#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8NEZ3 uniprotkb:Q9HBG6-3 intact:EBI-11903679|ensembl:ENSP00000382717|uniprotkb:B5MEF2|uniprotkb:Q8N5B4|uniprotkb:Q9H5S0|uniprotkb:Q9HCD4 intact:EBI-26854447|ensembl:ENSP00000323973 psi-mi:wdr19_human(display_long)|uniprotkb:WDR19(gene name)|psi-mi:WDR19(display_short)|uniprotkb:KIAA1638(gene name synonym)|uniprotkb:IFT144(gene name synonym)|uniprotkb:Intraflagellar transport 144 homolog(gene name synonym) psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26852464|imex:IM-28777-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000157796(gene)|ensembl:ENST00000399820(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0008406"(gonad development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0055123"(digestive system development)|go:"GO:0060271"(cilium assembly)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061055"(myotome development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR001680(WD40 repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR039468|interpro:IPR040379|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_001304853.1|refseq:NP_079408.3 ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) - - - figure legend:Fig. 1A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/01 rogid:fm4yqLgpeaZNceMZ1TWKfcy8pTo9606 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rigid:n/DwPcQn/KV2aaxBiIo+QsuZYr8 false necessary binding region:357-653|mcherry fluorescent protein tag:n-n|sufficient binding region:357-1342 enhanced green fluorescent protein tag:n-n|sufficient binding region:571-1182 - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96RY7 uniprotkb:Q8NEZ3 intact:EBI-308494|uniprotkb:O60332|uniprotkb:Q9UG52|uniprotkb:A2A2A8|uniprotkb:D3DU75|ensembl:ENSP00000406012 intact:EBI-11903679|ensembl:ENSP00000382717|uniprotkb:B5MEF2|uniprotkb:Q8N5B4|uniprotkb:Q9H5S0|uniprotkb:Q9HCD4 psi-mi:if140_human(display_long)|uniprotkb:IFT140(gene name)|psi-mi:IFT140(display_short)|uniprotkb:KIAA0590(gene name synonym)|uniprotkb:WDTC2(gene name synonym)|uniprotkb:WD and tetratricopeptide repeats protein 2(gene name synonym) psi-mi:wdr19_human(display_long)|uniprotkb:WDR19(gene name)|psi-mi:WDR19(display_short)|uniprotkb:KIAA1638(gene name synonym)|uniprotkb:IFT144(gene name synonym)|uniprotkb:Intraflagellar transport 144 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854306|imex:IM-28777-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055529.2|ensembl:ENSG00000187535(gene)|ensembl:ENST00000426508(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0021532"(neural tube patterning)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|reactome:R-HSA-5610787|reactome:R-HSA-5620924|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1905515"(non-motile cilium assembly)|refseq:XP_006721053.1|refseq:XP_006721054.1|refseq:XP_016879399.1 ensembl:ENSG00000157796(gene)|ensembl:ENST00000399820(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0008406"(gonad development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0055123"(digestive system development)|go:"GO:0060271"(cilium assembly)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061055"(myotome development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR001680(WD40 repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR039468|interpro:IPR040379|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_001304853.1|refseq:NP_079408.3 - - - figure legend:Fig. 1B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:LQ8zt35IhriM/UbIOoQXk72oLAQ9606 rogid:fm4yqLgpeaZNceMZ1TWKfcy8pTo9606 rigid:mX0ZPyt9aakd3xjXV6lG5sxb5yw false enhanced green fluorescent protein tag:n-n|sufficient binding region:754-1462 mcherry fluorescent protein tag:n-n|necessary binding region:653-1342 - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0815"(confirmation by molecular weight)|psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96RY7 uniprotkb:Q9HBG6-3 intact:EBI-308494|uniprotkb:O60332|uniprotkb:Q9UG52|uniprotkb:A2A2A8|uniprotkb:D3DU75|ensembl:ENSP00000406012 intact:EBI-26854447|ensembl:ENSP00000323973 psi-mi:if140_human(display_long)|uniprotkb:IFT140(gene name)|psi-mi:IFT140(display_short)|uniprotkb:KIAA0590(gene name synonym)|uniprotkb:WDTC2(gene name synonym)|uniprotkb:WD and tetratricopeptide repeats protein 2(gene name synonym) psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854306|imex:IM-28777-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055529.2|ensembl:ENSG00000187535(gene)|ensembl:ENST00000426508(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0021532"(neural tube patterning)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|reactome:R-HSA-5610787|reactome:R-HSA-5620924|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1905515"(non-motile cilium