#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P31943 uniprotkb:Q7Z333 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 intact:EBI-1220123|uniprotkb:A2A396|uniprotkb:Q5JUJ1|uniprotkb:O75120|uniprotkb:Q3KQX4|uniprotkb:Q68DW5|uniprotkb:Q6AZD7|uniprotkb:Q7Z3J6|uniprotkb:Q8WX33|uniprotkb:Q9H9D1|uniprotkb:Q9NVP9|uniprotkb:B2RPB2|uniprotkb:B5ME16|uniprotkb:C9JQ10|ensembl:ENSP00000224140 psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:setx_human(display_long)|uniprotkb:SETX(gene name)|psi-mi:SETX(display_short)|uniprotkb:ALS4(gene name synonym)|uniprotkb:KIAA0625(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:SEN1 homolog(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 4 protein(gene name synonym)|uniprotkb:Senataxin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bennett et al. (2018) pubmed:29725819|imex:IM-28836 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26900324|imex:IM-28836-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 refseq:NP_055861.3|refseq:XP_011516706.1|refseq:XP_011516707.1|refseq:XP_016869984.1|refseq:XP_005272228.1|refseq:XP_005272229.1|refseq:XP_005272230.1|dip:DIP-38360N|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060566"(positive regulation of DNA-templated transcription, termination)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000806"("positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled")|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|ensembl:ENSG00000107290(gene)|ensembl:ENST00000224140(transcript)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006396"(RNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|refseq:XP_016869986.1 - - - figure legend:f5a|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293a)|taxid:9606(Homo sapiens) - 2021/03/31 2021/04/02 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 rogid:Dc7CRsHfS4kFhGJhPv9mLYieKC09606 rigid:eD6Jeq+j5dM98hmCvJLRT/4tUKA false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31943 uniprotkb:Q13148 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bennett et al. (2018) pubmed:29725819|imex:IM-28836 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26900324|imex:IM-28836-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - figure legend:f5a|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293a)|taxid:9606(Homo sapiens) - 2021/03/31 2021/04/02 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rigid:eD6Jeq+j5dM98hmCvJLRT/4tUKA false flag tag:n-n myc tag:n-n|ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)