#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8C419	uniprotkb:Q9BQ16	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-8643358|ensembl:ENSP00000349677|ensembl:ENSP00000423421|ensembl:ENSP00000423606|ensembl:ENSP00000420920|intact:MINT-4830490|uniprotkb:Q6UW53|uniprotkb:E7EP61|intact:MINT-8163345|uniprotkb:O75705|uniprotkb:B4DHB4|uniprotkb:B4DHV3|uniprotkb:B3KR67|uniprotkb:B2R7M7|uniprotkb:B4DGK5|uniprotkb:F5H099|uniprotkb:Q96Q26|uniprotkb:B4DI46|uniprotkb:B4DJY3	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:ticn3_human(display_long)|uniprotkb:SPOCK3(gene name)|psi-mi:SPOCK3(display_short)|uniprotkb:TICN3(gene name synonym)|uniprotkb:UNQ409/PRO771(orf name)|uniprotkb:SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	ensembl:ENSG00000196104(gene)|ensembl:ENST00000357154(transcript)|ensembl:ENST00000502330(transcript)|ensembl:ENST00000506886(transcript)|ensembl:ENST00000511531(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0031012"(extracellular matrix)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR011992(EF-Hand type)|interpro:IPR019577|interpro:IPR036058|interpro:IPR036857|reactome:R-HSA-1592389|refseq:XP_011530320.1|refseq:NP_001191285.1|refseq:NP_001191281.1|refseq:NP_058646.2|refseq:NP_001191287.1|refseq:NP_001191282.1|refseq:NP_001191283.1|refseq:NP_001191284.1|refseq:NP_001035249.1|refseq:NP_001238896.1|refseq:XP_016863747.1	-	-	function:"May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion"	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:+AHZ78/Bp4Hll4bnGWg8INucnCM9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:P35052	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2	-	-	function:Cell surface proteoglycan that bears heparan sulfate|comment:mint	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:Q63HQ2	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-21327031|uniprotkb:A8K6D7|uniprotkb:Q5U643|uniprotkb:Q6P3V1|uniprotkb:Q8N124|uniprotkb:Q8N197|uniprotkb:Q8N7Y0|uniprotkb:Q8N8N5|uniprotkb:Q8NAL2|ensembl:ENSP00000346964	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:egfla_human(display_long)|uniprotkb:Agrin-like protein(gene name synonym)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:EGFLAM(gene name)|psi-mi:EGFLAM(display_short)|uniprotkb:AGRINL(gene name synonym)|uniprotkb:AGRNL(gene name synonym)|uniprotkb:PIKA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_001192230.1|refseq:NP_689616.2|refseq:NP_877950.1|refseq:NP_877953.1|ensembl:ENSG00000164318(gene)|ensembl:ENST00000354891(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:JLUJ4gpL9QzZgoh+9vAGps9Bg+Y9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:O14786	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-1187100|uniprotkb:O60461|uniprotkb:Q96IH5|uniprotkb:Q5T7F2|uniprotkb:Q5T7F3|uniprotkb:B0LPG9|uniprotkb:Q86T59|uniprotkb:Q5T7F1|uniprotkb:Q96I90|ensembl:ENSP00000265371|ensembl:ENSP00000364001	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:nrp1_human(display_long)|uniprotkb:Vascular endothelial cell growth factor 165 receptor(gene name synonym)|uniprotkb:NRP1(gene name)|psi-mi:NRP1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:VEGF165R(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_001019800.1|refseq:NP_001019799.1|refseq:NP_003864.4|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:O14786|rcsb pdb:1KEX|rcsb pdb:2QQI|rcsb pdb:2QQM|rcsb pdb:2QQN|rcsb pdb:3I97|rcsb pdb:4DEQ|rcsb pdb:4RN5|rcsb pdb:5C7G|rcsb pdb:5IJR|rcsb pdb:5IYY|rcsb pdb:5J1X|rcsb pdb:5JGI|rcsb pdb:5JGQ|rcsb pdb:5JHK|rcsb pdb:5L73|rcsb pdb:6FMC|rcsb pdb:6FMF|rcsb pdb:6TKK|rcsb pdb:7JJC|reactome:R-HSA-194306|reactome:R-HSA-376176|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-445144|reactome:R-HSA-447041|refseq:NP_001316997.1|ensembl:ENSG00000099250(gene)|ensembl:ENST00000265371(transcript)|ensembl:ENST00000374867(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060301"(positive regulation of cytokine activity)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|dip:DIP-5743N	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:q8i8R/AetWNGkscqBWAJPHhmF+E9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:P98160	