl:ENSP00000367637|uniprotkb:B4DQL2|uniprotkb:A8K4U3|uniprotkb:B3KNN2|uniprotkb:Q5T3Y1|uniprotkb:Q6NTG4|uniprotkb:Q96KF8|uniprotkb:Q9BVP1 psi-mi:mito_f1f0_atp_synthase_human(display_short)|psi-mi:"RHEA:57720"(display_long)|intact:Mitochondrial respiratory chain complex V(complex synonym)|intact:Mitochondrial proton-transporting ATP synthase complex(complex recommended name)|intact:"3xATP5F1A:3xATP5F1B:ATP5F1C:ATP5F1D:ATP5F1E:ATP5F1EP2:ATP5MC1:ATP5MC2:ATP5MC3:ATP5MD:ATP5ME:ATP5MF:ATP5MG:ATP5MGL:ATP5MPL:ATP5PB:ATP5PD:ATP5PF:ATP5PO:MT-ATP6:MT-ATP8:"(complex systematic name)|intact:F1-F0 ATP synthase complex(synonym)|intact:F1-Fo ATP synthase complex(synonym) psi-mi:mrs2_human(display_long)|uniprotkb:MRS2(gene name)|psi-mi:MRS2(display_short)|uniprotkb:HPT(gene name synonym)|uniprotkb:MRS2-like protein(gene name synonym)|uniprotkb:MRS2L(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27023797|imex:IM-29041-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1302"(stable complex) psi-mi:"MI:0326"(protein) efo:"Orphanet:254913"(see-also)|efo:"Orphanet:320360"(see-also)|efo:"Orphanet:480"(see-also)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0005743"(mitochondrial inner membrane)|evidence ontology:"ECO:0005547"|pubmed:25938092(see-also)|pubmed:26297831(see-also)|complex portal:CPX-6151(complex-primary)|efo:"Orphanet:644"(see-also)|efo:"Orphanet:104"(see-also)|efo:"Orphanet:255210"(see-also)|efo:"Orphanet:225154"(see-also)|efo:"Orphanet:397750"(see-also) ensembl:ENSG00000124532(gene)|ensembl:ENST00000378386(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045016"(mitochondrial magnesium ion transmembrane transport)|go:"GO:0055085"(transmembrane transport)|interpro:IPR039204|reactome:R-HSA-5223345|refseq:NP_001273193.1|refseq:NP_001273194.1|refseq:NP_001273195.1|refseq:NP_065713.1 go:"GO:0005739"(mitochondrion) complex-properties:"Multimeric enzyme complex with an overall molecular weight of about 600,000 Da, consisting of an extra-membranous F1 catalytic domain linked by a central stalk to an intrinsic Fo membrane domain. ATP5F1A and ATP5F1B subunits (the stator) are arranged alternately around a coiled coil of two anti-parallel alpha helices in the ATP5F1C subunit. The catalytic sites are in the ATP5F1B subunits at the ATP5F1A/B subunit interface. The proton pore of the ATP synthase consists of a ring of membrane-integrated c subunits (ATP5F1G1/2/3), which rotates, driven by downhill proton diffusion across the membrane. An essential carboxylate side chain in each subunit provides a proton-binding site. The entire central rotor shaft, made of the c-ring and ATP5F1C/D/E subunits, rotates and induces cyclic conformational changes in the ATP5F1A/B-heterohexamer necessary for the synthesis of ATP. To prevent dragged rotation, the peripheral stator stalk, consisting of ATP5PO/OSCP, /ATP5PFF6,ATP5PB/b- and ATP5PD/d-subunits, connects the stator casing in F1 and that in Fo (a-subunit)."|curated-complex:"Acts to convert the energy of oxidation-reduction reactions of the electron transport chain (respiration) to the phosphorylation of ADP. The synthesis of ATP is coupled to the respiratory chain via the proton potential. The ATP synthase is a molecular motor composed of two separable parts: F1 and Fo. The F1 portion contains the catalytic sites for ATP synthesis and protrudes into the mitochondrial matrix. Fo forms a proton turbine that is embedded in the inner membrane and connected to the rotor of F1. The flux of protons flowing down a potential gradient powers the rotation of the rotor driving the synthesis of ATP. Thus, the flow of protons though Fo is coupled to the synthesis of ATP."|rapid curation: - figure legend:Fig. 2K|comment:To further confirm the interaction between DNAJC30 and ATP synthase, we isolated mitochondria from human STC and immunoprecipitated the intact ATP synthase.|comment:"We captured proteins of both F0 and F1 subunits as well as DNAJC30 (Figure 2K) and were able to confirm another interacting protein from the Y2H screen, the magnesium transporter MRS2."