#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6UXV0	uniprotkb:Q99988	intact:EBI-27112718|ensembl:ENSP00000343636|uniprotkb:Q5VTF6	intact:EBI-2116863|uniprotkb:O14629|uniprotkb:P78360|uniprotkb:Q9NRT0|uniprotkb:Q9BWA0|ensembl:ENSP00000252809	psi-mi:gfral_human(display_long)|uniprotkb:GFRAL(gene name)|psi-mi:GFRAL(display_short)|uniprotkb:C6orf144(gene name synonym)|uniprotkb:UNQ9356/PRO34128(orf name)	psi-mi:gdf15_human(display_long)|uniprotkb:GDF15(gene name)|psi-mi:GDF15(display_short)|uniprotkb:MIC1(gene name synonym)|uniprotkb:PDF(gene name synonym)|uniprotkb:PLAB(gene name synonym)|uniprotkb:PTGFB(gene name synonym)|uniprotkb:Placental bone morphogenetic protein(gene name synonym)|uniprotkb:Placental TGF-beta(gene name synonym)|uniprotkb:Macrophage inhibitory cytokine 1(gene name synonym)|uniprotkb:Prostate differentiation factor(gene name synonym)|uniprotkb:NSAID-activated gene 1 protein(gene name synonym)|uniprotkb:NSAID-regulated gene 1 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hsu et al. (2017)	pubmed:28953886|imex:IM-29316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27112750|imex:IM-29316-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187871(gene)|ensembl:ENST00000340465(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002023"(reduction of food intake in response to dietary excess)|go:"GO:0007399"(nervous system development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016167"(glial cell-derived neurotrophic factor receptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR003438(Glial cell line-derived neurotrophic factor receptor)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR037193|rcsb pdb:5VZ4|rcsb pdb:6Q2J|rcsb pdb:6WMW|refseq:NP_997293.2	refseq:NP_004855.2|ensembl:ENSG00000130513(gene)|ensembl:ENST00000252809(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002023"(reduction of food intake in response to dietary excess)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060400"(negative regulation of growth hormone receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070700"(BMP receptor binding)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR029034|rcsb pdb:5VT2|rcsb pdb:5VZ3|rcsb pdb:5VZ4|rcsb pdb:6Q2J	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.0x10^-9(molar)	2021/10/27	2021/10/29	rogid:rkyXysBjMhPRzPlFg2hQiDyC5z09606	rogid:W0oAT+oBcB2pzGNCol0EAfF7CqA9606	rigid:7G1LR0LOnNZ54qlhxojpr/BlEIQ	false	sufficient binding region:115-351|his tag:?-?	sufficient binding region:197-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXV0	uniprotkb:Q99988	intact:EBI-27112718|ensembl:ENSP00000343636|uniprotkb:Q5VTF6	intact:EBI-2116863|uniprotkb:O14629|uniprotkb:P78360|uniprotkb:Q9NRT0|uniprotkb:Q9BWA0|ensembl:ENSP00000252809	psi-mi:gfral_human(display_long)|uniprotkb:GFRAL(gene name)|psi-mi:GFRAL(display_short)|uniprotkb:C6orf144(gene name synonym)|uniprotkb:UNQ9356/PRO34128(orf name)	psi-mi:gdf15_human(display_long)|uniprotkb:GDF15(gene name)|psi-mi:GDF15(display_short)|uniprotkb:MIC1(gene name synonym)|uniprotkb:PDF(gene name synonym)|uniprotkb:PLAB(gene name synonym)|uniprotkb:PTGFB(gene name synonym)|uniprotkb:Placental bone morphogenetic protein(gene name synonym)|uniprotkb:Placental TGF-beta(gene name synonym)|uniprotkb:Macrophage inhibitory cytokine 1(gene name synonym)|uniprotkb:Prostate differentiation factor(gene name synonym)|uniprotkb:NSAID-activated gene 1 protein(gene name synonym)|uniprotkb:NSAID-regulated gene 1 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hsu et al. (2017)	pubmed:28953886|imex:IM-29316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27112767|imex:IM-29316-3|wwpdb:5vz4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187871(gene)|ensembl:ENST00000340465(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002023"(reduction of food intake in response to dietary excess)|go:"GO:0007399"(nervous system development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016167"(glial cell-derived