#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8NCK7 uniprotkb:Q8NFD5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-679921|uniprotkb:Q5JRD1|uniprotkb:Q5VYC4|uniprotkb:Q8IZY8|uniprotkb:Q8TEV0|uniprotkb:Q8TF02|uniprotkb:Q99491|uniprotkb:Q9ULI5|intact:EBI-2560572|ensembl:ENSP00000055163 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ari1b_human(display_long)|uniprotkb:BAF250B(gene name synonym)|uniprotkb:Osa homolog 2(gene name synonym)|uniprotkb:p250R(gene name synonym)|uniprotkb:BRG1-binding protein hELD/OSA1(gene name synonym)|uniprotkb:BRG1-associated factor 250b(gene name synonym)|uniprotkb:ARID1B(gene name)|psi-mi:ARID1B(display_short)|uniprotkb:DAN15(gene name synonym)|uniprotkb:KIAA1235(gene name synonym)|uniprotkb:OSA2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001333742.1|refseq:NP_059989.2|refseq:NP_065783.3|ensembl:ENSG00000049618(gene)|ensembl:ENST00000350026(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0035060"(brahma complex)|go:"GO:0043044"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048096"|go:"GO:0071565"(nBAF complex)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR021906|interpro:IPR033388|interpro:IPR036431|interpro:IPR038040|mint:Q8NFD5|rcsb pdb:2CXY|rcsb pdb:2EH9|reactome:R-HSA-3214858|reactome:R-HSA-8939243 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:BeWhuwPk5f6HN+yasFEJRpkbM6A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14497 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-637887|intact:EBI-28988406|ensembl:ENSP00000320485|uniprotkb:D3DPL1|uniprotkb:Q53FK9|uniprotkb:Q5T0W1|uniprotkb:Q5T0W2|uniprotkb:Q5T0W3|uniprotkb:Q8NFD6|uniprotkb:Q96T89|uniprotkb:Q9BY33|uniprotkb:Q9HBJ5|uniprotkb:Q9UPZ1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ari1a_human(display_long)|uniprotkb:hELD(gene name synonym)|uniprotkb:SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1(gene name synonym)|uniprotkb:SWI/SNF complex protein p270(gene name synonym)|uniprotkb:B120(gene name synonym)|uniprotkb:SWI-like protein(gene name synonym)|uniprotkb:Osa homolog 1(gene name synonym)|uniprotkb:BRG1-associated factor 250(gene name synonym)|uniprotkb:BRG1-associated factor 250a(gene name synonym)|uniprotkb:ARID1A(gene name)|psi-mi:ARID1A(display_short)|uniprotkb:C1orf4(gene name synonym)|uniprotkb:SMARCF1(gene name synonym)|uniprotkb:OSA1(gene name synonym)|uniprotkb:BAF250(gene name synonym)|uniprotkb:BAF250A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) reactome:R-HSA-3214858|reactome:R-HSA-8939243|go:"GO:0005634"(nucleus)|ensembl:ENSG00000117713(gene)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000324856(transcript)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035060"(brahma complex)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043044"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048096"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021906|interpro:IPR030094|interpro:IPR033388|interpro:IPR036431|mint:O14497|rcsb pdb:1RYU|rcsb pdb:6LTH|rcsb pdb:6LTJ|refseq:NP_006006.3|refseq:NP_624361.1|dip:DIP-33016N|ensembl:ENSP00000320485|ensembl:ENST00000374152|ensembl:ENSP00000363267|ensembl:ENST00000457599|ensembl:ENSP00000387636 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:C3ZRlsnBUZV6SBEbISRImamhzoQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8IXI1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1396563|uniprotkb:Q8NF53|uniprotkb:Q96C13|uniprotkb:Q96S17|uniprotkb:Q9BT60|uniprotkb:Q9H7M8|uniprotkb:A2IDC2|ensembl:ENSP00000321971 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:miro2_human(display_long)|uniprotkb:RHOT2(gene name)|psi-mi:RHOT2(display_short)|uniprotkb:ARHT2(gene name synonym)|uniprotkb:C16orf39(gene name synonym)|uniprotkb:Ras homolog gene family member T2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_620124.1|ensembl:ENSG00000140983(gene)|ensembl:ENST00000315082(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|mint:Q8IXI1|rcsb pdb:5KUT|reactome:R-HSA-9013419 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:E+WoN8aoND+U/YkLBUTecrNbDXg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7Z6Z7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P00403 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5BKY9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6165724|ensembl:ENSP00000398401|uniprotkb:B2R994|uniprotkb:Q05D67|uniprotkb:Q6P5S6|uniprotkb:Q8N0W8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:f133b_human(display_long)|uniprotkb:FAM133B(gene name)|psi-mi:FAM133B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000234545(gene)|ensembl:ENST00000445716(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR026766|refseq:XP_011514306.1|refseq:NP_001035146.1|refseq:NP_690002.2|refseq:NP_001275513.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ozckFn8fi/3T9XNK3Si7qw2fEWw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UDW3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-7850213|ensembl:ENSP00000344241|uniprotkb:A8K9F6|intact:MINT-8330010 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zmat5_human(display_long)|uniprotkb:ZMAT5(gene name)|psi-mi:ZMAT5(display_short)|uniprotkb:U11/U12 small nuclear ribonucleoprotein 20 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001305058.1|ensembl:ENSG00000100319(gene)|ensembl:ENST00000344318(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036236|interpro:IPR036855|reactome:R-HSA-72165|refseq:NP_061976.1|refseq:NP_001003692.1 - - comment:mint|comment:homomint figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:f7EXzm4tFmtE/4Af1RurbNqXyTc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P48651 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-8652106|uniprotkb:B4DE85|uniprotkb:E5RFC5|uniprotkb:Q9BUQ5|intact:MINT-8163942|ensembl:ENSP00000430548 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ptss1_human(display_long)|uniprotkb:PTDSS1(gene name)|psi-mi:PTDSS1(display_short)|uniprotkb:KIAA0024(gene name synonym)|uniprotkb:PSSA(gene name synonym)|uniprotkb:Serine-exchange enzyme I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001277154.1|refseq:NP_055569.1|ensembl:ENSG00000156471(gene)|ensembl:ENST00000517309(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006659"(phosphatidylserine biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0106245"(L-serine-phosphatidylethanolamine phosphatidyltransferase activity)|go:"GO:0106258"(L-serine-phosphatidylcholine phosphatidyltransferase activity)|interpro:IPR004277(Phosphatidyl serine synthase)|mint:P48651|reactome:R-HSA-1483101 - - comment:mint figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FDSRlCB+/84r8jXnvywHmzAqq9s9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92643 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-8617711|ensembl:ENSP00000359848|intact:MINT-2813159|uniprotkb:O14822|uniprotkb:B2R7K3|uniprotkb:Q5TG77|uniprotkb:B4E2M3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gpi8_human(display_long)|uniprotkb:PIGK(gene name)|psi-mi:PIGK(display_short)|uniprotkb:GPI8(gene name synonym)|uniprotkb:Phosphatidylinositol-glycan biosynthesis class K protein(gene name synonym)|uniprotkb:GPI8 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000142892(gene)|ensembl:ENST00000370812(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003923"(GPI-anchor transamidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016255"(attachment of GPI anchor to protein)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042765"(GPI-anchor transamidase complex)|interpro:IPR001096(Peptidase C13, legumain)|interpro:IPR028361|mint:Q92643|reactome:R-HSA-162791|refseq:NP_005473.1 - - function:Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein|comment:mint figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FRRsPTVrMU/nfpydL7D59VLlXxY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13217 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6165721|ensembl:ENSP00000473631|uniprotkb:Q86WT9|uniprotkb:Q8N4N2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjc3_human(display_long)|uniprotkb:DNAJC3(gene name)|psi-mi:DNAJC3(display_short)|uniprotkb:Interferon-induced, double-stranded RNA-activated protein kinase inhibitor(gene name synonym)|uniprotkb:P58IPK(gene name synonym)|uniprotkb:PRKRI(gene name synonym)|uniprotkb:Protein kinase inhibitor of 58 kDa(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000102580(gene)|ensembl:ENST00000602402(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036494"(positive regulation of translation initiation in response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018704|interpro:IPR019734|interpro:IPR036869|rcsb pdb:2Y4T|rcsb pdb:2Y4U|reactome:R-HSA-192823|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275|refseq:NP_006251.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:p5PToTl/u3ZL9PtRSjDK01FKJmc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:J3KN16 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-8640159|ensembl:ENSP00000259335|intact:MINT-8163031 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:j3kn16_human(display_long)|uniprotkb:ECPAS(gene name)|psi-mi:ECPAS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000136813(gene)|ensembl:ENST00000259335(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043248"(proteasome assembly)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024372|refseq:NP_001073867.1 - - comment:mint figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:A8z9nT5VRn5nicTEpTnZcAXXjFs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5SRD1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11324733|uniprotkb:Q5SRD2|intact:EBI-11329702|uniprotkb:B4DDK6|uniprotkb:E7EP42|ensembl:ENSP00000502369 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ti23b_human(display_long)|uniprotkb:TIMM23B(gene name)|psi-mi:TIMM23B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_016870949.1|refseq:NP_001277046.1|refseq:NP_001277047.1|ensembl:ENSG00000204152(gene)|ensembl:ENST00000651259(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YuI5PSImVPxw0KcwZbSP3hSRSE89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P33993 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BPW8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-307125|uniprotkb:O43800|uniprotkb:B2RAY3|ensembl:ENSP00000216121 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nips1_human(display_long)|uniprotkb:NIPSNAP1(gene name)|psi-mi:NIPSNAP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001189431.1|refseq:NP_003625.2|ensembl:ENSG00000184117(gene)|ensembl:ENST00000216121(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:Q9BPW8 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mOosuRNhEeYvVB5cUbkMzTJ7X7s9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N9E0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10268158|ensembl:ENSP00000318974|ensembl:ENSP00000362169|ensembl:ENSP00000507109 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:f133a_human(display_long)|uniprotkb:FAM133A(gene name)|psi-mi:FAM133A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_016884943.1|refseq:XP_016884944.1|refseq:XP_016884945.1|refseq:NP_001164580.1|refseq:NP_001164581.1|refseq:NP_001164582.1|refseq:NP_775969.1|refseq:XP_006724704.1|refseq:XP_011529227.1|refseq:XP_011529228.1|refseq:XP_011529229.1|refseq:XP_011529230.1|refseq:XP_011529231.1|refseq:XP_011529233.1|ensembl:ENSG00000179083(gene)|ensembl:ENST00000322139(transcript)|ensembl:ENST00000332647(transcript)|ensembl:ENST00000683942(transcript)|interpro:IPR026766 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Jv8AtL9j8Xc+EQncR7vS8PYw0OU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13418 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-747644|uniprotkb:P57043|uniprotkb:Q68DZ3|uniprotkb:B7Z1I0|uniprotkb:D3DQU0|uniprotkb:B7Z418|ensembl:ENSP00000299421|ensembl:ENSP00000379975|ensembl:ENSP00000403487 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ilk_human(display_long)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:ILK(gene name)|psi-mi:ILK(display_short)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001265370.1|refseq:NP_001014794.1|refseq:NP_001014795.1|refseq:NP_004508.1|refseq:XP_005252961.1|refseq:NP_001265371.1|refseq:XP_005252962.1|refseq:XP_011518367.1|dip:DIP-38657N|rcsb pdb:3IXE|rcsb pdb:3KMU|rcsb pdb:3KMW|rcsb pdb:3REP|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIB|reactome:R-HSA-446343|reactome:R-HSA-446353|ensembl:ENSG00000166333(gene)|ensembl:ENST00000299421(transcript)|ensembl:ENST00000396751(transcript)|ensembl:ENST00000420936(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:Q13418|rcsb pdb:2KBX|rcsb pdb:3F6Q|go:"GO:0045663"(positive regulation of myoblast differentiation) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FrK/MsW7IcVWT9VbkHAIVHEh1P89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UNP9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-591818|uniprotkb:Q3S611|uniprotkb:Q5TGA3|uniprotkb:O43634|uniprotkb:O43635|uniprotkb:Q32Q72|uniprotkb:Q5TGA0|uniprotkb:Q5TGA2|uniprotkb:Q9UIZ5|uniprotkb:B2R971|ensembl:ENSP00000312769 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ppie_human(display_long)|uniprotkb:Cyclophilin E(gene name synonym)|uniprotkb:Cyclophilin-33(gene name synonym)|uniprotkb:PPIE(gene name)|psi-mi:PPIE(display_short)|uniprotkb:CYP33(gene name synonym)|uniprotkb:Rotamase E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006103.1|refseq:NP_982281.1|refseq:NP_001181936.1|refseq:XP_016855540.1|dip:DIP-34757N|ensembl:ENSG00000084072(gene)|ensembl:ENST00000324379(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR016304(Peptidyl-prolyl cis-trans isomerase E)|interpro:IPR020892|interpro:IPR029000|interpro:IPR034168|interpro:IPR035979|mint:Q9UNP9|rcsb pdb:1ZMF|rcsb pdb:2CQB|rcsb pdb:2KU7|rcsb pdb:2KYX|rcsb pdb:2R99|rcsb pdb:3LPY|rcsb pdb:3MDF|rcsb pdb:3UCH|rcsb pdb:5MQF|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:7A5P|rcsb pdb:7ABI|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6798695|reactome:R-HSA-72163 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zMkadgyIl5RwvoD3h3vetTqLjg49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q16637 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-395421|uniprotkb:Q13119|uniprotkb:Q549U5|uniprotkb:Q96J51|ensembl:ENSP00000305857|uniprotkb:A8K0V4|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENSP00000370119|ensembl:ENSP00000479920|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:smn_human(display_long)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000335.1|refseq:NP_059107.1|refseq:NP_075012.1|refseq:NP_075013.1|refseq:NP_075014.1|refseq:NP_075015.1|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0007399"(nervous system development)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR002999(Tudor)|interpro:IPR010304(Survival motor neuron)|mint:Q16637|rcsb pdb:1G5V|rcsb pdb:1MHN|rcsb pdb:2LEH|rcsb pdb:4A4E|rcsb pdb:4A4G|rcsb pdb:4GLI|rcsb pdb:4QQ6|rcsb pdb:5XJL|go:"GO:0034719"(SMN-Sm protein complex)|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|reactome:R-HSA-191859|go:"GO:0032797"(SMN complex)|refseq:NP_001284644.1|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENST00000380742|ensembl:ENSP00000370118|ensembl:ENSP00000370119|ensembl:ENST00000503079|ensembl:ENSP00000428128|ensembl:ENST00000506163|ensembl:ENSP00000424926|ensembl:ENST00000611442|ensembl:ENSP00000483768|ensembl:ENST00000614240|ensembl:ENSP00000479279|ensembl:ENSP00000479920|ensembl:ENST00000614773|ensembl:ENSP00000481427|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENST00000622158|ensembl:ENSP00000480906|ensembl:ENSP00000482966|ensembl:ENST00000624634|ensembl:ENSP00000485595|ensembl:ENST00000626847|ensembl:ENSP00000486152|ensembl:ENSP00000487421|ensembl:ENST00000628353|ensembl:ENSP00000487029|ensembl:ENST00000628642|ensembl:ENSP00000487015|ensembl:ENSP00000487206|refseq:XP_016865275.1|dip:DIP-31309N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O95817 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H078 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00488 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-726769|uniprotkb:B2R4S0|uniprotkb:Q5T2H7|ensembl:ENSP00000363384 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zn593_human(display_long)|uniprotkb:Zinc finger protein T86(gene name synonym)|uniprotkb:ZNF593(gene name)|psi-mi:ZNF593(display_short)|uniprotkb:ZT86(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056955.2|ensembl:ENSG00000142684(gene)|ensembl:ENST00000374266(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|rcsb pdb:1ZR9|rcsb pdb:6LSS|rcsb pdb:6LU8 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:AhrvTeBvx2U76x+1pY/U/q3FNK49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H5V9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1053419|uniprotkb:A8MPX7|uniprotkb:B4DQN2|uniprotkb:F5GWL7|uniprotkb:O43351|uniprotkb:D3DWH9|ensembl:ENSP00000494123 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:steep_human(display_long)|uniprotkb:STEEP1(gene name)|psi-mi:STEEP1(display_short)|uniprotkb:CXorf56(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001164040.1|refseq:NP_001164041.1|refseq:NP_071384.1|ensembl:ENSG00000018610(gene)|ensembl:ENST00000644802(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0044297"(cell body)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR029704 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:24LR5Wy5GnADosh247l7Yqfr4aQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P53396 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1042794|uniprotkb:Q13037|uniprotkb:Q9BRL0|uniprotkb:B4E3P0|uniprotkb:B4DIM0|ensembl:ENSP00000253792|ensembl:ENSP00000466259 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:acly_human(display_long)|uniprotkb:ACLY(gene name)|psi-mi:ACLY(display_short)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001087.2|refseq:NP_942127.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR014608(ATP-citrate synthase)|ensembl:ENSG00000131473(gene)|ensembl:ENST00000352035(transcript)|ensembl:ENST00000590151(transcript)|go:"GO:0003878"(ATP citrate synthase activity)|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0005524"(ATP binding)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|interpro:IPR017866|interpro:IPR032263|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0046872"(metal ion binding)|interpro:IPR033847|rcsb pdb:6O0H|interpro:IPR036291|rcsb pdb:6POE|interpro:IPR036969|rcsb pdb:6POF|rcsb pdb:6QFB|mint:P53396|rcsb pdb:6UI9|rcsb pdb:6UIA|rcsb pdb:3MWD|rcsb pdb:6UUW|rcsb pdb:6UUZ|rcsb pdb:6UV5|rcsb pdb:6Z2H|rcsb pdb:7LIW|rcsb pdb:7LJ9|rcsb pdb:7LLA|reactome:R-HSA-163765|rcsb pdb:3MWE|reactome:R-HSA-6798695|reactome:R-HSA-75105|rcsb pdb:3PFF|rcsb pdb:5TDE|rcsb pdb:5TDF|rcsb pdb:5TDM|rcsb pdb:5TDZ|rcsb pdb:5TE1|rcsb pdb:5TEQ|rcsb pdb:5TES|rcsb pdb:5TET|rcsb pdb:6HXH|rcsb pdb:6HXK|rcsb pdb:6HXL|rcsb pdb:6HXM|refseq:XP_005257452.1|refseq:NP_001290203.1|refseq:NP_001290204.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NaxO5aRi08GTrEV9aIboUdTlpAs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:C9JNU6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103305|ensembl:ENSP00000408289 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:c9jnu6_human(display_long)|uniprotkb:HIGD1A(gene name)|psi-mi:HIGD1A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000430190(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|interpro:IPR007667(Hypoxia induced protein conserved region)|ensembl:ENSG00000181061(gene) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:BwcQyTJ/3QT6oYJbLlEk6SJaWvo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N0V3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3232108|ensembl:ENSP00000305696|intact:EBI-3893359|uniprotkb:Q9H776|uniprotkb:Q6PF07|uniprotkb:Q8WZ65 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rbfa_human(display_long)|uniprotkb:C18orf22(gene name synonym)|uniprotkb:RBFA(gene name)|psi-mi:RBFA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000306735(transcript)|ensembl:ENSG00000101546(gene)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|interpro:IPR000238(Ribosome-binding factor A)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR020053|interpro:IPR023799|interpro:IPR039212|rcsb pdb:2E7G|refseq:NP_001165438.1|refseq:NP_079081.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:llnY0WFQiKpRzHxYcZ4UStspUu09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UJV9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046350|ensembl:ENSP00000330349|uniprotkb:Q96BK6|uniprotkb:Q96K05|uniprotkb:Q9NT96|uniprotkb:Q9NW04|uniprotkb:B2RDC8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ddx41_human(display_long)|uniprotkb:DEAD box protein 41(gene name synonym)|uniprotkb:DEAD box protein abstrakt homolog(gene name synonym)|uniprotkb:DDX41(gene name)|psi-mi:DDX41(display_short)|uniprotkb:ABS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000183258(gene)|ensembl:ENST00000330503(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044113|mint:Q9UJV9|rcsb pdb:2P6N|rcsb pdb:5GVS|rcsb pdb:5H1Y|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3270619|rcsb pdb:5GVR|refseq:NP_057306.2|refseq:NP_001308661.1|refseq:NP_001308759.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:a3HNDsQBaXs/1q8ZXjkcMgEhPes9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P23258 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-302589|ensembl:ENSP00000251413|uniprotkb:Q9BW59|uniprotkb:Q53X79 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbg1_human(display_long)|uniprotkb:TUBG1(gene name)|psi-mi:TUBG1(display_short)|uniprotkb:TUBG(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P23258|rcsb pdb:1Z5V|rcsb pdb:1Z5W|rcsb pdb:3CB2|rcsb pdb:6V5V|rcsb pdb:6V6S|rcsb pdb:7AS4|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|interpro:IPR017975|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000131462(gene)|ensembl:ENST00000251413(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|go:"GO:0005814"(centriole)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|refseq:NP_001061.2|dip:DIP-29890N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Y5WLH1ZKlS7FOa9ePmH3dpdE8Xk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13627 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1053596|uniprotkb:O60769|uniprotkb:Q92582|uniprotkb:Q92810|uniprotkb:Q9UNM5|ensembl:ENSP00000381932|ensembl:ENSP00000494544 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dyr1a_human(display_long)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:HP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:DYRK1A(gene name)|psi-mi:DYRK1A(display_short)|uniprotkb:DYRK(gene name synonym)|uniprotkb:MNB(gene name synonym)|uniprotkb:MNBH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001387.2|refseq:NP_567824.1|refseq:NP_569120.1|refseq:NP_569122.1|refseq:XP_011527785.1|refseq:XP_006724039.1|refseq:XP_006724040.1|refseq:XP_006724041.1|ensembl:ENSG00000157540(gene)|ensembl:ENST00000398960(transcript)|ensembl:ENST00000644942(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q13627|rcsb pdb:2VX3|rcsb pdb:2WO6|rcsb pdb:3ANQ|rcsb pdb:3ANR|rcsb pdb:4AZE|rcsb pdb:4MQ1|rcsb pdb:4MQ2|rcsb pdb:4NCT|rcsb pdb:4YLJ|rcsb pdb:4YLK|rcsb pdb:4YLL|rcsb pdb:4YU2|rcsb pdb:5A3X|rcsb pdb:5A4E|rcsb pdb:5A4L|rcsb pdb:5A4Q|rcsb pdb:5A4T|rcsb pdb:5A54|rcsb pdb:5AIK|rcsb pdb:6A1G|rcsb pdb:6EIF|rcsb pdb:6EIJ|rcsb pdb:6EIL|rcsb pdb:6EIP|rcsb pdb:6EIQ|rcsb pdb:6EIR|rcsb pdb:6EIS|rcsb pdb:6EIV|rcsb pdb:6EJ4|rcsb pdb:6QU2|rcsb pdb:6S11|rcsb pdb:6S14|rcsb pdb:6S17|rcsb pdb:6S1B|rcsb pdb:6S1H|rcsb pdb:6S1I|rcsb pdb:6S1J|rcsb pdb:6T6A|rcsb pdb:6UIP|rcsb pdb:6UWY|rcsb pdb:6YF8|rcsb pdb:7A4O|rcsb pdb:7A4R|rcsb pdb:7A4S|rcsb pdb:7A4W|rcsb pdb:7A4Z|rcsb pdb:7A51|rcsb pdb:7A52|rcsb pdb:7A53|rcsb pdb:7A55|rcsb pdb:7A5B|rcsb pdb:7A5D|rcsb pdb:7A5L|rcsb pdb:7A5N|rcsb pdb:7AJ2|rcsb pdb:7AJ4|rcsb pdb:7AJ5|rcsb pdb:7AJ7|rcsb pdb:7AJ8|rcsb pdb:7AJA|rcsb pdb:7AJM|rcsb pdb:7AJS|rcsb pdb:7AJV|rcsb pdb:7AJW|rcsb pdb:7AJY|rcsb pdb:7AK2|rcsb pdb:7AKA|rcsb pdb:7AKB|rcsb pdb:7AKE|rcsb pdb:7AKL|reactome:R-HSA-1538133|rcsb pdb:6A1F|refseq:XP_016883773.1|refseq:NP_001334650.1|refseq:NP_001334651.1|dip:DIP-39750N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:1Y5lOF9SszLsUVauAnydhzUh7fM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H0E9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-769266|uniprotkb:O43178|uniprotkb:Q15355|uniprotkb:Q58AB0|uniprotkb:Q59GN0|uniprotkb:Q969M9|intact:EBI-28979295|ensembl:ENSP00000254900 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:brd8_human(display_long)|uniprotkb:p120(gene name synonym)|uniprotkb:Skeletal muscle abundant protein 2(gene name synonym)|uniprotkb:Skeletal muscle abundant protein(gene name synonym)|uniprotkb:Thyroid hormone receptor coactivating protein of 120 kDa(gene name synonym)|uniprotkb:BRD8(gene name)|psi-mi:BRD8(display_short)|uniprotkb:SMAP(gene name synonym)|uniprotkb:SMAP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001157798.1|refseq:NP_006687.3|refseq:NP_631938.1|ensembl:ENST00000230901|ensembl:ENSP00000230901|ensembl:ENSP00000254900|ensembl:ENST00000411594|ensembl:ENSP00000394330|refseq:NP_001287890.1|refseq:NP_001287891.1|refseq:NP_001287895.1|dip:DIP-31762N|ensembl:ENSG00000112983(gene)|ensembl:ENST00000254900(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016573"(histone acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|interpro:IPR001487(Bromodomain)|interpro:IPR036427|interpro:IPR037966|interpro:IPR038002|mint:Q9H0E9|reactome:R-HSA-3214847|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:RUJbvq7VAMg7fzpCT4Hs6/FPej49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00303 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P63173 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359141|uniprotkb:P23411|uniprotkb:B2R5A8|ensembl:ENSP00000309830|ensembl:ENSP00000390279|ensembl:ENSP00000434243 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rl38_human(display_long)|uniprotkb:RPL38(gene name)|psi-mi:RPL38(display_short)|uniprotkb:Large ribosomal subunit protein eL38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000990.1|refseq:NP_001030335.1|ensembl:ENSG00000172809(gene)|ensembl:ENST00000311111(transcript)|ensembl:ENST00000439590(transcript)|ensembl:ENST00000533498(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0033291"(eukaryotic 80S initiation complex)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0048318"(axial mesoderm development)|interpro:IPR002675(Ribosomal protein L38e)|interpro:IPR038464|mint:P63173|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:5AJ0|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6kUSGJll3ldTTRzgVTSwBjgV19Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P46060 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15907 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722234|uniprotkb:Q2YDT2|uniprotkb:Q8NI07|uniprotkb:B2R7I4|uniprotkb:D6W671|uniprotkb:A5YM50|uniprotkb:Q5U0I1|uniprotkb:Q6FHR0|uniprotkb:Q6FI42|uniprotkb:B4DMK0|ensembl:ENSP00000333547 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rb11b_human(display_long)|uniprotkb:GTP-binding protein YPT3(gene name synonym)|uniprotkb:RAB11B(gene name)|psi-mi:RAB11B(display_short)|uniprotkb:YPT3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004209.2|dip:DIP-50898N|ensembl:ENSG00000185236(gene)|ensembl:ENST00000328024(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033572"(transferrin transport)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001135"(regulation of endocytic recycling)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q15907|rcsb pdb:2F9L|rcsb pdb:2F9M|rcsb pdb:4OJK|reactome:R-HSA-8854214|reactome:R-HSA-8873719 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:+fsu7NPmd5fgoe0TE67IcISlscA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:E9PCT1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21264344|ensembl:ENSP00000391430 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:e9pct1_human(display_long)|uniprotkb:SRRM1(gene name)|psi-mi:SRRM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000447431(transcript)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR036483|ensembl:ENSG00000133226(gene) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:b/naZLZtbOLg29t9OBnBfZxNTgs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P63167 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-349105|uniprotkb:Q15701|ensembl:ENSP00000242577|ensembl:ENSP00000376296|ensembl:ENSP00000376297|ensembl:ENSP00000446614|ensembl:ENSP00000447907 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dyl1_human(display_long)|uniprotkb:DYNLL1(gene name)|psi-mi:DYNLL1(display_short)|uniprotkb:DLC1(gene name synonym)|uniprotkb:DNCLC1(gene name synonym)|uniprotkb:HDLC1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)|uniprotkb:DNCL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001032583.1|refseq:NP_001032584.1|refseq:NP_003737.1|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097542"(ciliary tip)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63167|rcsb pdb:1CMI|rcsb pdb:3ZKE|rcsb pdb:3ZKF|rcsb pdb:6GZJ|rcsb pdb:6GZL|rcsb pdb:6RLB|rcsb pdb:6SC2|rcsb pdb:7D35|reactome:R-HSA-111446|reactome:R-HSA-141444|reactome:R-HSA-1632852|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0060271"(cilium assembly)|go:"GO:0005829"(cytosol)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007286"(spermatid development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|ensembl:ENSG00000088986(gene)|ensembl:ENST00000242577(transcript)|ensembl:ENST00000392508(transcript)|ensembl:ENST00000392509(transcript)|ensembl:ENST00000548342(transcript)|ensembl:ENST00000549989(transcript)|dip:DIP-33150N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv809606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P82912 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2371859|uniprotkb:Q969D7|uniprotkb:Q96GI3|uniprotkb:Q9BYC3|uniprotkb:B2RD52|ensembl:ENSP00000317376 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rt11_human(display_long)|uniprotkb:MRPS11(gene name)|psi-mi:MRPS11(display_short)|uniprotkb:RPMS11(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 2 protein(gene name synonym)|uniprotkb:HCC2(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS11m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001308899.1|refseq:NP_001308901.1|refseq:NP_001308902.1|refseq:NP_001308903.1|refseq:NP_001308905.1|refseq:NP_073750.2|refseq:NP_789775.1|ensembl:ENSG00000181991(gene)|ensembl:ENST00000325844(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P82912|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aw3XzNBYY0igd4AUE1OQyfFn8pk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14203 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-724352|uniprotkb:O95296|uniprotkb:Q9BRM9|uniprotkb:Q9UIU1|intact:EBI-28971695|ensembl:ENSP00000487279|uniprotkb:Q9UIU2|uniprotkb:E9PGE1|uniprotkb:G5E9H4|uniprotkb:Q6IQ37|intact:EBI-2560059|uniprotkb:B4DM45|uniprotkb:E9PFS5|uniprotkb:A8MY36|intact:EBI-10962300 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dctn1_human(display_long)|uniprotkb:DCTN1(gene name)|psi-mi:DCTN1(display_short)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:p135(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001128512.1|refseq:NP_001128513.1|refseq:NP_001177766.1|refseq:NP_004073.2|refseq:NP_075408.1|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-381038|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|reactome:R-HSA-380259|ensembl:ENSG00000204843(gene)|ensembl:ENST00000628224(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007399"(nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048156"(tau protein binding)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0099558"(maintenance of synapse structure)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:Q14203|rcsb pdb:1TXQ|rcsb pdb:2COY|rcsb pdb:2HKN|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2HQH|rcsb pdb:3E2U|rcsb pdb:3TQ7|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|ensembl:ENST00000394003|ensembl:ENSP00000377571|ensembl:ENST00000409240|ensembl:ENSP00000386406|ensembl:ENST00000409438|ensembl:ENSP00000387270|ensembl:ENST00000409567|ensembl:ENSP00000386843|ensembl:ENSP00000487279|ensembl:ENST00000633691|ensembl:ENSP00000487724|refseq:NP_001177765.1|dip:DIP-31365N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PKchWdLWycCErGzSVMXq/xCQJRM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92922 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355653|uniprotkb:Q6P172|uniprotkb:Q8IWH2|uniprotkb:Q17RS0|ensembl:ENSP00000254480 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:smrc1_human(display_long)|uniprotkb:SMARCC1(gene name)|psi-mi:SMARCC1(display_short)|uniprotkb:BAF155(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1(gene name synonym)|uniprotkb:SWI/SNF complex 155 kDa subunit(gene name synonym)|uniprotkb:BRG1-associated factor 155(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003065.3|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR030087|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|mint:Q92922|rcsb pdb:2YUS|rcsb pdb:5GJK|rcsb pdb:6KZ7|rcsb pdb:6YXO|rcsb pdb:6YXP|reactome:R-HSA-3214858|reactome:R-HSA-8939243|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|ensembl:ENSG00000173473(gene)|ensembl:ENST00000254480(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0030850"(prostate gland development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|ensembl:ENSP00000254480|dip:DIP-27545N|dip:DIP-33044N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Uv0bjPkUICLtOXJcETUXDTLIQhY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35637 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P01024 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q53G59 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-740929|ensembl:ENSP00000356230|uniprotkb:A6NEN8|uniprotkb:B7Z7B8|uniprotkb:Q9HBX5 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:klh12_human(display_long)|uniprotkb:CUL3-interacting protein 1(gene name synonym)|uniprotkb:KLHL12(gene name)|psi-mi:KLHL12(display_short)|uniprotkb:C3IP1(gene name synonym)|uniprotkb:DKIR homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048208"(COPII vesicle coating)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|mint:Q53G59|rcsb pdb:2VPJ|rcsb pdb:6TTK|rcsb pdb:6V7O|reactome:R-HSA-4641258|refseq:NP_067646.1|ensembl:ENSG00000117153(gene)|ensembl:ENST00000367261(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0034451"(centriolar satellite)|refseq:NP_001289980.1|refseq:NP_001290038.