#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4KLN8	uniprotkb:Q8R322	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-8458495|uniprotkb:Q9D4A6|uniprotkb:Q3TU23|intact:MINT-4126988|uniprotkb:Q3TT10|uniprotkb:A3KGV8|uniprotkb:Q8BT16|uniprotkb:Q3UD65|ensembl:ENSMUSP00000019859	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:gle1_mouse(display_long)|uniprotkb:Gle1(gene name)|psi-mi:Gle1(display_short)|uniprotkb:Gle1l(gene name synonym)|uniprotkb:GLE1-like protein(gene name synonym)|uniprotkb:GLE1 RNA export mediator(gene name synonym)|uniprotkb:Nucleoporin GLE1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_083199.1|ensembl:ENSMUSG00000019715(gene)|ensembl:ENSMUST00000019859(transcript)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0015031"(protein transport)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|interpro:IPR012476(GLE1-like)|interpro:IPR038506|mint:Q8R322|reactome:R-MMU-159236	-	-	comment:mint|function:"Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC)"	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:IIJUf8LFslScG59hytr/ymPy9bY10090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q99MS8	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-11707427|uniprotkb:Q3U5Q9|uniprotkb:Q9R0B5|ensembl:ENSMUSP00000159326	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:tpgs1_mouse(display_long)|uniprotkb:Gm16517(gene name synonym)|uniprotkb:Tpgs1(gene name)|psi-mi:Tpgs1(display_short)|uniprotkb:Gtrgeo22(gene name synonym)|uniprotkb:p32(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_683736.1|ensembl:ENSMUSG00000020308(gene)|ensembl:ENSMUST00000239401(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018095"(protein polyglutamylation)|go:"GO:0030424"(axon)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0045202"(synapse)|go:"GO:0051648"(vesicle localization)|go:"GO:0070740"(tubulin-glutamic acid ligase activity)|interpro:IPR039235|mint:Q99MS8|go:"GO:0030425"(dendrite)	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:CNNi+XO6HFs87Nv1puXz45++/OA10090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q9CYR0	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-9989649|ensembl:ENSMUSP00000031971	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:ssbp_mouse(display_long)|uniprotkb:Ssbp1(gene name)|psi-mi:Ssbp1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_082634.1|refseq:NP_997633.1|refseq:XP_006506392.1|refseq:XP_017177153.1|ensembl:ENSMUSG00000029911(gene)|ensembl:ENSMUST00000031971(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q9CYR0	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:mPiUWKFQ/gJufRp4aggO3UUJdG810090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q61595	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-775369|uniprotkb:Q8BG49|uniprotkb:Q8BHF4|uniprotkb:Q8BHM8|uniprotkb:Q8C9Y5|uniprotkb:Q8CG51|uniprotkb:Q8CG52|uniprotkb:Q8CG53|uniprotkb:Q8CG54|uniprotkb:Q8CG55|uniprotkb:Q8CG56|uniprotkb:Q8CG57|uniprotkb:Q8CG58|uniprotkb:Q8CG59|uniprotkb:Q8CG60|uniprotkb:Q8CG61|uniprotkb:Q8CG62|uniprotkb:Q8CG63	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:ktn1_mouse(display_long)|uniprotkb:Ktn1(gene name)|psi-mi:Ktn1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_032503.2|refseq:NP_001280564.1|refseq:NP_001280565.1|interpro:IPR024854|refseq:NP_001334448.1|refseq:NP_001334449.1|refseq:NP_001334450.1|refseq:NP_001334452.1|refseq:NP_001334453.1|refseq:NP_001334454.1|refseq:NP_001334455.1|refseq:NP_001334456.1|refseq:NP_001334457.1|mint:Q61595|interpro:IPR007794(Ribosome receptor lysine or proline rich)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0015031"(protein transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|reactome:R-MMU-381426|reactome:R-MMU-5625970|reactome:R-MMU-8957275|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:xgS8/yfp5yj+gPyaC6a/gmSrxTA10090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q6A065	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-2554140|uniprotkb:Q7TQD9|uniprotkb:Q8BJW2|uniprotkb:Q9D3Z0|ensembl:ENSMUSP00000141793	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:ce170_mouse(display_long)|uniprotkb:Kiaa0470(gene name synonym)|uniprotkb:Cep170(gene name)|psi-mi:Cep170(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	ensembl:ENSMUSG00000057335(gene)|ensembl:ENSMUST00000194727(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q6A065|refseq:XP_006497000.1	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:gawEp+b6DVpUroRU0JHmHzo7qPg10090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:P59672	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-2310776|uniprotkb:Q6ZQG0|ensembl:ENSMUSP00000110491	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:ans1a_mouse(display_long)|uniprotkb:Anks1a(gene name)|psi-mi:Anks1a(display_short)|uniprotkb:Anks1(gene name