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-947664|uniprotkb:Q16287|uniprotkb:Q9H3V5|uniprotkb:Q5SZI3|ensembl:ENSP00000363827	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:pgbm_human(display_long)|uniprotkb:Perlecan(gene name synonym)|uniprotkb:HSPG2(gene name)|psi-mi:HSPG2(display_short)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_001278789.1|refseq:NP_005520.4|ensembl:ENSG00000142798(gene)|ensembl:ENST00000374695(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030154"(cell differentiation)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072359"(circulatory system development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR000034(Laminin B)|interpro:IPR000082(SEA)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR023415|interpro:IPR036055|interpro:IPR036179|mint:P98160|rcsb pdb:3SH4|rcsb pdb:3SH5|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:5ctWru2Fde+1Twjd9B7u24hsIKY9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:O00468	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:Q9Y625	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-3046690|ensembl:ENSP00000366246|uniprotkb:Q9H1P4|uniprotkb:A8K279|uniprotkb:Q96SG8|uniprotkb:Q96SG5	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:gpc6_human(display_long)|uniprotkb:GPC6(gene name)|psi-mi:GPC6(display_short)|uniprotkb:UNQ369/PRO705(orf name)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	ensembl:ENST00000377047(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031183|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|ensembl:ENSG00000183098(gene)|refseq:NP_005699.1	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:j/F2dtbmfhijHXT5t7FR3CpIyfo9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:P51654	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-5654198|uniprotkb:C9JLE3|uniprotkb:Q2L880|uniprotkb:G3V1R0|uniprotkb:Q2L882|ensembl:ENSP00000359854	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:gpc3_human(display_long)|uniprotkb:GTR2-2(gene name synonym)|uniprotkb:Intestinal protein OCI-5(gene name synonym)|uniprotkb:MXR7(gene name synonym)|uniprotkb:OCI5(gene name synonym)|uniprotkb:GPC3(gene name)|psi-mi:GPC3(display_short)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_001158091.1|dip:DIP-61509N|refseq:NP_004475.1|refseq:NP_001158089.1|ensembl:ENSG00000147257(gene)|ensembl:ENST00000370818(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009617"(response to bacterium)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010171"(body morphogenesis)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0016477"(cell migration)|go:"GO:0030282"(bone mineralization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060422"(peptidyl-dipeptidase inhibitor activity)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072111"(cell proliferation involved in kidney development)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072180"(mesonephric duct morphogenesis)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001863(Glypican)|interpro:IPR015501(Glypican 3)|interpro:IPR019803|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|reactome:R-HSA-975634	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:+H2PtA0Y61S+2l56UPxwxBpCosc9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:Q08629	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-2682560|uniprotkb:Q8N630|uniprotkb:Q9UCL8|uniprotkb:Q59EW0|uniprotkb:B3KSW3|ensembl:ENSP00000378401	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:ticn1_human(display_long)|uniprotkb:SPOCK(gene name synonym)|uniprotkb:TIC1(gene name synonym)|uniprotkb:TICN1(gene name synonym)|uniprotkb:Protein SPOCK(gene name synonym)|uniprotkb:SPOCK1(gene name)|psi-mi:SPOCK1(display_short)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_004589.1|ensembl:ENSG00000152377(gene)|ensembl:ENST00000394945(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001764"(neuron migration)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016528"(sarcoplasm)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033268"(node