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:C4I/Ys9vqNqfG61HsXRZhywP4vE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P36873 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356283|ensembl:ENSP00000335084 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NU22 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1050480|uniprotkb:O15019|uniprotkb:Q5T794|ensembl:ENSP00000358400|ensembl:ENSP00000486270|ensembl:ENSP00000499843|ensembl:ENSP00000499895 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mdn1_human(display_long)|uniprotkb:MIDAS-containing protein(gene name synonym)|uniprotkb:Dynein-related AAA-ATPase MDN1(gene name synonym)|uniprotkb:MDN1(gene name)|psi-mi:MDN1(display_short)|uniprotkb:KIAA0301(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055426.1|ensembl:ENSG00000112159(gene)|ensembl:ENSG00000288121(gene)|ensembl:ENST00000369393(transcript)|ensembl:ENST00000629399(transcript)|ensembl:ENST00000672983(transcript)|ensembl:ENST00000673332(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR012099(Midasin)|interpro:IPR027417|interpro:IPR036465|interpro:IPR040848|interpro:IPR041190|mint:Q9NU22|go:"GO:0005829"(cytosol) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:/LVYhffZVpP0pYVM6hLNltoc6pY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P47914 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-714039|uniprotkb:Q6IPY3|ensembl:ENSP00000418346|ensembl:ENSP00000418868|ensembl:ENSP00000420673|ensembl:ENSP00000294189|ensembl:ENSP00000417048|ensembl:ENSP00000418153|uniprotkb:B2R4M8|uniprotkb:A8K0H3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rl29_human(display_long)|uniprotkb:Cell surface heparin-binding protein HIP(gene name synonym)|uniprotkb:RPL29(gene name)|psi-mi:RPL29(display_short)|uniprotkb:Large ribosomal subunit protein eL29(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000294189(transcript)|ensembl:ENST00000466397(transcript)|ensembl:ENST00000475248(transcript)|ensembl:ENST00000479017(transcript)|ensembl:ENST00000492277(transcript)|ensembl:ENST00000495383(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007566"(embryo implantation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR002673(Ribosomal protein L29e)|mint:P47914|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|ensembl:ENSG00000162244(gene)|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000983.1|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:XZUSMDDzycAi6QEXYbljXaeVg0U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P43487 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBU8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-399246|uniprotkb:O95899|uniprotkb:Q5QTS1|uniprotkb:Q6NVX8|uniprotkb:Q86YT7|uniprotkb:Q9HBP6|uniprotkb:Q9NSW5|uniprotkb:B4DKN6|uniprotkb:D3DW88|ensembl:ENSP00000331310|uniprotkb:B7Z6R1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mo4l1_human(display_long)|uniprotkb:HSPC008(orf name)|uniprotkb:HSPC061(orf name)|uniprotkb:PP368(orf name)|uniprotkb:MORF4L1(gene name)|psi-mi:MORF4L1(display_short)|uniprotkb:MRG15(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym)|uniprotkb:Protein MSL3-1(gene name synonym)|uniprotkb:FWP006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006782.1|refseq:NP_996670.1|dip:DIP-29017N|refseq:NP_001252532.1|refseq:NP_001252533.1|refseq:NP_001252534.1|ensembl:ENSG00000185787(gene)|ensembl:ENST00000331268(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:Q9UBU8|rcsb pdb:2AQL|rcsb pdb:2EFI|rcsb pdb:2F5J|rcsb pdb:2F5K|rcsb pdb:2LKM|rcsb pdb:2N1D|rcsb pdb:6AGO|rcsb pdb:6INE|reactome:R-HSA-3214847 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:28GQifqUMxwR32cneTXH+lpW4gM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P41223 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3904603|uniprotkb:A4D274|uniprotkb:Q9UDV1|uniprotkb:D6W5S6|uniprotkb:Q6IB53|uniprotkb:B7Z4S9|ensembl:ENSP00000222969|ensembl:ENSP00000386023 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bud31_human(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:EDG2(gene name synonym)|uniprotkb:Protein EDG-2(gene name synonym)|uniprotkb:Protein G10 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003901.2|refseq:XP_005250727.1|refseq:XP_005250728.1|ensembl:ENSG00000106245(gene)|ensembl:ENST00000222969(transcript)|ensembl:ENST00000403633(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:2000825"(positive regulation of androgen receptor activity)|interpro:IPR001748(G10 protein)|interpro:IPR018230|mint:P41223|rcsb pdb:4OED|rcsb pdb:4OH6|rcsb pdb:4OKB|rcsb pdb:5MQF|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:5XJC|refseq:XP_005250731.1|refseq:XP_016868249.1|refseq:XP_016868250.1|refseq:XP_016868251.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:UvZolFUc5ec1HwwyxDf1rJHJ0zQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BXF3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11784677|uniprotkb:A8MS90|uniprotkb:A8MX16|uniprotkb:Q658Z4|uniprotkb:Q96P58|uniprotkb:Q9C0C3|intact:EBI-28986490|ensembl:ENSP00000341219 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cecr2_human(display_long)|uniprotkb:CECR2(gene name)|psi-mi:CECR2(display_short)|uniprotkb:KIAA1740(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001276975.1|refseq:NP_001276976.1|ensembl:ENST00000262608|ensembl:ENSP00000262608|ensembl:ENSP00000341219|ensembl:ENSG00000099954(gene)|ensembl:ENST00000342247(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0001842"(neural fold formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007338"(single fertilization)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0043044"|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0090102"(cochlea development)|go:"GO:0090537"(CERF complex)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR029614|interpro:IPR036427|rcsb pdb:3NXB|rcsb pdb:5V84 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Szvu1VhiNbCbF5gDgyDtkWNDnTE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62136 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P26641 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9ULD9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-15637608|ensembl:ENSP00000307746|ensembl:ENSP00000421899|uniprotkb:A7E2W9|uniprotkb:Q3SYM6|uniprotkb:Q68D12|uniprotkb:Q8IY05|uniprotkb:Q9Y5A1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zn608_human(display_long)|uniprotkb:ZNF608(gene name)|psi-mi:ZNF608(display_short)|uniprotkb:KIAA1281(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000168916(gene)|ensembl:ENST00000306315(transcript)|ensembl:ENST00000513986(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR040010|mint:Q9ULD9|ensembl:ENSP00000307746|ensembl:ENST00000504926|ensembl:ENSP00000427657|ensembl:ENSP00000421899|refseq:NP_065798.2|refseq:XP_005272094.1|refseq:XP_005272095.1|dip:DIP-29419N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Zh0o9HcH3q3xBtISrHQz2LOS7kI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62873 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P50402 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N3R9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P02545 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NP92 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6393499|ensembl:ENSP00000424328|uniprotkb:Q96I91|uniprotkb:Q96Q19|uniprotkb:Q9H0P8|uniprotkb:Q9NSF9|uniprotkb:Q9NZ76 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rt30_human(display_long)|uniprotkb:MRPS30(gene name)|psi-mi:MRPS30(display_short)|uniprotkb:PDCD9(gene name synonym)|uniprotkb:Programmed cell death protein 9(gene name synonym)|uniprotkb:BM-047(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mS30(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL65(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000112996(gene)|ensembl:ENST00000507110(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|interpro:IPR010793(Ribosomal protein S30, mitochondrial)|interpro:IPR039982|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_057724.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:AyFqyCMR1Poix/xU7k195b8D+hw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P28074 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357828|uniprotkb:Q16242|uniprotkb:Q6PEW2|intact:EBI-1237472|uniprotkb:Q7Z3B5|uniprotkb:Q9TNN9|uniprotkb:B2R4N9|uniprotkb:D3DS43|uniprotkb:B4DUM9|uniprotkb:Q86T01|uniprotkb:E9PAV2|ensembl:ENSP00000355325 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psb5_human(display_long)|uniprotkb:PSMB5(gene name)|psi-mi:PSMB5(display_short)|uniprotkb:LMPX(gene name synonym)|uniprotkb:Proteasome epsilon chain(gene name synonym)|uniprotkb:Macropain epsilon chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex epsilon chain(gene name synonym)|uniprotkb:Proteasome subunit X(gene name synonym)|uniprotkb:Proteasome chain 6(gene name synonym)|uniprotkb:Proteasome subunit MB1(gene name synonym)|uniprotkb:MB1(gene name synonym)|uniprotkb:X(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124197.1|refseq:NP_001138404.1|refseq:NP_002788.1|dip:DIP-27540N|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610785|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|ensembl:ENSG00000100804(gene)|ensembl:ENST00000361611(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR037558|mint:P28074|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:73T59wniLri/465F3BhBvwL1/LM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NFQ8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-524567|ensembl:ENSP00000356584|ensembl:ENSP00000477486 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:toip2_human(display_long)|uniprotkb:Lumenal domain-like LAP1(gene name synonym)|uniprotkb:TOR1AIP2(gene name)|psi-mi:TOR1AIP2(display_short)|uniprotkb:LULL1(gene name synonym)|uniprotkb:IFRG15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_005244996.1|interpro:IPR008662(Lamina-associated polypeptide 1C)|ensembl:ENSG00000169905(gene)|ensembl:ENST00000367612(transcript)|ensembl:ENST00000609928(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0090435"(protein localization to nuclear envelope)|refseq:XP_016855963.1|refseq:XP_016855964.1|refseq:NP_001186189.1|refseq:NP_659471.1|interpro:IPR038599|rcsb pdb:5J1S|rcsb pdb:5J1T - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HjY3sLjzR1jmKq2EqIKRvY3GxKc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O96019 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355018|uniprotkb:Q8TAE5|uniprotkb:Q9BVS8|uniprotkb:Q9H0W6|uniprotkb:B3KMN1|uniprotkb:D3DNR9|ensembl:ENSP00000397552 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:acl6a_human(display_long)|uniprotkb:53 kDa BRG1-associated factor A(gene name synonym)|uniprotkb:Actin-related protein Baf53a(gene name synonym)|uniprotkb:ArpNbeta(gene name synonym)|uniprotkb:BAF53A(gene name synonym)|uniprotkb:ACTL6A(gene name)|psi-mi:ACTL6A(display_short)|uniprotkb:BAF53(gene name synonym)|uniprotkb:INO80K(gene name synonym)|uniprotkb:INO80 complex subunit K(gene name synonym)|uniprotkb:BRG1-associated factor 53A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004292.1|refseq:NP_817126.1|refseq:NP_829888.1|ensembl:ENSG00000136518(gene)|ensembl:ENST00000429709(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003407"(neural retina development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0021510"(spinal cord development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043044"|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0071564"(npBAF complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR043129|mint:O96019|rcsb pdb:6LTJ|reactome:R-HSA-3214847|reactome:R-HSA-3214858|go:"GO:0000785"(chromatin)|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-8939243|ensembl:ENST00000392662|ensembl:ENSP00000376430|ensembl:ENSP00000397552|ensembl:ENST00000450518|ensembl:ENSP00000394014|dip:DIP-27565N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FV8zvQxf2aeHbwFNUpo9JOpj5U49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H7B2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1051960|uniprotkb:Q8N4A1|uniprotkb:Q5VXN1|ensembl:ENSP00000402338 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rpf2_human(display_long)|uniprotkb:RPF2(gene name)|psi-mi:RPF2(display_short)|uniprotkb:BXDC1(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF2 homolog(gene name synonym)|uniprotkb:Brix domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115570.1|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007109(Brix)|interpro:IPR039770|mint:Q9H7B2|ensembl:ENSG00000197498(gene)|ensembl:ENST00000441448(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)") - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:CXU4CHQmcrISLS8GDIwEMGhiaQI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NWB6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2808785|uniprotkb:B4E0Y3|uniprotkb:Q6IQ34|uniprotkb:Q5T257|ensembl:ENSP00000383059 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:argl1_human(display_long)|uniprotkb:ARGLU1(gene name)|psi-mi:ARGLU1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060481.3|ensembl:ENSG00000134884(gene)|ensembl:ENST00000400198(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0045296"(cadherin binding)|interpro:IPR033371 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tZ/PMMjPF72fu4NqFOfhHWB0QWM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9P2R6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-948076|uniprotkb:O43393|uniprotkb:O75046|uniprotkb:O75359|uniprotkb:Q5VXL9|uniprotkb:Q6P6B9|uniprotkb:Q9Y2W4|ensembl:ENSP00000338629|ensembl:ENSP00000383700 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rere_human(display_long)|uniprotkb:Atrophin-1-related protein(gene name synonym)|uniprotkb:Atrophin-1-like protein(gene name synonym)|uniprotkb:RERE(gene name)|psi-mi:RERE(display_short)|uniprotkb:ARG(gene name synonym)|uniprotkb:ARP(gene name synonym)|uniprotkb:ATN1L(gene name synonym)|uniprotkb:KIAA0458(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001036146.1|refseq:NP_001036147.1|refseq:NP_036234.3|refseq:XP_005263521.1|refseq:XP_016856847.1|refseq:XP_016856848.1|dip:DIP-47606N|ensembl:ENSG00000142599(gene)|ensembl:ENST00000337907(transcript)|ensembl:ENST00000400908(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR002951(Atrophin)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|mint:Q9P2R6|rcsb pdb:2YQK - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fryo3nxpHdcexG2dqy00t0n4Nlw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y448 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-373334|uniprotkb:Q147U5|uniprotkb:Q32Q57|uniprotkb:Q5ISJ0|uniprotkb:Q6P2S5|uniprotkb:Q6PJM0|uniprotkb:Q86XB4|uniprotkb:B4DXA7|ensembl:ENSP00000249776|intact:EBI-2555320 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:skap_human(display_long)|uniprotkb:KNSTRN(gene name)|psi-mi:KNSTRN(display_short)|uniprotkb:C15orf23(gene name synonym)|uniprotkb:Kinetochore-localized astrin-binding protein(gene name synonym)|uniprotkb:Kinetochore-localized astrin/SPAG5-binding protein(gene name synonym)|uniprotkb:SKAP(gene name synonym)|uniprotkb:TRAF4-associated factor 1(gene name synonym)|uniprotkb:TRAF4AF1(gene name synonym)|uniprotkb:HSD11(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001136233.1|refseq:NP_001136234.1|refseq:NP_150628.3|ensembl:ENSG00000128944(gene)|ensembl:ENST00000249776(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|dip:DIP-31247N|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0001726"(ruffle)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016477"(cell migration)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072686"(mitotic spindle)|interpro:IPR033373 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:48DI5G7v8vAeEMOZpyhAOcmFhc49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P12268 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-353389|uniprotkb:Q6LEF3|ensembl:ENSP00000321584 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:imdh2_human(display_long)|uniprotkb:IMPDH2(gene name)|psi-mi:IMPDH2(display_short)|uniprotkb:IMPD2(gene name synonym)|uniprotkb:Inosine-5'-monophosphate dehydrogenase type II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000875.2|ensembl:ENSG00000178035(gene)|ensembl:ENST00000326739(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)|mint:P12268|rcsb pdb:1B3O|rcsb pdb:1NF7|rcsb pdb:1NFB|rcsb pdb:6I0M|rcsb pdb:6I0O|rcsb pdb:6U8E|rcsb pdb:6U8N|rcsb pdb:6U8R|rcsb pdb:6U8S|rcsb pdb:6U9O|rcsb pdb:6UA2|rcsb pdb:6UA4|rcsb pdb:6UA5|rcsb pdb:6UAJ|rcsb pdb:6UC2|rcsb pdb:6UDO|rcsb pdb:6UDP|rcsb pdb:6UDQ|reactome:R-HSA-6798695|reactome:R-HSA-73817|reactome:R-HSA-9679191 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qGPwBxhEgtYik3OetHZbpyktoLE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BRT8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054417|uniprotkb:A2RU55|uniprotkb:Q49AJ1|uniprotkb:Q5VVK2|uniprotkb:Q6VBU6|uniprotkb:Q7Z5Z0|uniprotkb:Q7Z652|uniprotkb:Q9BY38|uniprotkb:Q9NYD0|uniprotkb:B0AZR4|uniprotkb:A8K3N3|ensembl:ENSP00000348915|ensembl:ENSP00000366617 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cbwd1_human(display_long)|uniprotkb:Cobalamin synthase W domain-containing protein 1(gene name synonym)|uniprotkb:NPC-A-6 COBW domain-containing protein 1(gene name synonym)|uniprotkb:CBWD1(gene name)|psi-mi:CBWD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001138827.1|refseq:NP_001138828.1|refseq:NP_060961.3|ensembl:ENSG00000172785(gene)|ensembl:ENST00000356521(transcript)|ensembl:ENST00000377400(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR003495("Cobalamin (vitamin B12) biosynthesis CobW-like")|interpro:IPR011629("Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal")|interpro:IPR027417|interpro:IPR036627 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DfI5wHHX8Rmk+dKB/oW+68ImtcE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:B4DLN1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11028706|ensembl:ENSP00000461324 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:b4dln1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000262660(gene)|ensembl:ENST00000571730(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|interpro:IPR000206(Ribosomal protein L7/L12)|interpro:IPR002030(Mitochondrial brown fat uncoupling protein)|interpro:IPR008932(Ribosomal protein L7/L12, oligomerisation)|interpro:IPR013823(Ribosomal protein L7/L12, C-terminal)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR018108|interpro:IPR023395|interpro:IPR036235 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ONQ1ByBu5w5LjNK6o/VoUQ6HsN89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P07195 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P84090 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711389|uniprotkb:P70659|uniprotkb:Q14259|ensembl:ENSP00000451080|uniprotkb:B2R5H2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:erh_human(display_long)|uniprotkb:ERH(gene name)|psi-mi:ERH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100632(gene)|ensembl:ENST00000557016(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006213"(pyrimidine nucleoside metabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0030496"(midbody)|go:"GO:0034709"(methylosome)|interpro:IPR000781(Enhancer of rudimentary)|interpro:IPR035912|mint:P84090|rcsb pdb:1W9G|rcsb pdb:2NML|rcsb pdb:7CNC|refseq:NP_004441.1|dip:DIP-42473N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:foMOmvZ9wQyH0rrzBB2YlQhrT0g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P02786 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6DN90 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3044091|uniprotkb:Q96D85|uniprotkb:O94863|uniprotkb:A0A087WWK8|ensembl:ENSP00000273221 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:iqec1_human(display_long)|uniprotkb:IQSEC1(gene name)|psi-mi:IQSEC1(display_short)|uniprotkb:ARFGEP100(gene name synonym)|uniprotkb:BRAG2(gene name synonym)|uniprotkb:KIAA0763(gene name synonym)|uniprotkb:ADP-ribosylation factors guanine nucleotide-exchange protein 100(gene name synonym)|uniprotkb:ADP-ribosylation factors guanine nucleotide-exchange protein 2(gene name synonym)|uniprotkb:Brefeldin-resistant Arf-GEF 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055684.3|refseq:NP_001317548.1|refseq:NP_001127854.1|refseq:XP_011532617.1|ensembl:ENSG00000144711(gene)|ensembl:ENST00000273221(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0060996"(dendritic spine development)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR030737|interpro:IPR033742|interpro:IPR035999|rcsb pdb:3QWM|rcsb pdb:4C0A|rcsb pdb:5NLV|rcsb pdb:5NLY|rcsb pdb:6FNE - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IOpjszM2OA5kfLxShJv1S6+sANI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8IYB5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-9515558|uniprotkb:Q53H70|uniprotkb:Q5SYQ2|uniprotkb:Q6PK24|uniprotkb:Q8NDH4|uniprotkb:Q96L38|uniprotkb:Q96L39|uniprotkb:Q9H8X4|ensembl:ENSP00000359484 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:smap1_human(display_long)|uniprotkb:SMAP1(gene name)|psi-mi:SMAP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001037770.1|refseq:NP_001268368.1|refseq:NP_001268369.1|refseq:NP_068759.2|ensembl:ENSG00000112305(gene)|ensembl:ENST00000370455(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030276"(clathrin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|interpro:IPR044732|rcsb pdb:2CRR - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ekCA410aJA1XA4kedxUuB0VoGLI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5T3I0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2372076|uniprotkb:Q5T3I1|uniprotkb:Q6ZUE7|uniprotkb:Q8IWG8|uniprotkb:Q9NXH4 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gptc4_human(display_long)|uniprotkb:GPATCH4(gene name)|psi-mi:GPATCH4(display_short)|uniprotkb:GPATC4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR000467(D111/G-patch)|mint:Q5T3I0|go:"GO:0003723"(RNA binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:R2hFHYGQh2jmLbLg+BNATVimtNA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92545 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2681976|ensembl:ENSP00000186436 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tm131_human(display_long)|uniprotkb:KIAA0257(gene name synonym)|uniprotkb:RW1(gene name synonym)|uniprotkb:Protein RW1(gene name synonym)|uniprotkb:TMEM131(gene name)|psi-mi:TMEM131(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056163.1|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR022113|interpro:IPR039877|ensembl:ENSG00000075568(gene)|ensembl:ENST00000186436(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wTdksy19YsrD0HErJMPgrldzwTg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15014 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-399257|uniprotkb:B3KP92|uniprotkb:Q567V0|uniprotkb:Q8J026|uniprotkb:D3DXA5|ensembl:ENSP00000353643|ensembl:ENSP00000391969|ensembl:ENSP00000410532|ensembl:ENSP00000415476 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mo4l2_human(display_long)|uniprotkb:MORF4L2(gene name)|psi-mi:MORF4L2(display_short)|uniprotkb:KIAA0026(gene name synonym)|uniprotkb:MRGX(gene name synonym)|uniprotkb:MORF-related gene X protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRGX(gene name synonym)|uniprotkb:Protein MSL3-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001135894.1|refseq:NP_001135895.1|refseq:NP_001135896.1|refseq:NP_001135897.1|refseq:NP_001135898.1|refseq:NP_001135899.1|refseq:NP_001135900.1|refseq:NP_001135901.1|refseq:NP_001135902.1|refseq:NP_001135903.1|refseq:NP_001135904.1|refseq:NP_036418.1|refseq:NP_001135890.1|refseq:NP_001135891.1|refseq:NP_001135892.1|refseq:NP_001135893.1|ensembl:ENSG00000123562(gene)|ensembl:ENST00000360458(transcript)|ensembl:ENST00000433176(transcript)|ensembl:ENST00000441076(transcript)|ensembl:ENST00000451301(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR008676(MRG)|interpro:IPR026541|interpro:IPR038012|interpro:IPR038217|mint:Q15014|reactome:R-HSA-3214847 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7SlnJWNVhfdzirTHBEseWbJQjyU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:E7EMK3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-4324570|ensembl:ENSP00000378366 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:e7emk3_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000132589(gene)|ensembl:ENST00000394906(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:inO0D/kla3D3I6lEZTPji5R38ko9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96S52 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2908273|uniprotkb:Q6UVX6|ensembl:ENSP00000309430 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pigs_human(display_long)|uniprotkb:PIGS(gene name)|psi-mi:PIGS(display_short)|uniprotkb:Phosphatidylinositol-glycan biosynthesis class S protein(gene name synonym)|uniprotkb:UNQ1873/PRO4316(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000087111(gene)|ensembl:ENST00000308360(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016255"(attachment of GPI anchor to protein)|go:"GO:0042765"(GPI-anchor transamidase complex)|interpro:IPR019540|reactome:R-HSA-162791|refseq:NP_149975.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:X+q1ME1DzmszMrPZZ4kjsUrFhGs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBV2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5M775 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-350473|uniprotkb:Q5IBP1|uniprotkb:Q5IBP2|uniprotkb:Q5IBP3|uniprotkb:Q5IBP4|uniprotkb:Q5M772|uniprotkb:Q5M773|uniprotkb:Q5M774|uniprotkb:Q86XT8|uniprotkb:Q8N4U4|uniprotkb:Q8WU84|uniprotkb:Q9HCQ3|uniprotkb:B4DHH0|ensembl:ENSP00000261503|ensembl:ENSP00000378898|ensembl:ENSP00000502924|ensembl:ENSP00000503971|ensembl:ENSP00000504211|uniprotkb:B7WNS8|intact:EBI-2556892 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cytsb_human(display_long)|uniprotkb:Nuclear structure protein 5(gene name synonym)|uniprotkb:Sperm antigen HCMOGT-1(gene name synonym)|uniprotkb:SPECC1(gene name)|psi-mi:SPECC1(display_short)|uniprotkb:CYTSB(gene name synonym)|uniprotkb:Sperm antigen with calponin homology and coiled-coil domains 1(gene name synonym)|uniprotkb:NSP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001028725.1|refseq:NP_001028726.1|refseq:NP_001028727.1|refseq:NP_001230367.1|refseq:NP_001230368.1|refseq:NP_690868.3|ensembl:ENSG00000128487(gene)|ensembl:ENST00000261503(transcript)|ensembl:ENST00000395527(transcript)|ensembl:ENST00000677914(transcript)|ensembl:ENST00000679058(transcript)|ensembl:ENST00000679255(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR036872|mint:Q5M775|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_016880814.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:iF+19RpfJDyn5whTFnPmDxxECz09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q08945 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-353771|uniprotkb:Q5BJG8|ensembl:ENSP00000278412 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ssrp1_human(display_long)|uniprotkb:SSRP1(gene name)|psi-mi:SSRP1(display_short)|uniprotkb:FACT80(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SSRP1(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex 80 kDa subunit(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 80 kDa subunit(gene name synonym)|uniprotkb:Structure-specific recognition protein 1(gene name synonym)|uniprotkb:Recombination signal sequence recognition protein 1(gene name synonym)|uniprotkb:T160(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003137.1|ensembl:ENSG00000149136(gene)|ensembl:ENST00000278412(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035101"(FACT complex)|go:"GO:0042393"(histone binding)|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000969(Structure-specific recognition protein)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR024954|interpro:IPR035417|interpro:IPR036910|interpro:IPR038167|mint:Q08945|rcsb pdb:4IFS|rcsb pdb:5UMR|rcsb pdb:5UMS|rcsb pdb:5VWE|rcsb pdb:6L1E|rcsb pdb:6L1R|rcsb pdb:6L34|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|dip:DIP-169N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WmdGVZadHdcS6Nk9SI41xKm+OrU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P40939 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P61163 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-774234|uniprotkb:P42024|uniprotkb:B2R6B0|ensembl:ENSP00000358921 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:actz_human(display_long)|uniprotkb:Centrosome-associated actin homolog(gene name synonym)|uniprotkb:Actin-RPV(gene name synonym)|uniprotkb:ARP1(gene name synonym)|uniprotkb:ACTR1A(gene name)|psi-mi:ACTR1A(display_short)|uniprotkb:CTRN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005727.1|ensembl:ENSG00000138107(gene)|ensembl:ENST00000369905(transcript)|go:"GO:0002177"(manchette)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P61163|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aJHKOSj1qmZ7Pk8aZAyWWd8DEdw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P00367 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356544|uniprotkb:Q5TBU3|ensembl:ENSP00000277865|uniprotkb:B3KV55|uniprotkb:B4DGN5 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dhe3_human(display_long)|uniprotkb:GLUD1(gene name)|psi-mi:GLUD1(display_short)|uniprotkb:GLUD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000148672(gene)|ensembl:ENST00000277865(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0042802"(identical protein binding)|refseq:NP_005262.1|refseq:NP_001305829.1|refseq:NP_001305830.1|refseq:NP_001305831.1|refseq:NP_001305833.1|refseq:NP_001305834.1|refseq:NP_001305835.1|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|mint:P00367|rcsb pdb:1L1F|rcsb pdb:1NR1|rcsb pdb:6DQG|reactome:R-HSA-2151201|reactome:R-HSA-8964539 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:rWYi7otiOLlUvfEl7Vy6ELkY+BM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y4W6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8WZ42 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14527 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045161|uniprotkb:Q14536|uniprotkb:Q16051|uniprotkb:Q7KYJ6|uniprotkb:Q86YA5|uniprotkb:Q92652|uniprotkb:Q96KM9|uniprotkb:D3DNH3|ensembl:ENSP00000308944|ensembl:ENSP00000376644|ensembl:ENSP00000420429 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hltf_human(display_long)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2-like 3(gene name synonym)|uniprotkb:DNA-binding protein/plasminogen activator inhibitor 1 regulator(gene name synonym)|uniprotkb:HIP116(gene name synonym)|uniprotkb:RING finger protein 80(gene name synonym)|uniprotkb:HLTF(gene name)|psi-mi:HLTF(display_short)|uniprotkb:HIP116A(gene name synonym)|uniprotkb:RNF80(gene name synonym)|uniprotkb:SNF2L3(gene name synonym)|uniprotkb:ZBU1(gene name synonym)|uniprotkb:SMARCA3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HLTF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001305863.1|refseq:NP_001305864.1|refseq:NP_003062.2|refseq:NP_620636.1|refseq:XP_016862568.1|dip:DIP-29828N|ensembl:ENSG00000071794(gene)|ensembl:ENST00000310053(transcript)|ensembl:ENST00000392912(transcript)|ensembl:ENST00000494055(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014905(HIRAN)|interpro:IPR017907|interpro:IPR027417|interpro:IPR038718|mint:Q14527|rcsb pdb:2MZN|rcsb pdb:4HRE|rcsb pdb:4HRH|rcsb pdb:4S0N|rcsb pdb:4XZF|rcsb pdb:4XZG|rcsb pdb:5BNH|rcsb pdb:5K5F|rcsb pdb:6KCS|reactome:R-HSA-8866654 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ozxGwYPSrDJ+Fg3F64VfE0Bc0wM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8ND56 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1384320|uniprotkb:Q76LX7|uniprotkb:Q96AR3|uniprotkb:Q96K73|uniprotkb:Q96SN5|uniprotkb:Q9UFR3|intact:EBI-2563702|uniprotkb:B4DTG6|ensembl:ENSP00000413964|ensembl:ENSP00000459843 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ls14a_human(display_long)|uniprotkb:C19orf13(gene name synonym)|uniprotkb:FAM61A(gene name synonym)|uniprotkb:Protein SCD6 homolog(gene name synonym)|uniprotkb:Protein FAM61A(gene name synonym)|uniprotkb:Putative alpha-synuclein-binding protein(gene name synonym)|uniprotkb:LSM14A(gene name)|psi-mi:LSM14A(display_short)|uniprotkb:RAP55(gene name synonym)|uniprotkb:RAP55A(gene name synonym)|uniprotkb:RNA-associated protein 55A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001107565.1|refseq:NP_056393.2|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025761|interpro:IPR025762|interpro:IPR025768|mint:Q8ND56|rcsb pdb:6F9W|ensembl:ENSG00000257103(gene)|ensembl:ENSG00000262860(gene)|ensembl:ENST00000433627(transcript)|ensembl:ENST00000570462(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YW/zx4XyhcZZr3WCZIr1OVpyakA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q04637 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96P70 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P20340 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15392 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-5457558|uniprotkb:B7Z817|ensembl:ENSP00000360316|ensembl:ENSP00000416585|uniprotkb:D3DQ51|uniprotkb:Q9HBA8|intact:EBI-10964490 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dhc24_human(display_long)|uniprotkb:DHCR24(gene name)|psi-mi:DHCR24(display_short)|uniprotkb:KIAA0018(gene name synonym)|uniprotkb:24-dehydrocholesterol reductase(gene name synonym)|uniprotkb:Diminuto/dwarf1 homolog(gene name synonym)|uniprotkb:Seladin-1(gene name synonym)|uniprotkb:3-beta-hydroxysterol Delta-24-reductase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000116133(gene)|ensembl:ENST00000371269(transcript)|ensembl:ENST00000436604(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016628"(oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0050614"(delta24-sterol reductase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061024"(membrane organization)|go:"GO:0071949"(FAD binding)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016166(FAD-binding, type 2)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR040165|go:"GO:0005737"(cytoplasm)|mint:Q15392|reactome:R-HSA-6807047|reactome:R-HSA-6807062|refseq:NP_055577.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:kg8bxZHxFFTUmvP9UQMeVFRNWQM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00264 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00311 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-374980|uniprotkb:O00558|uniprotkb:Q5T5U5|ensembl:ENSP00000234626|ensembl:ENSP00000393139|uniprotkb:D3DT31 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cdc7_human(display_long)|uniprotkb:CDC7(gene name)|psi-mi:CDC7(display_short)|uniprotkb:CDC7L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) rcsb pdb:5UWR|rcsb pdb:6YA6|rcsb pdb:6YA7|rcsb pdb:6YA8|reactome:R-HSA-176187|reactome:R-HSA-68962|reactome:R-HSA-8953750|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00311|rcsb pdb:4F99|rcsb pdb:4F9A|rcsb pdb:4F9B|rcsb pdb:4F9C|rcsb pdb:5UWQ|ensembl:ENSG00000097046(gene)|ensembl:ENST00000234626(transcript)|ensembl:ENST00000428239(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|refseq:NP_001127891.1|refseq:NP_001127892.1|refseq:NP_003494.1|refseq:XP_005271298.1|dip:DIP-31728N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:p5yHRwdn0crHmH8EXAFyM5R0xwM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P29401 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1050560|uniprotkb:Q8TBA3|uniprotkb:Q96HH3|uniprotkb:A8K089|uniprotkb:B4DE31|uniprotkb:E7EPA7|ensembl:ENSP00000405455|ensembl:ENSP00000417773|intact:EBI-11110174 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tkt_human(display_long)|uniprotkb:TKT(gene name)|psi-mi:TKT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001055.1|refseq:NP_001128527.1|refseq:NP_001244957.1|ensembl:ENSG00000163931(gene)|ensembl:ENST00000423525(transcript)|ensembl:ENST00000462138(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004802"(transketolase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0016604"(nuclear body)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0031982"(vesicle)|go:"GO:0040008"(regulation of growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|go:"GO:0046390"(ribose phosphate biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005474(Transketolase, N-terminal)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR020826|interpro:IPR029061|interpro:IPR033248|mint:P29401|rcsb pdb:3MOS|rcsb pdb:3OOY|rcsb pdb:4KXU|rcsb pdb:4KXV|rcsb pdb:4KXW|rcsb pdb:4KXX|rcsb pdb:4KXY|rcsb pdb:6HA3|rcsb pdb:6HAD|rcsb pdb:6RJB|reactome:R-HSA-163754|reactome:R-HSA-71336|refseq:XP_011532356.