assembly)|refseq:XP_006721053.1|refseq:XP_006721054.1|refseq:XP_016879399.1 ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) - - - figure legend:Fig. 1B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:LQ8zt35IhriM/UbIOoQXk72oLAQ9606 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rigid:mX0ZPyt9aakd3xjXV6lG5sxb5yw false enhanced green fluorescent protein tag:n-n|sufficient binding region:754-1462 mcherry fluorescent protein tag:n-n|sufficient binding region:571-1182 - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0815"(confirmation by molecular weight)|psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9HBG6-3 uniprotkb:Q96FT9 intact:EBI-26854447|ensembl:ENSP00000323973 intact:EBI-10189681|uniprotkb:G3V385|uniprotkb:Q9ULA9|uniprotkb:O95418|uniprotkb:B4DZI9|uniprotkb:B3KPT6|ensembl:ENSP00000324177|ensembl:ENSP00000440064 psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:ift43_human(display_long)|uniprotkb:IFT43(gene name)|psi-mi:IFT43(display_short)|uniprotkb:C14orf179(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854414|imex:IM-28777-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) refseq:NP_001096034.1|refseq:NP_001242924.1|refseq:NP_443105.2|ensembl:ENSG00000119650(gene)|ensembl:ENST00000314067(transcript)|ensembl:ENST00000542766(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0060271"(cilium assembly)|go:"GO:0097542"(ciliary tip)|interpro:IPR029302|reactome:R-HSA-5620924 - - - figure legend:Fig. 2B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rogid:Wpmyr9k+DOjqrt6OHyzYObrP2s09606 rigid:TePQjNNoMREMqjnW08tbQGLrZ9E false enhanced green fluorescent protein tag:n-n|mutation with no effect:263-263|mutation disrupting interaction strength:436-436|mutation disrupting interaction strength:443-443|mutation with no effect:7-7|mutation disrupting interaction strength:513-513 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9HBG6-3 uniprotkb:Q9P2L0 intact:EBI-26854447|ensembl:ENSP00000323973 intact:EBI-766448|uniprotkb:Q8NE11|uniprotkb:B3KVI5|uniprotkb:Q4ZG01|ensembl:ENSP00000314444 psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:wdr35_human(display_long)|uniprotkb:WDR35(gene name)|psi-mi:WDR35(display_short)|uniprotkb:KIAA1336(gene name synonym)|uniprotkb:IFT121(gene name synonym)|uniprotkb:Intraflagellar transport protein 121 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854414|imex:IM-28777-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) refseq:NP_001006658.1|refseq:NP_065830.2|ensembl:ENSG00000118965(gene)|ensembl:ENST00000345530(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:1905705"(cellular response to paclitaxel)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017233(WD repeat protein 35)|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-5610787|reactome:R-HSA-5620924 - - - figure legend:Fig. 2B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rogid:FrWDs7c4/UjYg6xK6zMl6P0RcO09606 rigid:TePQjNNoMREMqjnW08tbQGLrZ9E false enhanced green fluorescent protein tag:n-n|mutation with no effect:263-263|mutation disrupting interaction strength:436-436|mutation disrupting interaction strength:443-443|mutation with no effect:7-7|mutation disrupting interaction strength:513-513 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9HBG6-3 uniprotkb:Q7Z4L5 intact:EBI-26854447|ensembl:ENSP00000323973 intact:EBI-2851301|uniprotkb:Q53T84|uniprotkb:Q6PIF5|uniprotkb:A8MUZ3|uniprotkb:Q8NCN3|uniprotkb:Q9HAK8|uniprotkb:Q96MA4|uniprotkb:Q6P4A1|uniprotkb:Q3LIE4|ensembl:ENSP00000243344|ensembl:ENSP00000506276|ensembl:ENSP00000506400 psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:tt21b_human(display_long)|uniprotkb:TTC21B(gene name)|psi-mi:TTC21B(display_short)|uniprotkb:KIAA1992(gene name synonym)|uniprotkb:Nbla10696(orf name)|uniprotkb:IFT139(gene name synonym)|uniprotkb:Intraflagellar transport 139 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854528|imex:IM-28777-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) refseq:NP_079029.3|ensembl:ENSG00000123607(gene)|ensembl:ENST00000243344(transcript)|ensembl:ENST00000680888(transcript)|ensembl:ENST00000681952(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021591"(ventricular system development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097499"(protein localization to non-motile cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1905799"(regulation of intraciliary retrograde transport)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040364|reactome:R-HSA-5610787|reactome:R-HSA-5620924 intact:EBI-26854569(see-also) - - figure legend:Fig. 