neurotrophic factor receptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR003438(Glial cell line-derived neurotrophic factor receptor)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR037193|rcsb pdb:5VZ4|rcsb pdb:6Q2J|rcsb pdb:6WMW|refseq:NP_997293.2	refseq:NP_004855.2|ensembl:ENSG00000130513(gene)|ensembl:ENST00000252809(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002023"(reduction of food intake in response to dietary excess)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060400"(negative regulation of growth hormone receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070700"(BMP receptor binding)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR029034|rcsb pdb:5VT2|rcsb pdb:5VZ3|rcsb pdb:5VZ4|rcsb pdb:6Q2J	-	-	-	figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/27	2021/10/27	rogid:rkyXysBjMhPRzPlFg2hQiDyC5z09606	rogid:W0oAT+oBcB2pzGNCol0EAfF7CqA9606	rigid:7G1LR0LOnNZ54qlhxojpr/BlEIQ	false	sufficient binding region:115-351|his tag:?-?	sufficient binding region:197-308	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99988	uniprotkb:Q99988	intact:EBI-2116863|uniprotkb:O14629|uniprotkb:P78360|uniprotkb:Q9NRT0|uniprotkb:Q9BWA0|ensembl:ENSP00000252809	intact:EBI-2116863|uniprotkb:O14629|uniprotkb:P78360|uniprotkb:Q9NRT0|uniprotkb:Q9BWA0|ensembl:ENSP00000252809	psi-mi:gdf15_human(display_long)|uniprotkb:GDF15(gene name)|psi-mi:GDF15(display_short)|uniprotkb:MIC1(gene name synonym)|uniprotkb:PDF(gene name synonym)|uniprotkb:PLAB(gene name synonym)|uniprotkb:PTGFB(gene name synonym)|uniprotkb:Placental bone morphogenetic protein(gene name synonym)|uniprotkb:Placental TGF-beta(gene name synonym)|uniprotkb:Macrophage inhibitory cytokine 1(gene name synonym)|uniprotkb:Prostate differentiation factor(gene name synonym)|uniprotkb:NSAID-activated gene 1 protein(gene name synonym)|uniprotkb:NSAID-regulated gene 1 protein(gene name synonym)	psi-mi:gdf15_human(display_long)|uniprotkb:GDF15(gene name)|psi-mi:GDF15(display_short)|uniprotkb:MIC1(gene name synonym)|uniprotkb:PDF(gene name synonym)|uniprotkb:PLAB(gene name synonym)|uniprotkb:PTGFB(gene name synonym)|uniprotkb:Placental bone morphogenetic protein(gene name synonym)|uniprotkb:Placental TGF-beta(gene name synonym)|uniprotkb:Macrophage inhibitory cytokine 1(gene name synonym)|uniprotkb:Prostate differentiation factor(gene name synonym)|uniprotkb:NSAID-activated gene 1 protein(gene name synonym)|uniprotkb:NSAID-regulated gene 1 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hsu et al. (2017)	pubmed:28953886|imex:IM-29316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27112779|imex:IM-29316-5|wwpdb:5vz3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004855.2|ensembl:ENSG00000130513(gene)|ensembl:ENST00000252809(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002023"(reduction of food intake in response to dietary excess)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060400"(negative regulation of growth hormone receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070700"(BMP receptor binding)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR029034|rcsb pdb:5VT2|rcsb pdb:5VZ3|rcsb pdb:5VZ4|rcsb pdb:6Q2J	refseq:NP_004855.2|ensembl:ENSG00000130513(gene)|ensembl:ENST00000252809(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002023"(reduction of food intake in response to dietary excess)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060400"(negative regulation of growth hormone receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070700"(BMP receptor binding)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR029034|rcsb pdb:5VT2|rcsb pdb:5VZ3|rcsb pdb:5VZ4|rcsb pdb:6Q2J	-	-	-	figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/27	2021/10/27	rogid:W0oAT+oBcB2pzGNCol0EAfF7CqA9606	rogid:W0oAT+oBcB2pzGNCol0EAfF7CqA9606	rigid:g5zBBbguNOWLOq0z5PsBhteY0rY	false	sufficient binding region:197-308	sufficient binding region:197-308	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)