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Z3Ad5GdEd0rFCT9uHv85N+2KAAY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43819 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357012|uniprotkb:Q3T1B5|uniprotkb:Q9UK87|ensembl:ENSP00000252785|ensembl:ENSP00000379046|ensembl:ENSP00000444242|ensembl:ENSP00000444433 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sco2_human(display_long)|uniprotkb:SCO2(gene name)|psi-mi:SCO2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001162580.1|refseq:NP_001162581.1|refseq:NP_001162582.1|refseq:NP_005129.2|dip:DIP-46088N|go:"GO:0003012"(muscle system process)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0014823"(response to activity)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|mint:O43819|rcsb pdb:2RLI|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000284194(gene)|ensembl:ENST00000252785(transcript)|ensembl:ENST00000395693(transcript)|ensembl:ENST00000535425(transcript)|ensembl:ENST00000543927(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001701"(in utero embryonic development) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:RaD9DPaOnFKJvwNRUK9KQdptmqc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H307 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-681904|uniprotkb:Q9UQR9|uniprotkb:O60899|uniprotkb:Q53EM7|uniprotkb:Q6P5X4|uniprotkb:Q7KYL1|uniprotkb:Q99738|uniprotkb:Q9UHZ9|uniprotkb:B4DZX8|ensembl:ENSP00000216832 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pinin_human(display_long)|uniprotkb:140 kDa nuclear and cell adhesion-related phosphoprotein(gene name synonym)|uniprotkb:Domain-rich serine protein(gene name synonym)|uniprotkb:Melanoma metastasis clone A protein(gene name synonym)|uniprotkb:Desmosome-associated protein(gene name synonym)|uniprotkb:SR-like protein(gene name synonym)|uniprotkb:Nuclear protein SDK3(gene name synonym)|uniprotkb:PNN(gene name)|psi-mi:PNN(display_short)|uniprotkb:DRS(gene name synonym)|uniprotkb:MEMA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002678.2|dip:DIP-32950N|ensembl:ENSG00000100941(gene)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030057"(desmosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR006786(Pinin/SDK/memA protein)|interpro:IPR006787(Pinin/SDK)|interpro:IPR039853|mint:Q9H307|ensembl:ENST00000216832(transcript) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:1pAhD0z8tks+HkWaYWkdMmSjk3s9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P07197 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1105035|ensembl:ENSP00000221166|uniprotkb:Q4QRK6|uniprotkb:B4DGN2|uniprotkb:E9PBF7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nfm_human(display_long)|uniprotkb:NEFM(gene name)|psi-mi:NEFM(display_short)|uniprotkb:NEF3(gene name synonym)|uniprotkb:NFM(gene name synonym)|uniprotkb:Neurofilament triplet M protein(gene name synonym)|uniprotkb:160 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097418"(neurofibrillary tangle)|interpro:IPR002957(Keratin, type I)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027697|interpro:IPR039008|ensembl:ENSG00000104722(gene)|ensembl:ENST00000221166(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005883"(neurofilament)|go:"GO:0008017"(microtubule binding)|go:"GO:0030424"(axon)|go:"GO:0033693"(neurofilament bundle assembly)|refseq:NP_005373.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:dHWWqVqLrWoJXAH3BHzBeqyYJEE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13409 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NDQ6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103264|ensembl:ENSP00000324598|ensembl:ENSP00000343768|ensembl:ENSP00000466274|uniprotkb:A0AVS5|uniprotkb:A8K371|uniprotkb:Q05D58|uniprotkb:Q3LIC5|uniprotkb:Q6ZN36|uniprotkb:Q7Z3C8|uniprotkb:Q86T31 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zn540_human(display_long)|uniprotkb:ZNF540(gene name)|psi-mi:ZNF540(display_short)|uniprotkb:Nbla10512(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000171817(gene)|ensembl:ENST00000316433(transcript)|ensembl:ENST00000343599(transcript)|ensembl:ENST00000592533(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|refseq:NP_001165696.1|refseq:NP_001165697.1|refseq:NP_689819.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FENZseJr8egsRLj1CE4XrGUqMzU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13123 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HAF1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-399266|uniprotkb:B1AK64|uniprotkb:Q4F967|uniprotkb:Q7Z311|uniprotkb:Q86WE3|ensembl:ENSP00000296214 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:eaf6_human(display_long)|uniprotkb:Sarcoma antigen NY-SAR-91(gene name synonym)|uniprotkb:MEAF6(gene name)|psi-mi:MEAF6(display_short)|uniprotkb:EAF6(gene name synonym)|uniprotkb:Esa1-associated factor 6 homolog(gene name synonym)|uniprotkb:C1orf149(gene name synonym)|uniprotkb:CENP-28(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001257804.1|refseq:NP_073593.2|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0043972"(histone H3-K23 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:1990467"(NuA3a histone acetyltransferase complex)|go:"GO:1990468"(NuA3b histone acetyltransferase complex)|interpro:IPR015418(Histone H4 acetyltransferase, NuA4 complex, Eaf6)|mint:Q9HAF1|reactome:R-HSA-3214847|reactome:R-HSA-6804758|ensembl:ENSG00000163875(gene)|ensembl:ENST00000296214(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_001257805.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:v0eU3uwnLihcUQhLKYma3WIhofk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TCJ2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2256290|uniprotkb:Q96JZ4|uniprotkb:Q96KY7|ensembl:ENSP00000295770 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:stt3b_human(display_long)|uniprotkb:STT3B(gene name)|psi-mi:STT3B(display_short)|uniprotkb:SIMP(gene name synonym)|uniprotkb:Source of immunodominant MHC-associated peptides homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_849193.1|ensembl:ENSG00000163527(gene)|ensembl:ENST00000295770(transcript)|go:"GO:0004579"(dolichyl-diphosphooligosaccharide-protein glycotransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034998"(oligosaccharyltransferase I complex)|go:"GO:0043686"(co-translational protein modification)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0046872"(metal ion binding)|interpro:IPR003674(Oligosaccharyl transferase, STT3 subunit)|mint:Q8TCJ2|rcsb pdb:6S7T - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4F+9LbIZTFRoczuphd1jzuhnFDo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BYJ9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1051237|uniprotkb:Q8N3G5|uniprotkb:Q8TBT1|uniprotkb:Q96AN4|uniprotkb:Q96S57|uniprotkb:Q9BTI7|uniprotkb:Q9NX79|ensembl:ENSP00000359364 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ythd1_human(display_long)|uniprotkb:Dermatomyositis associated with cancer putative autoantigen 1(gene name synonym)|uniprotkb:YTHDF1(gene name)|psi-mi:YTHDF1(display_short)|uniprotkb:C20orf21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060268.2|ensembl:ENSG00000149658(gene)|ensembl:ENST00000370339(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002376"(immune system process)|go:"GO:0002577"(regulation of antigen processing and presentation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q9BYJ9|rcsb pdb:4RCI|rcsb pdb:4RCJ - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:uzNKPfwF7I+6hLk6l8iiDOhuBcQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P48643 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BWJ5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2555428|uniprotkb:Q7RTV1|uniprotkb:B2R568|ensembl:ENSP00000356541 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sf3b5_human(display_long)|uniprotkb:SF3B10(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 10 kDa subunit(gene name synonym)|uniprotkb:SF3B5(gene name)|psi-mi:SF3B5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_112577.1|ensembl:ENSG00000169976(gene)|ensembl:ENST00000367569(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR009846(Splicing factor 3B subunit 5/RDS3 complex subunit 10)|interpro:IPR017089(Splicing factor 3B, subunit 5)|mint:Q9BWJ5|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5Z56|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5Z57 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wuQBsSytGhSg64IQSmEJXe+26zQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75970 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P56524 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EJhE8LikofmF9H8ubNsola4pSpc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P49207 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1051893|uniprotkb:Q6FG66|uniprotkb:Q9BUZ2|ensembl:ENSP00000378160|ensembl:ENSP00000378162|ensembl:ENSP00000378163|ensembl:ENSP00000423316|ensembl:ENSP00000423983 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rl34_human(display_long)|uniprotkb:RPL34(gene name)|psi-mi:RPL34(display_short)|uniprotkb:Large ribosomal subunit protein eL34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000986.2|refseq:NP_296374.1|refseq:NP_001306161.1|refseq:NP_001306163.1|refseq:NP_001306164.1|refseq:NP_001306165.1|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|rcsb pdb:6Y6X|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR008195(Ribosomal protein L34e)|interpro:IPR018065|mint:P49207|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|ensembl:ENSG00000109475(gene)|ensembl:ENST00000394665(transcript)|ensembl:ENST00000394667(transcript)|ensembl:ENST00000394668(transcript)|ensembl:ENST00000502534(transcript)|ensembl:ENST00000506397(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NSGnIE6uSimeraPQ7ZZ+xRugABg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P60228 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BYW2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-945869|uniprotkb:O75397|uniprotkb:O75405|uniprotkb:Q17RW8|uniprotkb:Q5BKS9|uniprotkb:Q5QGN2|uniprotkb:Q69YI5|uniprotkb:Q6IN64|uniprotkb:Q6ZN53|uniprotkb:Q6ZS25|uniprotkb:Q8N3R0|uniprotkb:Q8TCN0|uniprotkb:Q9C0D1|uniprotkb:Q9H696|uniprotkb:Q9NZW9|ensembl:ENSP00000386759 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:setd2_human(display_long)|uniprotkb:Protein-lysine N-methyltransferase SETD2(gene name synonym)|uniprotkb:KMT3A(gene name synonym)|uniprotkb:SET domain-containing protein 2(gene name synonym)|uniprotkb:Huntingtin-interacting protein B(gene name synonym)|uniprotkb:Huntingtin yeast partner B(gene name synonym)|uniprotkb:Huntingtin-interacting protein 1(gene name synonym)|uniprotkb:HIF-1(gene name synonym)|uniprotkb:p231HBP(gene name synonym)|uniprotkb:Lysine N-methyltransferase 3A(gene name synonym)|uniprotkb:SETD2(gene name)|psi-mi:SETD2(display_short)|uniprotkb:HIF1(gene name synonym)|uniprotkb:HYPB(gene name synonym)|uniprotkb:KIAA1732(gene name synonym)|uniprotkb:SET2(gene name synonym)|uniprotkb:HSPC069(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_054878.5|ensembl:ENSG00000181555(gene)|ensembl:ENST00000409792(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018023"(peptidyl-lysine trimethylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018026"(peptidyl-lysine monomethylation)|go:"GO:0030900"(forebrain development)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048332"(mesoderm morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0048864"(stem cell development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060039"(pericardium development)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0097198"(histone H3-K36 trimethylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|go:"GO:1902850"(microtubule cytoskeleton organization involved in mitosis)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR013257(SRI, Set2 Rpb1 interacting)|interpro:IPR035441|interpro:IPR036020|interpro:IPR038190|interpro:IPR042294|interpro:IPR044437|mint:Q9BYW2|rcsb pdb:2A7O|rcsb pdb:2MDC|rcsb pdb:2MDI|rcsb pdb:2MDJ|rcsb pdb:4FMU|rcsb pdb:4H12|rcsb pdb:5JJY|rcsb pdb:5JLB|rcsb pdb:5JLE|rcsb pdb:5LSS|rcsb pdb:5LSX|rcsb pdb:5LSY|rcsb pdb:5LSZ|rcsb pdb:5LT6|rcsb pdb:5LT7|rcsb pdb:5LT8|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:6J9J|rcsb pdb:6VDB|reactome:R-HSA-3214841 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9f0NjyLj+lCSDh5yRP9lVMMepuw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92665 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-720602|uniprotkb:Q8WTV8|uniprotkb:Q5VYC8|uniprotkb:B2RCS3|ensembl:ENSP00000315397 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rt31_human(display_long)|uniprotkb:Imogen 38(gene name synonym)|uniprotkb:MRPS31(gene name)|psi-mi:MRPS31(display_short)|uniprotkb:IMOGN38(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005821.2|ensembl:ENSG00000102738(gene)|ensembl:ENST00000323563(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR026299|mint:Q92665|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Le0Lq+WW56dP5NLuMB2eKFeg6b09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H0U4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045214|ensembl:ENSP00000310226|uniprotkb:A8K7S1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rab1b_human(display_long)|uniprotkb:RAB1B(gene name)|psi-mi:RAB1B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000174903(gene)|ensembl:ENST00000311481(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0019068"(virion assembly)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_112243.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9H0U4|rcsb pdb:3JZA|rcsb pdb:3NKV|rcsb pdb:4HLQ|rcsb pdb:4I1O|rcsb pdb:5O74|rcsb pdb:5SZH|rcsb pdb:5SZK|rcsb pdb:6SKU|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42462N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EI6DHq7xCboSkoqGY5NmVY4Iqf09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P04908 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358971|uniprotkb:Q76P63|uniprotkb:P28001|ensembl:ENSP00000303373|ensembl:ENSP00000483842 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2a1b_human(display_long)|uniprotkb:H2AC4(gene name)|psi-mi:H2AC4(display_short)|uniprotkb:H2AC8(gene name)|psi-mi:H2AC8(display_short)|uniprotkb:H2AFA(gene name synonym)|uniprotkb:H2AFM(gene name synonym)|uniprotkb:HIST1H2AB(gene name synonym)|uniprotkb:HIST1H2AE(gene name synonym)|uniprotkb:Histone H2A.2(gene name synonym)|uniprotkb:Histone H2A/a(gene name synonym)|uniprotkb:Histone H2A/m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003504.2|refseq:NP_066390.1|ensembl:ENSG00000277075(gene)|ensembl:ENSG00000278463(gene)|ensembl:ENST00000303910(transcript)|ensembl:ENST00000615868(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P04908|rcsb pdb:2CV5|rcsb pdb:2RVQ|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1V|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B40|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5GSE|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JRG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Z23|rcsb pdb:5ZBX|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:6A5P|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACL|rcsb pdb:6AEE|rcsb pdb:6BUZ|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6KE9|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6O1D|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6USJ|rcsb pdb:6V92|rcsb pdb:6YOV|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|rcsb pdb:6JXD|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|dip:DIP-44197N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4Qno1mMYZB6FdNoojrzulWLVq849606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P49454 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-968343|ensembl:ENSP00000355922|uniprotkb:Q13171|uniprotkb:Q13246|uniprotkb:Q5VVM7|intact:EBI-2563723|intact:EBI-21028103 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cenpf_human(display_long)|uniprotkb:CENPF(gene name)|psi-mi:CENPF(display_short)|uniprotkb:Kinetochore protein CENPF(gene name synonym)|uniprotkb:Mitosin(gene name synonym)|uniprotkb:AH antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000117724(gene)|ensembl:ENST00000366955(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0001822"(kidney development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0042493"|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045120"(pronucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR018302|interpro:IPR018463|interpro:IPR019513|interpro:IPR043513|mint:P49454|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-156711|refseq:NP_057427.3|refseq:XP_016855575.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:gPlJiOCF1/MAVT80oKwlQlLgluo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P34897 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UI12 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-724719|uniprotkb:Q6PK44|uniprotkb:Q9H3E3|uniprotkb:Q9Y300|uniprotkb:B3KMR0|ensembl:ENSP00000352522|ensembl:ENSP00000379995 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vath_human(display_long)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 50/57 kDa subunits(gene name synonym)|uniprotkb:Vacuolar proton pump subunit SFD(gene name synonym)|uniprotkb:Protein VMA13 homolog(gene name synonym)|uniprotkb:Nef-binding protein 1(gene name synonym)|uniprotkb:ATP6V1H(gene name)|psi-mi:ATP6V1H(display_short)|uniprotkb:CGI-11(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_057025.2|refseq:NP_998784.1|refseq:NP_998785.1|ensembl:ENSG00000047249(gene)|ensembl:ENST00000359530(transcript)|ensembl:ENST00000396774(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|mint:Q9UI12|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-167590|reactome:R-HSA-182218|reactome:R-HSA-917977|reactome:R-HSA-9636467|reactome:R-HSA-9639288|reactome:R-HSA-983712|reactome:R-HSA-77387|refseq:XP_006716518.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:n2fyA8m4qnlSmS3R1xBBE3RRV9A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P20671 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-4407441|uniprotkb:A0PK91|uniprotkb:P57754|uniprotkb:Q6FGY6|ensembl:ENSP00000341094 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2a1d_human(display_long)|uniprotkb:H2AC7(gene name)|psi-mi:H2AC7(display_short)|uniprotkb:H2AFG(gene name synonym)|uniprotkb:HIST1H2AD(gene name synonym)|uniprotkb:Histone H2A.3(gene name synonym)|uniprotkb:Histone H2A/g(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_066409.1|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|ensembl:ENSG00000196866(gene)|ensembl:ENST00000341023(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:5GT3|rcsb pdb:6KBB|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Geraq+dGw3pvAAhgzzXQnYxDOOw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P02768 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H583 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62258 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NPF5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-399105|uniprotkb:Q0JSM4|uniprotkb:Q5TG41|uniprotkb:Q7Z3H7|uniprotkb:Q9H0S8|uniprotkb:Q9P2C2|uniprotkb:A8K001|uniprotkb:D3DPY8|ensembl:ENSP00000312697|ensembl:ENSP00000354697|ensembl:ENSP00000361363 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dmap1_human(display_long)|uniprotkb:DMAP1(gene name)|psi-mi:DMAP1(display_short)|uniprotkb:KIAA1425(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001029195.1|refseq:NP_001029196.1|refseq:NP_061973.1|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR008468(DNA methyltransferase 1-associated 1)|interpro:IPR027109|interpro:IPR032563|mint:Q9NPF5|rcsb pdb:3HM5|rcsb pdb:4IEJ|reactome:R-HSA-3214847|ensembl:ENSG00000178028(gene)|ensembl:ENST00000315913(transcript)|ensembl:ENST00000361745(transcript)|ensembl:ENST00000372289(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006306"(DNA methylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043486"(histone exchange)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:XP_016857297.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ujgZ1NbKKo/pw//CZvIGWfY2ob49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P56537 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-372243|uniprotkb:Q6IBN8|uniprotkb:Q96TD5|uniprotkb:B7ZBG9|ensembl:ENSP00000363559|ensembl:ENSP00000363574|ensembl:ENSP00000502429 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:if6_human(display_long)|uniprotkb:EIF6(gene name)|psi-mi:EIF6(display_short)|uniprotkb:ITGB4BP(gene name synonym)|uniprotkb:OK/SW-cl.27(orf name)|uniprotkb:B4 integrin interactor(gene name synonym)|uniprotkb:CAB(gene name synonym)|uniprotkb:"p27(BBP)"(gene name synonym)|uniprotkb:"B(2)GCN homolog"(gene name synonym)|uniprotkb:EIF3A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002203.1|refseq:NP_852131.1|refseq:NP_852133.1|refseq:NP_001254739.1|ensembl:ENSG00000242372(gene)|ensembl:ENST00000374436(transcript)|ensembl:ENST00000374450(transcript)|ensembl:ENST00000675032(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0032868"(response to insulin)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR002769(Translation initiation factor IF6)|mint:P56537|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:A0pOylQptNBlSiBKiZre7INejF49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13283 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P20700 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35606 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1056534|uniprotkb:B4DZI8|intact:EBI-11019844|ensembl:ENSP00000329419 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:copb2_human(display_long)|uniprotkb:COPB2(gene name)|psi-mi:COPB2(display_short)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004757.1|ensembl:ENSG00000184432(gene)|ensembl:ENST00000333188(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:1901998"(toxin transport)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR020472|interpro:IPR036322|mint:P35606|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_016863001.1|dip:DIP-27603N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zkd7lOeV+OvHglnAJg6cXoMhgbg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6P4A7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1049439|uniprotkb:Q6WSU4|uniprotkb:Q86TD9|ensembl:ENSP00000347924 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sfxn4_human(display_long)|uniprotkb:Breast cancer resistance marker 1(gene name synonym)|uniprotkb:SFXN4(gene name)|psi-mi:SFXN4(display_short)|uniprotkb:BCRM1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_998814.1|refseq:XP_011537584.1|refseq:XP_005269583.1|refseq:XP_005269584.1|ensembl:ENSG00000183605(gene)|ensembl:ENST00000355697(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006865"(amino acid transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|interpro:IPR028825 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:D/Ae1Kd5aIiliqNVmS7aFaIpwsk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:J3KNF5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21448477|ensembl:ENSP00000308021 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:j3knf5_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000198707(gene)|ensembl:ENST00000309041(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0030030"(cell projection organization)|go:"GO:0042995"(cell projection)|interpro:IPR026201|interpro:IPR032321|refseq:XP_011537065.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Q9fYRRza+hStPjxrMcUcL06bVNU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P0C0S5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1199859|uniprotkb:P17317|uniprotkb:Q6I9U0|uniprotkb:B2RD56|ensembl:ENSP00000296417 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2az_human(display_long)|uniprotkb:H2AZ1(gene name)|psi-mi:H2AZ1(display_short)|uniprotkb:H2AFZ(gene name synonym)|uniprotkb:H2AZ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002097.1|ensembl:ENSG00000164032(gene)|ensembl:ENST00000296417(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S5|rcsb pdb:1F66|rcsb pdb:3WA9|rcsb pdb:4CAY|rcsb pdb:4NFT|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5CHL|rcsb pdb:5FUG|rcsb pdb:5Z30|rcsb pdb:6JOU|rcsb pdb:6KO2|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|dip:DIP-38593N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0FrzM1TXlduSQ0NNVl0C9uqCUGI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TBF4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11124401|uniprotkb:Q96TA6|uniprotkb:Q6PJX0|ensembl:ENSP00000266529|ensembl:ENSP00000503171|ensembl:ENSP00000503413 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zcrb1_human(display_long)|uniprotkb:ZCRB1(gene name)|psi-mi:ZCRB1(display_short)|uniprotkb:U11/U12 small nuclear ribonucleoprotein 31 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_149105.3|ensembl:ENSG00000139168(gene)|ensembl:ENST00000266529(transcript)|ensembl:ENST00000677694(transcript)|ensembl:ENST00000679269(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034219|interpro:IPR035979|interpro:IPR036875|interpro:IPR044598|rcsb pdb:2E5H|reactome:R-HSA-72165|reactome:R-HSA-9682706|reactome:R-HSA-9694686 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Gdxf685UuFfi2yaQkySjYFE/5VY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NV56 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-399076|uniprotkb:A8C4L5|ensembl:ENSP00000359518 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mrgbp_human(display_long)|uniprotkb:MRGBP(gene name)|psi-mi:MRGBP(display_short)|uniprotkb:C20orf20(gene name synonym)|uniprotkb:MRG-binding protein(gene name synonym)|uniprotkb:Up-regulated in colon cancer 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060740.1|ensembl:ENSG00000101189(gene)|ensembl:ENST00000370487(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016573"(histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|interpro:IPR012423(CT20)|mint:Q9NV56|rcsb pdb:2N1D|reactome:R-HSA-3214847|dip:DIP-29018N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4bfrpXA+a7207TVMYyOyu9MVmKQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q86X55 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2339854|uniprotkb:A6NN38|ensembl:ENSP00000325690 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:carm1_human(display_long)|uniprotkb:CARM1(gene name)|psi-mi:CARM1(display_short)|uniprotkb:PRMT4(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_954592.1|refseq:XP_005259765.1|dip:DIP-44071N|ensembl:ENSG00000142453(gene)|ensembl:ENST00000327064(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q86X55|rcsb pdb:2Y1W|rcsb pdb:2Y1X|rcsb pdb:4IKP|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5DX1|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5DXJ|rcsb pdb:5U4X|rcsb pdb:6ARJ|rcsb pdb:6ARV|rcsb pdb:6D2L|rcsb pdb:6DVR|rcsb pdb:6IZQ|rcsb pdb:6S70|rcsb pdb:6S71|rcsb pdb:6S74|rcsb pdb:6S77|rcsb pdb:6S79|rcsb pdb:6S7A|rcsb pdb:6S7B|rcsb pdb:6S7C|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-6804114|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|go:"GO:0051591"(response to cAMP) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:1x1bUjqcA/ZpmrSsSM545ReYH2A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P28070 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-603350|uniprotkb:P31148|uniprotkb:Q5SZS5|uniprotkb:Q969L6|uniprotkb:B2R9L3|uniprotkb:Q6IBI4|ensembl:ENSP00000290541 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psb4_human(display_long)|uniprotkb:PSMB4(gene name)|psi-mi:PSMB4(display_short)|uniprotkb:Macropain beta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex beta chain(gene name synonym)|uniprotkb:Proteasome chain 3(gene name synonym)|uniprotkb:26 kDa prosomal protein(gene name synonym)|uniprotkb:PROS26(gene name synonym)|uniprotkb:Proteasome beta chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002787.2|dip:DIP-33844N|ensembl:ENSG00000159377(gene)|ensembl:ENST00000290541(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR016295(Proteasome endopeptidase complex, beta subunit)|interpro:IPR023333|interpro:IPR029055|mint:P28070|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:drR+ktPXQK9ep6hs7OYb5SmQnXU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99805 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2852254|uniprotkb:Q2TAY5|uniprotkb:A8K399|ensembl:ENSP00000365567|ensembl:ENSP00000493515 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tm9s2_human(display_long)|uniprotkb:TM9SF2(gene name)|psi-mi:TM9SF2(display_short)|uniprotkb:p76(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004791.1|ensembl:ENSG00000125304(gene)|ensembl:ENST00000376387(transcript)|ensembl:ENST00000642475(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR004240("Nonaspanin (TM9SF)")|mint:Q99805 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qg5QSnzX8+4H0Nfab7Ci9n9igc09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43809 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355720|uniprotkb:Q6IB85|uniprotkb:Q6NE84|ensembl:ENSP00000300291 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cpsf5_human(display_long)|uniprotkb:NUDT21(gene name)|psi-mi:NUDT21(display_short)|uniprotkb:CFIM25(gene name synonym)|uniprotkb:CPSF25(gene name synonym)|uniprotkb:CPSF5(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 25 kDa subunit(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 21(gene name synonym)|uniprotkb:Cleavage factor Im complex 25 kDa subunit(gene name synonym)|uniprotkb:Nudix hydrolase 21(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008937.1|ensembl:ENSG00000167005(gene)|ensembl:ENST00000300291(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031439"(positive regulation of mRNA cleavage)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2000975"(positive regulation of pro-B cell differentiation)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR016706(Cleavage and polyadenylation specificity factor, 25 kDa subunit)|mint:O43809|rcsb pdb:2CL3|rcsb pdb:2J8Q|rcsb pdb:3BAP|rcsb pdb:3BHO|rcsb pdb:3MDG|rcsb pdb:3MDI|rcsb pdb:3N9U|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:5R4P|rcsb pdb:5R4Q|rcsb pdb:5R4R|rcsb pdb:5R4S|rcsb pdb:5R4T|rcsb pdb:5R4U|rcsb pdb:5R64|rcsb pdb:5R65|rcsb pdb:5R66|rcsb pdb:5R67|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-42502N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Acad4mYVuS+Eox+X2CH8PYUkGAA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00287 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3929296|uniprotkb:Q5VZM6|uniprotkb:B2R9T8|uniprotkb:Q8TC40|ensembl:ENSP00000255476 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rfxap_human(display_long)|uniprotkb:RFXAP(gene name)|psi-mi:RFXAP(display_short)|uniprotkb:RFX DNA-binding complex 36 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000133111(gene)|ensembl:ENST00000255476(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016607"(nuclear speck)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR029316|interpro:IPR038308|rcsb pdb:2KW3|refseq:NP_000529.