of Ranvier)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR011992(EF-Hand type)|interpro:IPR019577|interpro:IPR036058|interpro:IPR036857	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:6O1NutpCGMNokrA0U4/2x+c8Ydo9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:O75487	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-3050469|uniprotkb:B4E2C0|ensembl:ENSP00000359864|uniprotkb:B2R6J7|uniprotkb:Q9UPD9|uniprotkb:Q96L43|uniprotkb:Q9NU08|uniprotkb:Q6ZMA6|uniprotkb:Q9UJN1	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:gpc4_human(display_long)|uniprotkb:GPC4(gene name)|psi-mi:GPC4(display_short)|uniprotkb:K-glypican(gene name synonym)|uniprotkb:UNQ474/PRO937(orf name)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	ensembl:ENSG00000076716(gene)|ensembl:ENST00000370828(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|mint:O75487|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031180|go:"GO:0016055"(Wnt signaling pathway)|refseq:NP_001439.2	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:6IC3ItqIRoNTmnS+hi/U34DlXN09606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:P31431	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8C419	uniprotkb:Q8N158	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	intact:EBI-27085752|ensembl:ENSP00000292377|uniprotkb:A4D2A7	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:gpc2_human(display_long)|uniprotkb:GPC2(gene name)|psi-mi:GPC2(display_short)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085750|imex:IM-29228-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|reactome:R-HSA-2022928|ensembl:ENSG00000213420(gene)|ensembl:ENST00000292377(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0030182"(neuron differentiation)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1905475"(regulation of protein localization to membrane)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031181|rcsb pdb:6WJL|reactome:R-HSA-1971475|refseq:NP_689955.1	-	-	-	figure legend:Figs. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/24	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rogid:LrMLRrMm4YJu1gUQXDeswK7zzN09606	rigid:7CGQXs7T4VGWhfk2/cQVr4l5dM4	false	fc-igg tag:?-?|sufficient binding region:1-380	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P35052	uniprotkb:Q8C419	intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085808|imex:IM-29228-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	function:Cell surface proteoglycan that bears heparan sulfate|comment:mint	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:bA1E3bN10ITSeknZtednQGi55sM	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P78333	uniprotkb:Q8C419	intact:EBI-2558325|uniprotkb:Q9BX27|uniprotkb:B2R726|uniprotkb:O60436|ensembl:ENSP00000366267	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:gpc5_human(display_long)|uniprotkb:GPC5(gene name)|psi-mi:GPC5(display_short)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085824|imex:IM-29228-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004457.1|ensembl:ENSG00000179399(gene)|ensembl:ENST00000377067(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031188|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-5362798|reactome:R-HSA-975634	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:Gcy9S91rADjM2ixSpPD0nLDlKz89606	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:bZhrWWsCyt7XdU3M3KnFI3UoY7Y	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P78333	uniprotkb:Q6PRD1	intact:EBI-2558325|uniprotkb:Q9BX27|uniprotkb:B2R726|uniprotkb:O60436|ensembl:ENSP00000366267	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:gpc5_human(display_long)|uniprotkb:GPC5(gene name)|psi-mi:GPC5(display_short)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085836|imex:IM-29228-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004457.1|ensembl:ENSG00000179399(gene)|ensembl:ENST00000377067(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031188|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-5362798|reactome:R-HSA-975634	