#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z2E2	uniprotkb:O88508	intact:EBI-7541947|uniprotkb:Q3U101|uniprotkb:Q792D6|intact:MINT-1342412|uniprotkb:Q6NSW0|uniprotkb:Q8CCL9|uniprotkb:Q9DC19|uniprotkb:Q3TMA4	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:mbd1_mouse(display_long)|uniprotkb:Mbd1(gene name)|psi-mi:Mbd1(display_short)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mo et al. (2018)	imex:IM-28765|pubmed:30266739	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687119|imex:IM-28765-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|mint:Q9Z2E2|interpro:IPR016177(DNA-binding, integrase-type)|refseq:NP_038622.2|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|reactome:R-MMU-3899300	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	go:"GO:0005634"(nucleus)	comment:mint|function:"Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters"	-	figure legend:f9a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dorsal root ga)|taxid:10090(Mus musculus)	-	2021/02/24	2021/02/24	rogid:CONEJVaJPFhN4ugPthhUXcCsw/k10090	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:gg+ANDU8gp21dYiPTMNFdSaxEbc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)