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:r+XmZDak1gN3ZSNz3qypJUrb0hg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y3Y2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347794|uniprotkb:Q2VPI9|uniprotkb:Q5T7Y8|uniprotkb:Q5T7Z0|uniprotkb:Q6NSM4|uniprotkb:Q6PB28|uniprotkb:Q8WYT9|uniprotkb:Q9BUC5|uniprotkb:Q9H034|uniprotkb:Q9H2L0|uniprotkb:Q0VAQ8|uniprotkb:D3DV55|uniprotkb:Q5T7Y9|ensembl:ENSP00000357683 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:chtop_human(display_long)|uniprotkb:HT031(orf name)|uniprotkb:PP7704(orf name)|uniprotkb:FOP(gene name synonym)|uniprotkb:CHTOP(gene name)|psi-mi:CHTOP(display_short)|uniprotkb:C1orf77(gene name synonym)|uniprotkb:Friend of PRMT1 protein(gene name synonym)|uniprotkb:Small arginine- and glycine-rich protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001304006.1|refseq:NP_001193541.1|refseq:NP_056422.2|refseq:NP_001231593.1|ensembl:ENSG00000160679(gene)|ensembl:ENST00000368694(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0051096"(positive regulation of helicase activity)|interpro:IPR025715|mint:Q9Y3Y2|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mNq0QTGQnGABQwIL2S90Hbp3Nm89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q4VC05 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359917|uniprotkb:Q13843|uniprotkb:B4DJN6|uniprotkb:B7ZB21|uniprotkb:Q14CT7|intact:EBI-2560561|ensembl:ENSP00000261822|ensembl:ENSP00000489305 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bcl7a_human(display_long)|uniprotkb:BCL7A(gene name)|psi-mi:BCL7A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001019979.1|refseq:NP_066273.1|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR006804(BCL7, N-terminal)|mint:Q4VC05|ensembl:ENSG00000110987(gene)|ensembl:ENSG00000282873(gene)|ensembl:ENST00000261822(transcript)|ensembl:ENST00000635403(transcript)|dip:DIP-27608N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ZEtiQWH57T+t+gCMVVPHAJUO10w9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P13995 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1058895|ensembl:ENSP00000377617|uniprotkb:Q7Z650|uniprotkb:Q53G90|uniprotkb:Q53GV5|uniprotkb:Q53S36 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mtdc_human(display_long)|uniprotkb:MTHFD2(gene name)|psi-mi:MTHFD2(display_short)|uniprotkb:NMDMC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000065911(gene)|ensembl:ENST00000394053(transcript)|go:"GO:0000287"(magnesium ion binding)|rcsb pdb:1ZN4|rcsb pdb:5TC4|rcsb pdb:6JIB|rcsb pdb:6JID|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR036291|rcsb pdb:6KG2|refseq:XP_006711987.1|refseq:NP_006627.2|reactome:R-HSA-196757 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:dzNq2WEcKJ3DptZUIAnyKCITCsk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92804 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2255091|uniprotkb:B2R837|uniprotkb:Q92751|intact:EBI-3867593|uniprotkb:Q86X94|ensembl:ENSP00000474096|ensembl:ENSP00000480040 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rbp56_human(display_long)|uniprotkb:TAF15(gene name)|psi-mi:TAF15(display_short)|uniprotkb:RBP56(gene name synonym)|uniprotkb:TAF2N(gene name synonym)|uniprotkb:RNA-binding protein 56(gene name synonym)|uniprotkb:68 kDa TATA-binding protein-associated factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003478.1|refseq:NP_631961.1|dip:DIP-52760N|ensembl:ENSG00000270647(gene)|ensembl:ENSG00000276833(gene)|ensembl:ENST00000605844(transcript)|ensembl:ENST00000617382(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034870|interpro:IPR034875|interpro:IPR035979|interpro:IPR036443|mint:Q92804|rcsb pdb:2MMY|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9+wyDu+1dvocxFI4GKvLqkvChDc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75607 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-721544|uniprotkb:Q9UNY6|intact:EBI-28974425|ensembl:ENSP00000359128 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:npm3_human(display_long)|uniprotkb:NPM3(gene name)|psi-mi:NPM3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008924.1|ensembl:ENSP00000359128|ensembl:ENSG00000107833(gene)|ensembl:ENST00000370110(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0009303"(rRNA transcription)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042393"(histone binding)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR036824|mint:O75607 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:lryH+qFG3/zmXWyn25dmU44prpk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P48382 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-923266|uniprotkb:Q5VWC3|uniprotkb:D3DV19|uniprotkb:B7Z848|uniprotkb:E9PFU4|ensembl:ENSP00000290524|ensembl:ENSP00000357864|ensembl:ENSP00000389130 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rfx5_human(display_long)|uniprotkb:RFX5(gene name)|psi-mi:RFX5(display_short)|uniprotkb:Regulatory factor X 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000440.1|refseq:NP_001020774.1|refseq:XP_005245462.1|refseq:XP_005245463.1|refseq:XP_011508149.1|refseq:XP_011508150.1|refseq:XP_011508151.1|refseq:XP_011508152.1|ensembl:ENSG00000143390(gene)|ensembl:ENST00000290524(transcript)|ensembl:ENST00000368870(transcript)|ensembl:ENST00000452671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR029298|interpro:IPR033486|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|interpro:IPR040889|mint:P48382|rcsb pdb:2KW3|rcsb pdb:3V30|go:"GO:1990837"(sequence-specific double-stranded DNA binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:kElLakR+ct4K8Mw6q91im3K8Zh89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N1F7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pkk5pooUC4yQShpqjiwNLddfy149606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75600 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2959690|ensembl:ENSP00000248924|uniprotkb:Q96CA9|uniprotkb:E2QC23|uniprotkb:Q6ZWF1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:kbl_human(display_long)|uniprotkb:GCAT(gene name)|psi-mi:GCAT(display_short)|uniprotkb:KBL(gene name synonym)|uniprotkb:Aminoacetone synthase(gene name synonym)|uniprotkb:Glycine acetyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100116(gene)|ensembl:ENST00000248924(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0008890"(glycine C-acetyltransferase activity)|go:"GO:0009058"(biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019518"(L-threonine catabolic process to glycine)|go:"GO:0030170"(pyridoxal phosphate binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR011282(2-amino-3-ketobutyrate coenzyme A ligase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|reactome:R-HSA-8849175|refseq:NP_055106.1|refseq:NP_001165161.1|refseq:XP_005261467.1|refseq:XP_016884166.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:JcxSdpqnWgMx3m5s6nO38OjqO+I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P52756 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-714003|uniprotkb:Q93021|uniprotkb:Q9BU14|uniprotkb:Q9UKY8|uniprotkb:Q9UL24|ensembl:ENSP00000343054|uniprotkb:B2RA45|uniprotkb:B4DM16|uniprotkb:B4DMF9|uniprotkb:B4DZ63|uniprotkb:Q9HDA6|intact:EBI-16431417 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rbm5_human(display_long)|uniprotkb:RNA-binding motif protein 5(gene name synonym)|uniprotkb:Putative tumor suppressor LUCA15(gene name synonym)|uniprotkb:Protein G15(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-9(gene name synonym)|uniprotkb:RBM5(gene name)|psi-mi:RBM5(display_short)|uniprotkb:H37(orf name)|uniprotkb:LUCA15(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000003756(gene)|ensembl:ENST00000347869(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR033094|interpro:IPR034991|interpro:IPR034993|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036443|interpro:IPR041591|mint:P52756|rcsb pdb:2LK0|rcsb pdb:2LK1|rcsb pdb:2LKZ|rcsb pdb:5MF9|rcsb pdb:5MFY|reactome:R-HSA-72163|refseq:NP_005769.1|refseq:XP_016860992.1|dip:DIP-47277N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LsPTpaKrGY2xtpYofHbFVXjSi/A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96FV9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1765605|uniprotkb:Q15219|uniprotkb:B2RBP6|uniprotkb:Q64I72|uniprotkb:Q64I73|intact:EBI-28984554|ensembl:ENSP00000261600 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:thoc1_human(display_long)|uniprotkb:hTREX84(gene name synonym)|uniprotkb:THOC1(gene name)|psi-mi:THOC1(display_short)|uniprotkb:HPR1(gene name synonym)|uniprotkb:Nuclear matrix protein p84(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005122.2|ensembl:ENSP00000261600|ensembl:ENSG00000079134(gene)|ensembl:ENST00000261600(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000346"(transcription export complex)|go:"GO:0000347"(THO complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0031297"(replication fork processing)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0048297"(negative regulation of isotype switching to IgA isotypes)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR021861|mint:Q96FV9|rcsb pdb:1WXP|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:D+lk5iFzcmd1bQRa2cx/nUyq4sI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96L91 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-399163|uniprotkb:O15411|uniprotkb:Q6P2F5|uniprotkb:Q8N8Q7|uniprotkb:Q8NE05|uniprotkb:Q96JK7|uniprotkb:Q9P230 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ep400_human(display_long)|uniprotkb:p400 kDa SWI2/SNF2-related protein(gene name synonym)|uniprotkb:Domino homolog(gene name synonym)|uniprotkb:CAG repeat protein 32(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 12 protein(gene name synonym)|uniprotkb:CAGH32(gene name synonym)|uniprotkb:KIAA1498(gene name synonym)|uniprotkb:KIAA1818(gene name synonym)|uniprotkb:TNRC12(gene name synonym)|uniprotkb:EP400(gene name)|psi-mi:EP400(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056224.3|ensembl:ENST00000389561|ensembl:ENSP00000374212|ensembl:ENSG00000183495|go:"GO:0000812"(Swr1 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0070615"|go:"GO:1990405"(protein antigen binding)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR027417|interpro:IPR031575|interpro:IPR038718|reactome:R-HSA-2559584|reactome:R-HSA-2559586|reactome:R-HSA-3214847|mint:Q96L91|dip:DIP-29915N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DrQFsyaSlUxjJBloZPFrjXooDpU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BSD7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2689235|ensembl:ENSP00000355587 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ntpcr_human(display_long)|uniprotkb:Nucleoside triphosphate phosphohydrolase(gene name synonym)|uniprotkb:NTPCR(gene name)|psi-mi:NTPCR(display_short)|uniprotkb:C1orf57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115700.1|interpro:IPR027417|mint:Q9BSD7|rcsb pdb:2I3B|ensembl:ENSG00000135778(gene)|ensembl:ENST00000366628(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|refseq:NP_001316382.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tJoP+XQzoa4urq6g1rdZhMWO49g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q52LR7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-769498|uniprotkb:Q7L9J1|uniprotkb:Q96RR7|uniprotkb:Q9NUT8|uniprotkb:Q9NVR1|uniprotkb:Q9UFM9|uniprotkb:B3KWT7|uniprotkb:D3DP89|ensembl:ENSP00000258484 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:epc2_human(display_long)|uniprotkb:EPC-like(gene name synonym)|uniprotkb:EPC2(gene name)|psi-mi:EPC2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056445.3|ensembl:ENSG00000135999(gene)|ensembl:ENST00000258484(transcript)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016573"(histone acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|interpro:IPR009607(Enhancer of polycomb, C-terminal)|interpro:IPR019542|interpro:IPR024943 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:/xsgjMFT0Dh3fQalLVsbGJ1kEn89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NQH7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1171467|uniprotkb:Q6I9V9|uniprotkb:Q8NDA6|uniprotkb:Q9BV27|uniprotkb:Q9BVH0|uniprotkb:B7Z790|uniprotkb:B7Z7B2|uniprotkb:B2R9G1|intact:EBI-2562323|ensembl:ENSP00000349658 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:xpp3_human(display_long)|uniprotkb:Aminopeptidase P3(gene name synonym)|uniprotkb:XPNPEP3(gene name)|psi-mi:XPNPEP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_071381.1|ensembl:ENSG00000196236(gene)|ensembl:ENST00000357137(transcript)|go:"GO:0003094"(glomerular filtration)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR007865(Peptidase M24B, X-Pro dipeptidase/aminopeptidase P N-terminal)|interpro:IPR029149|interpro:IPR036005|rcsb pdb:5X49|interpro:IPR000994(Peptidase M24, catalytic core) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:hRjwsoqTVtJ1YTaVzYWomQGmJOE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TC07 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14974 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14683 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62140 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P11177 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1035872|uniprotkb:B2R7L0|uniprotkb:Q6FH45|uniprotkb:Q9BQ27|uniprotkb:Q9UFK3|ensembl:ENSP00000307241|uniprotkb:B4DDD7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:odpb_human(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000168291(gene)|ensembl:ENST00000302746(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR027110|interpro:IPR029061|interpro:IPR033248|mint:P11177|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|refseq:NP_000916.2|refseq:NP_001166939.1|refseq:NP_001302465.1|dip:DIP-37651N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UH99 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044964|uniprotkb:O75156|uniprotkb:Q2NKN8|uniprotkb:Q6B4H1|uniprotkb:Q7Z3E3|uniprotkb:Q2T9F7|ensembl:ENSP00000383992|ensembl:ENSP00000385740|uniprotkb:B0QY62|uniprotkb:Q504T5 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sun2_human(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Rab5-interacting protein(gene name synonym)|uniprotkb:SUN2(gene name)|psi-mi:SUN2(display_short)|uniprotkb:FRIGG(gene name synonym)|uniprotkb:KIAA0668(gene name synonym)|uniprotkb:RAB5IP(gene name synonym)|uniprotkb:UNC84B(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001186508.1|refseq:NP_001186509.1|refseq:NP_056189.1|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008017"(microtubule binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:0000781"(chromosome, telomeric region)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|mint:Q9UH99|ensembl:ENSG00000100242(gene)|ensembl:ENST00000405510(transcript)|ensembl:ENST00000406622(transcript)|rcsb pdb:4DXS|rcsb pdb:4DXT|rcsb pdb:4FI9|rcsb pdb:6WMD|rcsb pdb:6WME|rcsb pdb:6WMF|rcsb pdb:6WMG|reactome:R-HSA-1221632|rcsb pdb:4DXR|rcsb pdb:3UNP - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:nG0s5eHv6AGh8rcdhTIJ1RdpfbU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5C9Z4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2685618|uniprotkb:Q96I08|ensembl:ENSP00000275820 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nom1_human(display_long)|uniprotkb:C7orf3(gene name synonym)|uniprotkb:SGD1 homolog(gene name synonym)|uniprotkb:NOM1(gene name)|psi-mi:NOM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_612409.1|ensembl:ENSG00000146909(gene)|ensembl:ENST00000275820(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0048820"(hair follicle maturation)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:Q5C9Z4 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:1LScd95yytIZJ1/UFg9WTUiCmqg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5BKZ1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2560158|uniprotkb:Q6NSA2|uniprotkb:B4DLN0|uniprotkb:Q7Z638|uniprotkb:Q7Z6C2|uniprotkb:Q5VW97|uniprotkb:Q5VW96|uniprotkb:Q5VW94|uniprotkb:Q5VW93|ensembl:ENSP00000340796|uniprotkb:A8MYX1|uniprotkb:B4E179 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zn326_human(display_long)|uniprotkb:ZNF326(gene name)|psi-mi:ZNF326(display_short)|uniprotkb:ZIRD(gene name synonym)|uniprotkb:Zinc finger protein 326(gene name synonym)|uniprotkb:Zinc finger protein interacting with mRNPs and DBC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_892020.1|refseq:NP_892021.1|refseq:XP_011539592.1|ensembl:ENSG00000162664(gene)|ensembl:ENST00000340281(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044609"(DBIRD complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q5BKZ1|refseq:XP_005270836.1|refseq:NP_001307114.1|refseq:NP_861446.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:y4ZeI0cWMpNA2nQN/hDk6Zn7XRA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H2F5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-769270|uniprotkb:Q8NAQ4|uniprotkb:Q8NE21|uniprotkb:Q96LF4|uniprotkb:Q96RR6|uniprotkb:Q9H7T7|uniprotkb:Q5VW54|uniprotkb:Q5VW56|uniprotkb:Q5VW58|uniprotkb:B4DSC3|uniprotkb:D3DRX7|ensembl:ENSP00000263062 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:epc1_human(display_long)|uniprotkb:EPC1(gene name)|psi-mi:EPC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_079485.1|refseq:NP_001269320.1|refseq:NP_001258933.1|refseq:NP_001258948.1|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR009607(Enhancer of polycomb, C-terminal)|interpro:IPR019542|interpro:IPR024943|rcsb pdb:6NFX|reactome:R-HSA-3214847|reactome:R-HSA-8953750|ensembl:ENSG00000120616(gene)|ensembl:ENST00000263062(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9UXmKEZyFg6gQZhrhzTj+mb8j2U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O95347 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355822|intact:EBI-1058371|uniprotkb:Q9P1P2|uniprotkb:Q6IEE0|ensembl:ENSP00000286398|ensembl:ENSP00000363919|ensembl:ENSP00000363925 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:smc2_human(display_long)|uniprotkb:PRO0324(orf name)|uniprotkb:SMC2(gene name)|psi-mi:SMC2(display_short)|uniprotkb:CAPE(gene name synonym)|uniprotkb:SMC2L1(gene name synonym)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001036015.1|refseq:NP_001036016.1|refseq:NP_006435.2|refseq:XP_011516451.1|refseq:XP_011516455.1|refseq:XP_011516450.1|refseq:NP_001252531.1|refseq:XP_006716996.1|refseq:XP_016869695.1|refseq:XP_016869696.1|refseq:XP_016869697.1|dip:DIP-35422N|ensembl:ENSG00000136824(gene)|ensembl:ENST00000286398(transcript)|ensembl:ENST00000374787(transcript)|ensembl:ENST00000374793(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:O95347|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:k7RHRDmgiucuAOIfh8vjbqnlv3E9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13573 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75953 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-5655937|uniprotkb:J3KQM9|uniprotkb:Q8TDR7|uniprotkb:Q96EM4|uniprotkb:B3KN14|uniprotkb:Q5T656|uniprotkb:B4DSA6|uniprotkb:J3KR08|ensembl:ENSP00000312517|ensembl:ENSP00000441999|ensembl:ENSP00000506753 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjb5_human(display_long)|uniprotkb:HSC40(gene name synonym)|uniprotkb:Heat shock protein Hsp40-2(gene name synonym)|uniprotkb:Heat shock protein Hsp40-3(gene name synonym)|uniprotkb:Heat shock protein cognate 40(gene name synonym)|uniprotkb:DNAJB5(gene name)|psi-mi:DNAJB5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011516144.1|refseq:NP_001128476.2|refseq:NP_001128477.1|refseq:NP_036398.3|refseq:XP_005251485.1|refseq:XP_006716814.1|ensembl:ENSG00000137094(gene)|ensembl:ENST00000312316(transcript)|ensembl:ENST00000545841(transcript)|ensembl:ENST00000684748(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:O75953 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tXimNOFcGTGvoThdisoSYm9koR89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H147 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2795449|uniprotkb:B2RA18|uniprotkb:Q96DE3|uniprotkb:Q9BQP2|uniprotkb:Q9H148|ensembl:ENSP00000361705 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tdif1_human(display_long)|uniprotkb:DNTTIP1(gene name)|psi-mi:DNTTIP1(display_short)|uniprotkb:C20orf167(gene name synonym)|uniprotkb:TDIF1(gene name synonym)|uniprotkb:Terminal deoxynucleotidyltransferase-interacting factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_443183.1|ensembl:ENSG00000101457(gene)|ensembl:ENST00000372622(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR026064|interpro:IPR041384|mint:Q9H147|rcsb pdb:2MWI|rcsb pdb:4D6K|rcsb pdb:6Z2J|rcsb pdb:6Z2K|go:"GO:0003677"(DNA binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:KoYRvfphwSt5VO2ufdh6/sScYI89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UPQ9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-947158|uniprotkb:B0QY78|uniprotkb:Q5TH52|uniprotkb:Q8TBX2|uniprotkb:B4DGC0|uniprotkb:B0QY73|ensembl:ENSP00000401946 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tnr6b_human(display_long)|uniprotkb:TNRC6B(gene name)|psi-mi:TNRC6B(display_short)|uniprotkb:KIAA1093(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001020014.1|refseq:NP_001155973.1|refseq:NP_055903.2|dip:DIP-29624N|ensembl:ENSG00000100354(gene)|ensembl:ENST00000454349(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019486|interpro:IPR032226|interpro:IPR033500|interpro:IPR034925|interpro:IPR035979|mint:Q9UPQ9|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426496|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:A4yGG9Gt++0QN+6jFzfhWVYN+Dw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96CK0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-12217757|intact:EBI-28987760|ensembl:ENSP00000293771|uniprotkb:Q96AS7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zn653_human(display_long)|uniprotkb:ZNF653(gene name)|psi-mi:ZNF653(display_short)|uniprotkb:67 kDa zinc finger protein(gene name synonym)|uniprotkb:ZIP67(gene name synonym)|uniprotkb:Zinc finger protein Zip67(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000161914(gene)|ensembl:ENST00000293771(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:1900116"(extracellular negative regulation of signal transduction)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSP00000293771|refseq:NP_620138.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fpj8SQ98sBwWa4FTjQKfhdFeVDk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P19474 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8WUM0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-295695|uniprotkb:Q5T8N0|uniprotkb:Q9H9W2|uniprotkb:Q9NV71|uniprotkb:Q9NVC4|uniprotkb:B2RAZ8|ensembl:ENSP00000261396 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nu133_human(display_long)|uniprotkb:NUP133(gene name)|psi-mi:NUP133(display_short)|uniprotkb:Nucleoporin Nup133(gene name synonym)|uniprotkb:133 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060700.2|ensembl:ENSG00000069248(gene)|ensembl:ENST00000261396(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0061053"(somite development)|go:"GO:0072006"(nephron development)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037624|mint:Q8WUM0|rcsb pdb:1XKS|rcsb pdb:3CQC|rcsb pdb:3CQG|rcsb pdb:3I4R|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:J89Ja9KNryxKNUd9rqNbi8EC09g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P30837 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1237410|uniprotkb:Q8WX76|uniprotkb:Q9BV45|uniprotkb:B2R8F0|ensembl:ENSP00000366927 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:al1b1_human(display_long)|uniprotkb:ALDH1B1(gene name)|psi-mi:ALDH1B1(display_short)|uniprotkb:ALDH5(gene name synonym)|uniprotkb:ALDHX(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 1 member B1(gene name synonym)|uniprotkb:Aldehyde dehydrogenase 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000683.3|ensembl:ENSG00000137124(gene)|ensembl:ENST00000377698(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0051287"(NAD binding)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P30837|reactome:R-HSA-71384|go:"GO:0005654"(nucleoplasm) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:esHIXlANuM3Gmcr8ldyTq/nAyUM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6PJG2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2795569|uniprotkb:Q6PK13|uniprotkb:Q6PK59|uniprotkb:Q6ZS23|intact:EBI-28972055|ensembl:ENSP00000286523|ensembl:ENSP00000377634 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mdeas_human(display_long)|uniprotkb:MIDEAS(gene name)|psi-mi:MIDEAS(display_short)|uniprotkb:C14orf117(gene name synonym)|uniprotkb:C14orf43(gene name synonym)|uniprotkb:ELM2 and SANT domain-containing protein 1(gene name synonym)|uniprotkb:ELMSAN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000286523|ensembl:ENSP00000377634|refseq:NP_001036783.1|refseq:NP_919254.2|ensembl:ENSG00000156030(gene)|ensembl:ENST00000286523(transcript)|ensembl:ENST00000394071(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|rcsb pdb:6Z2J|rcsb pdb:6Z2K - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wZyVPfF6zuF0ObDUtE0t0e0IK1M9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P38606 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15773 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43251 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-746056|uniprotkb:Q5TF71|uniprotkb:Q6IC09|uniprotkb:Q8TD00|uniprotkb:Q8WYB1|uniprotkb:Q96DZ6|uniprotkb:Q96NL7|uniprotkb:Q9UGW4|uniprotkb:Q9UH33|uniprotkb:Q0VH35|uniprotkb:A4F5G8|uniprotkb:A8K5Z5|uniprotkb:Q0PRL5|uniprotkb:B0QYY8|uniprotkb:B0QYY9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rfox2_human(display_long)|uniprotkb:FOX2(gene name synonym)|uniprotkb:RNA-binding motif protein 9(gene name synonym)|uniprotkb:Fox-1 homolog B(gene name synonym)|uniprotkb:Hexaribonucleotide-binding protein 2(gene name synonym)|uniprotkb:Repressor of tamoxifen transcriptional activity(gene name synonym)|uniprotkb:RBFOX2(gene name)|psi-mi:RBFOX2(display_short)|uniprotkb:HRNBP2(gene name synonym)|uniprotkb:RTA(gene name synonym)|uniprotkb:RBM9(gene name synonym)|uniprotkb:RNA-binding protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001026865.1|refseq:NP_001076045.1|refseq:NP_001076046.1|refseq:NP_055124.1|interpro:IPR017325(RNA-binding protein 9/Ataxin-2-binding protein)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0140297"(DNA-binding transcription factor binding)|rcsb pdb:2CQ3|reactome:R-HSA-6803529|interpro:IPR025670|refseq:XP_005261494.1|interpro:IPR034237|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:O43251|interpro:IPR035979|refseq:NP_001076047.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eIocECpScMWGhrZslIle29WUyKs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UPT5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-720048|uniprotkb:Q96FF0|uniprotkb:Q9H8C3|uniprotkb:Q9H9X3|uniprotkb:Q9HA32|uniprotkb:Q8ND93|uniprotkb:Q8WV91|uniprotkb:B5MC69|uniprotkb:B8XXP2|ensembl:ENSP00000334100 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:exoc7_human(display_long)|uniprotkb:EXOC7(gene name)|psi-mi:EXOC7(display_short)|uniprotkb:EXO70(gene name synonym)|uniprotkb:KIAA1067(gene name synonym)|uniprotkb:Exocyst complex component Exo70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001013861.1|refseq:NP_001138769.1|refseq:NP_001138770.1|refseq:NP_001138771.1|refseq:NP_056034.2|ensembl:ENSG00000182473(gene)|ensembl:ENST00000335146(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032584"(growth cone membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR004140(Exo70 exocyst complex subunit)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UPT5|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_001269242.1|dip:DIP-37604N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:f/uwscxIcAuG96QZzNMQtrzTmeU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q86Y07 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8WUH6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1042811|uniprotkb:B3KMN9|ensembl:ENSP00000280756|ensembl:ENSP00000446537|ensembl:ENSP00000446717|ensembl:ENSP00000449106|ensembl:ENSP00000449785|ensembl:ENSP00000450350 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tm263_human(display_long)|uniprotkb:TMEM263(gene name)|psi-mi:TMEM263(display_short)|uniprotkb:C12orf23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001306590.1|refseq:NP_001306591.1|refseq:NP_001306592.1|refseq:NP_001306593.1|refseq:NP_001306595.1|refseq:NP_689474.1|ensembl:ENSG00000151135(gene)|ensembl:ENST00000280756(transcript)|ensembl:ENST00000547081(transcript)|ensembl:ENST00000547242(transcript)|ensembl:ENST00000548125(transcript)|ensembl:ENST00000550344(transcript)|ensembl:ENST00000551813(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR028153 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7ndvPlnfctdWgCYMvx/yNZ8jyQE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96GD4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P06737 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2511865|ensembl:ENSP00000216392|uniprotkb:O60567|uniprotkb:O60913|uniprotkb:O60752|uniprotkb:A6NDQ4|uniprotkb:Q501V9|uniprotkb:Q96G82|uniprotkb:Q641R5|uniprotkb:B4DUB7|uniprotkb:F5H816 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pygl_human(display_long)|uniprotkb:PYGL(gene name)|psi-mi:PYGL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100504(gene)|ensembl:ENST00000216392(transcript)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0008184"(glycogen phosphorylase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0016208"(AMP binding)|go:"GO:0019842"(vitamin binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032052"(bile acid binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070266"(necroptotic process)|go:"GO:0102250"(linear malto-oligosaccharide phosphorylase activity)|go:"GO:0102499"(SHG alpha-glucan phosphorylase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000811(Glycosyl transferase, family 35)|interpro:IPR011833(Glycogen/starch/alpha-glucan phosphorylase)|interpro:IPR035090|mint:P06737|rcsb pdb:1EM6|rcsb pdb:1EXV|rcsb pdb:1FA9|rcsb pdb:1FC0|rcsb pdb:1L5Q|rcsb pdb:1L5R|rcsb pdb:1L5S|rcsb pdb:1L7X|rcsb pdb:1XOI|rcsb pdb:2ATI|rcsb pdb:2QLL|rcsb pdb:2ZB2|rcsb pdb:3CEH|rcsb pdb:3CEJ|rcsb pdb:3CEM|rcsb pdb:3DD1|rcsb pdb:3DDS|rcsb pdb:3DDW|reactome:R-HSA-70221|reactome:R-HSA-6798695|refseq:NP_001157412.1|refseq:NP_002854.3 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8h3TR7UB7SC/CFh5TXcjHvE/C709606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HCU5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2553896|uniprotkb:Q9UH94|ensembl:ENSP00000260643|uniprotkb:Q53SZ8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:preb_human(display_long)|uniprotkb:SEC12(gene name synonym)|uniprotkb:Mammalian guanine nucleotide exchange factor mSec12(gene name synonym)|uniprotkb:PREB(gene name)|psi-mi:PREB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_037520.1|ensembl:ENSG00000138073(gene)|ensembl:ENST00000260643(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051020"(GTPase binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|rcsb pdb:5TF2|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|refseq:NP_001317414.1|refseq:NP_001317415.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:3xjABrP1KtfZUMb/BSbe8ZN6dJ49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7RTV0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2555365|uniprotkb:Q9UH06|ensembl:ENSP00000216252 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:phf5a_human(display_long)|uniprotkb:Splicing factor 3B-associated 14 kDa protein(gene name synonym)|uniprotkb:PHF5A(gene name)|psi-mi:PHF5A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_116147.1|ensembl:ENSG00000100410(gene)|ensembl:ENST00000216252(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR005345(PHF5-like)|mint:Q7RTV0|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5SYB|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|go:"GO:0048863"(stem cell differentiation) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TrngLk+KyJ+qRs8HGvH1LZH2Tsg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q86X95 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DMnBG746eQpvLsf9D+lgeUKnni09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P31946 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y4Y9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-373007|ensembl:ENSP00000410758 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lsm5_human(display_long)|uniprotkb:LSM5(gene name)|psi-mi:LSM5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124182.1|refseq:NP_001132971.1|refseq:NP_036454.1|dip:DIP-31162N|ensembl:ENSG00000106355(gene)|ensembl:ENST00000450169(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR033871|mint:Q9Y4Y9|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EeF2r4qY+BFrZTyTCT+i4ccskf49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HCJ0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6507625|uniprotkb:Q86UE5|uniprotkb:Q8N3D8|uniprotkb:Q96MU9|uniprotkb:G3XAB8|ensembl:ENSP00000301624|ensembl:ENSP00000468647 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tnr6c_human(display_long)|uniprotkb:TNRC6C(gene name)|psi-mi:TNRC6C(display_short)|uniprotkb:KIAA1582(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001136112.1|refseq:NP_061869.2|ensembl:ENSG00000078687(gene)|ensembl:ENST00000301624(transcript)|ensembl:ENST00000588061(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR009060(UBA-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019486|interpro:IPR026805|interpro:IPR032226|interpro:IPR033499|interpro:IPR034927|interpro:IPR035979|interpro:IPR041917|rcsb pdb:2DKL|rcsb pdb:2X04|rcsb pdb:3KTP|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426496|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|dip:DIP-48569N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OZUDlEQ+h+8y51DpPQfEGB7tfx89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P49720 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-603340|uniprotkb:P31147|uniprotkb:Q0P6J7|uniprotkb:Q96E27|ensembl:ENSP00000483688|ensembl:ENSP00000483956 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psb3_human(display_long)|uniprotkb:PSMB3(gene name)|psi-mi:PSMB3(display_short)|uniprotkb:Proteasome theta chain(gene name synonym)|uniprotkb:Proteasome chain 13(gene name synonym)|uniprotkb:Proteasome component C10-II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002786.2|dip:DIP-33846N|ensembl:ENSG00000275903(gene)|ensembl:ENSG00000277791(gene)|ensembl:ENST00000619426(transcript)|ensembl:ENST00000619951(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR033811|mint:P49720|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:H4UDdXV1BaXHp6mEPafNy+Iv8389606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13724 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-720141|uniprotkb:Q17RN9|uniprotkb:Q8TCT5|uniprotkb:A8K938|ensembl:ENSP00000410992|uniprotkb:F5H6D0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mogs_human(display_long)|uniprotkb:Processing A-glucosidase I(gene name synonym)|uniprotkb:MOGS(gene name)|psi-mi:MOGS(display_short)|uniprotkb:GCS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001139630.1|refseq:NP_006293.2|ensembl:ENSG00000115275(gene)|ensembl:ENST00000448666(transcript)|go:"GO:0004573"(Glc3Man9GlcNAc2 oligosaccharide glucosidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0015926"(glucosidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004888(Glycoside hydrolase, family 63)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR031335|interpro:IPR031631|interpro:IPR038518|mint:Q13724|reactome:R-HSA-4793954|reactome:R-HSA-532668|reactome:R-HSA-9683686|reactome:R-HSA-9694548 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:odbL3NUcP483ilKg/CMVn2GtdVs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P52701 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92782 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-726953|uniprotkb:B3KSY8|uniprotkb:Q08AJ0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dpf1_human(display_long)|uniprotkb:D4, zinc and double PHD fingers family 1(gene name synonym)|uniprotkb:DPF1(gene name)|psi-mi:DPF1(display_short)|uniprotkb:NEUD4(gene name synonym)|uniprotkb:BAF45B(gene name synonym)|uniprotkb:BRG1-associated factor 45B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001128627.1|refseq:NP_001128628.1|refseq:NP_004638.2|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR019787|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071565"(nBAF complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|mint:Q92782|interpro:IPR025750|refseq:NP_001276907.1|interpro:IPR038046 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WnpwDXkyVSACQWBHcW9Rcj12O/o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HCJ0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6507625|uniprotkb:Q86UE5|uniprotkb:Q8N3D8|uniprotkb:Q96MU9|uniprotkb:G3XAB8|ensembl:ENSP00000301624|ensembl:ENSP00000468647 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tnr6c_human(display_long)|uniprotkb:TNRC6C(gene name)|psi-mi:TNRC6C(display_short)|uniprotkb:KIAA1582(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001136112.1|refseq:NP_061869.2|ensembl:ENSG00000078687(gene)|ensembl:ENST00000301624(transcript)|ensembl:ENST00000588061(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR009060(UBA-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019486|interpro:IPR026805|interpro:IPR032226|interpro:IPR033499|interpro:IPR034927|interpro:IPR035979|interpro:IPR041917|rcsb pdb:2DKL|rcsb pdb:2X04|rcsb pdb:3KTP|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426496|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|dip:DIP-48569N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OZUDlEQ+h+8y51DpPQfEGB7tfx89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NSG2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11128910|uniprotkb:Q9NVJ0|uniprotkb:B3KU42|uniprotkb:Q9H8L5|uniprotkb:Q3KNQ1|uniprotkb:A6NFP1|ensembl:ENSP00000286031|ensembl:ENSP00000352276 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ca112_human(display_long)|uniprotkb:C1orf112(gene name)|psi-mi:C1orf112(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001306976.1|refseq:NP_001306977.1|refseq:NP_060656.2|refseq:XP_011508037.1|refseq:NP_001306979.1|refseq:NP_001306980.1|refseq:XP_016857213.1|refseq:XP_016857214.1|ensembl:ENSG00000000460(gene)|ensembl:ENST00000286031(transcript)|ensembl:ENST00000359326(transcript)|interpro:IPR027902 