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:Gcy9S91rADjM2ixSpPD0nLDlKz89606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:ZeluHNEmGciJEIgHGWtEbUM/kyk	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31431	uniprotkb:Q8C419	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085844|imex:IM-29228-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:7zRp6BXOr8fyn2UMutDgwLuPqdU	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35052	uniprotkb:Q6PRD1	intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085852|imex:IM-29228-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	function:Cell surface proteoglycan that bears heparan sulfate|comment:mint	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:tXdH2P19a0K/MQH9ZVggAA20rqA	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31431	uniprotkb:Q6PRD1	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085860|imex:IM-29228-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:XsJimpOIHQtbh8Oa1/8EZQXKyB8	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63HQ2	uniprotkb:Q6PRD1	intact:EBI-21327031|uniprotkb:A8K6D7|uniprotkb:Q5U643|uniprotkb:Q6P3V1|uniprotkb:Q8N124|uniprotkb:Q8N197|uniprotkb:Q8N7Y0|uniprotkb:Q8N8N5|uniprotkb:Q8NAL2|ensembl:ENSP00000346964	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:egfla_human(display_long)|uniprotkb:Agrin-like protein(gene name synonym)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:EGFLAM(gene name)|psi-mi:EGFLAM(display_short)|uniprotkb:AGRINL(gene name synonym)|uniprotkb:AGRNL(gene name synonym)|uniprotkb:PIKA(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085910|imex:IM-29228-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192230.1|refseq:NP_689616.2|refseq:NP_877950.1|refseq:NP_877953.1|ensembl:ENSG00000164318(gene)|ensembl:ENST00000354891(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/10	rogid:JLUJ4gpL9QzZgoh+9vAGps9Bg+Y9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:nPVVZKKPK/J6u5Nbp5nMXTAxosg	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63HQ2	uniprotkb:Q6PRD1	intact:EBI-21327031|uniprotkb:A8K6D7|uniprotkb:Q5U643|uniprotkb:Q6P3V1|uniprotkb:Q8N124|uniprotkb:Q8N197|uniprotkb:Q8N7Y0|uniprotkb:Q8N8N5|uniprotkb:Q8NAL2|ensembl:ENSP00000346964	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:egfla_human(display_long)|uniprotkb:Agrin-like protein(gene name synonym)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:EGFLAM(gene name)|psi-mi:EGFLAM(display_short)|uniprotkb:AGRINL(gene name synonym)|uniprotkb:AGRNL(gene name synonym)|uniprotkb:PIKA(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085918|imex:IM-29228-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192230.1|refseq:NP_689616.2|refseq:NP_877950.1|refseq:NP_877953.1|ensembl:ENSG00000164318(gene)|ensembl:ENST00000354891(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:JLUJ4gpL9QzZgoh+9vAGps9Bg+Y9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:nPVVZKKPK/J6u5Nbp5nMXTAxosg	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35052	uniprotkb:Q8C419	intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088897|imex:IM-29228-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	function:Cell surface proteoglycan that bears heparan sulfate|comment:mint	-	figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:bA1E3bN10ITSeknZtednQGi55sM	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P78333	uniprotkb:Q8C419	intact:EBI-2558325|uniprotkb:Q9BX27|uniprotkb:B2R726|uniprotkb:O60436|ensembl:ENSP00000366267	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:gpc5_human(display_long)|uniprotkb:GPC5(gene name)|psi-mi:GPC5(display_short)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088905|imex:IM-29228-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004457.1|ensembl:ENSG00000179399(gene)|ensembl:ENST00000377067(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031188|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-5362798|reactome:R-HSA-975634	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:Gcy9S91rADjM2ixSpPD0nLDlKz89606	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:bZhrWWsCyt7XdU3M3KnFI3UoY7Y	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31431	uniprotkb:Q8C419	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088913|imex:IM-29228-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:7zRp6BXOr8fyn2UMutDgwLuPqdU	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35052	uniprotkb:Q6PRD1	intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088921|imex:IM-29228-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	function:Cell surface proteoglycan that bears heparan sulfate|comment:mint	-	figure legend:Supp. Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:tXdH2P19a0K/MQH9ZVggAA20rqA	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P78333	uniprotkb:Q6PRD1	intact:EBI-2558325|uniprotkb:Q9BX27|uniprotkb:B2R726|uniprotkb:O60436|ensembl:ENSP00000366267	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:gpc5_human(display_long)|uniprotkb:GPC5(gene name)|psi-mi:GPC5(display_short)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088929|imex:IM-29228-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004457.1|ensembl:ENSG00000179399(gene)|ensembl:ENST00000377067(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031188|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-5362798|reactome:R-HSA-975634	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Supp. Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:Gcy9S91rADjM2ixSpPD0nLDlKz89606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:ZeluHNEmGciJEIgHGWtEbUM/kyk	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31431	uniprotkb:Q6PRD1	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088937|imex:IM-29228-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Supp. Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/09/10	2021/09/20	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:XsJimpOIHQtbh8Oa1/8EZQXKyB8	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:28304"	uniprotkb:Q8C419	intact:EBI-1379423	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085878|imex:IM-29228-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	comment:Membrane-enriched brain extract is assumed to be mouse based on previous work by the same authors.|comment:The interaction is insensitive to either addition of excess Ca2+/Mg2+ or their chelation by EDTA|figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/10	2021/09/24	-	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:28304"	uniprotkb:E9PY61	intact:EBI-1379423	intact:EBI-27085890|ensembl:ENSMUSP00000091474	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:e9py61_mouse(display_long)|uniprotkb:Gpr179(gene name)|psi-mi:Gpr179(display_short)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27085884|imex:IM-29228-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000070337(gene)|ensembl:ENSMUST00000093942(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044292"(dendrite terminus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|refseq:NP_001074689.1|refseq:XP_006533087.1	-	-	-	comment:The interaction is insensitive to either addition of excess Ca2+/Mg2+ or their chelation by EDTA|figure legend:Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/10	2021/09/24	-	rogid:GnlW5ouxCAeZV01VpGmUMuYutYs10090	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4VBE4	uniprotkb:Q6PRD1	intact:EBI-2025048|uniprotkb:Q80WX4|uniprotkb:Q8BGP3|uniprotkb:B2RWU6|uniprotkb:B6JU28|ensembl:ENSMUSP00000094238	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:egfla_mouse(display_long)|uniprotkb:Egflam(gene name)|psi-mi:Egflam(display_short)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:Nectican(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27086565|imex:IM-29228-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276425.1|refseq:XP_017172117.1|refseq:NP_848863.1|ensembl:ENSMUSG00000042961(gene)|ensembl:ENSMUST00000096494(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/10	2021/09/27	rogid:4HMU4/rUDXwTUdVF4m176LXbpvg10090	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:9308kj2QDMJ72AJqN9O7gEnZk5w	false	mcherry fluorescent protein tag:c-c|sufficient binding region:766-1017	myc tag:c-c|enhanced green fluorescent protein tag:?