#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687348|imex:IM-28771-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F1B F2F|comment:The  interaction  between  DNMT3A2  and  GST-TRD  is  resistant  to  high  salt washes.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/02/25	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	his tag:n-n|sufficient binding region:220-908	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687399|imex:IM-28771-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F2E|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/02/25	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	his tag:n-n|sufficient binding region:104-486	glutathione s tranferase tag:n-n|sufficient binding region:472-610	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687310|imex:IM-28771-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F1C|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/24	2021/02/25	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	yellow fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z2D6	uniprotkb:O88508	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687366|imex:IM-28771-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F1D|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/24	2021/02/25	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:/0wqB1RtWN1hi94c9qiPD13ytxA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687470|imex:IM-28771-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:SF11|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/02/25	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	maltose binding protein tag:?-?|sufficient binding region:472-610	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0071"(molecular sieving)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687491|imex:IM-28771-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:SF12|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/02/25	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	maltose binding protein tag:?-?|sufficient binding region:472-610	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687386|imex:IM-28771-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F2G SF14|comment:"Pull-down experiments in the presence of the non-specific and highly active nuclease from S. marcescens demonstrated that the interaction of both proteins was not mediated by nucleic acids (SupplementaryFigure S14)."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/02/25	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325|mutation with no effect:306-306	maltose binding protein tag:?-?|sufficient binding region:472-610	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51608-1	uniprotkb:P68431	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-79722|ensembl:ENSP00000352252|ensembl:ENSP00000358160|ensembl:ENSP00000366999|ensembl:ENSP00000480826|ensembl:ENSP00000482271|ensembl:ENSP00000483283|ensembl:ENSP00000484095|ensembl:ENSP00000484638|ensembl:ENSP00000484658|ensembl:ENSP00000484841|ensembl:ENSP00000489282|intact:EBI-1560041|uniprotkb:A0PJT7|uniprotkb:P02295|uniprotkb:P02296|uniprotkb:P16106|uniprotkb:Q6ISV8|uniprotkb:Q6NWP8|uniprotkb:Q6NWP9|uniprotkb:Q6NXU4|uniprotkb:Q71DJ3|uniprotkb:Q93081|uniprotkb:A5PLR1	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:h31_human(display_long)|uniprotkb:H3FA(gene name synonym)|uniprotkb:H3FL(gene name synonym)|uniprotkb:H3FD(gene name synonym)|uniprotkb:H3FI(gene name synonym)|uniprotkb:H3FH(gene name synonym)|uniprotkb:H3FK(gene name synonym)|uniprotkb:H3FF(gene name synonym)|uniprotkb:H3FJ(gene name synonym)|uniprotkb:H3FB(gene name synonym)|uniprotkb:Histone H3/a(gene name synonym)|uniprotkb:Histone H3/b(gene name synonym)|uniprotkb:Histone H3/c(gene name synonym)|uniprotkb:Histone H3/d(gene name synonym)|uniprotkb:Histone H3/f(gene name synonym)|uniprotkb:Histone H3/h(gene name synonym)|uniprotkb:Histone H3/i(gene name synonym)|uniprotkb:Histone H3/j(gene name synonym)|uniprotkb:Histone H3/k(gene name synonym)|uniprotkb:Histone H3/l(gene name synonym)|uniprotkb:H3C1(gene name)|psi-mi:H3C1(display_short)|uniprotkb:HIST1H3A(gene name synonym)|uniprotkb:H3C2(gene name)|psi-mi:H3C2(display_short)|uniprotkb:HIST1H3B(gene name synonym)|uniprotkb:H3C3(gene name)|psi-mi:H3C3(display_short)|uniprotkb:H3FC HIST1H3C(gene name synonym)|uniprotkb:H3C4(gene name)|psi-mi:H3C4(display_short)|uniprotkb:HIST1H3D(gene name synonym)|uniprotkb:H3C6(gene name)|psi-mi:H3C6(display_short)|uniprotkb:HIST1H3E(gene name synonym)|uniprotkb:H3C7(gene name)|psi-mi:H3C7(display_short)|uniprotkb:HIST1H3F(gene name synonym)|uniprotkb:H3C8(gene name)|psi-mi:H3C8(display_short)|uniprotkb:HIST1H3G(gene name synonym)|uniprotkb:H3C10(gene name)|psi-mi:H3C10(display_short)|uniprotkb:HIST1H3H(gene name synonym)|uniprotkb:H3C11(gene name)|psi-mi:H3C11(display_short)|uniprotkb:HIST1H3I(gene name synonym)|uniprotkb:H3C12(gene name)|psi-mi:H3C12(display_short)|uniprotkb:HIST1H3J(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687535|imex:IM-28771-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	rcsb pdb:4TN7|rcsb pdb:4U68|rcsb pdb:4UP0|rcsb pdb:4UY4|rcsb pdb:4X3K|rcsb pdb:4Y6L|rcsb pdb:4YHP|rcsb pdb:4YHZ|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z0R|rcsb pdb:4Z2M|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:4QBS|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B31|rcsb pdb:5C11|rcsb pdb:5C13|rcsb pdb:5C3I|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5D6Y|rcsb pdb:5DAH|rcsb pdb:5FB0|rcsb pdb:5FB1|rcsb pdb:5FFV|rcsb pdb:5GH9|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5H6Q|rcsb pdb:5H6R|rcsb pdb:5HJB|rcsb pdb:5HJC|rcsb pdb:5HJD|rcsb pdb:5HYN|rcsb pdb:5IQL|rcsb pdb:5J3V|rcsb pdb:5J9S|rcsb pdb:5JHN|rcsb pdb:5JIN|rcsb pdb:5JIY|rcsb pdb:5JJ0|rcsb pdb:5B2J|rcsb pdb:5JRG|rcsb pdb:5KJH|rcsb pdb:5KJI|rcsb pdb:5KKL|rcsb pdb:5LUG|rcsb pdb:5M5G|rcsb pdb:5MR8|rcsb pdb:5NNC|rcsb pdb:5OY3|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:5SZB|rcsb pdb:5SZC|rcsb pdb:5T0K|rcsb pdb:5T0M|rcsb pdb:5T1G|rcsb pdb:5T1I|rcsb pdb:5T8R|rcsb pdb:5TBN|rcsb pdb:5TDR|rcsb pdb:5TDW|rcsb pdb:5U2J|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:5VA6|rcsb pdb:5VAB|rcsb pdb:5VGE|rcsb pdb:5VNB|rcsb pdb:5NND|rcsb pdb:5WLE|rcsb pdb:5WVO|rcsb pdb:5WXG|rcsb pdb:5WXH|rcsb pdb:5WYI|rcsb pdb:5X60|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5XFQ|rcsb pdb:5XFR|rcsb pdb:5XNV|rcsb pdb:5XTZ|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Y20|rcsb pdb:5Y2F|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:6AXJ|rcsb pdb:6AZE|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6D07|rcsb pdb:6D08|rcsb pdb:6E83|rcsb pdb:6E86|rcsb pdb:5WFC|rcsb pdb:6F6D|rcsb pdb:6HTS|rcsb pdb:6IEU|rcsb pdb:6IIS|rcsb pdb:6IIT|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6JXD|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6LS6|rcsb pdb:6LSD|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MIL|rcsb pdb:6MIM|rcsb pdb:6MIN|rcsb pdb:6MIO|rcsb pdb:6MIQ|rcsb pdb:6PA1|rcsb pdb:6PAG|rcsb pdb:6HKT|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2H|rcsb pdb:6V2K|rcsb pdb:6V3N|rcsb pdb:6V41|rcsb pdb:6V92|rcsb pdb:6VIL|rcsb pdb:6WAV|rcsb pdb:6WW4|rcsb pdb:6YIF|rcsb pdb:6YIH|rcsb pdb:6YOV|rcsb pdb:7BWD|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:6R92|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7DBP|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7KLR|rcsb pdb:7LYC|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|ensembl:ENSG00000197153(gene)|ensembl:ENSG00000197409(gene)|ensembl:ENSG00000273983(gene)|ensembl:ENSG00000274750(gene)|ensembl:ENSG00000275379(gene)|ensembl:ENSG00000275714(gene)|ensembl:ENSG00000277775(gene)|ensembl:ENSG00000278828(gene)|ensembl:ENSG00000286522(gene)|ensembl:ENSG00000287080(gene)|ensembl:ENST00000356476(transcript)|ensembl:ENST00000359303(transcript)|ensembl:ENST00000369163(transcript)|ensembl:ENST00000612966(transcript)|ensembl:ENST00000613854(transcript)|ensembl:ENST00000614378(transcript)|ensembl:ENST00000614911(transcript)|ensembl:ENST00000616365(transcript)|ensembl:ENST00000618052(transcript)|ensembl:ENST00000621411(transcript)|ensembl:ENST00000634733(transcript)|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-3247509|reactome:R-HSA-9710421|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P68431|rcsb pdb:1CS9|rcsb pdb:1CT6|rcsb pdb:1O9S|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|rcsb pdb:1Q3L|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|rcsb pdb:2B2T|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|rcsb pdb:2B2U|rcsb pdb:2B2V|rcsb pdb:2B2W|rcsb pdb:2C1J|rcsb pdb:2C1N|go:"GO:0016020"(membrane)|rcsb pdb:2CO0|rcsb pdb:2CV5|rcsb pdb:2FSA|rcsb pdb:2KWJ|rcsb pdb:2KWK|rcsb pdb:2L75|rcsb pdb:2LBM|rcsb pdb:2LGG|rcsb pdb:2M0O|reactome:R-HSA-983231|reactome:R-HSA-977225|rcsb pdb:2NDG|rcsb