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Jy6nCLVYtB3BgdCuu0RLRfmAAVc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q09161 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P27348 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P56589 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-594885|uniprotkb:Q6FGP5|ensembl:ENSP00000356563 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pex3_human(display_long)|uniprotkb:Peroxisomal assembly protein PEX3(gene name synonym)|uniprotkb:PEX3(gene name)|psi-mi:PEX3(display_short)|uniprotkb:Peroxin-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003621.1|ensembl:ENSG00000034693(gene)|ensembl:ENST00000367591(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032994"(protein-lipid complex)|go:"GO:0045046"(protein import into peroxisome membrane)|interpro:IPR006966(Peroxin-3)|rcsb pdb:3AJB|rcsb pdb:3MK4|reactome:R-HSA-1369062|reactome:R-HSA-9603798 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zB+V5tVREEww2DOugIl6YVsUqdM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P61006 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TEQ8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11722765|uniprotkb:B1AML3|uniprotkb:Q6P154|uniprotkb:Q6UX80|uniprotkb:Q8TDS8|uniprotkb:Q96CS9|uniprotkb:Q9BVN9|uniprotkb:Q9Y4B0|ensembl:ENSP00000367880 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pigo_human(display_long)|uniprotkb:PIGO(gene name)|psi-mi:PIGO(display_short)|uniprotkb:Phosphatidylinositol-glycan biosynthesis class O protein(gene name synonym)|uniprotkb:UNQ632/PRO1249(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001188413.1|refseq:NP_116023.2|refseq:NP_690577.2|refseq:XP_005251676.1|refseq:XP_016870711.1|refseq:XP_016870712.1|refseq:XP_016870713.1|ensembl:ENSG00000165282(gene)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006506"(GPI anchor biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0051377"(mannose-ethanolamine phosphotransferase activity)|interpro:IPR002591(Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR037675|interpro:IPR039524|reactome:R-HSA-162710|ensembl:ENST00000378617(transcript) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WGLdye0wC84/xsJ6DbkSRdB3Q/U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P40937 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-712376|ensembl:ENSP00000408295|uniprotkb:A8MZ62|uniprotkb:B3KSX8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rfc5_human(display_long)|uniprotkb:Activator 1 subunit 5(gene name synonym)|uniprotkb:Replication factor C 36 kDa subunit(gene name synonym)|uniprotkb:Activator 1 36 kDa subunit(gene name synonym)|uniprotkb:RFC5(gene name)|psi-mi:RFC5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_031396.1|refseq:NP_853556.2|ensembl:ENSG00000111445(gene)|ensembl:ENST00000454402(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0019899"(enzyme binding)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|mint:P40937|rcsb pdb:1LFS|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-176187|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|refseq:XP_011536945.1|refseq:XP_011536947.1|refseq:NP_001123584.1|refseq:NP_001123585.1|dip:DIP-36433N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:F7oadHDk6fkhHn+3rDF9K2JHSl49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6IEG0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2876632|uniprotkb:Q5THM2|uniprotkb:Q96MK1|uniprotkb:Q5THM1|uniprotkb:Q14C91|uniprotkb:Q5T339|uniprotkb:A8K8P4|ensembl:ENSP00000339834 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:snr48_human(display_long)|uniprotkb:SNRNP48(gene name)|psi-mi:SNRNP48(display_short)|uniprotkb:C6orf151(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_689764.3|ensembl:ENSG00000168566(gene)|ensembl:ENST00000342415(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0046872"(metal ion binding)|interpro:IPR022776|interpro:IPR032845|interpro:IPR036236|rcsb pdb:2VY4|rcsb pdb:2VY5|reactome:R-HSA-72165 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:xKzG44rRn2jI0igYZDuk2eP7+Eg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P06730 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-73440|uniprotkb:Q96E95|ensembl:ENSP00000389624|uniprotkb:D6RCQ6|uniprotkb:B7Z6V1|intact:EBI-28969298 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:if4e_human(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:EIF4E(gene name)|psi-mi:EIF4E(display_short)|uniprotkb:EIF4EL1(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124151.1|refseq:NP_001959.1|ensembl:ENST00000280892|ensembl:ENSP00000280892|ensembl:ENSP00000389624|ensembl:ENST00000505992|ensembl:ENSP00000425561|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:2W97|rcsb pdb:3AM7|rcsb pdb:3TF2|rcsb pdb:3U7X|rcsb pdb:4AZA|rcsb pdb:4BEA|rcsb pdb:4DT6|rcsb pdb:4DUM|rcsb pdb:4TPW|rcsb pdb:4TQB|rcsb pdb:4TQC|rcsb pdb:4UED|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5EKV|rcsb pdb:5GW6|rcsb pdb:5T46|rcsb pdb:5ZJY|rcsb pdb:5ZJZ|rcsb pdb:5ZK5|rcsb pdb:5ZK7|rcsb pdb:5ZK9|ensembl:ENSG00000151247(gene)|rcsb pdb:5ZML|rcsb pdb:7MEU|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-159231|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-159230|reactome:R-HSA-159227|ensembl:ENST00000450253(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:P06730|rcsb pdb:1IPB|rcsb pdb:1IPC|rcsb pdb:1WKW|rcsb pdb:2GPQ|rcsb pdb:2V8W|refseq:NP_001124150.1|refseq:NP_001317946.1|dip:DIP-22N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9173bxjOdBfKj36pWVvzw7M6g1A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92947 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1236978|uniprotkb:O14719|uniprotkb:A8K2Z2|ensembl:ENSP00000222214|ensembl:ENSP00000466845 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gcdh_human(display_long)|uniprotkb:GCDH(gene name)|psi-mi:GCDH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000150.1|refseq:NP_039663.1|ensembl:ENSG00000105607(gene)|ensembl:ENST00000222214(transcript)|ensembl:ENST00000591470(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004361"(glutaryl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:Q92947|rcsb pdb:1SIQ|rcsb pdb:1SIR|rcsb pdb:2R0M|rcsb pdb:2R0N|reactome:R-HSA-71064|go:"GO:0050660"(flavin adenine dinucleotide binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:W192IQEAyP1SdNxhI62Fh8C2UPU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N5P1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-5280267|uniprotkb:Q9BZ75|ensembl:ENSP00000272570|ensembl:ENSP00000386488 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zc3h8_human(display_long)|uniprotkb:ZC3H8(gene name)|psi-mi:ZC3H8(display_short)|uniprotkb:ZC3HDC8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115883.2|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|mint:Q8N5P1|reactome:R-HSA-6807505|ensembl:ENSG00000144161(gene)|ensembl:ENST00000272570(transcript)|ensembl:ENST00000409573(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0035327" - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ltW8I583M/LV8XKPzLRvojXc+AA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UQL6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-715576|uniprotkb:O60340|uniprotkb:O60528|uniprotkb:Q96DY4|intact:EBI-28970762|uniprotkb:C9JFV9|ensembl:ENSP00000468004|ensembl:ENSP00000507606 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hdac5_human(display_long)|uniprotkb:Antigen NY-CO-9(gene name synonym)|uniprotkb:HDAC5(gene name)|psi-mi:HDAC5(display_short)|uniprotkb:KIAA0600(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001015053.1|refseq:NP_005465.2|refseq:XP_005256963.1|ensembl:ENST00000225983|ensembl:ENSP00000225983|ensembl:ENST00000336057|ensembl:ENSP00000337290|ensembl:ENSP00000468004|ensembl:ENSP00000507606|dip:DIP-38260N|rcsb pdb:5UWI|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8943724|mint:Q9UQL6|ensembl:ENSG00000108840(gene)|ensembl:ENST00000586802(transcript)|ensembl:ENST00000682912(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fI8A5VuOawGthBb/65R47AEGZ/Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96PK6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-954272|ensembl:ENSP00000311747|uniprotkb:O75932|uniprotkb:Q53GV1|uniprotkb:Q68DQ9|uniprotkb:Q96PK5|uniprotkb:B3KMN4|uniprotkb:Q2PYN1|uniprotkb:D6RGD8|uniprotkb:B0LM41|intact:EBI-16430855|intact:EBI-16472484 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rbm14_human(display_long)|uniprotkb:RNA-binding motif protein 14(gene name synonym)|uniprotkb:RRM-containing coactivator activator/modulator(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein(gene name synonym)|uniprotkb:RBM14(gene name)|psi-mi:RBM14(display_short)|uniprotkb:SIP(gene name synonym)|uniprotkb:Paraspeckle protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000239306(gene)|ensembl:ENST00000310137(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009725"(response to hormone)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034506|interpro:IPR034507|go:"GO:0098534"(centriole assembly)|interpro:IPR035979|mint:Q96PK6|rcsb pdb:2DNP|reactome:R-HSA-8941326|refseq:NP_001185765.1|refseq:NP_006319.1|ensembl:ENSP00000311747|ensembl:ENST00000393979|ensembl:ENSP00000377548|ensembl:ENST00000409738|ensembl:ENSP00000386995|refseq:NP_001185766.1|refseq:NP_001185774.1|dip:DIP-50126N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Q0UBl2qmfwQTPwUQ7ZDwGIMOYoA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P68104 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NTJ3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356173|uniprotkb:A6NLT9|uniprotkb:O95752|uniprotkb:Q8NDL4|uniprotkb:Q9UNT9|uniprotkb:D3DNL8|ensembl:ENSP00000341382|ensembl:ENSP00000349961 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:smc4_human(display_long)|uniprotkb:SMC4(gene name)|psi-mi:SMC4(display_short)|uniprotkb:CAPC(gene name synonym)|uniprotkb:SMC4L1(gene name synonym)|uniprotkb:Chromosome-associated polypeptide C(gene name synonym)|uniprotkb:XCAP-C homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001002800.1|refseq:NP_005487.3|refseq:XP_011510613.1|refseq:NP_001275682.1|ensembl:ENSG00000113810(gene)|ensembl:ENST00000344722(transcript)|ensembl:ENST00000357388(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041738|mint:Q9NTJ3|rcsb pdb:4U4P|reactome:R-HSA-2299718|reactome:R-HSA-2514853|dip:DIP-32946N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:+2lnTSgTXZwRawJ/ASBRa6EDgv09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P63104 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P51617 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q04917 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96A33 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-720151|uniprotkb:Q96D00|uniprotkb:Q96JZ7|uniprotkb:Q9H3E4|uniprotkb:Q9NRG3|uniprotkb:B2RAS8|uniprotkb:D3DU20|ensembl:ENSP00000225726|ensembl:ENSP00000384888 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ccd47_human(display_long)|uniprotkb:CCDC47(gene name)|psi-mi:CCDC47(display_short)|uniprotkb:Calumin(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 47(gene name synonym)|uniprotkb:GK001(orf name)|uniprotkb:MSTP041(orf name)|uniprotkb:PSEC0077(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064583.2|ensembl:ENSG00000108588(gene)|ensembl:ENST00000225726(transcript)|ensembl:ENST00000403162(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006983"(ER overload response)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043022"(ribosome binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045048"(protein insertion into ER membrane)|interpro:IPR012879(Protein of unknown function DUF1682)|mint:Q96A33|rcsb pdb:6W6L|go:"GO:0030867"(rough endoplasmic reticulum membrane)|refseq:XP_005257584.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DdZFzZrrc4culfYoex0Czf/X6SQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14694 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P21796 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14681 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2339413|uniprotkb:Q9BUQ1|uniprotkb:A8K7D6|uniprotkb:B4DKL6|ensembl:ENSP00000278903|ensembl:ENSP00000484510 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ei24_human(display_long)|uniprotkb:EI24(gene name)|psi-mi:EI24(display_short)|uniprotkb:PIG8(gene name synonym)|uniprotkb:p53-induced gene 8 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011541371.1|refseq:NP_001277064.1|refseq:NP_004870.3|ensembl:ENSG00000149547(gene)|ensembl:ENST00000278903(transcript)|ensembl:ENST00000620753(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061676"(importin-alpha family protein binding)|interpro:IPR009890(Etoposide-induced 2.4)|mint:O14681 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mb5BoJ3ithOKYe8mN+ZRB4UoltI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96HA1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-739990|ensembl:ENSP00000405562|uniprotkb:A8MXF9|uniprotkb:O75115|uniprotkb:Q9Y4S7|intact:EBI-948778|uniprotkb:A6NFS9|uniprotkb:A8CDT4|uniprotkb:A8K933|uniprotkb:Q96DI0|uniprotkb:Q9H9X1|uniprotkb:Q9Y2N3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:p121a_human(display_long)|uniprotkb:POM121(gene name)|psi-mi:POM121(display_short)|uniprotkb:KIAA0618(gene name synonym)|uniprotkb:NUP121(gene name synonym)|uniprotkb:POM121A(gene name synonym)|uniprotkb:Pore membrane protein of 121 kDa(gene name synonym)|uniprotkb:Nuclear envelope pore membrane protein POM 121A(gene name synonym)|uniprotkb:Nucleoporin Nup121(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000196313(gene)|ensembl:ENST00000434423(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|interpro:IPR026054|interpro:IPR026090|rcsb pdb:5T6W|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|refseq:NP_001244119.1|ensembl:ENST00000358357|ensembl:ENSP00000351124|ensembl:ENST00000395270|ensembl:ENSP00000378687|ensembl:ENSP00000405562|ensembl:ENST00000446813|ensembl:ENSP00000393020|ensembl:ENST00000627934|ensembl:ENSP00000486504|reactome:R-HSA-165054|refseq:NP_742017.1|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005250783.1|refseq:XP_006716259.1|refseq:XP_016868342.1|refseq:XP_016868343.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:lQ9VaBl42KMRJaM4UdF4ng9ZX549606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92973 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P51648 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1391128|uniprotkb:Q93011|uniprotkb:Q96J37|uniprotkb:Q6I9T3|ensembl:ENSP00000176643|ensembl:ENSP00000461916|ensembl:ENSP00000463637|ensembl:ENSP00000500092 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:al3a2_human(display_long)|uniprotkb:Aldehyde dehydrogenase 10(gene name synonym)|uniprotkb:Microsomal aldehyde dehydrogenase(gene name synonym)|uniprotkb:ALDH3A2(gene name)|psi-mi:ALDH3A2(display_short)|uniprotkb:ALDH10(gene name synonym)|uniprotkb:FALDH(gene name synonym)|uniprotkb:Fatty aldehyde dehydrogenase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000373.1|refseq:NP_001026976.1|refseq:XP_011522034.1|refseq:XP_011522035.1|refseq:XP_016879845.1|refseq:XP_016879846.1|ensembl:ENST00000672357(transcript)|go:"GO:0004028"(3-chloroallyl aldehyde dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006714"(sesquiterpenoid metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008544"(epidermis development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033306"(phytol metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0046458"(hexadecanal metabolic process)|go:"GO:0046577"(long-chain-alcohol oxidase activity)|go:"GO:0050061"(long-chain-aldehyde dehydrogenase activity)|go:"GO:0052814"(medium-chain-aldehyde dehydrogenase activity)|interpro:IPR012394("Aldehyde dehydrogenase NAD(P)-dependent")|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P51648|rcsb pdb:4QGK|reactome:R-HSA-1660661|reactome:R-HSA-389599|reactome:R-HSA-9603798|reactome:R-HSA-9609523|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENSG00000072210(gene)|ensembl:ENST00000176643(transcript)|ensembl:ENST00000579855(transcript)|ensembl:ENST00000581518(transcript) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ADi5/NMf5JsjzaonzFIbHZebIlQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:A2AEA2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103244|ensembl:ENSP00000372819 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:a2aea2_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000204525(gene)|ensembl:ENST00000383329(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:F8Dwv1iC12B53GCbu/zh4Rpe1249606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P17987 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UL15 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15942 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-444225|ensembl:ENSP00000324422|ensembl:ENSP00000494798|uniprotkb:Q6I9S4|uniprotkb:A4D2G6|uniprotkb:B4DQX7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zyx_human(display_long)|uniprotkb:Zyxin-2(gene name synonym)|uniprotkb:ZYX(gene name)|psi-mi:ZYX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000159840(gene)|ensembl:ENSG00000285443(gene)|ensembl:ENST00000322764(transcript)|ensembl:ENST00000646695(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0043149"(stress fiber assembly)|refseq:NP_001010972.1|refseq:NP_003452.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4UC6NVZHDUrTy4sPhz7e7RpPwho9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q12797 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2967294|ensembl:ENSP00000368767|uniprotkb:B4E2K4|uniprotkb:F5H667|uniprotkb:Q9NRI0|uniprotkb:Q9Y4J0|uniprotkb:Q9H2C4|uniprotkb:A6NDF4|uniprotkb:Q9NRI1|uniprotkb:A6NHI2|uniprotkb:B4DIC9|uniprotkb:B7ZM95|uniprotkb:E5RGP5|uniprotkb:Q6NXR7|uniprotkb:Q8TB28|uniprotkb:Q9H291|intact:EBI-8994140|uniprotkb:A0A0A0MSK8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:asph_human(display_long)|uniprotkb:ASPH(gene name)|psi-mi:ASPH(display_short)|uniprotkb:Aspartate beta-hydroxylase(gene name synonym)|uniprotkb:Peptide-aspartate beta-dioxygenase(gene name synonym)|uniprotkb:BAH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000198363(gene)|ensembl:ENST00000379454(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033198"(response to ATP)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0062101"(peptidyl-aspartic acid 3-dioxygenase activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR007803(Aspartyl/Asparaginyl beta-hydroxylase)|interpro:IPR007943(Aspartyl beta-hydroxylase, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5APA|rcsb pdb:5JQY|interpro:IPR019734|rcsb pdb:5JTC|interpro:IPR027443|interpro:IPR039038|rcsb pdb:5JZ6|mint:Q12797|rcsb pdb:5JZ8|rcsb pdb:5JZA|rcsb pdb:5JZU|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6QA5|rcsb pdb:6RK9|rcsb pdb:6YYU|rcsb pdb:6YYV|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|reactome:R-HSA-5578775|reactome:R-HSA-2672351|refseq:NP_001158222.1|refseq:NP_004309.2|refseq:NP_064549.1|refseq:NP_115855.1|refseq:NP_115856.1|refseq:NP_001158223.1|refseq:NP_001158225.1|refseq:NP_001158227.1|refseq:NP_001158228.1|refseq:NP_115857.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8Sv1CuwqdVCK6/PF6kL0hkX3/tw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P22102 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5JPE7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2680477|ensembl:ENSP00000370883|ensembl:ENSP00000477502|intact:EBI-3957033|uniprotkb:Q4G177 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nomo2_human(display_long)|uniprotkb:pM5 protein 2(gene name synonym)|uniprotkb:NOMO2(gene name)|psi-mi:NOMO2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001004060.1|refseq:NP_775885.1|ensembl:ENSG00000185164(gene)|ensembl:ENST00000381474(transcript)|ensembl:ENST00000621364(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR041033 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Nqg3PkM8MmXjl/n314IAbUrY4C89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75477 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7L5D6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P17066 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355106|uniprotkb:Q8IYK7|uniprotkb:Q9BT95|uniprotkb:Q1HBA8|ensembl:ENSP00000310219 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hsp76_human(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002146.2|ensembl:ENSG00000173110(gene)|ensembl:ENST00000309758(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P17066|rcsb pdb:3FE1|reactome:R-HSA-3371453|reactome:R-HSA-6798695 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:AcNwJ2S/RD3n/8iRNy5ioetVZ+U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BTY2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-9050116|uniprotkb:E9PEB6|uniprotkb:Q7Z6V1|uniprotkb:Q7Z6Y2|uniprotkb:Q8NBK4|ensembl:ENSP00000002165 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:fuco2_human(display_long)|uniprotkb:FUCA2(gene name)|psi-mi:FUCA2(display_short)|uniprotkb:Alpha-L-fucoside fucohydrolase 2(gene name synonym)|uniprotkb:PSEC0151(orf name)|uniprotkb:UNQ227/PRO260(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_114409.2|ensembl:ENSG00000001036(gene)|ensembl:ENST00000002165(transcript)|go:"GO:0004560"(alpha-L-fucosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR000933("Glycoside hydrolase, family 29 (alpha-L-fucosidase)")|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR016286(Alpha-L-fucosidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR018526|interpro:IPR031919|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:cBWxxpX9fUF1KQjkaIWoq2n0Vqg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y4L1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054186|uniprotkb:Q2I204|uniprotkb:Q53H25|uniprotkb:B7Z909|uniprotkb:A8C1Z0|ensembl:ENSP00000480150|ensembl:ENSP00000486825 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hyou1_human(display_long)|uniprotkb:150 kDa oxygen-regulated protein(gene name synonym)|uniprotkb:GRP170(gene name synonym)|uniprotkb:HYOU1(gene name)|psi-mi:HYOU1(display_short)|uniprotkb:ORP150(gene name synonym)|uniprotkb:170 kDa glucose-regulated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124463.1|refseq:NP_006380.1|refseq:XP_016872585.1|refseq:XP_016872586.1|ensembl:ENSG00000149428(gene)|ensembl:ENSG00000280682(gene)|ensembl:ENST00000617285(transcript)|ensembl:ENST00000630669(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:Q9Y4L1|reactome:R-HSA-3000484|reactome:R-HSA-381038|go:"GO:0005790"(smooth endoplasmic reticulum) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:xqSFRaiiHJLNVqgh87tHx9lfnS49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y5B9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046849|uniprotkb:Q6GMT8|uniprotkb:Q6P2F1|uniprotkb:Q6PJM1|uniprotkb:Q9NRX0|ensembl:ENSP00000216297 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sp16h_human(display_long)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:SUPT16H(gene name)|psi-mi:SUPT16H(display_short)|uniprotkb:FACT140(gene name synonym)|uniprotkb:FACTP140(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000092201(gene)|ensembl:ENST00000216297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|interpro:IPR029148|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|mint:Q9Y5B9|rcsb pdb:4Z2M|rcsb pdb:4Z2N|rcsb pdb:5E5B|rcsb pdb:5UMT|rcsb pdb:5UMU|rcsb pdb:5XM2|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|refseq:NP_009123.1|dip:DIP-42757N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jLK5dOF3mEyI0UbZhcNgtdlG+WI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14444 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P27708 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355504|uniprotkb:Q6P0Q0|uniprotkb:D6W552|ensembl:ENSP00000264705|uniprotkb:Q96CK3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pyr1_human(display_long)|uniprotkb:CAD(gene name)|psi-mi:CAD(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004332.2|ensembl:ENSG00000084774(gene)|ensembl:ENST00000264705(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004070"(aspartate carbamoyltransferase activity)|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004151"(dihydroorotase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014075"(response to amine)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017144"|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044205"('de novo' UMP biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051414"(response to cortisol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070335"(aspartate binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR002082(Aspartate carbamoyltransferase, eukaryotic)|interpro:IPR002195(Dihydroorotase, conserved site)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR032466|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036901|interpro:IPR036914|mint:P27708|go:"GO:0016020"(membrane)|rcsb pdb:4BY3|rcsb pdb:4C6B|rcsb pdb:4C6C|rcsb pdb:4C6D|rcsb pdb:4C6E|rcsb pdb:4C6F|rcsb pdb:4C6I|rcsb pdb:4C6J|rcsb pdb:4C6K|rcsb pdb:4C6L|rcsb pdb:4C6M|rcsb pdb:4C6N|rcsb pdb:4C6O|rcsb pdb:4C6P|rcsb pdb:4C6Q|rcsb pdb:5G1N|rcsb pdb:5G1O|rcsb pdb:5G1P|rcsb pdb:5YNZ|rcsb pdb:6HFD|rcsb pdb:6HFE|rcsb pdb:6HFF|rcsb pdb:6HFH|rcsb pdb:6HFI|rcsb pdb:6HFJ|rcsb pdb:6HFK|rcsb pdb:6HFL|rcsb pdb:6HFP|rcsb pdb:6HFQ|rcsb pdb:6HFR|rcsb pdb:6HFS|rcsb pdb:6HFU|rcsb pdb:6HG1|reactome:R-HSA-500753|rcsb pdb:6HFN|refseq:NP_001293008.1|dip:DIP-39484N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:m5iR4BQz6t2dbQxtP1MARVW0LAw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P53985 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054708|uniprotkb:Q9NSJ9|uniprotkb:Q5T8R6|uniprotkb:Q49A45|ensembl:ENSP00000416167|ensembl:ENSP00000441065|ensembl:ENSP00000485688|ensembl:ENSP00000358640|ensembl:ENSP00000397106|ensembl:ENSP00000399104|ensembl:ENSP00000486000|ensembl:ENSP00000505879 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mot1_human(display_long)|uniprotkb:Solute carrier family 16 member 1(gene name synonym)|uniprotkb:SLC16A1(gene name)|psi-mi:SLC16A1(display_short)|uniprotkb:MCT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001159968.1|refseq:NP_003042.3|refseq:XP_011540328.1|refseq:XP_011540329.1|ensembl:ENSG00000155380(gene)|ensembl:ENSG00000281917(gene)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0032094"(response to food)|ensembl:ENST00000369626(transcript)|ensembl:ENST00000429288(transcript)|ensembl:ENST00000443580(transcript)|ensembl:ENST00000458229(transcript)|ensembl:ENST00000538576(transcript)|ensembl:ENST00000628110(transcript)|ensembl:ENST00000630362(transcript)|ensembl:ENST00000679803(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015129"(lactate transmembrane transporter activity)|go:"GO:0015130"(mevalonate transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0015728"(mevalonate transport)|go:"GO:0016020"(membrane)|go:"GO:0035879"(plasma membrane lactate transport)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0046943"(carboxylic acid transmembrane transporter activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051780"(behavioral response to nutrient)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004743(Monocarboxylate transporter)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030757|interpro:IPR036259|mint:P53985|go:"GO:1905039"(carboxylic acid transmembrane transport)|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-210991|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pwaf5lRwviMRyOg4DN2/6J/iMwc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BUJ2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1018153|uniprotkb:O76022|uniprotkb:Q6ZSZ0|uniprotkb:Q7L8P4|uniprotkb:Q8N6Z4|uniprotkb:Q96G37|uniprotkb:Q9HAL3|uniprotkb:Q9UG75|intact:EBI-3183399|intact:EBI-2339292|uniprotkb:B3KMW7|ensembl:ENSP00000375863|intact:EBI-2563529 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hnrl1_human(display_long)|uniprotkb:E1BAP5(gene name synonym)|uniprotkb:HNRNPUL1(gene name)|psi-mi:HNRNPUL1(display_short)|uniprotkb:HNRPUL1(gene name synonym)|uniprotkb:Adenovirus early region 1B-associated protein 5(gene name synonym)|uniprotkb:E1B-55 kDa-associated protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008971.2|refseq:NP_653333.1|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027025|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q9BUJ2|reactome:R-HSA-72163|ensembl:ENSG00000105323(gene)|ensembl:ENST00000392006(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_001308140.1|refseq:NP_001308137.1|dip:DIP-39419N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IahA7SVR1NmvldrWKQlAwApinQE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H9E1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:U3KQK0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-12142839|ensembl:ENSP00000475942 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:u3kqk0_human(display_long)|uniprotkb:H2BC15(gene name)|psi-mi:H2BC15(display_short)|uniprotkb:HIST1H2BN(gene name synonym)|uniprotkb:hCG_1743059(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000233822(gene)|ensembl:ENST00000606613(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Hs/lqO9F2951gmJ5sO1NOyNhMUI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P61962 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P08670 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P51665 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UNM6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:iOxE62MMeGx+aqsrir/LukJqeho9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NDV7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2269715|uniprotkb:O15408|uniprotkb:Q658L5|uniprotkb:Q6NVB5|uniprotkb:Q8NEZ0|uniprotkb:Q8TBT8|uniprotkb:Q8TCR0|uniprotkb:Q9NV59|uniprotkb:Q9P268|uniprotkb:C9JAR8|ensembl:ENSP00000379144|ensembl:ENSP00000500873 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tnr6a_human(display_long)|uniprotkb:TNRC6A(gene name)|psi-mi:TNRC6A(display_short)|uniprotkb:CAGH26(gene name synonym)|uniprotkb:KIAA1460(gene name synonym)|uniprotkb:TNRC6(gene name synonym)|uniprotkb:CAG repeat protein 26(gene name synonym)|uniprotkb:Glycine-tryptophan protein of 182 kDa(gene name synonym)|uniprotkb:GW182 autoantigen(gene name synonym)|uniprotkb:EMSY interactor protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000315183|ensembl:ENSP00000326900|ensembl:ENSP00000379144|ensembl:ENST00000672933|ensembl:ENSP00000500125|ensembl:ENSP00000500873|refseq:NP_055309.2|refseq:NP_001317449.1|refseq:XP_016878642.1|refseq:XP_005255314.1|dip:DIP-54489N|ensembl:ENSG00000090905(gene)|ensembl:ENSG00000288130(gene)|ensembl:ENST00000395799(transcript)|ensembl:ENST00000673084(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016442"(RISC complex)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019486|interpro:IPR026805|interpro:IPR032226|interpro:IPR033501|interpro:IPR034924|interpro:IPR035979|mint:Q8NDV7|rcsb pdb:5W6V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426496|reactome:R-HSA-5578749|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:CovOl6RsNKv9t55lEGnLPo2gafY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P61981 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q16531 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TA86 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-630339|ensembl:ENSP00000297157 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rp9_human(display_long)|uniprotkb:Pim-1-associated protein(gene name synonym)|uniprotkb:RP9(gene name)|psi-mi:RP9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_976033.1|ensembl:ENSG00000164610(gene)|ensembl:ENST00000297157(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:0050890"(cognition)|interpro:IPR034585 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aLu5MPtPUaFvJYBLKJ+ObI4c0OQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P04844 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-719731|uniprotkb:Q5JYR6|uniprotkb:Q9UBE1|uniprotkb:Q6IBA5|uniprotkb:Q96E21|uniprotkb:Q9BUQ3|ensembl:ENSP00000237530 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rpn2_human(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:RIBIIR(gene name synonym)|uniprotkb:RPN2(gene name)|psi-mi:RPN2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001129243.1|refseq:NP_002942.2|ensembl:ENSG00000118705(gene)|ensembl:ENST00000237530(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:P04844|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|refseq:NP_001311234.1|refseq:NP_001311235.1|refseq:NP_001311228.1|refseq:NP_001311230.1|refseq:NP_001311231.1|refseq:NP_001311232.1|refseq:NP_001311233.