synonym)|uniprotkb:Kiaa0229(gene name synonym)|uniprotkb:Odin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_001272970.1|refseq:NP_852078.1|ensembl:ENSMUSG00000024219(gene)|ensembl:ENSMUST00000114842(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:P59672|rcsb pdb:5ZRY	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:nnkofMZa8AUPqZcbgGAYSHS4Lk810090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q5NCX5	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-4284398|uniprotkb:Q3U090|uniprotkb:Q5NCX4|uniprotkb:Q69ZA2|uniprotkb:Q8R1V5|ensembl:ENSMUSP00000053235	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:neul4_mouse(display_long)|uniprotkb:Neurl4(gene name)|psi-mi:Neurl4(display_short)|uniprotkb:Kiaa1787(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_001013432.1|refseq:NP_001278047.1|refseq:NP_001278048.1|ensembl:ENSMUSG00000047284(gene)|ensembl:ENSMUST00000061837(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q5NCX5|refseq:XP_017169947.1	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:ptQRCtQs60MpIBFD5++Vnv69Sfc10090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q8VC56	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-15954293|ensembl:ENSMUSP00000024817|uniprotkb:Q4FJV7|uniprotkb:Q9JK13	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:rnf8_mouse(display_long)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)|uniprotkb:ActA-interacting protein 37(gene name synonym)|uniprotkb:LaXp180(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	ensembl:ENSMUSG00000090083(gene)|ensembl:ENSMUST00000024817(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q8VC56|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|refseq:NP_067394.1|dip:DIP-59448N	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:7RJ8fgXIsuQwllMXAXcU812QZLY10090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q4U2R1	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596375|imex:IM-28645-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	-	-	-	figure legend:table 1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rigid:AyuCXGV+8pGXN6xpwnrKbRrfqhE	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q4KLN8	uniprotkb:Q5NCX5	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-4284398|uniprotkb:Q3U090|uniprotkb:Q5NCX4|uniprotkb:Q69ZA2|uniprotkb:Q8R1V5|ensembl:ENSMUSP00000053235	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:neul4_mouse(display_long)|uniprotkb:Neurl4(gene name)|psi-mi:Neurl4(display_short)|uniprotkb:Kiaa1787(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596470|imex:IM-28645-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_001013432.1|refseq:NP_001278047.1|refseq:NP_001278048.1|ensembl:ENSMUSG00000047284(gene)|ensembl:ENSMUST00000061837(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q5NCX5|refseq:XP_017169947.1	-	-	-	figure legend:fig. 6a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:ptQRCtQs60MpIBFD5++Vnv69Sfc10090	rigid:GdR/CnY4GDlvFQtCgukfBcsvJUw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4KLN8	uniprotkb:Q4U2R1	intact:EBI-26596395|ensembl:ENSRNOP00000059852	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596470|imex:IM-28645-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	-	-	-	figure legend:fig. 6a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2021/01/18	2021/01/18	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rigid:GdR/CnY4GDlvFQtCgukfBcsvJUw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D4ACN3	uniprotkb:Q4KLN8	intact:EBI-26596484|ensembl:ENSRNOP00000019245	intact:EBI-26596395|ensembl:ENSRNOP00000059852	psi-mi:d4acn3_rat(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:Herc2_predicted(gene name synonym)|uniprotkb:rCG_45123(orf name)	psi-mi:rnf8_rat(display_long)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)|uniprotkb:Rnf8(gene name)|psi-mi:Rnf8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Valnegri et al. (2017)	imex:IM-28645|pubmed:29097665	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26596525|imex:IM-28645-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013718(gene)|ensembl:ENSRNOT00000019245(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:D4ACN3|go:"GO:0005634"(nucleus)|refseq:NP_001100990.1|rgd:1307989	ensembl:ENSRNOG00000047171(gene)|ensembl:ENSRNOT00000065629(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|interpro:IPR017907|interpro:IPR018957|mint:Q4KLN8|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-69473|refseq:NP_001020898.1|rgd:1308035	go:"GO:0005737"(cytoplasm)	-	-	figure legend:fig. 6b|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-primary cerebell)|taxid:10116(Rattus norvegicus)	-	2021/01/18	2021/01/18	rogid:zAkpmZxA8RDOmlKASY6wnVqTLwM10116	rogid:h2giF4EB0dT5jISCSdEW53RJinc10116	rigid:U/me87YCGNyD3c1wZLbDd25oZHo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)