-?|sufficient binding region:1-380	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4VBE4	uniprotkb:Q6PRD1	intact:EBI-2025048|uniprotkb:Q80WX4|uniprotkb:Q8BGP3|uniprotkb:B2RWU6|uniprotkb:B6JU28|ensembl:ENSMUSP00000094238	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:egfla_mouse(display_long)|uniprotkb:Egflam(gene name)|psi-mi:Egflam(display_short)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:Nectican(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088240|imex:IM-29228-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276425.1|refseq:XP_017172117.1|refseq:NP_848863.1|ensembl:ENSMUSG00000042961(gene)|ensembl:ENSMUST00000096494(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/10	2021/09/20	rogid:4HMU4/rUDXwTUdVF4m176LXbpvg10090	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:9308kj2QDMJ72AJqN9O7gEnZk5w	false	-	sufficient binding region:1-380|fc-igg tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63HQ2	uniprotkb:Q6PRD1	intact:EBI-21327031|uniprotkb:A8K6D7|uniprotkb:Q5U643|uniprotkb:Q6P3V1|uniprotkb:Q8N124|uniprotkb:Q8N197|uniprotkb:Q8N7Y0|uniprotkb:Q8N8N5|uniprotkb:Q8NAL2|ensembl:ENSP00000346964	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:egfla_human(display_long)|uniprotkb:Agrin-like protein(gene name synonym)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:EGFLAM(gene name)|psi-mi:EGFLAM(display_short)|uniprotkb:AGRINL(gene name synonym)|uniprotkb:AGRNL(gene name synonym)|uniprotkb:PIKA(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27086543|imex:IM-29228-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192230.1|refseq:NP_689616.2|refseq:NP_877950.1|refseq:NP_877953.1|ensembl:ENSG00000164318(gene)|ensembl:ENST00000354891(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	go:"GO:0031012"(extracellular matrix)	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/10	2021/09/24	rogid:JLUJ4gpL9QzZgoh+9vAGps9Bg+Y9606	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:nPVVZKKPK/J6u5Nbp5nMXTAxosg	false	ha tag:c-c	sufficient binding region:1-380|fc-igg tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q4VBE4	uniprotkb:E9PY61	intact:EBI-2025048|uniprotkb:Q80WX4|uniprotkb:Q8BGP3|uniprotkb:B2RWU6|uniprotkb:B6JU28|ensembl:ENSMUSP00000094238	intact:EBI-27085890|ensembl:ENSMUSP00000091474	psi-mi:egfla_mouse(display_long)|uniprotkb:Egflam(gene name)|psi-mi:Egflam(display_short)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:Nectican(gene name synonym)	psi-mi:e9py61_mouse(display_long)|uniprotkb:Gpr179(gene name)|psi-mi:Gpr179(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088255|imex:IM-29228-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276425.1|refseq:XP_017172117.1|refseq:NP_848863.1|ensembl:ENSMUSG00000042961(gene)|ensembl:ENSMUST00000096494(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSMUSG00000070337(gene)|ensembl:ENSMUST00000093942(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044292"(dendrite terminus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|refseq:NP_001074689.1|refseq:XP_006533087.1	go:"GO:0045202"(synapse)	-	-	figure legend:Fig. 3C, 3E, Supp. Fig. 2C|comment:The GPR179-Pikachurin interaction at the photoreceptor synapses was severely disrupted in Dmdmdx−4Cv retinas.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2021/09/10	2021/09/20	rogid:4HMU4/rUDXwTUdVF4m176LXbpvg10090	rogid:GnlW5ouxCAeZV01VpGmUMuYutYs10090	rigid:vnbgTcYS3lviTVDAnbdKk0AXHKI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:E9PY61	uniprotkb:Q4VBE4	intact:EBI-27085890|ensembl:ENSMUSP00000091474	intact:EBI-2025048|uniprotkb:Q80WX4|uniprotkb:Q8BGP3|uniprotkb:B2RWU6|uniprotkb:B6JU28|ensembl:ENSMUSP00000094238	psi-mi:e9py61_mouse(display_long)|uniprotkb:Gpr179(gene name)|psi-mi:Gpr179(display_short)	psi-mi:egfla_mouse(display_long)|uniprotkb:Egflam(gene name)|psi-mi:Egflam(display_short)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:Nectican(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088277|imex:IM-29228-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000070337(gene)|ensembl:ENSMUST00000093942(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044292"(dendrite