#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HB09	uniprotkb:Q07817-1	intact:EBI-3940897|uniprotkb:Q9HB08|uniprotkb:Q96I96|uniprotkb:Q3SY11|ensembl:ENSP00000246785|ensembl:ENSP00000482218|uniprotkb:Q3SY13	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:b2l12_human(display_long)|uniprotkb:BCL2L12(gene name)|psi-mi:BCL2L12(display_short)|uniprotkb:BPR(gene name synonym)|uniprotkb:Bcl-2-related proline-rich protein(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086218|imex:IM-29224-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269445.1|refseq:NP_001269446.1|refseq:NP_001269448.1|refseq:NP_001269449.1|refseq:NP_001269450.1|ensembl:ENST00000246785(transcript)|ensembl:ENST00000616144(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR036834|ensembl:ENSG00000126453(gene)|refseq:NP_001035758.1|refseq:NP_619580.1|refseq:XP_016882835.1	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:QQy4TzaEEwe/g1lS2GRsocVnvW09606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:C653hTvPCEMwoKLXzZqZvifFPWs	false	sufficient binding region:70-266|mutation disrupting interaction strength:213-213	sufficient binding region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HB09	uniprotkb:P10415	intact:EBI-3940897|uniprotkb:Q9HB08|uniprotkb:Q96I96|uniprotkb:Q3SY11|ensembl:ENSP00000246785|ensembl:ENSP00000482218|uniprotkb:Q3SY13	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:b2l12_human(display_long)|uniprotkb:BCL2L12(gene name)|psi-mi:BCL2L12(display_short)|uniprotkb:BPR(gene name synonym)|uniprotkb:Bcl-2-related proline-rich protein(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086233|imex:IM-29224-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269445.1|refseq:NP_001269446.1|refseq:NP_001269448.1|refseq:NP_001269449.1|refseq:NP_001269450.1|ensembl:ENST00000246785(transcript)|ensembl:ENST00000616144(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR036834|ensembl:ENSG00000126453(gene)|refseq:NP_001035758.1|refseq:NP_619580.1|refseq:XP_016882835.1	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:QQy4TzaEEwe/g1lS2GRsocVnvW09606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rigid:11+PSkVitB+75MEABRhUViK7KbA	false	sufficient binding region:70-266|mutation disrupting interaction strength:213-213	sufficient binding region:1-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HB09	uniprotkb:Q07812	intact:EBI-3940897|uniprotkb:Q9HB08|uniprotkb:Q96I96|uniprotkb:Q3SY11|ensembl:ENSP00000246785|ensembl:ENSP00000482218|uniprotkb:Q3SY13	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	psi-mi:b2l12_human(display_long)|uniprotkb:BCL2L12(gene name)|psi-mi:BCL2L12(display_short)|uniprotkb:BPR(gene name synonym)|uniprotkb:Bcl-2-related proline-rich protein(gene name synonym)	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086243|imex:IM-29224-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269445.1|refseq:NP_001269446.1|refseq:NP_001269448.1|refseq:NP_001269449.1|refseq:NP_001269450.1|ensembl:ENST00000246785(transcript)|ensembl:ENST00000616144(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR036834|ensembl:ENSG00000126453(gene)|refseq:NP_001035758.1|refseq:NP_619580.1|refseq:XP_016882835.1	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:QQy4TzaEEwe/g1lS2GRsocVnvW09606	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rigid:nSr5BOV2wArfV8tAWIUEEYDxCk8	false	sufficient binding region:70-266	sufficient binding region:1-171	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:Q07817-1	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086253|imex:IM-29224-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:FRmYa5YKFIiI1hSR1a0/71ki46o	false	sufficient binding region:1-171|mutation disrupting interaction strength:63-63	sufficient binding region:1-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:P10415	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086263|imex:IM-29224-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rigid:irZ1m/EPz627BLaZUIVhB4xVK7E	false	sufficient binding region:1-171|mutation disrupting interaction strength:63-63	sufficient binding region:1-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:Q9HB09	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-3940897|uniprotkb:Q9HB08|uniprotkb:Q96I96|uniprotkb:Q3SY11|ensembl:ENSP00000246785|ensembl:ENSP00000482218|uniprotkb:Q3SY13	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:b2l12_human(display_long)|uniprotkb:BCL2L12(gene name)|psi-mi:BCL2L12(display_short)|uniprotkb:BPR(gene name synonym)|uniprotkb:Bcl-2-related proline-rich protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086273|imex:IM-29224-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	refseq:NP_001269445.1|refseq:NP_001269446.1|refseq:NP_001269448.1|refseq:NP_001269449.1|refseq:NP_001269450.1|ensembl:ENST00000246785(transcript)|ensembl:ENST00000616144(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR036834|ensembl:ENSG00000126453(gene)|refseq:NP_001035758.1|refseq:NP_619580.1|refseq:XP_016882835.1	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:QQy4TzaEEwe/g1lS2GRsocVnvW09606	rigid:nSr5BOV2wArfV8tAWIUEEYDxCk8	false	sufficient binding region:1-171	mutation with no effect:216-216|mutation with no effect:220-220|mutation with no effect:218-218|mutation with no effect:217-217|mutation with no effect:213-213|sufficient binding region:90-229|mutation with no effect:209-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49841	uniprotkb:Q9HB09	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-3940897|uniprotkb:Q9HB08|uniprotkb:Q96I96|uniprotkb:Q3SY11|ensembl:ENSP00000246785|ensembl:ENSP00000482218|uniprotkb:Q3SY13	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:b2l12_human(display_long)|uniprotkb:BCL2L12(gene name)|psi-mi:BCL2L12(display_short)|uniprotkb:BPR(gene name synonym)|uniprotkb:Bcl-2-related proline-rich protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chu et al. (2018)	pubmed:29749471|imex:IM-29224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27086288|imex:IM-29224-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_001269445.1|refseq:NP_001269446.1|refseq:NP_001269448.1|refseq:NP_001269449.1|refseq:NP_001269450.1|ensembl:ENST00000246785(transcript)|ensembl:ENST00000616144(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR036834|ensembl:ENSG00000126453(gene)|refseq:NP_001035758.1|refseq:NP_619580.1|refseq:XP_016882835.1	-	-	-	figure legend:Table 1|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/09/12	2021/09/12	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:QQy4TzaEEwe/g1lS2GRsocVnvW09606	rigid:kZVgivSvuHJky/1+JI1m+EaZB5c	false	-	sufficient binding region:153-191|mutation disrupting interaction strength:209-209	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)