pdb:2OQ6|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2RI7|rcsb pdb:2RR4|rcsb pdb:2UXN|rcsb pdb:2V85|rcsb pdb:2V89|rcsb pdb:2VNF|rcsb pdb:2VPG|rcsb pdb:2X0L|rcsb pdb:3A1B|rcsb pdb:2NDF|rcsb pdb:3AFA|rcsb pdb:3AVR|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3B95|rcsb pdb:3FDT|rcsb pdb:3KMT|rcsb pdb:3KQI|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3MP1|rcsb pdb:3O34|rcsb pdb:3O35|rcsb pdb:3O37|rcsb pdb:3QJ6|rcsb pdb:3RIG|rcsb pdb:3RIY|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3U31|rcsb pdb:3U3D|rcsb pdb:3U4S|rcsb pdb:3U5N|rcsb pdb:3U5O|rcsb pdb:3AZK|rcsb pdb:3U5P|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UII|rcsb pdb:3UIK|rcsb pdb:3V43|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:3ZG6|rcsb pdb:3ZVY|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:4A7J|rcsb pdb:3UIG|rcsb pdb:4BD3|rcsb pdb:4C1Q|rcsb pdb:4F4U|rcsb pdb:4F56|rcsb pdb:4FWF|rcsb pdb:4HON|rcsb pdb:4I51|rcsb pdb:4L7X|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:4LXL|rcsb pdb:4N4H|rcsb pdb:4QBQ|rcsb pdb:4QBR|refseq:NP_003520.1|refseq:NP_003521.2|refseq:NP_003522.1|refseq:NP_003523.1|refseq:NP_003524.1|refseq:NP_003525.1|refseq:NP_003526.1|refseq:NP_003527.1|refseq:NP_003528.1|refseq:NP_066298.1|dip:DIP-29371N	-	-	-	figure legend:F6B|comment:addition of histone H3 abolished the ADD–TRD interaction, suggesting that H3 and TRD binding to the ADD domain is mutually exclusive.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/03/09	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ood0OohxZHuhsWZtO7U7GMc+LwM9606	rigid:GWHwEzP8DPFOOhiKrcjSxqQmwAo	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26687535|imex:IM-28771-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F6B|comment:addition of histone H3 abolished the ADD–TRD interaction, suggesting that H3 and TRD binding to the ADD domain is mutually exclusive.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/03/09	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:GWHwEzP8DPFOOhiKrcjSxqQmwAo	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	his tag:n-n|sufficient binding region:220-908	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26906478|imex:IM-28771-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F6B|comment:addition of histone H3 abolished the ADD–TRD interaction, suggesting that H3 and TRD binding to the ADD domain is mutually exclusive.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/04/09	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	his tag:n-n|sufficient binding region:220-908	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26906797|imex:IM-28771-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:SF13 SF16|comment:The  interaction  between  DNMT3A2  and  GST-TRD  is  resistant  to  high  salt washes.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/04/09	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:170-325	his tag:n-n|sufficient binding region:220-908|mutation with no effect:522-522|mutation with no effect:527-527	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51608-1	uniprotkb:O88508	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26906885|imex:IM-28771-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	-	-	-	figure legend:F2A|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/04/09	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	rigid:u/9xx4+xfTN/4GIlz/vOgU7+ekw	false	glutathione s tranferase tag:n-n|sufficient binding region:104-486	his tag:n-n|sufficient binding region:220-908	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51608-1	uniprotkb:Q9CWR8	intact:EBI-26687319|ensembl:ENSP00000301948	intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562	psi-mi:p51608-1(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)|uniprotkb:Beta(isoform synonym)	psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short)	psi-mi:"MI:0096"(pull down)	Rajavelu et al. (2018)	pubmed:30102379|imex:IM-28771	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26906898|imex:IM-28771-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|intact:EBI-1189067(isoform-parent)	refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N	-	-	-	figure legend:F2B|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/24	2021/04/09	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090	rigid:cwr2pr5lMYzk09HX4lejRHdkaw8	false	glutathione s tranferase tag:n-n|sufficient binding region:104-486	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)