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7bTuuEb3ykWQvkI/5DKpga48s/w9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14654 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P53007 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359163|uniprotkb:Q9BSK6|uniprotkb:A8K8E8|ensembl:ENSP00000215882 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:txtp_human(display_long)|uniprotkb:SLC25A1(gene name)|psi-mi:SLC25A1(display_short)|uniprotkb:SLC20A3(gene name synonym)|uniprotkb:Citrate transport protein(gene name synonym)|uniprotkb:Tricarboxylate carrier protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005975.1|ensembl:ENSG00000100075(gene)|ensembl:ENST00000215882(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006843"(mitochondrial citrate transmembrane transport)|go:"GO:0015137"(citrate transmembrane transporter activity)|go:"GO:0015142"(tricarboxylic acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071913"(citrate secondary active transmembrane transporter activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|mint:P53007|reactome:R-HSA-70263|reactome:R-HSA-75105 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:MB0RrMAQme4F8M4IivU1AqUxlgA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8WTW3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-368371|uniprotkb:Q9P2G6|uniprotkb:Q9NPV9|ensembl:ENSP00000299886 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cog1_human(display_long)|uniprotkb:COG1(gene name)|psi-mi:COG1(display_short)|uniprotkb:KIAA1381(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 1(gene name synonym)|uniprotkb:LDLB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_061184.1|ensembl:ENSG00000166685(gene)|ensembl:ENST00000299886(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|interpro:IPR033370|mint:Q8WTW3|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|go:"GO:0015031"(protein transport) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zUXskbnET4Wp0wRsjxwtE33ccCA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BSJ2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357881|uniprotkb:O43632|ensembl:ENSP00000252936|ensembl:ENSP00000506731|ensembl:ENSP00000507482|ensembl:ENSP00000507610|uniprotkb:Q5VWX7|uniprotkb:B4DM18|uniprotkb:F5H4E0|uniprotkb:B7ZKL8|uniprotkb:F5H4L0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gcp2_human(display_long)|uniprotkb:TUBGCP2(gene name)|psi-mi:TUBGCP2(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:Spindle pole body protein Spc97 homolog(gene name synonym)|uniprotkb:Gamma-ring complex protein 103 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006650.1|ensembl:ENSG00000130640(gene)|ensembl:ENST00000252936(transcript)|ensembl:ENST00000682123(transcript)|ensembl:ENST00000682515(transcript)|ensembl:ENST00000683612(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001243547.1|refseq:NP_001243546.1|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q9BSJ2|rcsb pdb:6V6B|rcsb pdb:6V6S|rcsb pdb:6X0V|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:vhamYv9ZNsZkSBkGQCwVylqx9wE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HD45 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2814047|uniprotkb:Q9NWL8|uniprotkb:Q5TB57|uniprotkb:Q9UHW8|uniprotkb:Q6UWE7|uniprotkb:Q9P0G9|ensembl:ENSP00000360184 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tm9s3_human(display_long)|uniprotkb:TM9SF3(gene name)|psi-mi:TM9SF3(display_short)|uniprotkb:SMBP(gene name synonym)|uniprotkb:EP70-P-iso(gene name synonym)|uniprotkb:SM-11044-binding protein(gene name synonym)|uniprotkb:UNQ245/PRO282(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064508.3|ensembl:ENSG00000077147(gene)|ensembl:ENST00000371142(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR004240("Nonaspanin (TM9SF)")|mint:Q9HD45 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:/9Z/a+36wE2FTbIyQ/zWPPGo9Rs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:A1L0T0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-720553|uniprotkb:O43341|uniprotkb:Q99651|uniprotkb:Q9BWN5|uniprotkb:Q9UEB2|intact:EBI-3184145|intact:EBI-1236857|uniprotkb:Q96F08|ensembl:ENSP00000263383 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hacl2_human(display_long)|uniprotkb:Acetolactate synthase-like protein(gene name synonym)|uniprotkb:HACL2(gene name synonym)|uniprotkb:ILVBL(gene name)|psi-mi:ILVBL(display_short)|uniprotkb:AHAS(gene name synonym)|uniprotkb:IlvB-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006835.2|refseq:XP_005259774.1|ensembl:ENSG00000105135(gene)|ensembl:ENST00000263383(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001561"(fatty acid alpha-oxidation)|go:"GO:0003984"(acetolactate synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005948"(acetolactate synthase complex)|go:"GO:0009097"(isoleucine biosynthetic process)|go:"GO:0009099"(valine biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016829"(lyase activity)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR000399(TPP-binding enzymes, conserved site)|interpro:IPR011766(Thiamine pyrophosphate enzyme, C-terminal TPP-binding)|interpro:IPR012000(Thiamine pyrophosphate enzyme, central region)|interpro:IPR012001(Thiamine pyrophosphate enzyme, N-terminal TPP binding region)|interpro:IPR029035|interpro:IPR029061 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WDj/FsULgscGSIgcTe8+1+vKhS09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y285 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-725361|uniprotkb:Q9NSD8|uniprotkb:Q9Y4W8|uniprotkb:B4E363|ensembl:ENSP00000320309 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:syfa_human(display_long)|uniprotkb:CML33(gene name synonym)|uniprotkb:FARSA(gene name)|psi-mi:FARSA(display_short)|uniprotkb:FARS(gene name synonym)|uniprotkb:FARSLA(gene name synonym)|uniprotkb:FARSL(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase alpha subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004452.1|ensembl:ENSG00000179115(gene)|ensembl:ENST00000314606(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004529(Phenylalanyl-tRNA synthetase, class IIc, alpha subunit)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036390|interpro:IPR040586|interpro:IPR040724|interpro:IPR040725|mint:Q9Y285|rcsb pdb:3L4G|reactome:R-HSA-379716|dip:DIP-53610N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FpOCk4Mzmsb2CnIUwUKg5nRg7/U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q69YQ0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351113|uniprotkb:O15081|intact:EBI-10965349|uniprotkb:B7Z758|uniprotkb:F5H1H6|ensembl:ENSP00000325785|ensembl:ENSP00000393363|ensembl:ENSP00000439633 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cytsa_human(display_long)|uniprotkb:SPECC1L(gene name)|psi-mi:SPECC1L(display_short)|uniprotkb:Renal carcinoma antigen NY-REN-22(gene name synonym)|uniprotkb:CYTSA(gene name synonym)|uniprotkb:KIAA0376(gene name synonym)|uniprotkb:Sperm antigen with calponin homology and coiled-coil domains 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056145.4|refseq:NP_001241661.2|dip:DIP-33173N|ensembl:ENSG00000100014(gene)|ensembl:ENST00000314328(transcript)|ensembl:ENST00000437398(transcript)|ensembl:ENST00000541492(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005921"(gap junction)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0051301"(cell division)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|interpro:IPR040166|mint:Q69YQ0 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:iYg2RCRo/dMtmwyppU7ywkhkolI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P33778 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357986|uniprotkb:Q4KN36|ensembl:ENSP00000482674 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2b1b_human(display_long)|uniprotkb:H2BC3(gene name)|psi-mi:H2BC3(display_short)|uniprotkb:H2B-clustered histone 3(gene name synonym)|uniprotkb:H2BFF(gene name synonym)|uniprotkb:HIST1H2BB(gene name synonym)|uniprotkb:Histone H2B.1(gene name synonym)|uniprotkb:Histone H2B.f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_066406.1|dip:DIP-47505N|ensembl:ENSG00000276410(gene)|ensembl:ENST00000615966(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P33778|rcsb pdb:3X1S|rcsb pdb:3X1U|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:l15lrchv4onuihbdZ+yWJQd35Ss9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6NXE6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1053802|uniprotkb:O94999|uniprotkb:Q9BTH5|uniprotkb:B4DI98|ensembl:ENSP00000376148|ensembl:ENSP00000444156 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:armc6_human(display_long)|uniprotkb:ARMC6(gene name)|psi-mi:ARMC6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001186125.1|refseq:NP_219483.1|refseq:XP_005260214.1|ensembl:ENSG00000105676(gene)|ensembl:ENST00000392336(transcript)|ensembl:ENST00000535612(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040104|refseq:XP_016882974.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GmBkkkIiwWSjy2KIay/KQ8VTZgk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P55786 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046129|uniprotkb:Q6P145|uniprotkb:Q9NP16|uniprotkb:Q9UEM2|ensembl:ENSP00000320324|ensembl:ENSP00000503682|uniprotkb:B7Z463 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psa_human(display_long)|uniprotkb:NPEPPS(gene name)|psi-mi:NPEPPS(display_short)|uniprotkb:PSA(gene name synonym)|uniprotkb:Cytosol alanyl aminopeptidase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006301.3|ensembl:ENSG00000141279(gene)|ensembl:ENST00000322157(transcript)|ensembl:ENST00000677120(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|reactome:R-HSA-983168|refseq:NP_001317186.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:gDl9SPlJhCOhA8uF4OEw+lIPh2M9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N5F7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-721539|uniprotkb:Q96BQ2|uniprotkb:Q9H638|intact:EBI-745962|intact:EBI-1055594|uniprotkb:Q6IPW6|ensembl:ENSP00000360464 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nkap_human(display_long)|uniprotkb:NKAP(gene name)|psi-mi:NKAP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_078804.2|ensembl:ENSG00000101882(gene)|ensembl:ENST00000371410(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|interpro:IPR009269(Protein of unknown function DUF926)|interpro:IPR040466|mint:Q8N5F7|rcsb pdb:6QDV - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:AiSgP+Qr12IZX1LBTsna82wmkks9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62805 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-302023|ensembl:ENSP00000244537|ensembl:ENSP00000347168|ensembl:ENSP00000350767|ensembl:ENSP00000366974|ensembl:ENSP00000366956|ensembl:ENSP00000462667|ensembl:ENSP00000367034|ensembl:ENSP00000478519|ensembl:ENSP00000478786|ensembl:ENSP00000443017|ensembl:ENSP00000462355|ensembl:ENSP00000479106|ensembl:ENSP00000479461|uniprotkb:A2VCL0|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6DRA9|uniprotkb:Q6FGB8|uniprotkb:Q6NWP7|ensembl:ENSP00000479794|ensembl:ENSP00000480960|ensembl:ENSP00000481343|ensembl:ENSP00000481486|ensembl:ENSP00000481507|ensembl:ENSP00000482412|ensembl:ENSP00000484789|ensembl:ENSP00000489319|ensembl:ENSP00000489567 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h4_human(display_long)|uniprotkb:H4-16(gene name)|psi-mi:H4-16(display_short)|uniprotkb:H4C1(gene name)|psi-mi:H4C1(display_short)|uniprotkb:H4C11(gene name)|psi-mi:H4C11(display_short)|uniprotkb:H4C12(gene name)|psi-mi:H4C12(display_short)|uniprotkb:H4C13(gene name)|psi-mi:H4C13(display_short)|uniprotkb:H4C14(gene name)|psi-mi:H4C14(display_short)|uniprotkb:H4C15(gene name)|psi-mi:H4C15(display_short)|uniprotkb:H4C2(gene name)|psi-mi:H4C2(display_short)|uniprotkb:H4C3(gene name)|psi-mi:H4C3(display_short)|uniprotkb:H4C4(gene name)|psi-mi:H4C4(display_short)|uniprotkb:H4C5(gene name)|psi-mi:H4C5(display_short)|uniprotkb:H4C6(gene name)|psi-mi:H4C6(display_short)|uniprotkb:H4C8(gene name)|psi-mi:H4C8(display_short)|uniprotkb:H4C9(gene name)|psi-mi:H4C9(display_short)|uniprotkb:H4/A(gene name synonym)|uniprotkb:H4/B(gene name synonym)|uniprotkb:H4/C(gene name synonym)|uniprotkb:H4/D(gene name synonym)|uniprotkb:H4/E(gene name synonym)|uniprotkb:H4/G(gene name synonym)|uniprotkb:H4/H(gene name synonym)|uniprotkb:H4/I(gene name synonym)|uniprotkb:H4/J(gene name synonym)|uniprotkb:H4/K(gene name synonym)|uniprotkb:H4/M(gene name synonym)|uniprotkb:H4/N(gene name synonym)|uniprotkb:H4/O(gene name synonym)|uniprotkb:H4F2(gene name synonym)|uniprotkb:H4FA(gene name synonym)|uniprotkb:H4FB(gene name synonym)|uniprotkb:H4FC(gene name synonym)|uniprotkb:H4FD(gene name synonym)|uniprotkb:H4FE(gene name synonym)|uniprotkb:H4FG(gene name synonym)|uniprotkb:H4FH(gene name synonym)|uniprotkb:H4FI(gene name synonym)|uniprotkb:H4FJ(gene name synonym)|uniprotkb:H4FK(gene name synonym)|uniprotkb:H4FM(gene name synonym)|uniprotkb:H4FN(gene name synonym)|uniprotkb:H4FO(gene name synonym)|uniprotkb:HIST1H4A(gene name synonym)|uniprotkb:HIST1H4B(gene name synonym)|uniprotkb:HIST1H4C(gene name synonym)|uniprotkb:HIST1H4D(gene name synonym)|uniprotkb:HIST1H4E(gene name synonym)|uniprotkb:HIST1H4F(gene name synonym)|uniprotkb:HIST1H4H(gene name synonym)|uniprotkb:HIST1H4I(gene name synonym)|uniprotkb:HIST1H4J(gene name synonym)|uniprotkb:HIST1H4K(gene name synonym)|uniprotkb:HIST1H4L(gene name synonym)|uniprotkb:HIST2H4(gene name synonym)|uniprotkb:HIST2H4A(gene name synonym)|uniprotkb:HIST2H4B(gene name synonym)|uniprotkb:HIST4H4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000197061(gene)|ensembl:ENSG00000276180(gene)|ensembl:ENSG00000197238(gene)|ensembl:ENSG00000276966(gene)|ensembl:ENSG00000277157(gene)|ensembl:ENSG00000270276(gene)|ensembl:ENSG00000197837(gene)|ensembl:ENSG00000270882(gene)|ensembl:ENSG00000278637(gene)|ensembl:ENSG00000273542(gene)|ensembl:ENSG00000274618(gene)|ensembl:ENSG00000278705(gene)|ensembl:ENSG00000275126(gene)|ensembl:ENSG00000158406(gene)|dip:DIP-33079N|ensembl:ENST00000244537(transcript)|ensembl:ENST00000355057(transcript)|ensembl:ENST00000358064(transcript)|ensembl:ENST00000377727(transcript)|ensembl:ENST00000377745(transcript)|ensembl:ENST00000377803(transcript)|ensembl:ENST00000539745(transcript)|ensembl:ENST00000578186(transcript)|ensembl:ENST00000579512(transcript)|ensembl:ENST00000611927(transcript)|ensembl:ENST00000612061(transcript)|ensembl:ENST00000613412(transcript)|ensembl:ENST00000614247(transcript)|ensembl:ENST00000614272(transcript)|ensembl:ENST00000615164(transcript)|ensembl:ENST00000615353(transcript)|ensembl:ENST00000617569(transcript)|ensembl:ENST00000618193(transcript)|ensembl:ENST00000618305(transcript)|ensembl:ENST00000621520(transcript)|ensembl:ENST00000634560(transcript)|ensembl:ENST00000634956(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0005576"(extracellular region)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AYW|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:3F9W|rcsb pdb:3F9X|rcsb pdb:3F9Y|rcsb pdb:3F9Z|rcsb pdb:3IJ1|rcsb pdb:3JPX|rcsb pdb:3NQJ|rcsb pdb:3NQU|rcsb pdb:3O36|rcsb pdb:3QBY|rcsb pdb:3QZS|rcsb pdb:3QZT|rcsb pdb:3QZV|rcsb pdb:3R45|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:4GQB|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4M38|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4QUT|rcsb pdb:4QUU|rcsb pdb:4QYD|rcsb pdb:4U9W|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4YY6|rcsb pdb:4YYD|rcsb pdb:4YYG|rcsb pdb:4YYH|rcsb pdb:4YYI|rcsb pdb:4YYJ|rcsb pdb:4YYK|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:4Z2M|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5B40|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5CPI|interpro:IPR019809|interpro:IPR035425|mint:P62805|rcsb pdb:1ZKK|rcsb pdb:2BQZ|rcsb pdb:2CV5|rcsb pdb:2IG0|rcsb pdb:2KWN|rcsb pdb:2KWO|rcsb pdb:2LVM|rcsb pdb:2QQS|rcsb pdb:2RJE|rcsb pdb:2RNY|interpro:IPR009072(Histone-fold)|rcsb pdb:2RS9|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JA4|rcsb pdb:5JRG|rcsb pdb:5KDM|rcsb pdb:5TEG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5YE3|rcsb pdb:5YE4|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:5ZBX|rcsb pdb:5ZGC|rcsb pdb:5CPJ|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:5CPK|rcsb pdb:6A5P|rcsb pdb:5FA5|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACP|rcsb pdb:6BUZ|rcsb pdb:6C0W|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6FML|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:5FFW|rcsb pdb:5FWE|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MLC|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6O1D|rcsb pdb:6R0C|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|refseq:NP_001029249.1|refseq:NP_003486.1|refseq:NP_003529.1|refseq:NP_003530.1|refseq:NP_003531.1|refseq:NP_003532.1|refseq:NP_003533.1|refseq:NP_003534.1|refseq:NP_003535.1|refseq:NP_003536.1|refseq:NP_003537.1|refseq:NP_003539.1|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6RNY|rcsb pdb:6RXS|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2K|rcsb pdb:6V92|rcsb pdb:6VO5|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6YOV|rcsb pdb:7A08|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7CIZ|rcsb pdb:7CJ0|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7JO9|rcsb pdb:7JOA|rcsb pdb:7JZV|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LMK|rcsb pdb:7LMM|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|refseq:NP_068803.1|refseq:NP_778224.1|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O15269 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P61026 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NYA4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1052346|uniprotkb:Q8IV27|uniprotkb:D3DTZ6|uniprotkb:Q9Y4D5|ensembl:ENSP00000325285 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mtmr4_human(display_long)|uniprotkb:FYVE domain-containing dual specificity protein phosphatase 2(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 11(gene name synonym)|uniprotkb:MTMR4(gene name)|psi-mi:MTMR4(display_short)|uniprotkb:KIAA0647(gene name synonym)|uniprotkb:ZFYVE11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004678.3|refseq:XP_005257843.1|ensembl:ENSG00000108389(gene)|ensembl:ENST00000323456(transcript)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR029021|interpro:IPR030564|interpro:IPR030590|interpro:IPR035997|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-2173788|refseq:XP_006722231.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:b6qLW87NCvRJbpqRYguOZRZC2sI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y2J4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-746752|intact:EBI-28986657|ensembl:ENSP00000409999|uniprotkb:Q53EP1|uniprotkb:Q96F99|uniprotkb:Q9UKB4|uniprotkb:A8K6F1|uniprotkb:B7Z5Q1|uniprotkb:E9PHW3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:amol2_human(display_long)|uniprotkb:Leman coiled-coil protein(gene name synonym)|uniprotkb:AMOTL2(gene name)|psi-mi:AMOTL2(display_short)|uniprotkb:KIAA0989(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001265612.1|refseq:NP_001265614.1|ensembl:ENSG00000114019(gene)|refseq:XP_006713717.1|refseq:NP_057285.3|refseq:XP_011511183.1|ensembl:ENST00000422605(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035329"(hippo signaling)|go:"GO:0055037"(recycling endosome)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q9Y2J4|reactome:R-HSA-2028269|refseq:XP_016862069.1|refseq:XP_016862070.1|refseq:XP_016862071.1|ensembl:ENST00000249883|ensembl:ENSP00000249883|ensembl:ENSP00000409999|ensembl:ENST00000513145|ensembl:ENSP00000425475|ensembl:ENST00000514516|ensembl:ENSP00000424765|dip:DIP-57510N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:SHtKAcLLnTpSSLwVE7yQ1WECoZk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q86VP6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P33981 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1645856|uniprotkb:Q15272|uniprotkb:Q5TCS0|uniprotkb:Q9BW51|uniprotkb:Q9NTM0|uniprotkb:E1P543|uniprotkb:B2RDW2|uniprotkb:A8K8U5|ensembl:ENSP00000358813 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ttk_human(display_long)|uniprotkb:TTK(gene name)|psi-mi:TTK(display_short)|uniprotkb:MPS1L1(gene name synonym)|uniprotkb:Phosphotyrosine picked threonine-protein kinase(gene name synonym)|uniprotkb:MPS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003309.2|refseq:XP_011534401.1|refseq:XP_011534402.1|refseq:NP_001160163.1|dip:DIP-40642N|ensembl:ENSG00000112742(gene)|ensembl:ENST00000369798(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033316"(meiotic spindle assembly checkpoint signaling)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051304"(chromosome separation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903096"(protein localization to meiotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027084|rcsb pdb:2X9E|rcsb pdb:2ZMC|rcsb pdb:2ZMD|rcsb pdb:3CEK|rcsb pdb:3DBQ|rcsb pdb:3GFW|rcsb pdb:3H9F|rcsb pdb:3HMN|rcsb pdb:3HMO|rcsb pdb:3HMP|rcsb pdb:3VQU|rcsb pdb:3W1F|rcsb pdb:3WYX|rcsb pdb:3WYY|rcsb pdb:3WZK|rcsb pdb:4B94|rcsb pdb:4BHZ|rcsb pdb:4BI0|rcsb pdb:4BI1|rcsb pdb:4BI2|rcsb pdb:4C4E|rcsb pdb:4C4F|rcsb pdb:4C4G|rcsb pdb:4C4H|rcsb pdb:4C4I|rcsb pdb:4C4J|rcsb pdb:4CV8|rcsb pdb:4CV9|rcsb pdb:4CVA|rcsb pdb:4D2S|rcsb pdb:4H7X|rcsb pdb:4H7Y|rcsb pdb:4JS8|rcsb pdb:4JT3|rcsb pdb:4O6L|rcsb pdb:4ZEG|rcsb pdb:5AP0|rcsb pdb:5AP1|rcsb pdb:5AP2|rcsb pdb:5AP3|rcsb pdb:5AP4|rcsb pdb:5AP5|rcsb pdb:5AP6|rcsb pdb:5AP7|rcsb pdb:5EH0|rcsb pdb:5EHL|rcsb pdb:5EHO|rcsb pdb:5EHY|rcsb pdb:5EI2|rcsb pdb:5EI6|rcsb pdb:5EI8|rcsb pdb:5LJJ|rcsb pdb:5MRB|rcsb pdb:5N7V|rcsb pdb:5N84|rcsb pdb:5N87|rcsb pdb:5N93|rcsb pdb:5N9S|rcsb pdb:5NA0|rcsb pdb:5NAD|rcsb pdb:5NTT|rcsb pdb:5O91|rcsb pdb:6B4W|rcsb pdb:6GVJ|rcsb pdb:6H3K|rcsb pdb:6N6O|rcsb pdb:6TN9|rcsb pdb:6TNB|rcsb pdb:6TNC|rcsb pdb:6TND|rcsb pdb:7CHM|rcsb pdb:7CHN|rcsb pdb:7CHT|rcsb pdb:7CIL|rcsb pdb:7CJA|rcsb pdb:7CLH|rcsb pdb:3WZJ - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Bun+wKtw2D6kl9OWIZK8l5i4n4g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NUP9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1171517|ensembl:ENSP00000278193 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lin7c_human(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:LIN7C(gene name)|psi-mi:LIN7C(display_short)|uniprotkb:MALS3(gene name synonym)|uniprotkb:VELI3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060832.1|ensembl:ENSG00000148943(gene)|ensembl:ENST00000278193(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:Q9NUP9|rcsb pdb:3LRA|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:F2rasaJ64Olc9qScN79LJRqsUEE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UN37 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14974 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351726|uniprotkb:Q2NKL4|uniprotkb:Q569H0|uniprotkb:Q86WU3|uniprotkb:Q8NFR6|uniprotkb:Q9BYH0|intact:EBI-28988491|uniprotkb:B4DZ09|uniprotkb:F8VWB4|ensembl:ENSP00000261207|ensembl:ENSP00000389168 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mypt1_human(display_long)|uniprotkb:PPP1R12A(gene name)|psi-mi:PPP1R12A(display_short)|uniprotkb:MBS(gene name synonym)|uniprotkb:MYPT1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001137357.1|refseq:NP_001137358.1|refseq:NP_002471.1|refseq:NP_001231919.1|refseq:NP_001231921.1|refseq:XP_011536685.1|ensembl:ENSP00000261207|ensembl:ENST00000437004|ensembl:ENSP00000416769|ensembl:ENSP00000389168|ensembl:ENSP00000449514|ensembl:ENST00000550107|ensembl:ENSP00000446855|ensembl:ENST00000546369|dip:DIP-33186N|ensembl:ENSG00000058272(gene)|ensembl:ENST00000261207(transcript)|ensembl:ENST00000450142(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:O14974|rcsb pdb:2KJY|rcsb pdb:5HUZ|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Xi5lGskc0tWQCHtbYlgR45ERMSk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96BR5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00410 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:A2A2Q9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-9977257|ensembl:ENSP00000380455 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:a2a2q9_human(display_long)|uniprotkb:Protein AAR2 homolog(gene name synonym)|uniprotkb:AAR2(gene name)|psi-mi:AAR2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000131043(gene)|ensembl:ENST00000397286(transcript)|interpro:IPR007946(AAR2)|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:uYSPGjNrDkRpjeOaEJN9SIC9YrM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75964 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044001|uniprotkb:Q96BV6|uniprotkb:Q9UBZ7|ensembl:ENSP00000300688|uniprotkb:A8K0K3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atp5l_human(display_long)|uniprotkb:ATP5MG(gene name)|psi-mi:ATP5MG(display_short)|uniprotkb:ATP synthase membrane subunit g(gene name synonym)|uniprotkb:ATP5L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006467.4|ensembl:ENSG00000167283(gene)|ensembl:ENST00000300688(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR006808(ATPase, F0 complex, subunit G, mitochondrial)|interpro:IPR016702(Mitochondrial ATP synthase subunit g, animal)|mint:O75964|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mn5/fFqk4xCCHb/MEuLAi5/lqmI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96PM9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1539778|uniprotkb:Q5VH53|uniprotkb:Q9H7R6|uniprotkb:Q9UFU3|uniprotkb:F1T0F1|uniprotkb:J3KNS3|uniprotkb:B2RDN5|uniprotkb:B4DKH2|ensembl:ENSP00000338927 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:z385a_human(display_long)|uniprotkb:ZNF385A(gene name)|psi-mi:ZNF385A(display_short)|uniprotkb:HZF(gene name synonym)|uniprotkb:RZF(gene name synonym)|uniprotkb:ZNF385(gene name synonym)|uniprotkb:Hematopoietic zinc finger protein(gene name synonym)|uniprotkb:Retinal zinc finger protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001276930.1|refseq:NP_001276931.1|refseq:NP_001276933.1|refseq:XP_006719405.1|refseq:NP_001124439.1|refseq:NP_001124440.1|refseq:NP_056296.1|refseq:XP_016874663.1|refseq:XP_005268840.1|ensembl:ENSG00000161642(gene)|ensembl:ENST00000338010(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010609"(mRNA localization resulting in posttranscriptional regulation of gene expression)|go:"GO:0030425"(dendrite)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:1902164"(positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000765"(regulation of cytoplasmic translation)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-6804114|reactome:R-HSA-6804116|reactome:R-HSA-6804759|reactome:R-HSA-69895 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ByEoeQHgyddhhGc72IiuttMNpGw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:A5PL33 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2361962|uniprotkb:Q8N4X0|uniprotkb:Q96JG5|uniprotkb:A7E2F5|uniprotkb:E7ENE9|ensembl:ENSP00000317165 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:krba1_human(display_long)|uniprotkb:KRBA1(gene name)|psi-mi:KRBA1(display_short)|uniprotkb:KIAA1862(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115923.2|refseq:NP_001277116.1|ensembl:ENSG00000133619(gene)|ensembl:ENST00000319551(transcript)|interpro:IPR029317|interpro:IPR040095|reactome:R-HSA-212436 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:82+SQo83RDOZkUPKU8hNiPCL5SI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99733 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2255116|uniprotkb:B2R6J4|uniprotkb:F5HFY4|ensembl:ENSP00000369915|ensembl:ENSP00000483728 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:np1l4_human(display_long)|uniprotkb:NAP1L4(gene name)|psi-mi:NAP1L4(display_short)|uniprotkb:NAP2(gene name synonym)|uniprotkb:Nucleosome assembly protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005960.1|ensembl:ENSG00000205531(gene)|ensembl:ENSG00000273562(gene)|ensembl:ENST00000380542(transcript)|ensembl:ENST00000619695(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q99733 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tES8IJDlW4JONR/pdC8dq49I/7Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UHI6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347658|uniprotkb:Q96F72|uniprotkb:Q9NVM3|uniprotkb:Q9UF59|uniprotkb:Q9UIY0|uniprotkb:Q9Y659|uniprotkb:B4DWV7|ensembl:ENSP00000358716|ensembl:ENSP00000505857 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ddx20_human(display_long)|uniprotkb:DDX20(gene name)|psi-mi:DDX20(display_short)|uniprotkb:DP103(gene name synonym)|uniprotkb:GEMIN3(gene name synonym)|uniprotkb:DEAD box protein 20(gene name synonym)|uniprotkb:DEAD box protein DP 103(gene name synonym)|uniprotkb:Component of gems 3(gene name synonym)|uniprotkb:Gemin-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_009135.4|ensembl:ENSP00000358716|ensembl:ENST00000533164|ensembl:ENSP00000434085|ensembl:ENSP00000505857|dip:DIP-32606N|ensembl:ENSG00000064703(gene)|ensembl:ENST00000369702(transcript)|ensembl:ENST00000679724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048477"(oogenesis)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9UHI6|rcsb pdb:2OXC|rcsb pdb:3B7G|reactome:R-HSA-191859|go:"GO:0043065"(positive regulation of apoptotic process) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Q9IGbhb825yL12imyTlBAHZ4YyU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q66K89 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P07900 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P53621 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q2TAC2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2808286|ensembl:ENSP00000374292|uniprotkb:Q8IWG2|uniprotkb:A8MQC7|uniprotkb:Q8TER3|uniprotkb:A6NP51 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ccd57_human(display_long)|uniprotkb:CCDC57(gene name)|psi-mi:CCDC57(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000176155(gene)|ensembl:ENST00000389641(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007099"(centriole replication)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0060271"(cilium assembly)|interpro:IPR042481|refseq:NP_001303250.1|refseq:NP_932348.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YDj66sk5KcrdUoP6zw9gIxHkomg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UKV0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-765444|uniprotkb:O94845|uniprotkb:O95028|uniprotkb:Q2M2R6|uniprotkb:Q86SL1|uniprotkb:Q86US3|uniprotkb:A7E2F3|uniprotkb:B7Z917|uniprotkb:B7Z4I4|uniprotkb:B7Z928|uniprotkb:B7Z940|uniprotkb:C9JS87|uniprotkb:E7EX34|uniprotkb:F8W9E0|intact:EBI-28970749|ensembl:ENSP00000410337 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hdac9_human(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:HDAC9(gene name)|psi-mi:HDAC9(display_short)|uniprotkb:HDAC7(gene name synonym)|uniprotkb:HDAC7B(gene name synonym)|uniprotkb:KIAA0744(gene name synonym)|uniprotkb:HDRP(gene name synonym)|uniprotkb:MITR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001308818.1|ensembl:ENST00000441542|ensembl:ENSP00000408617|ensembl:ENST00000456174|ensembl:ENSP00000388568|ensembl:ENST00000524023|ensembl:ENSP00000430036|ensembl:ENST00000401921|ensembl:ENSP00000383912|ensembl:ENST00000405010|ensembl:ENSP00000384382|ensembl:ENST00000406451|ensembl:ENSP00000384657|ensembl:ENST00000417496|ensembl:ENSP00000401669|ensembl:ENST00000428307|ensembl:ENSP00000395655|ensembl:ENSP00000410337|refseq:NP_848510.1|refseq:NP_848512.1|refseq:NP_001191073.1|refseq:NP_001191074.1|refseq:NP_001191075.1|refseq:NP_001191076.1|refseq:NP_001191077.1|refseq:NP_055522.1|refseq:NP_478056.1|refseq:XP_016868315.1|refseq:XP_016868317.1|refseq:XP_011513940.1|refseq:XP_011513941.1|refseq:NP_001308797.1|refseq:NP_001308798.1|refseq:NP_001308799.1|refseq:NP_001308800.1|refseq:NP_001308801.1|refseq:NP_001308802.1|refseq:NP_001308803.1|refseq:NP_001308804.1|refseq:NP_001308805.1|refseq:NP_001308806.1|refseq:NP_001308807.1|refseq:NP_001308808.1|refseq:NP_001308813.1|refseq:NP_001308814.1|refseq:NP_001308815.1|refseq:NP_001308816.1|refseq:NP_001308817.1|refseq:NP_001308819.1|refseq:NP_001308820.1|refseq:NP_001308822.1|refseq:NP_001308823.1|refseq:NP_001308824.1|refseq:NP_001308825.1|refseq:NP_001308826.1|refseq:NP_001308827.1|refseq:NP_001308828.1|refseq:NP_001308829.1|refseq:NP_001308830.1|refseq:NP_001308831.1|dip:DIP-39904N|ensembl:ENSG00000048052(gene)|ensembl:ENST00000432645(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR037138|mint:Q9UKV0|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:oFAc6CP+RY58lEB4qPxWnM90ecg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43164 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1996038|uniprotkb:D3DSZ5|uniprotkb:Q68D49|uniprotkb:Q8N1G5|uniprotkb:A8K6U4|ensembl:ENSP00000354775|ensembl:ENSP00000355284 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pja2_human(display_long)|uniprotkb:PJA2(gene name)|psi-mi:PJA2(display_short)|uniprotkb:KIAA0438(gene name synonym)|uniprotkb:RNF131(gene name synonym)|uniprotkb:RING finger protein 131(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Praja-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055634.3|refseq:XP_016865588.1|ensembl:ENSG00000198961(gene)|ensembl:ENST00000361189(transcript)|ensembl:ENST00000361557(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007616"(long-term memory)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035329"(hippo signaling)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR030639|mint:O43164|reactome:R-HSA-983168|dip:DIP-47040N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:z0OkXLozXymqwyF+xQR+PFa+bQI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P28066 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355475|uniprotkb:B4E2V4|uniprotkb:Q6IBF7|uniprotkb:Q3T1C1|uniprotkb:B2R8F6|ensembl:ENSP00000271308 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psa5_human(display_long)|uniprotkb:PSMA5(gene name)|psi-mi:PSMA5(display_short)|uniprotkb:Proteasome zeta chain(gene name synonym)|uniprotkb:Macropain zeta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex zeta chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001186701.1|refseq:NP_001186702.1|refseq:NP_001186703.1|refseq:NP_002781.2|ensembl:ENSG00000143106(gene)|ensembl:ENST00000271308(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR033812|mint:P28066|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEY|rcsb pdb:5LEX|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29368N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:bfMG3npzVetUH1tahr2MAI4R+3g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O60237 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2558026|uniprotkb:B7ZMN6|uniprotkb:Q9HCB7|uniprotkb:Q5VUK2|uniprotkb:Q8N179|uniprotkb:Q9HCB8|uniprotkb:A8MYF5|uniprotkb:Q5T506|ensembl:ENSP00000476755|uniprotkb:Q2TAI8|uniprotkb:A0A0A0MS24 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mypt2_human(display_long)|uniprotkb:PPP1R12B(gene name)|psi-mi:PPP1R12B(display_short)|uniprotkb:MYPT2(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001161330.1|refseq:NP_001184060.1|refseq:NP_002472.2|refseq:NP_115286.1|refseq:NP_115287.1|ensembl:ENSG00000077157(gene)|ensembl:ENST00000608999(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0031672"(A band)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_001161329.1|refseq:XP_016856841.1|refseq:XP_016856842.1|refseq:XP_016856843.1|refseq:NP_001317958.