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex) - 2021/06/26 2021/06/26 - rogid:qvKwgSW3lcwro4mQsW0ex2yN6IM9606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00846 uniprotkb:Q96LL9 intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym) psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27023813|imex:IM-29041-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 - - comment:mint figure legend:Fig. 2L|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/06/26 2021/06/26 rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rigid:o95r3Uyl/hkJmn9RQXiRhLAk/ec false ha tag:c-c|flag tag:c-c|tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00846 uniprotkb:Q06055 intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632 intact:EBI-3912136|uniprotkb:B3KQQ6|ensembl:ENSP00000340315|ensembl:ENSP00000377878|ensembl:ENSP00000447317|ensembl:ENSP00000448801 psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym) psi-mi:at5g2_human(display_long)|uniprotkb:ATP5MC2(gene name)|psi-mi:ATP5MC2(display_short)|uniprotkb:ATP synthase lipid-binding protein(gene name synonym)|uniprotkb:ATP synthase membrane subunit c locus 2(gene name synonym)|uniprotkb:ATP synthase proteolipid P2(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit C2"(gene name synonym)|uniprotkb:ATP5G2(gene name synonym)|uniprotkb:ATPase protein 9(gene name synonym)|uniprotkb:ATPase subunit c(gene name synonym)|uniprotkb:PSEC0033(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27023813|imex:IM-29041-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001002031.1|refseq:NP_005167.2|ensembl:ENSG00000135390(gene)|ensembl:ENST00000338662(transcript)|ensembl:ENST00000394349(transcript)|ensembl:ENST00000552242(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|interpro:IPR000454(ATPase, F0 complex, subunit C)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR020537|interpro:IPR035921|interpro:IPR038662|mint:Q06055|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENST00000549164(transcript)|refseq:NP_001317198.1|refseq:XP_016874949.1|refseq:XP_016874950.1 - - - figure legend:Fig. 2L|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/06/26 2021/06/26 rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606 rogid:4ZhP9IXjOV0f7aZYk2/ReIVZsDk9606 rigid:o95r3Uyl/hkJmn9RQXiRhLAk/ec false ha tag:c-c|flag tag:c-c|tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00846 uniprotkb:P25705 intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-27023834|imex:IM-29041-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 2J|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ren)|taxid:9606(human mesothelioma cell line) - 2021/06/26 2021/06/26 rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 rigid:qknEYcBTirGvCnoOf9klyR6WLZk false ha tag:c-c|flag tag:c-c|tag:n-n - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P00846 uniprotkb:Q96LL9 intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632 intact:EBI-8639143|ensembl:ENSP00000378605|uniprotkb:Q9BSG8|intact:MINT-8162893 psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym) psi-mi:djc30_human(display_long)|uniprotkb:DNAJC30(gene name)|psi-mi:DNAJC30(display_short)|uniprotkb:WBSCR18(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 18 protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Tebbenkamp et al. (2018) pubmed:30318146|imex:IM-29041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-27023834|imex:IM-29041-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000176410(gene)|ensembl:ENST00000395176(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:1905706"(regulation of mitochondrial ATP synthesis coupled proton transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|rcsb pdb:2YUA|refseq:NP_115693.2 go:"GO:0005739"(mitochondrion) - comment:mint figure legend:Fig. 2J|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ren)|taxid:9606(human mesothelioma cell line) - 2021/06/26 2021/06/26 rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606 rogid:jHySdLN0GaYJTi3C2VNpRraWdfk9606 rigid:qknEYcBTirGvCnoOf9klyR6WLZk false ha tag:c-c|flag tag:c-c|tag:n-n green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence)