#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:K7EJ46-3	uniprotkb:O43291	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1	-	-	comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:Q14534	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-3905171|uniprotkb:Q9UEK6|ensembl:ENSP00000265896|uniprotkb:Q9UNR6	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:erg1_human(display_long)|uniprotkb:SQLE(gene name)|psi-mi:SQLE(display_short)|uniprotkb:ERG1(gene name synonym)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_003120.2|ensembl:ENSG00000104549(gene)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071949"(FAD binding)|go:"GO:0140042"(lipid droplet formation)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125|mint:Q14534|rcsb pdb:6C6N|rcsb pdb:6C6P|rcsb pdb:6C6R|reactome:R-HSA-191273|reactome:R-HSA-2426168|ensembl:ENST00000265896(transcript)	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:jZnV6eRSD75A7YVspfL6SBq8XkA9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:P27824	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:Q9H3U1	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:P78527	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:P39656	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:P04843	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:P04844	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-719731|uniprotkb:Q5JYR6|uniprotkb:Q9UBE1|uniprotkb:Q6IBA5|uniprotkb:Q96E21|uniprotkb:Q9BUQ3|ensembl:ENSP00000237530	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:rpn2_human(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:RIBIIR(gene name synonym)|uniprotkb:RPN2(gene name)|psi-mi:RPN2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_001129243.1|refseq:NP_002942.2|ensembl:ENSG00000118705(gene)|ensembl:ENST00000237530(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:P04844|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|refseq:NP_001311234.1|refseq:NP_001311235.1|refseq:NP_001311228.1|refseq:NP_001311230.1|refseq:NP_001311231.1|refseq:NP_001311232.1|refseq:NP_001311233.1	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:7bTuuEb3ykWQvkI/5DKpga48s/w9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:P50416	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-2817330|uniprotkb:Q9BWK0|uniprotkb:Q8TCU0|ensembl:ENSP00000265641|ensembl:ENSP00000446108	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:cpt1a_human(display_long)|uniprotkb:CPT1A(gene name)|psi-mi:CPT1A(display_short)|uniprotkb:CPT1(gene name synonym)|uniprotkb:Carnitine O-palmitoyltransferase I, liver isoform(gene name synonym)|uniprotkb:Carnitine palmitoyltransferase 1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_001027017.1|refseq:NP_001867.2|refseq:XP_016872709.1|ensembl:ENSG00000110090(gene)|ensembl:ENST00000265641(transcript)|ensembl:ENST00000539743(transcript)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004095"(carnitine O-palmitoyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006853"(carnitine shuttle)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0097421"(liver regeneration)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990698"(palmitoleoyltransferase activity)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR032476|interpro:IPR039551|interpro:IPR042231|mint:P50416|rcsb pdb:2LE3|reactome:R-HSA-1368082|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-5362517	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:fmB4d9VHyWPyV0uTf00NkOr/fM49606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:Q9BSJ8	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-355956|ensembl:ENSP00000377612|uniprotkb:A0FGR7|uniprotkb:A8K2S2|uniprotkb:O94848|uniprotkb:Q6PJN4|uniprotkb:Q9H6J1|uniprotkb:Q9H6W2|uniprotkb:Q9Y416|intact:EBI-4399548	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:esyt1_human(display_long)|uniprotkb:KIAA0747(gene name synonym)|uniprotkb:MBC2(gene name synonym)|uniprotkb:ESYT1(gene name)|psi-mi:ESYT1(display_short)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:FAM62A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	interpro:IPR037752|interpro:IPR039010|mint:Q9BSJ8|reactome:R-HSA-1660662|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9035034|interpro:IPR037749|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037733|go:"GO:0005544"(calcium-dependent phospholipid binding)|ensembl:ENSG00000139641(gene)|ensembl:ENST00000394048(transcript)|go:"GO:0005509"(calcium ion binding)|refseq:NP_001171725.1|refseq:NP_056107.1|dip:DIP-57197N	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:MYbYK3357LLH0TP1qU7CsvJenGk9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:Q5K4L6	