terminus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|refseq:NP_001074689.1|refseq:XP_006533087.1	refseq:NP_001276425.1|refseq:XP_017172117.1|refseq:NP_848863.1|ensembl:ENSMUSG00000042961(gene)|ensembl:ENSMUST00000096494(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	go:"GO:0045202"(synapse)	-	-	figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2021/09/10	2021/09/20	rogid:GnlW5ouxCAeZV01VpGmUMuYutYs10090	rogid:4HMU4/rUDXwTUdVF4m176LXbpvg10090	rigid:dxwbvXqm5w5M1dO2VknO9F9Izy8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:E9PY61	uniprotkb:Q6PRD1	intact:EBI-27085890|ensembl:ENSMUSP00000091474	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:e9py61_mouse(display_long)|uniprotkb:Gpr179(gene name)|psi-mi:Gpr179(display_short)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088277|imex:IM-29228-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000070337(gene)|ensembl:ENSMUST00000093942(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044292"(dendrite terminus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|refseq:NP_001074689.1|refseq:XP_006533087.1	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	go:"GO:0045202"(synapse)	-	-	figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2021/09/10	2021/09/20	rogid:GnlW5ouxCAeZV01VpGmUMuYutYs10090	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:dxwbvXqm5w5M1dO2VknO9F9Izy8	false	-	sufficient binding region:1-380|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q4VBE4	uniprotkb:E9PY61	intact:EBI-2025048|uniprotkb:Q80WX4|uniprotkb:Q8BGP3|uniprotkb:B2RWU6|uniprotkb:B6JU28|ensembl:ENSMUSP00000094238	intact:EBI-27085890|ensembl:ENSMUSP00000091474	psi-mi:egfla_mouse(display_long)|uniprotkb:Egflam(gene name)|psi-mi:Egflam(display_short)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:Nectican(gene name synonym)	psi-mi:e9py61_mouse(display_long)|uniprotkb:Gpr179(gene name)|psi-mi:Gpr179(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088318|imex:IM-29228-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276425.1|refseq:XP_017172117.1|refseq:NP_848863.1|ensembl:ENSMUSG00000042961(gene)|ensembl:ENSMUST00000096494(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSMUSG00000070337(gene)|ensembl:ENSMUST00000093942(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044292"(dendrite terminus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|refseq:NP_001074689.1|refseq:XP_006533087.1	go:"GO:0045202"(synapse)	-	-	figure legend:Fig. 3B, 3H, 3I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2021/09/10	2021/09/20	rogid:4HMU4/rUDXwTUdVF4m176LXbpvg10090	rogid:GnlW5ouxCAeZV01VpGmUMuYutYs10090	rigid:vnbgTcYS3lviTVDAnbdKk0AXHKI	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q8C8T7	uniprotkb:Q5NCH9	intact:EBI-27088853|ensembl:ENSMUSP00000053869	intact:EBI-27092209|ensembl:ENSMUSP00000000631|ensembl:ENSMUSP00000130728	psi-mi:elfn1_mouse(display_long)|uniprotkb:Elfn1(gene name)|psi-mi:Elfn1(display_short)|uniprotkb:Ppp1r28(gene name synonym)|uniprotkb:Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 28(gene name synonym)	psi-mi:grm6_mouse(display_long)|uniprotkb:Grm6(gene name)|psi-mi:Grm6(display_short)|uniprotkb:Gprc1f(gene name synonym)|uniprotkb:Mglur6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088879|imex:IM-29228-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000048988(gene)|ensembl:ENSMUST00000050519(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050808"(synapse organization)|go:"GO:0060076"(excitatory synapse)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_780731.1|refseq:XP_006504764.1|refseq:XP_006504765.1|refseq:XP_006504766.1|refseq:XP_006504767.1|refseq:XP_017176371.1	ensembl:ENSMUSG00000000617(gene)|ensembl:ENSMUST00000000631(transcript)|ensembl:ENSMUST00000171427(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0035841"(new growing cell tip)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090280"(positive regulation of calcium ion import)|interpro:IPR000112(GPCR, family 