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rogid:y1VB2y4oBho3fxf1gOl0LAz2u8o9606 rigid:9I2W5D/+6D3V3Eq3v0Boi5Es+6w false enhanced green fluorescent protein tag:n-n|mutation with complex effect:263-263|mutation disrupting interaction strength:436-436|mutation disrupting interaction strength:443-443|mutation with complex effect:7-7|mutation disrupting interaction strength:513-513 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9HBG6-3 uniprotkb:Q96FT9 intact:EBI-26854447|ensembl:ENSP00000323973 intact:EBI-10189681|uniprotkb:G3V385|uniprotkb:Q9ULA9|uniprotkb:O95418|uniprotkb:B4DZI9|uniprotkb:B3KPT6|ensembl:ENSP00000324177|ensembl:ENSP00000440064 psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:ift43_human(display_long)|uniprotkb:IFT43(gene name)|psi-mi:IFT43(display_short)|uniprotkb:C14orf179(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854528|imex:IM-28777-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) refseq:NP_001096034.1|refseq:NP_001242924.1|refseq:NP_443105.2|ensembl:ENSG00000119650(gene)|ensembl:ENST00000314067(transcript)|ensembl:ENST00000542766(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0060271"(cilium assembly)|go:"GO:0097542"(ciliary tip)|interpro:IPR029302|reactome:R-HSA-5620924 intact:EBI-26854569(see-also) - - figure legend:Fig. 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rogid:Wpmyr9k+DOjqrt6OHyzYObrP2s09606 rigid:9I2W5D/+6D3V3Eq3v0Boi5Es+6w false enhanced green fluorescent protein tag:n-n|mutation with complex effect:263-263|mutation disrupting interaction strength:436-436|mutation disrupting interaction strength:443-443|mutation with complex effect:7-7|mutation disrupting interaction strength:513-513 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9HBG6-3 uniprotkb:Q9P2L0 intact:EBI-26854447|ensembl:ENSP00000323973 intact:EBI-766448|uniprotkb:Q8NE11|uniprotkb:B3KVI5|uniprotkb:Q4ZG01|ensembl:ENSP00000314444 psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:wdr35_human(display_long)|uniprotkb:WDR35(gene name)|psi-mi:WDR35(display_short)|uniprotkb:KIAA1336(gene name synonym)|uniprotkb:IFT121(gene name synonym)|uniprotkb:Intraflagellar transport protein 121 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854528|imex:IM-28777-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) refseq:NP_001006658.1|refseq:NP_065830.2|ensembl:ENSG00000118965(gene)|ensembl:ENST00000345530(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:1905705"(cellular response to paclitaxel)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017233(WD repeat protein 35)|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-5610787|reactome:R-HSA-5620924 intact:EBI-26854569(see-also) - - figure legend:Fig. 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/09 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rogid:FrWDs7c4/UjYg6xK6zMl6P0RcO09606 rigid:9I2W5D/+6D3V3Eq3v0Boi5Es+6w false enhanced green fluorescent protein tag:n-n|mutation with complex effect:263-263|mutation disrupting interaction strength:436-436|mutation disrupting interaction strength:443-443|mutation with complex effect:7-7|mutation disrupting interaction strength:513-513 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z4L5 uniprotkb:Q9HBG6-3 intact:EBI-2851301|uniprotkb:Q53T84|uniprotkb:Q6PIF5|uniprotkb:A8MUZ3|uniprotkb:Q8NCN3|uniprotkb:Q9HAK8|uniprotkb:Q96MA4|uniprotkb:Q6P4A1|uniprotkb:Q3LIE4|ensembl:ENSP00000243344|ensembl:ENSP00000506276|ensembl:ENSP00000506400 intact:EBI-26854447|ensembl:ENSP00000323973 psi-mi:tt21b_human(display_long)|uniprotkb:TTC21B(gene name)|psi-mi:TTC21B(display_short)|uniprotkb:KIAA1992(gene name synonym)|uniprotkb:Nbla10696(orf name)|uniprotkb:IFT139(gene name synonym)|uniprotkb:Intraflagellar transport 139 homolog(gene name synonym) psi-mi:q9hbg6-3(display_long)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takahara et al. (2018) pubmed:29220510|imex:IM-28777 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26854569|imex:IM-28777-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079029.3|ensembl:ENSG00000123607(gene)|ensembl:ENST00000243344(transcript)|ensembl:ENST00000680888(transcript)|ensembl:ENST00000681952(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021591"(ventricular system development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097499"(protein localization to non-motile cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1905799"(regulation of intraciliary retrograde transport)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040364|reactome:R-HSA-5610787|reactome:R-HSA-5620924 ensembl:ENSG00000163913(gene)|ensembl:ENST00000347300(transcript)|intact:EBI-2805994(isoform-parent) intact:EBI-26854528(see-also) - - figure legend:Fig. 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/02/23 2021/03/01 rogid:y1VB2y4oBho3fxf1gOl0LAz2u8o9606 rogid:T8IiCdI9wK6NDFpzyr0eTMVFc9M9606 rigid:1viOF8wHQDF2+D3g5Nms4T7cUB0 false mcherry fluorescent protein tag:n-n enhanced green fluorescent protein tag:n-n|mutation:263-263|mutation:7-7 - - psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0705"(anti tag western blot)