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-11733324|ensembl:ENSP00000485061|ensembl:ENSP00000485585|uniprotkb:Q5VUQ7|uniprotkb:Q5VUQ8|uniprotkb:Q5VUR3|uniprotkb:Q6ZV16|uniprotkb:Q8N2X7|uniprotkb:Q8TEJ0|uniprotkb:Q96SW5|uniprotkb:Q9BTJ5|uniprotkb:Q9BTY5	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:s27a3_human(display_long)|uniprotkb:SLC27A3(gene name)|psi-mi:SLC27A3(display_short)|uniprotkb:ACSVL3(gene name synonym)|uniprotkb:FATP3(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Very long-chain acyl-CoA synthetase homolog 3(gene name synonym)|uniprotkb:PSEC0067(orf name)|uniprotkb:UNQ367/PRO703(orf name)|uniprotkb:Long-chain fatty acid transport protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	ensembl:ENSG00000143554(gene)|ensembl:ENSG00000263163(gene)|ensembl:ENST00000623839(transcript)|ensembl:ENST00000624995(transcript)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015908"(fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031957"(very long-chain fatty acid-CoA ligase activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0047676"(arachidonate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR030307|interpro:IPR042099|reactome:R-HSA-75876|refseq:NP_001304858.2|refseq:NP_077306.2	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:l707ITB0BdR+f+VaYhtbXUBsFqs9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:Q12907	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-3915406|uniprotkb:Q53HH1|ensembl:ENSP00000303366	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:lman2_human(display_long)|uniprotkb:LMAN2(gene name)|psi-mi:LMAN2(display_short)|uniprotkb:C5orf8(gene name synonym)|uniprotkb:Glycoprotein GP36b(gene name synonym)|uniprotkb:Lectin mannose-binding 2(gene name synonym)|uniprotkb:Vesicular integral-membrane protein 36(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120449|imex:IM-29329-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_006807.1|ensembl:ENSG00000169223(gene)|ensembl:ENST00000303127(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035664|mint:Q12907|reactome:R-HSA-204005|reactome:R-HSA-5694530	-	-	-	figure legend:Fig. 7A,  Supp Table 5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:goqUZGW9/lvVMWDAZS9csH3TqWY9606	rigid:uC79/6y74bH/jGPZre4c/v6sRJ8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:K7EJ46-3	uniprotkb:Q14534	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-3905171|uniprotkb:Q9UEK6|ensembl:ENSP00000265896|uniprotkb:Q9UNR6	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:erg1_human(display_long)|uniprotkb:SQLE(gene name)|psi-mi:SQLE(display_short)|uniprotkb:ERG1(gene name synonym)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120527|imex:IM-29329-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_003120.2|ensembl:ENSG00000104549(gene)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071949"(FAD binding)|go:"GO:0140042"(lipid droplet formation)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125|mint:Q14534|rcsb pdb:6C6N|rcsb pdb:6C6P|rcsb pdb:6C6R|reactome:R-HSA-191273|reactome:R-HSA-2426168|ensembl:ENST00000265896(transcript)	-	-	-	figure legend:Fig. 7B, Supp Fig 7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:jZnV6eRSD75A7YVspfL6SBq8XkA9606	rigid:0bFZuuK7bh2VJMeplg5/uYUONfM	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:K7EJ46-3	uniprotkb:P39656	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120527|imex:IM-29329-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548	-	-	-	figure legend:Fig. 7B, Supp Fig 7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606	rigid:0bFZuuK7bh2VJMeplg5/uYUONfM	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:K7EJ46-3	uniprotkb:P27824	intact:EBI-27120454|ensembl:ENSP00000464737|ensembl:ENSP00000465660|ensembl:ENSP00000467010	intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3	psi-mi:k7ej46-3(display_long)|uniprotkb:Cancer-associated small integral membrane open reading frame 1(gene name synonym)|uniprotkb:SMIM22(gene name)|psi-mi:SMIM22(display_short)|uniprotkb:CASIMO1(gene name synonym)	psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Polycarpou-Schwarz et al. (2018)	pubmed:29765154|imex:IM-29329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27120527|imex:IM-29329-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-28929226(isoform-parent)|ensembl:ENSG00000267795(gene)|ensembl:ENST00000588606(transcript)|ensembl:ENST00000589721(transcript)|ensembl:ENST00000591870(transcript)	refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N	-	-	-	figure legend:Fig. 7B, Supp Fig 7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2021/11/03	2021/11/04	rogid:tm5J6Ft+koUbj4VbnX6H0ucfGsQ9606	rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606	rigid:0bFZuuK7bh2VJMeplg5/uYUONfM	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)