3, metabotropic glutamate receptor 6)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-MMU-418594|reactome:R-MMU-420499|go:"GO:0030425"(dendrite)|refseq:NP_775548.2|refseq:XP_006532024.1	-	-	-	comment:Interaction observed in Egflam  -/- mice|figure legend:Fig. 5K|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2021/09/10	2021/09/27	rogid:JAmLfyoJrRzjA9w/IrzljBMDclU10090	rogid:wRtk/Vf0hBdVW1XVZN6qc80iQRE10090	rigid:NCDva0aU80LzSiyGMdOTh9drZuo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8C8T7	uniprotkb:Q5NCH9	intact:EBI-27088853|ensembl:ENSMUSP00000053869	intact:EBI-27092209|ensembl:ENSMUSP00000000631|ensembl:ENSMUSP00000130728	psi-mi:elfn1_mouse(display_long)|uniprotkb:Elfn1(gene name)|psi-mi:Elfn1(display_short)|uniprotkb:Ppp1r28(gene name synonym)|uniprotkb:Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 28(gene name synonym)	psi-mi:grm6_mouse(display_long)|uniprotkb:Grm6(gene name)|psi-mi:Grm6(display_short)|uniprotkb:Gprc1f(gene name synonym)|uniprotkb:Mglur6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27088890|imex:IM-29228-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000048988(gene)|ensembl:ENSMUST00000050519(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050808"(synapse organization)|go:"GO:0060076"(excitatory synapse)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_780731.1|refseq:XP_006504764.1|refseq:XP_006504765.1|refseq:XP_006504766.1|refseq:XP_006504767.1|refseq:XP_017176371.1	ensembl:ENSMUSG00000000617(gene)|ensembl:ENSMUST00000000631(transcript)|ensembl:ENSMUST00000171427(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0035841"(new growing cell tip)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090280"(positive regulation of calcium ion import)|interpro:IPR000112(GPCR, family 3, metabotropic glutamate receptor 6)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-MMU-418594|reactome:R-MMU-420499|go:"GO:0030425"(dendrite)|refseq:NP_775548.2|refseq:XP_006532024.1	go:"GO:0045202"(synapse)	-	-	comment:Interaction observed in Egflam  -/- mice and WT.|figure legend:Fig. 5I, 5J|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2021/09/10	2021/09/27	rogid:JAmLfyoJrRzjA9w/IrzljBMDclU10090	rogid:wRtk/Vf0hBdVW1XVZN6qc80iQRE10090	rigid:NCDva0aU80LzSiyGMdOTh9drZuo	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q4VBE4	uniprotkb:Q6PRD1	intact:EBI-2025048|uniprotkb:Q80WX4|uniprotkb:Q8BGP3|uniprotkb:B2RWU6|uniprotkb:B6JU28|ensembl:ENSMUSP00000094238	intact:EBI-20895185|ensembl:ENSP00000484951	psi-mi:egfla_mouse(display_long)|uniprotkb:Egflam(gene name)|psi-mi:Egflam(display_short)|uniprotkb:EGF-like, fibronectin type-III and laminin G-like domain-containing protein(gene name synonym)|uniprotkb:Nectican(gene name synonym)	psi-mi:gp179_human(display_long)|uniprotkb:Probable G-protein coupled receptor 158-like 1(gene name synonym)|uniprotkb:GPR179(gene name)|psi-mi:GPR179(display_short)|uniprotkb:GPR158L(gene name synonym)|uniprotkb:GPR158L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Orlandi et al. (2018)	pubmed:30282023|imex:IM-29228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27086556|imex:IM-29228-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276425.1|refseq:XP_017172117.1|refseq:NP_848863.1|ensembl:ENSMUSG00000042961(gene)|ensembl:ENSMUST00000096494(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042995"(cell projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048786"(presynaptic active zone)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116	ensembl:ENSP00000484951|ensembl:ENSG00000276469(gene)|ensembl:ENST00000610650(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|interpro:IPR017978|interpro:IPR032964|interpro:IPR043458|mint:Q6PRD1|refseq:NP_001004334.3	-	-	-	figure legend:Fig. 2D|comment:Treatment with heparinase III had no effect on the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/09/10	2021/09/24	rogid:4HMU4/rUDXwTUdVF4m176LXbpvg10090	rogid:G+ereWBWFI9EVs5KWBE1FTXsWrs9606	rigid:9308kj2QDMJ72AJqN9O7gEnZk5w	false	mcherry fluorescent protein tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)