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ykCXwp8fMkCrEkx6fqU5vrnTS549606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P22695 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1051424|uniprotkb:Q9BQ05|uniprotkb:B3KSN4|ensembl:ENSP00000268379 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:qcr2_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:UQCRC2(gene name)|psi-mi:UQCRC2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003357.2|ensembl:ENSG00000140740(gene)|ensembl:ENST00000268379(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0009060"(aerobic respiration)|go:"GO:0042493"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P22695|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:++DmwaVpqzRyxFl7mh62L4ku4P09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q2KHR2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1222187|uniprotkb:Q6ZRR1|uniprotkb:Q6ZTY6|uniprotkb:Q8N3J0|uniprotkb:Q9H7A9|uniprotkb:Q9H956|ensembl:ENSP00000501248|ensembl:ENSP00000501278 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rfx7_human(display_long)|uniprotkb:RFXDC2(gene name synonym)|uniprotkb:Regulatory factor X 7(gene name synonym)|uniprotkb:Regulatory factor X domain-containing protein 2(gene name synonym)|uniprotkb:RFX7(gene name)|psi-mi:RFX7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_073752.5|refseq:XP_011520227.1|refseq:XP_016877996.1|refseq:XP_016877997.1|ensembl:ENSG00000181827(gene)|ensembl:ENST00000673997(transcript)|ensembl:ENST00000674082(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|rcsb pdb:4QQI|rcsb pdb:6MEW - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:rs7zpZEFUplmE+r8TgFcmQ9LYrU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P51571 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054539|uniprotkb:Q53XY1|uniprotkb:A8K378|ensembl:ENSP00000317331|ensembl:ENSP00000359103|ensembl:ENSP00000359104 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ssrd_human(display_long)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)|uniprotkb:SSR4(gene name)|psi-mi:SSR4(display_short)|uniprotkb:TRAPD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001191455.1|refseq:NP_006271.1|refseq:XP_011529488.1|refseq:XP_011529489.1|ensembl:ENSG00000180879(gene)|ensembl:ENST00000320857(transcript)|ensembl:ENST00000370086(transcript)|ensembl:ENST00000370087(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008855(Translocon-associated)|mint:P51571|reactome:R-HSA-1799339 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:2SNgZQH/jwi61UcuHUf7RYKZH589606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q53R41 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3957005|uniprotkb:Q8N583|uniprotkb:Q8TEA9|uniprotkb:Q96JM5|uniprotkb:Q96N71|uniprotkb:Q9H6T4|ensembl:ENSP00000400513 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:fakd1_human(display_long)|uniprotkb:FASTKD1(gene name)|psi-mi:FASTKD1(display_short)|uniprotkb:KIAA1800(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_078898.3|refseq:NP_001268405.1|refseq:NP_001308975.1|refseq:NP_001308977.1|refseq:NP_001308978.1|refseq:XP_016860400.1|ensembl:ENSG00000138399(gene)|ensembl:ENST00000453153(transcript)|go:"GO:0000959"(mitochondrial RNA metabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eizlBY2w9CXu4y4WE8R4QOUWoXA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P11172 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-723452|uniprotkb:O00758|uniprotkb:O00759|uniprotkb:O00760|uniprotkb:Q16862|uniprotkb:Q9H3Q2|uniprotkb:Q9UG49|ensembl:ENSP00000232607|uniprotkb:B5LY68|uniprotkb:B5LY72 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:umps_human(display_long)|uniprotkb:UMPS(gene name)|psi-mi:UMPS(display_short)|uniprotkb:OK/SW-cl.21(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000364.1|interpro:IPR014732(Orotidine 5'-phosphate decarboxylase, subfamily 1, core)|interpro:IPR018089|interpro:IPR023031|interpro:IPR029057|mint:P11172|rcsb pdb:2EAW|rcsb pdb:2JGY|rcsb pdb:2P1F|rcsb pdb:2QCC|rcsb pdb:2QCD|rcsb pdb:2QCE|rcsb pdb:2QCF|rcsb pdb:2QCG|rcsb pdb:2QCH|rcsb pdb:2QCL|go:"GO:0006222"(UMP biosynthetic process)|rcsb pdb:2QCM|rcsb pdb:2QCN|rcsb pdb:2V30|rcsb pdb:2WNS|rcsb pdb:3BGG|rcsb pdb:3BGJ|rcsb pdb:3BK0|go:"GO:0007565"(female pregnancy)|rcsb pdb:3BVJ|rcsb pdb:3DBP|go:"GO:0007595"(lactation)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044205"('de novo' UMP biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR001754(Orotidine 5'-phosphate decarboxylase, core)|interpro:IPR004467(Orotate phosphoribosyl transferase)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:3EWU|rcsb pdb:3EWW|rcsb pdb:3EWY|rcsb pdb:3EWZ|rcsb pdb:3EX1|rcsb pdb:3EWX|rcsb pdb:3EX2|rcsb pdb:3EX3|rcsb pdb:3EX4|rcsb pdb:3EX6|rcsb pdb:3G3D|rcsb pdb:3G3M|rcsb pdb:3L0K|rcsb pdb:3L0N|rcsb pdb:3MI2|rcsb pdb:3MO7|rcsb pdb:3MW7|rcsb pdb:4HIB|rcsb pdb:4HKP|reactome:R-HSA-500753|ensembl:ENSG00000114491(gene)|ensembl:ENST00000232607(transcript)|go:"GO:0004588"(orotate phosphoribosyltransferase activity)|go:"GO:0004590"(orotidine-5'-phosphate decarboxylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|dip:DIP-29595N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8HKx6eTv3pMPMJQzUhhFjyGXGZI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P57740 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-295687|uniprotkb:B4DZ67|uniprotkb:Q6PJE1|intact:EBI-10966404|ensembl:ENSP00000229179 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nu107_human(display_long)|uniprotkb:NUP107(gene name)|psi-mi:NUP107(display_short)|uniprotkb:Nucleoporin Nup107(gene name synonym)|uniprotkb:107 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_065134.1|refseq:NP_001317121.1|ensembl:ENSG00000111581(gene)|ensembl:ENST00000229179(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000973"(posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008585"(female gonad development)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0072006"(nephron development)|interpro:IPR007252(Nuclear pore protein 84/107)|mint:P57740|rcsb pdb:3CQC|rcsb pdb:3CQG|rcsb pdb:3I4R|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:76eAOFdL5JLBp0giaH8nhc3BMEI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P05067 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBS4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96F45 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-8832437|uniprotkb:Q96E25|uniprotkb:Q8NAC5|uniprotkb:Q96IJ0|ensembl:ENSP00000361602 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zn503_human(display_long)|uniprotkb:NOLZ1(gene name synonym)|uniprotkb:ZNF503(gene name)|psi-mi:ZNF503(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_116161.2|ensembl:ENSG00000165655(gene)|ensembl:ENST00000372524(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022129 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NpN+RnNBhDISreteXZIxozWoURI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UET6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1055987|uniprotkb:O75670|uniprotkb:B2RCJ0|ensembl:ENSP00000326948 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:trm7_human(display_long)|uniprotkb:FTSJ1(gene name)|psi-mi:FTSJ1(display_short)|uniprotkb:JM23(orf name)|uniprotkb:Protein ftsJ homolog 1(gene name synonym)|uniprotkb:2'-O-ribose RNA methyltransferase TRM7 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036412.1|refseq:NP_803188.1|refseq:NP_001269086.1|refseq:XP_005272652.1|ensembl:ENST00000348411(transcript)|go:"GO:0001510"(RNA methylation)|go:"GO:0002128"(tRNA nucleoside ribose methylation)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0009020"("tRNA (guanosine-2'-O-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0052666"("tRNA (cytosine-2'-O-)-methyltransferase activity")|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR015507(Ribosomal RNA methyltransferase J)|interpro:IPR028590|interpro:IPR029063|mint:Q9UET6|reactome:R-HSA-6782315|ensembl:ENSG00000068438(gene) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:N4L9nsU0Wj3FMVjYALdxpx56aZs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NYU2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:J3KPX7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-26955584|ensembl:ENSP00000382362 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:j3kpx7_human(display_long)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000215021(gene)|ensembl:ENST00000399433(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:W0f+9J1rF/3y0Mfgpyznf3XCJ5I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00483 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1049381|uniprotkb:Q6FHN5|uniprotkb:A4D109|ensembl:ENSP00000339720 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ndua4_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase MLRQ subunit(gene name synonym)|uniprotkb:Complex I-MLRQ(gene name synonym)|uniprotkb:NDUFA4(gene name)|psi-mi:NDUFA4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002480.1|ensembl:ENSG00000189043(gene)|ensembl:ENST00000339600(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|interpro:IPR010530(B12D)|mint:O00483|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TnrYlkH8abl42/yGsvfc8Bh6Mu09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O95831 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15006 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359031|uniprotkb:Q8WUE1|ensembl:ENSP00000220853 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:emc2_human(display_long)|uniprotkb:EMC2(gene name)|psi-mi:EMC2(display_short)|uniprotkb:KIAA0103(gene name synonym)|uniprotkb:TTC35(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055488.1|ensembl:ENSG00000104412(gene)|ensembl:ENST00000220853(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039856|mint:Q15006|rcsb pdb:6WW7|rcsb pdb:6Y4L|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HMRmqsVdjJybM/A4VCzAFbGsHu09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H773 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-723569|intact:EBI-1384169|ensembl:ENSP00000322524 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dctp1_human(display_long)|uniprotkb:DCTPP1(gene name)|psi-mi:DCTPP1(display_short)|uniprotkb:RS21C6(gene name synonym)|uniprotkb:CDA03(orf name)|uniprotkb:XTP3TPA(gene name synonym)|uniprotkb:Deoxycytidine-triphosphatase 1(gene name synonym)|uniprotkb:XTP3-transactivated gene A protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_077001.1|ensembl:ENST00000319285(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006253"(dCTP catabolic process)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0032556"(pyrimidine deoxyribonucleotide binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0047840"(dCTP diphosphatase activity)|interpro:IPR025984|mint:Q9H773|reactome:R-HSA-499943|ensembl:ENSG00000179958(gene) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4EfV2ZU2MgDiFXShthfualZnat09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5LJA5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11023745|ensembl:ENSP00000356421 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:q5lja5_human(display_long)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000116750(gene)|ensembl:ENST00000367451(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031011"(Ino80 complex)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:JUOzvEsOYjtkzNUcZta6kWzyKz89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O94888 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1993627|uniprotkb:D3DXB3|uniprotkb:Q6ZP77|uniprotkb:Q86X20|uniprotkb:Q8N327|ensembl:ENSP00000296328 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ubxn7_human(display_long)|uniprotkb:UBXD7(gene name synonym)|uniprotkb:UBXN7(gene name)|psi-mi:UBXN7(display_short)|uniprotkb:KIAA0794(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056377.1|dip:DIP-47029N|ensembl:ENSG00000163960(gene)|ensembl:ENST00000296328(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR017346(Uncharacterised conserved protein UCP037991, UAS, UBX)|interpro:IPR029071|interpro:IPR036249|rcsb pdb:1WJ4|rcsb pdb:2DAL|rcsb pdb:2DLX|rcsb pdb:5X3P|rcsb pdb:5X4L|reactome:R-HSA-8951664 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TyFBtC4hXtG1WTSl8wLgPIoDxpg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14746 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-389449|uniprotkb:Q86U99|ensembl:ENSP00000355629 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cog2_human(display_long)|uniprotkb:COG2(gene name)|psi-mi:COG2(display_short)|uniprotkb:LDLC(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 2(gene name synonym)|uniprotkb:Low density lipoprotein receptor defect C-complementing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_031383.1|refseq:NP_001138508.1|ensembl:ENSG00000135775(gene)|ensembl:ENST00000366669(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR009316(COG complex component, COG2)|interpro:IPR024602|interpro:IPR024603|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LikqIIuX72shymiuUF977aVlfpE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BRX2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1043580|uniprotkb:Q9GZS6|uniprotkb:Q9Y306|ensembl:ENSP00000274311 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pelo_human(display_long)|uniprotkb:PELO(gene name)|psi-mi:PELO(display_short)|uniprotkb:CGI-17(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000152684(gene)|ensembl:ENST00000274311(transcript)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007049"(cell cycle)|go:"GO:0007492"(endoderm development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|mint:Q9BRX2|rcsb pdb:1X52|rcsb pdb:5EO3|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|refseq:NP_057030.3 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EZIi8JN2tu0u4oH06fOus3LKjoo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P11142 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y3C7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-394707|uniprotkb:B2R4L9|ensembl:ENSP00000225728 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:med31_human(display_long)|uniprotkb:CGI-125(orf name)|uniprotkb:SOH1(gene name synonym)|uniprotkb:MED31(gene name)|psi-mi:MED31(display_short)|uniprotkb:Mediator complex subunit 31(gene name synonym)|uniprotkb:Mediator complex subunit SOH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_057144.1|ensembl:ENSG00000108590(gene)|ensembl:ENST00000225728(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070847"(core mediator complex)|interpro:IPR008831(SOH1)|interpro:IPR038089|mint:Q9Y3C7|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:QRmf6b+uoUOubBcvJbBfl9NgRTQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P08195 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-702356|uniprotkb:Q13543|ensembl:ENSP00000367122 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:4f2_human(display_long)|uniprotkb:Lymphocyte activation antigen 4F2 large subunit(gene name synonym)|uniprotkb:4F2 heavy chain antigen(gene name synonym)|uniprotkb:SLC3A2(gene name)|psi-mi:SLC3A2(display_short)|uniprotkb:MDU1(gene name synonym)|uniprotkb:Solute carrier family 3 member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001012680.1|refseq:NP_001012682.1|refseq:NP_001013269.1|refseq:NP_002385.3|ensembl:ENSG00000168003(gene)|ensembl:ENST00000377890(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003824"(catalytic activity)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015173"(aromatic amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0015820"(leucine transport)|go:"GO:0015823"(phenylalanine transport)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044225"(apical pole of neuron)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098713"(leucine import across plasma membrane)|go:"GO:1903801"(L-leucine import across plasma membrane)|go:"GO:1904273"(L-alanine import across plasma membrane)|go:"GO:1990184"(amino acid transport complex)|interpro:IPR006047(Glycosyl hydrolase, family 13, catalytic region)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR031984|interpro:IPR042280|mint:P08195|rcsb pdb:2DH2|rcsb pdb:2DH3|rcsb pdb:6IRS|rcsb pdb:6IRT|rcsb pdb:6JMQ|rcsb pdb:6JMR|rcsb pdb:6S8V|rcsb pdb:7CCS|reactome:R-HSA-210991|reactome:R-HSA-352230|reactome:R-HSA-5660862|reactome:R-HSA-71240 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:+7lJ/35nXzIs8SLCor0Vh5fAZYQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q53EU6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11337979|uniprotkb:Q6GPI6|uniprotkb:Q68CJ4|uniprotkb:Q96NA3|ensembl:ENSP00000264409|ensembl:ENSP00000378651|ensembl:ENSP00000482571 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gpat3_human(display_long)|uniprotkb:GPAT3(gene name)|psi-mi:GPAT3(display_short)|uniprotkb:1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10(gene name synonym)|uniprotkb:1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9(gene name synonym)|uniprotkb:AGPAT9(gene name synonym)|uniprotkb:"Acyl-CoA:glycerol-3-phosphate acyltransferase 3"(gene name synonym)|uniprotkb:Lung cancer metastasis-associated protein 1(gene name synonym)|uniprotkb:Lysophosphatidic acid acyltransferase theta(gene name synonym)|uniprotkb:MAG-1(gene name synonym)|uniprotkb:MAG1(gene name synonym)|uniprotkb:HMFN0839(orf name)|uniprotkb:UNQ2753/PRO6492(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001243350.1|refseq:NP_001243351.1|refseq:NP_116106.2|ensembl:ENST00000264409(transcript)|ensembl:ENST00000395226(transcript)|ensembl:ENST00000611707(transcript)|go:"GO:0003841"(1-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0004366"(glycerol-3-phosphate O-acyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006072"(glycerol-3-phosphate metabolic process)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0102420"("sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity")|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|reactome:R-HSA-1483166|ensembl:ENSG00000138678(gene)|refseq:XP_016864270.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LofyvxRlpiC9Y80bR/S4/i1Y7UQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O95433 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99653 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NBJ5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1057068|uniprotkb:Q8NC64|ensembl:ENSP00000252599 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gt251_human(display_long)|uniprotkb:COLGALT1(gene name)|psi-mi:COLGALT1(display_short)|uniprotkb:"Collagen beta(1-O)galactosyltransferase 1"(gene name synonym)|uniprotkb:GLT25D1(gene name synonym)|uniprotkb:Glycosyltransferase 25 family member 1(gene name synonym)|uniprotkb:Hydroxylysine galactosyltransferase 1(gene name synonym)|uniprotkb:PSEC0241(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_078932.2|ensembl:ENSG00000130309(gene)|ensembl:ENST00000252599(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0050211"(procollagen galactosyltransferase activity)|go:"GO:1904028"(positive regulation of collagen fibril organization)|interpro:IPR002654(Glycosyl transferase, family 25)|interpro:IPR029044|mint:Q8NBJ5|reactome:R-HSA-1650814 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:nB7wFmsUKfA2+PrPaqw08fQpJRs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P48047 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P42677 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356336|ensembl:ENSP00000499044|uniprotkb:Q5T4L6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rs27_human(display_long)|uniprotkb:RPS27(gene name)|psi-mi:RPS27(display_short)|uniprotkb:MPS1(gene name synonym)|uniprotkb:Metallopan-stimulin 1(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS27(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001021.1|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000177954(gene)|ensembl:ENST00000651669(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:P42677|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-141444|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2500257|rcsb pdb:6OM7|reactome:R-HSA-5663220|reactome:R-HSA-6791226|reactome:R-HSA-68877|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-9648025|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-44182N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P31948 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P20618 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-372273|uniprotkb:Q9BWA8|ensembl:ENSP00000262193|uniprotkb:B5BU76 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psb1_human(display_long)|uniprotkb:PSMB1(gene name)|psi-mi:PSMB1(display_short)|uniprotkb:PSC5(gene name synonym)|uniprotkb:Proteasome component C5(gene name synonym)|uniprotkb:Macropain subunit C5(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C5(gene name synonym)|uniprotkb:Proteasome gamma chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000008018(gene)|ensembl:ENST00000262193(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035202|mint:P20618|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5B|rcsb pdb:5L5D|rcsb pdb:5L5E|rcsb pdb:5L5F|refseq:NP_002784.1|rcsb pdb:5L5H|rcsb pdb:5L5I|rcsb pdb:5L5J|rcsb pdb:5L5O|rcsb pdb:5L5P|rcsb pdb:5L5Q|rcsb pdb:5L5R|rcsb pdb:5L5S|rcsb pdb:5L5T|rcsb pdb:5L5U|rcsb pdb:5L5V|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M2B|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5LF1|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4608870|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-983168|reactome:R-HSA-9604323|dip:DIP-31193N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DfIS480BUnqbXus9/KoojdkWgw09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:G3V5Z7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21351644|ensembl:ENSP00000452603 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:g3v5z7_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100902(gene)|ensembl:ENST00000553809(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OMPJcyijldDirVXKoRx6LIqUVjU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:H3BMF4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103229|ensembl:ENSP00000454360 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h3bmf4_human(display_long)|uniprotkb:SPNS1(gene name)|psi-mi:SPNS1(display_short)|uniprotkb:SPIN1(gene name synonym)|uniprotkb:hCG_2002366(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000169682(gene)|ensembl:ENST00000565975(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|interpro:IPR044770|refseq:XP_016879248.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LJ3CYxcA6i6n01dsoRkA/gRDse09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14204 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P78318 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1055954|uniprotkb:Q8TAB2|ensembl:ENSP00000348784|ensembl:ENSP00000363661 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:igbp1_human(display_long)|uniprotkb:IGBP1(gene name)|psi-mi:IGBP1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:CD79a-binding protein 1(gene name synonym)|uniprotkb:B-cell signal transduction molecule alpha 4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-16(gene name synonym)|uniprotkb:Protein phosphatase 2/4/6 regulatory subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001542.1|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR007304(TAP42-like protein)|interpro:IPR038511|mint:P78318|rcsb pdb:4IYP|ensembl:ENSG00000089289(gene)|ensembl:ENST00000342206(transcript)|ensembl:ENST00000356413(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035303"(regulation of dephosphorylation)|go:"GO:0042113"(B cell activation)|refseq:XP_016884978.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:N8w92upYivqH3rjdqNbAcIjDu7I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P51970 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14257 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P38435 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10963113|ensembl:ENSP00000233838|uniprotkb:B4DMC5|uniprotkb:E9PEE1|uniprotkb:Q6GU45|uniprotkb:Q14415 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vkgc_human(display_long)|uniprotkb:GGCX(gene name)|psi-mi:GGCX(display_short)|uniprotkb:GC(gene name synonym)|uniprotkb:Gamma-glutamyl carboxylase(gene name synonym)|uniprotkb:Peptidyl-glutamate 4-carboxylase(gene name synonym)|uniprotkb:Vitamin K gamma glutamyl carboxylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000812.2|refseq:NP_001135741.1|ensembl:ENSG00000115486(gene)|ensembl:ENST00000233838(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007596"(blood coagulation)|go:"GO:0008488"(gamma-glutamyl carboxylase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0019842"(vitamin binding)|interpro:IPR007782(Vitamin K-dependent gamma-carboxylase)|interpro:IPR011020(HTTM)|interpro:IPR011051(Cupin, RmlC-type)|interpro:IPR014710(RmlC-like jelly roll fold)|mint:P38435|reactome:R-HSA-159740|reactome:R-HSA-9673240 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:icDLv1KyH9HC3h9enCp9S/nXPmM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75915 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2860752|uniprotkb:B2R6V5|uniprotkb:Q53ES3|uniprotkb:Q5KU08|ensembl:ENSP00000273258 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:praf3_human(display_long)|uniprotkb:ARL6IP5(gene name)|psi-mi:ARL6IP5(display_short)|uniprotkb:DERP11(gene name synonym)|uniprotkb:JWA(gene name synonym)|uniprotkb:PRA2(gene name synonym)|uniprotkb:PRAF3(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 6-interacting protein 5(gene name synonym)|uniprotkb:Cytoskeleton-related vitamin A-responsive protein(gene name synonym)|uniprotkb:Dermal papilla-derived protein 11(gene name synonym)|uniprotkb:GTRAP3-18(gene name synonym)|uniprotkb:Glutamate transporter EAAC1-interacting protein(gene name synonym)|uniprotkb:JM5(gene name synonym)|uniprotkb:Prenylated Rab acceptor protein 2(gene name synonym)|uniprotkb:Protein JWa(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM27(gene name synonym)|uniprotkb:HSPC127(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006398.1|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051051"(negative regulation of transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098712"(L-glutamate import across plasma membrane)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:O75915|reactome:R-HSA-210500|ensembl:ENSG00000144746(gene)|ensembl:ENST00000273258(transcript)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007611"(learning or memory)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015031"(protein transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TG2yH1gqzVhFgxBtuZqsE1dLAvQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62820 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96BY9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722561|uniprotkb:Q53HE8|uniprotkb:Q9UNZ3|uniprotkb:Q9Y683|uniprotkb:D3DSU7|uniprotkb:B3KQQ4|uniprotkb:B7Z9J1|uniprotkb:H9MHJ8|uniprotkb:H9MHJ9|ensembl:ENSP00000256255 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:saraf_human(display_long)|uniprotkb:SARAF(gene name)|psi-mi:SARAF(display_short)|uniprotkb:HBV X-transactivated gene 3 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 3(gene name synonym)|uniprotkb:Protein FOAP-7(gene name synonym)|uniprotkb:TMEM66(gene name synonym)|uniprotkb:Transmembrane protein 66(gene name synonym)|uniprotkb:XTP3(gene name synonym)|uniprotkb:HSPC035(orf name)|uniprotkb:NPD003(orf name)|uniprotkb:PSEC0019(orf name)|uniprotkb:UNQ1967/PRO4499(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001271168.1|refseq:NP_057211.4|ensembl:ENSG00000133872(gene)|ensembl:ENST00000256255(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006816"(calcium ion transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR009567(Protein of unknown function DUF1183)|rcsb pdb:6O2U|rcsb pdb:6O2V|rcsb pdb:6O2W - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qxgObw0slMLCKeF+2YAHTxjlkQk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P51570 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BRK5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q58EX7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-949255|uniprotkb:Q4G0J8|uniprotkb:Q4H485|uniprotkb:Q56A69|uniprotkb:Q9H7K4|uniprotkb:Q9UFW0|ensembl:ENSP00000353646|ensembl:ENSP00000368649|ensembl:ENSP00000401118 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pkhg4_human(display_long)|uniprotkb:Pleckstrin homology domain-containing family G member 4(gene name synonym)|uniprotkb:Purkinje cell atrophy-associated protein 1(gene name synonym)|uniprotkb:PLEKHG4(gene name)|psi-mi:PLEKHG4(display_short)|uniprotkb:PRTPHN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001123199.1|refseq:NP_001123200.1|refseq:NP_001123201.1|refseq:NP_001123203.1|refseq:XP_011521287.1|refseq:XP_011521288.1|refseq:XP_011521289.1|refseq:XP_011521290.1|ensembl:ENSG00000196155(gene)|ensembl:ENST00000360461(transcript)|ensembl:ENST00000379344(transcript)|ensembl:ENST00000427155(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036865|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:SnuXZYAmifcqahtFQWTe/ZThU1k9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y5A9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2878081|uniprotkb:B4E1G7|uniprotkb:A6NKG4|uniprotkb:Q5VSZ9|uniprotkb:Q8TDH0|uniprotkb:Q9BUJ5|uniprotkb:A8K966|uniprotkb:D3DPM8|ensembl:ENSP00000362918|ensembl:ENSP00000444660 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ythd2_human(display_long)|uniprotkb:HGRG8(gene name synonym)|uniprotkb:CLL-associated antigen KW-14(gene name synonym)|uniprotkb:High-glucose-regulated protein 8(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-2(gene name synonym)|uniprotkb:YTHDF2(gene name)|psi-mi:YTHDF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001166299.1|refseq:NP_001166599.1|refseq:NP_057342.2|ensembl:ENSG00000198492(gene)|ensembl:ENST00000373812(transcript)|ensembl:ENST00000542507(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|mint:Q9Y5A9|rcsb pdb:4RDO|rcsb pdb:4WQN|rcsb pdb:4RDN - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PF4C2t/728HqnrTyBQDJydH0G709606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P52789 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P50454 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-350723|uniprotkb:P29043|uniprotkb:Q5XPB4|uniprotkb:Q6NSJ6|uniprotkb:Q8IY96|uniprotkb:Q9NP88|uniprotkb:B3KVJ3|ensembl:ENSP00000350894|ensembl:ENSP00000434412|ensembl:ENSP00000434657 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:serph_human(display_long)|uniprotkb:SERPINH1(gene name)|psi-mi:SERPINH1(display_short)|uniprotkb:CBP2(gene name synonym)|uniprotkb:Collagen-binding protein(gene name synonym)|uniprotkb:47 kDa heat shock protein(gene name synonym)|uniprotkb:Rheumatoid arthritis-related antigen RA-A47(gene name synonym)|uniprotkb:Arsenic-transactivated protein 3(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 14 protein(gene name synonym)|uniprotkb:CBP1(gene name synonym)|uniprotkb:HSP47(gene name synonym)|uniprotkb:SERPINH2(gene name synonym)|uniprotkb:PIG14(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001193943.1|refseq:NP_001226.2|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033547|interpro:IPR033830|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P50454|reactome:R-HSA-1650814|ensembl:ENSG00000149257(gene)|ensembl:ENST00000358171(transcript)|ensembl:ENST00000524558(transcript)|ensembl:ENST00000533603(transcript)|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|refseq:XP_011543629.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:cO3NR2hb0NyOs99Sq1aODePlDR09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NI60 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-745535|uniprotkb:Q8NCJ6|intact:EBI-1384330|uniprotkb:Q5T7A5|uniprotkb:Q63HK0|uniprotkb:Q9HBQ1|uniprotkb:Q9NQ67|ensembl:ENSP00000355739 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:coq8a_human(display_long)|uniprotkb:COQ8A(gene name)|psi-mi:COQ8A(display_short)|uniprotkb:ADCK3(gene name synonym)|uniprotkb:CABC1(gene name synonym)|uniprotkb:Chaperone activity of bc1 complex-like(gene name synonym)|uniprotkb:Coenzyme Q protein 8A(gene name synonym)|uniprotkb:aarF domain-containing protein kinase 3(gene name synonym)|uniprotkb:PP265(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064632.2|refseq:XP_011542540.1|refseq:XP_011542541.1|refseq:XP_011542542.1|refseq:XP_011542543.1|refseq:XP_005273258.1|refseq:XP_016857341.1|ensembl:ENSG00000163050(gene)|ensembl:ENST00000366777(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0043531"(ADP binding)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034640|interpro:IPR034646|rcsb pdb:4PED|rcsb pdb:5I35 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mR2b+x/tnfsqK1fAzS0qYPijtvw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P54652 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6UW78 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1047692|uniprotkb:Q5FVD5|ensembl:ENSP00000367189|ensembl:ENSP00000432692 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:uqcc3_human(display_long)|uniprotkb:UQCC3(gene name)|psi-mi:UQCC3(display_short)|uniprotkb:Assembly factor CBP4 homolog(gene name synonym)|uniprotkb:C11orf83(gene name synonym)|uniprotkb:UNQ655/PRO1286(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001078841.1|ensembl:ENSG00000204922(gene)|ensembl:ENST00000377953(transcript)|ensembl:ENST00000531323(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0042407"(cristae formation)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR027896 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PEUU7HuGGnPq2W4+E6OiIFOpMTM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P28072 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBF2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045840|uniprotkb:A6NH74|uniprotkb:Q54AC3|uniprotkb:Q8WVW8|ensembl:ENSP00000402346|uniprotkb:Q2NLA0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:copg2_human(display_long)|uniprotkb:Gamma-2-coat protein(gene name synonym)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001276962.1|refseq:NP_036265.3|ensembl:ENSG00000158623(gene)|ensembl:ENST00000425248(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9UBF2|reactome:R-HSA-6807878|reactome:R-HSA-6811434|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VEvct8z8lwNWbLs2GFPrKwk1GpE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14980 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HD20 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3940599|uniprotkb:B3KTA7|uniprotkb:B3KPJ2|uniprotkb:Q9H6C6|ensembl:ENSP00000349877|uniprotkb:Q6NT90|uniprotkb:Q6ZMG7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at131_human(display_long)|uniprotkb:ATP13A1(gene name)|psi-mi:ATP13A1(display_short)|uniprotkb:ATP13A(gene name synonym)|uniprotkb:KIAA1825(gene name synonym)|uniprotkb:CGI-152(orf name)|uniprotkb:Endoplasmic reticulum P5A-ATPase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000105726(gene)|ensembl:ENST00000357324(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0140567"(transmembrane protein dislocase activity)|go:"GO:0140569"(extraction of mislocalized protein from ER membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006544("P-type ATPase of unknown pump specificity (type V)")|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:Q9HD20|reactome:R-HSA-936837|go:"GO:0015410"(ABC-type manganese transporter activity)|refseq:NP_065143.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:p4PEgZhH5QhoHI+InDMbLvdIBP09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:C9JRZ6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-25630196|ensembl:ENSP00000389297 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:c9jrz6_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000106554(gene)|ensembl:ENST00000448878(transcript)|go:"GO:0005739"(mitochondrion)|refseq:NP_001304106.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:uOXS6DrgWesk9Zbn51t9yeE2/Zg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92621 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045046|uniprotkb:Q86YC1|uniprotkb:A6H8X3|ensembl:ENSP00000285968 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nu205_human(display_long)|uniprotkb:Nucleoporin Nup205(gene name synonym)|uniprotkb:205 kDa nucleoporin(gene name synonym)|uniprotkb:NUP205(gene name)|psi-mi:NUP205(display_short)|uniprotkb:C7orf14(gene name synonym)|uniprotkb:KIAA0225(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000155561(gene)|ensembl:ENST00000285968(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|interpro:IPR021827|mint:Q92621|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:NP_055950.1|refseq:NP_001316363.1|dip:DIP-44021N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5lulE2tOZ4V1UZPwkEvOo9reZWE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P08243 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722989|uniprotkb:P08184|uniprotkb:Q15666|uniprotkb:Q549T9|uniprotkb:Q96HD0|ensembl:ENSP00000175506|ensembl:ENSP00000377845|ensembl:ENSP00000377846|uniprotkb:A4D1I8|uniprotkb:D6W5R3|uniprotkb:B4DXZ1|uniprotkb:B7ZAA9|uniprotkb:E9PCI3|uniprotkb:E9PCX6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:asns_human(display_long)|uniprotkb:Glutamine-dependent asparagine synthetase(gene name synonym)|uniprotkb:Cell cycle control protein TS11(gene name synonym)|uniprotkb:ASNS(gene name)|psi-mi:ASNS(display_short)|uniprotkb:TS11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001171546.1|refseq:NP_001171547.1|refseq:NP_001171548.1|refseq:NP_001664.3|refseq:NP_597680.2|refseq:NP_899199.2|ensembl:ENSG00000070669(gene)|ensembl:ENST00000175506(transcript)|ensembl:ENST00000394308(transcript)|ensembl:ENST00000394309(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004066"("asparagine synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006529"(asparagine biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0070981"(L-asparagine biosynthetic process)|interpro:IPR001962(Asparagine synthase)|interpro:IPR006426(Asparagine synthase, glutamine-hydrolyzing)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017932|interpro:IPR029055|interpro:IPR033738|rcsb pdb:6GQ3|reactome:R-HSA-380994|reactome:R-HSA-8963693|reactome:R-HSA-9633012|reactome:R-HSA-9648895 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:McR8Ve0DzWhe3JWMYLsCRChiBaY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P53618 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TAT6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1994109|uniprotkb:Q8N3J1|uniprotkb:Q9H8V2|uniprotkb:Q9H964|uniprotkb:Q9NWR5|uniprotkb:Q9P229|ensembl:ENSP00000331487 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:npl4_human(display_long)|uniprotkb:NPLOC4(gene name)|psi-mi:NPLOC4(display_short)|uniprotkb:KIAA1499(gene name synonym)|uniprotkb:NPL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011523281.1|refseq:NP_060391.2|dip:DIP-44059N|ensembl:ENSG00000182446(gene)|ensembl:ENST00000331134(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR007716(NPL4, zinc-binding putative)|interpro:IPR007717(NPL4)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR024682|interpro:IPR029071|interpro:IPR036443|interpro:IPR037518|mint:Q8TAT6|reactome:R-HSA-110320 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GXRNmG7yqEf5aFMo7yPDih93yfk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96JJ7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2514069|intact:EBI-28973673|uniprotkb:B3KV75|uniprotkb:Q52LT7|uniprotkb:Q8N5J0|uniprotkb:Q9NWJ9|ensembl:ENSP00000299608 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tmx3_human(display_long)|uniprotkb:TMX3(gene name)|psi-mi:TMX3(display_short)|uniprotkb:KIAA1830(gene name synonym)|uniprotkb:TXNDC10(gene name synonym)|uniprotkb:Thioredoxin-related transmembrane protein 3(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000299608|ensembl:ENST00000562706|ensembl:ENSP00000457262|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0031092"(platelet alpha granule membrane)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|reactome:R-HSA-114608|ensembl:ENST00000299608(transcript)|ensembl:ENSG00000166479(gene)|refseq:NP_061895.3 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Qber8pA1sCprlKl8Yoc5XtVEd5s9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:G3V325 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10967175|ensembl:ENSP00000400168 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:g3v325_human(display_long)|uniprotkb:ATP5MF-PTCD1(gene name)|psi-mi:ATP5MF-PTCD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001185808.1|ensembl:ENSG00000248919(gene)|ensembl:ENST00000413834(transcript)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:e4grYV8hYVnC3Eewghl5AAnqoHc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BXW9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13509 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-350989|uniprotkb:Q9BTZ0|uniprotkb:Q9BW10|ensembl:ENSP00000320295|uniprotkb:A8K854 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb3_human(display_long)|uniprotkb:TUBB3(gene name)|psi-mi:TUBB3(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:Tubulin beta-III(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001184110.1|refseq:NP_006077.2|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-6807878|ensembl:ENSG00000258947(gene)|ensembl:ENST00000315491(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007411"(axon guidance)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990890"(netrin receptor binding)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13509|rcsb pdb:5IJ9|rcsb pdb:5JCO|rcsb pdb:6E7B|rcsb pdb:6S8L|rcsb pdb:6WSL|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|rcsb pdb:5IJ0|dip:DIP-31505N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:A69G+idFQmuzkmCsGyBtGVqglSo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P36542 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43242 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5SNT2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10986145|ensembl:ENSP00000344503|uniprotkb:Q5SNT3|uniprotkb:B9EH90 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tm201_human(display_long)|uniprotkb:TMEM201(gene name)|psi-mi:TMEM201(display_short)|uniprotkb:NET5(gene name synonym)|uniprotkb:SAMP1(gene name synonym)|uniprotkb:Spindle-associated membrane protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001010866.1|refseq:NP_001124396.2|refseq:XP_011539212.1|ensembl:ENSG00000188807(gene)|ensembl:ENST00000340381(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0090435"(protein localization to nuclear envelope)|interpro:IPR018617|interpro:IPR018861|interpro:IPR040041 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YAYQ9viEL2HvpBxeStvJQrQ/z2c9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H1K4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6269587|ensembl:ENSP00000329033|ensembl:ENSP00000382710 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ghc2_human(display_long)|uniprotkb:SLC25A18(gene name)|psi-mi:SLC25A18(display_short)|uniprotkb:GC2(gene name synonym)|uniprotkb:"Glutamate/H(+) symporter 2"(gene name synonym)|uniprotkb:Solute carrier family 25 member 18(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000182902(gene)|ensembl:ENST00000327451(transcript)|ensembl:ENST00000399813(transcript)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006811"(ion transport)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0043490"(malate-aspartate shuttle)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-428643|refseq:NP_001290413.1|refseq:XP_011544453.1|refseq:XP_011544454.1|refseq:XP_011544455.1|refseq:XP_011544456.1|refseq:XP_016884457.1|refseq:NP_113669.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FJtx8LcwErI49B7GZPX71nCLQwg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y277 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P06493 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q02978 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359174|uniprotkb:O75537|uniprotkb:Q969P7|ensembl:ENSP00000225665|uniprotkb:F5GY65 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:m2om_human(display_long)|uniprotkb:SLC25A11(gene name)|psi-mi:SLC25A11(display_short)|uniprotkb:SLC20A4(gene name synonym)|uniprotkb:Solute carrier family 25 member 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003553.2|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q02978|reactome:R-HSA-70263|ensembl:ENSG00000108528(gene)|ensembl:ENST00000225665(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015367"("oxoglutarate:malate antiporter activity")|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TPeF6k/rQq+WJ9omeDK4V6NY4/o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P08238 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P25685 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P55209 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75746 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P49593 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5JWF2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-4400880|uniprotkb:A2A2S3|uniprotkb:E1P5G3|uniprotkb:O75684|uniprotkb:O75685|uniprotkb:Q5JW67|uniprotkb:Q5JWF1|uniprotkb:Q9NY42|ensembl:ENSP00000360141 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gnas1_human(display_long)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:Extra large alphas protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001296812.1|refseq:NP_536350.2|refseq:XP_016883302.1|ensembl:ENSG00000087460(gene)|ensembl:ENST00000371100(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0060348"(bone development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q5JWF2|reactome:R-HSA-163359|reactome:R-HSA-164378|reactome:R-HSA-381676|reactome:R-HSA-392851|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-432040|reactome:R-HSA-5610787|reactome:R-HSA-9660821 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:UmsO2DSEM3LmGMPwxSdkmlrKMLc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBB4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P45954 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2511905|ensembl:ENSP00000357873|uniprotkb:Q96CX7|uniprotkb:B4DQ51|uniprotkb:Q5SQN6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:acdsb_human(display_long)|uniprotkb:ACADSB(gene name)|psi-mi:ACADSB(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000196177(gene)|ensembl:ENST00000358776(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|rcsb pdb:2JIF|reactome:R-HSA-70895|refseq:NP_001600.1|refseq:NP_001317103.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:phnlWtZGT21VyKrhWj9a3Wjfijw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5W0B1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2562035|uniprotkb:Q9H8M0|uniprotkb:B2RN99|uniprotkb:Q9H0T2|uniprotkb:Q8TBY2|ensembl:ENSP00000282003 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:obi1_human(display_long)|uniprotkb:OBI1(gene name)|psi-mi:OBI1(display_short)|uniprotkb:C13orf7(gene name synonym)|uniprotkb:RING finger protein 219(gene name synonym)|uniprotkb:RNF219(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_078822.3|ensembl:ENSG00000152193(gene)|ensembl:ENST00000282003(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035691|interpro:IPR039209|mint:Q5W0B1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:MCzyMLZ+OMynQerFlsiwIHPRc0M9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6PI48 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3917045|ensembl:ENSP00000497569 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sydm_human(display_long)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:DARS2(gene name)|psi-mi:DARS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060592.2|ensembl:ENSG00000117593(gene)|ensembl:ENST00000649689(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043039"(tRNA aminoacylation)|go:"GO:0050560"("aspartate-tRNA(Asn) ligase activity")|go:"GO:0070145"(mitochondrial asparaginyl-tRNA aminoacylation)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004115(GAD)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004524(Aspartyl-tRNA synthetase, class IIb, bacterial/mitochondrial type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR029351|rcsb pdb:4AH6|reactome:R-HSA-379726|go:"GO:0005759"(mitochondrial matrix) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6tNhPqrlJ5dCXoDIgUjcUB/gA7s9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P52429 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1057499|uniprotkb:Q9UKQ3|uniprotkb:Q8TBM4|ensembl:ENSP00000284061 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dgke_human(display_long)|uniprotkb:DGKE(gene name)|psi-mi:DGKE(display_short)|uniprotkb:DAGK5(gene name synonym)|uniprotkb:Diglyceride kinase epsilon(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003638.1|ensembl:ENSG00000153933(gene)|ensembl:ENST00000284061(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0030168"(platelet activation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR037607|reactome:R-HSA-114508 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Fh3ky/ncwvXmjfiyJTdn5HTLRk89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5TEC6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11156283|ensembl:ENSP00000476960|ensembl:ENSP00000499501 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h3ps2_human(display_long)|uniprotkb:H3-2(gene name)|psi-mi:H3-2(display_short)|uniprotkb:HIST2H3PS2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000273213(gene)|ensembl:ENST00000392948(transcript)|ensembl:ENST00000609879(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:4H75 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5iHpsKKi7ckJhUKd9K8gnhdf8+g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:M0QXB4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103211|ensembl:ENSP00000469035 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:m0qxb4_human(display_long)|uniprotkb:COPE(gene name)|psi-mi:COPE(display_short)|uniprotkb:Epsilon-coat protein(gene name synonym)|uniprotkb:hCG_2001439(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000600932(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR006822(Coatomer, epsilon subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|ensembl:ENSG00000105669(gene)|refseq:NP_001317398.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tt5SKfwvuhJE01ciiu76KdoUGdY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HDC9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-723950|ensembl:ENSP00000217456|uniprotkb:Q6UVZ8|uniprotkb:Q9GZS8|uniprotkb:Q9NUB2|uniprotkb:A8K514|uniprotkb:B4DXG1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:apmap_human(display_long)|uniprotkb:Protein BSCv(gene name synonym)|uniprotkb:APMAP(gene name)|psi-mi:APMAP(display_short)|uniprotkb:C20orf3(gene name synonym)|uniprotkb:UNQ1869/PRO4305(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_065392.1|ensembl:ENSG00000101474(gene)|ensembl:ENST00000217456(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0009058"(biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016844"(strictosidine synthase activity)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018119|mint:Q9HDC9|refseq:XP_005260820.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IRPAV+sieIBDPYsV4ypu35eSrkQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P42704 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13885 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711595|ensembl:ENSP00000369703|uniprotkb:Q6FGZ8|uniprotkb:Q8IWR2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb2a_human(display_long)|uniprotkb:TUBB2A(gene name)|psi-mi:TUBB2A(display_short)|uniprotkb:TUBB2(gene name synonym)|uniprotkb:Tubulin beta class IIa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-389957|reactome:R-HSA-983189|reactome:R-HSA-9668328|ensembl:ENSG00000137267(gene)|ensembl:ENST00000333628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13885|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|refseq:NP_001060.1|refseq:NP_001297244.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:XN9uTGU0KxQjMod0AGnM+XJoHyk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62987 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357304|ensembl:ENSP00000388107|ensembl:ENSP00000396910|ensembl:ENSP00000470419|ensembl:ENSP00000470507|ensembl:ENSP00000471062|ensembl:ENSP00000471464|ensembl:ENSP00000471622|ensembl:ENSP00000472264|ensembl:ENSP00000472545|ensembl:ENSP00000473048|uniprotkb:P14793|uniprotkb:Q9BX98|uniprotkb:Q9UPK7|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P62988|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rl40_human(display_long)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)|uniprotkb:UBCEP2(gene name synonym)|uniprotkb:CEP52(gene name synonym)|uniprotkb:Ubiquitin A-52 residue ribosomal protein fusion product 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000221983(gene)|ensembl:ENST00000430157(transcript)|ensembl:ENST00000442744(transcript)|ensembl:ENST00000595158(transcript)|rcsb pdb:2MBH|rcsb pdb:2MJB|rcsb pdb:2MUR|ensembl:ENST00000595683(transcript)|ensembl:ENST00000596273(transcript)|rcsb pdb:2N3U|rcsb pdb:2N3V|rcsb pdb:2N3W|rcsb pdb:2NBD|ensembl:ENST00000596304(transcript)|rcsb pdb:2NBE|rcsb pdb:2RSU|rcsb pdb:4HJK|ensembl:ENST00000597451(transcript)|ensembl:ENST00000598780(transcript)|rcsb pdb:4JIO|rcsb pdb:4P4H|rcsb pdb:4PIG|ensembl:ENST00000599551(transcript)|ensembl:ENST00000599595(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:4PIH|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017085"(response to insecticide)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR001975(Ribosomal protein L40e)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038587|mint:P62987|rcsb pdb:2LJ5|rcsb pdb:4PIJ|rcsb pdb:4RF0|rcsb pdb:4S1Z|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4XKL|rcsb pdb:5AJ0|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5HPK|rcsb pdb:5HPL|rcsb pdb:5HPS|rcsb pdb:5HPT|rcsb pdb:5J26|rcsb pdb:5J8P|rcsb pdb:5JBV|rcsb pdb:5JBY|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:4RF1|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7AY1|rcsb pdb:7BHP|rcsb pdb:7M3Q|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|rcsb pdb:6Z6N|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-1799339|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-192823|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6791226|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-69231|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9633012|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-977225|reactome:R-HSA-983168|refseq:NP_001029102.1|refseq:NP_003324.1|refseq:NP_001307947.1|refseq:NP_001307948.1|refseq:NP_001307949.1|refseq:NP_001307946.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:x9O/Pbww4D28M1+hIj+p0xrUXgU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5T160 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1050546|uniprotkb:Q96FU5|uniprotkb:Q9H8K8|uniprotkb:B2RDT7|ensembl:ENSP00000358549 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:syrm_human(display_long)|uniprotkb:RARS2(gene name)|psi-mi:RARS2(display_short)|uniprotkb:RARSL(gene name synonym)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064716.2|ensembl:ENSG00000146282(gene)|ensembl:ENST00000369536(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q5T160|reactome:R-HSA-379726 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jslLCkjYCriiVlR94nHAhNIYVeY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P25787 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92890 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5QPK2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103197|ensembl:ENSP00000360638 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:q5qpk2_human(display_long)|uniprotkb:DPM1(gene name)|psi-mi:DPM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000000419(gene)|ensembl:ENST00000371582(transcript)|go:"GO:0004582"(dolichyl-phosphate beta-D-mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR039528|refseq:NP_001303964.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Plnxu7TEh40W3c1LDSgmK52Nu1o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P25705 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BVA1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355665|uniprotkb:A8K068|ensembl:ENSP00000259818 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb2b_human(display_long)|uniprotkb:TUBB2B(gene name)|psi-mi:TUBB2B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_821080.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BVA1|rcsb pdb:6E7C|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|ensembl:ENST00000259818(transcript)|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-5663220|ensembl:ENSG00000137285(gene) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:sluQMryNuOvp6xlV558+agiRwvE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:A0FGR8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3184170|uniprotkb:Q9ULJ2|uniprotkb:Q9NW47|uniprotkb:Q69YJ2|uniprotkb:Q6ZVU1|uniprotkb:Q6UKI4|uniprotkb:Q6ZTU0|uniprotkb:Q9BQS0|uniprotkb:A4D229 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:esyt2_human(display_long)|uniprotkb:ESYT2(gene name)|psi-mi:ESYT2(display_short)|uniprotkb:FAM62B(gene name synonym)|uniprotkb:KIAA1228(gene name synonym)|uniprotkb:Chr2Syt(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0006897"(endocytosis)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044232"(organelle membrane contact site)|go:"GO:0045296"(cadherin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|go:"GO:0005789"(endoplasmic reticulum membrane)|interpro:IPR037733|interpro:IPR037749|interpro:IPR037752|interpro:IPR039010|rcsb pdb:2DMG|rcsb pdb:4NPJ|rcsb pdb:4NPK|rcsb pdb:4P42|reactome:R-HSA-1660662|refseq:NP_065779.1|mint:A0FGR8|dip:DIP-61039N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mOkUWt8oia02xtJYM6gQz3tsav89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P20020 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:kCpUNLYDF38hciXj32D8rXbXULg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TEX9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P14625 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359129|uniprotkb:Q96A97|ensembl:ENSP00000299767 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:enpl_human(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:TRA1(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:GRP94(gene name synonym)|uniprotkb:gp96 homolog(gene name synonym)|uniprotkb:Tumor rejection antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003290.1|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P14625|rcsb pdb:4NH9|reactome:R-HSA-1679131|reactome:R-HSA-3000480|reactome:R-HSA-381183|reactome:R-HSA-381426|reactome:R-HSA-6785807|reactome:R-HSA-8957275|ensembl:ENSG00000166598(gene)|ensembl:ENST00000299767(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|dip:DIP-36060N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:m5CdlplqVyMUWYe75aKDuMzztMY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35232 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UJS0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P07437 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92538 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359050|uniprotkb:Q5VXX3|uniprotkb:Q96CK6|uniprotkb:Q96HZ3|uniprotkb:Q9H473|uniprotkb:Q149P0|uniprotkb:Q149P1|ensembl:ENSP00000503207|ensembl:ENSP00000503981 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gbf1_human(display_long)|uniprotkb:GBF1(gene name)|psi-mi:GBF1(display_short)|uniprotkb:KIAA0248(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001186307.1|refseq:NP_001186308.1|refseq:NP_004184.1|ensembl:ENSP00000503207|ensembl:ENSP00000503981|ensembl:ENST00000676993|ensembl:ENSP00000503918|ensembl:ENST00000677240|ensembl:ENSP00000503428|ensembl:ENSG00000107862(gene)|ensembl:ENST00000676513(transcript)|ensembl:ENST00000676939(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002263"(cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0060271"(cilium assembly)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|go:"GO:1903420"(protein localization to endoplasmic reticulum tubular network)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000904(SEC7-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032691|interpro:IPR035999|mint:Q92538|reactome:R-HSA-199992|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4rA/2NVw35m+b6O7/+9noI3EO4o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y3D0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-744045|ensembl:ENSP00000387471 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cia2b_human(display_long)|uniprotkb:CIAO2B(gene name)|psi-mi:CIAO2B(display_short)|uniprotkb:CIAB(gene name synonym)|uniprotkb:FAM96B(gene name synonym)|uniprotkb:MIP18(gene name synonym)|uniprotkb:MSS19-interacting protein of 18 kDa(gene name synonym)|uniprotkb:Mitotic spindle-associated MMXD complex subunit MIP18(gene name synonym)|uniprotkb:Protein FAM96B(gene name synonym)|uniprotkb:CGI-128(orf name)|uniprotkb:HSPC118(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_057146.1|ensembl:ENSG00000166595(gene)|ensembl:ENST00000422424(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030496"(midbody)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002744(Protein of unknown function DUF59)|interpro:IPR034904|interpro:IPR039796|mint:Q9Y3D0|reactome:R-HSA-2564830 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6LfOUjTAKuEjop3XVyyxx6c4Wl09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:B5MDF5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11602390|ensembl:ENSP00000376174 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:b5mdf5_human(display_long)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:hCG_1744585(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000132341(gene)|ensembl:ENST00000392367(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0015031"(protein transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:EUJF61ZDzP5EZBxpv45vt1aO9cE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P84243 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-120658|uniprotkb:P06351|uniprotkb:P33155|uniprotkb:Q5VV55|uniprotkb:Q5VV56|uniprotkb:Q66I33|uniprotkb:Q9V3W4|ensembl:ENSP00000254810|ensembl:ENSP00000355778|ensembl:ENSP00000355780|ensembl:ENSP00000355781|ensembl:ENSP00000465813|ensembl:ENSP00000466020|ensembl:ENSP00000468714|ensembl:ENSP00000499275|ensembl:ENSP00000499385|ensembl:ENSP00000499800 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h33_human(display_long)|uniprotkb:H3-3A(gene name)|psi-mi:H3-3A(display_short)|uniprotkb:H3-3B(gene name)|psi-mi:H3-3B(display_short)|uniprotkb:H3.3A(gene name synonym)|uniprotkb:H3.3B(gene name synonym)|uniprotkb:H3F3(gene name synonym)|uniprotkb:H3F3A(gene name synonym)|uniprotkb:H3F3B(gene name synonym)|uniprotkb:PP781(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002098.1|refseq:NP_005315.1|rcsb pdb:4H9N|rcsb pdb:3QL9|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:3QLA|rcsb pdb:3QLC|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4L58|rcsb pdb:4N4I|rcsb pdb:3WTP|rcsb pdb:4O62|rcsb pdb:4QQ4|rcsb pdb:4TMP|rcsb pdb:4GNE|rcsb pdb:4GNF|rcsb pdb:4U7T|rcsb pdb:4GNG|rcsb pdb:4W5A|rcsb pdb:4GU0|rcsb pdb:4GUR|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:4GUS|rcsb pdb:4GY5|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5JA4|rcsb pdb:5JJY|ensembl:ENSG00000132475(gene)|ensembl:ENSG00000163041(gene)|rcsb pdb:5JLB|rcsb pdb:5KDM|rcsb pdb:5X7X|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:6A5P|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6HGT|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6J9J|rcsb pdb:6PZV|rcsb pdb:6QXZ|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6U04|rcsb pdb:7A08|reactome:R-HSA-427413|rcsb pdb:7CIZ|reactome:R-HSA-5250924|reactome:R-HSA-5334118|rcsb pdb:7CJ0|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-983231|rcsb pdb:7CWH|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-427359|reactome:R-HSA-427389|ensembl:ENST00000254810(transcript)|ensembl:ENST00000366813(transcript)|ensembl:ENST00000366815(transcript)|ensembl:ENST00000366816(transcript)|ensembl:ENST00000586607(transcript)|ensembl:ENST00000587560(transcript)|ensembl:ENST00000589599(transcript)|ensembl:ENST00000655399(transcript)|ensembl:ENST00000661429(transcript)|ensembl:ENST00000666609(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P84243|rcsb pdb:2L43|rcsb pdb:3ASK|rcsb pdb:3ASL|rcsb pdb:3AV2|rcsb pdb:3JVK|rcsb pdb:3MUK|rcsb pdb:3MUL|dip:DIP-40046N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:cRqA5/IBNfIbbxAnbwLqzXip20I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14568 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2826582 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hs902_human(display_long)|uniprotkb:HSP90AA2P(gene name)|psi-mi:HSP90AA2P(display_short)|uniprotkb:HSP90AA2(gene name synonym)|uniprotkb:HSPCAL3(gene name synonym)|uniprotkb:Heat shock 90 kDa protein 1 alpha-like 3(gene name synonym)|uniprotkb:Heat shock protein HSP 90-alpha A2 pseudogene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR020575|interpro:IPR020568|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR036890|mint:Q14568 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HN+Hui0dI60DoXKDmTqZRgIEyK49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P68371 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BUF5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P04350 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5VWC4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11026615|ensembl:ENSP00000357876 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:q5vwc4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:hCG_1741224(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000159352(gene)|ensembl:ENST00000368881(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|refseq:NP_001317621.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:etYRTzLchCq5+w5ujsw8IE74nog9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15008 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359701|uniprotkb:E9PHI9|uniprotkb:A8K2E0|ensembl:ENSP00000295901|uniprotkb:Q6UV22 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psmd6_human(display_long)|uniprotkb:PSMD6(gene name)|psi-mi:PSMD6(display_short)|uniprotkb:KIAA0107(gene name synonym)|uniprotkb:PFAAP4(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S10(gene name synonym)|uniprotkb:p42A(gene name synonym)|uniprotkb:Proteasome regulatory particle subunit p44S10(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 4(gene name synonym)|uniprotkb:Breast cancer-associated protein SGA-113M(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055629.1|ensembl:ENSG00000163636(gene)|ensembl:ENST00000295901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|mint:Q15008|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-5358346|reactome:R-HSA-1236978|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-1236974|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-69481|refseq:NP_001258708.1|refseq:NP_001258709.1|refseq:NP_001258710.1|dip:DIP-27590N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ULOM02v6J56vZLlAGn7wN3N6Efw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14697 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H5Q4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1043912|ensembl:ENSP00000355471|uniprotkb:Q9H626 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tfb2m_human(display_long)|uniprotkb:TFB2M(gene name)|psi-mi:TFB2M(display_short)|uniprotkb:NS5ATP5(gene name synonym)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 2(gene name synonym)|uniprotkb:Mitochondrial transcription factor B2(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_071761.1|ensembl:ENST00000366514(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR016861(Mitochondrial dimethyladenosine transferase 2, mitochondrial precursor)|interpro:IPR020598|interpro:IPR029063|mint:Q9H5Q4|rcsb pdb:6ERO|rcsb pdb:6ERP|rcsb pdb:6ERQ|reactome:R-HSA-163282|reactome:R-HSA-2151201|ensembl:ENSG00000162851(gene)|dip:DIP-50540N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qg7FnDzaxjvzpH+KxQFk52NyvUI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75947 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99570 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046979|uniprotkb:Q2TBF4|ensembl:ENSP00000349205 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pi3r4_human(display_long)|uniprotkb:PI3-kinase p150 subunit(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase adaptor protein(gene name synonym)|uniprotkb:PIK3R4(gene name)|psi-mi:PIK3R4(display_short)|uniprotkb:VPS15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055417.1|ensembl:ENSG00000196455(gene)|ensembl:ENST00000356763(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR036322|mint:Q99570|rcsb pdb:7BL1|reactome:R-HSA-109704|reactome:R-HSA-1632852|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-168138|reactome:R-HSA-5668599|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0071561"(nucleus-vacuole junction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001680(WD40 repeat)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-42310N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:CjToF5FvjyANBQtA1wuWQxC82889606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5SRE5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1049404|uniprotkb:Q14675|uniprotkb:Q2TA87|uniprotkb:Q7Z3K8|uniprotkb:Q8IWF1|intact:EBI-2555229|ensembl:ENSP00000361658 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nu188_human(display_long)|uniprotkb:NUP188(gene name)|psi-mi:NUP188(display_short)|uniprotkb:KIAA0169(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056169.1|ensembl:ENSG00000095319(gene)|ensembl:ENST00000372577(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018864|interpro:IPR044840|mint:Q5SRE5|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eoj+tg9RAVKcVlT9ku1ozXCa3u89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8WVX9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045879|uniprotkb:Q5CZA3|uniprotkb:D3DQW8|ensembl:ENSP00000346874 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:facr1_human(display_long)|uniprotkb:Male sterility domain-containing protein 2(gene name synonym)|uniprotkb:FAR1(gene name)|psi-mi:FAR1(display_short)|uniprotkb:MLSTD2(gene name synonym)|uniprotkb:UNQ2423/PRO4981(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115604.1|ensembl:ENSG00000197601(gene)|ensembl:ENST00000354817(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0010025"(wax biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|go:"GO:0080019"("fatty-acyl-CoA reductase (alcohol-forming) activity")|go:"GO:0102965"(alcohol-forming fatty acyl-CoA reductase activity)|interpro:IPR013120(Male sterility, NAD-binding)|interpro:IPR026055|interpro:IPR033640|interpro:IPR036291|mint:Q8WVX9|reactome:R-HSA-9640463 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YKZzt4lpIwBaWwckb0ZP9Wh8Q8k9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NS69 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1047508|intact:EBI-1180569|ensembl:ENSP00000216034 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tom22_human(display_long)|uniprotkb:TOMM22(gene name)|psi-mi:TOMM22(display_short)|uniprotkb:TOM22(gene name synonym)|uniprotkb:Translocase of outer membrane 22 kDa subunit homolog(gene name synonym)|uniprotkb:1C9-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064628.1|ensembl:ENSG00000100216(gene)|ensembl:ENST00000216034(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|interpro:IPR005683(Mitochondrial import translocase, subunit Tom22)|mint:Q9NS69|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DI3BGFSB04B1/mMHJsBpOsCxrYk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P18859 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P60604 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1051028|uniprotkb:P56554|uniprotkb:A8K3L4|uniprotkb:D3DSL7|uniprotkb:A6NMQ7|ensembl:ENSP00000338348 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ub2g2_human(display_long)|uniprotkb:Ubiquitin-protein ligase G2(gene name synonym)|uniprotkb:Ubiquitin carrier protein G2(gene name synonym)|uniprotkb:UBE2G2(gene name)|psi-mi:UBE2G2(display_short)|uniprotkb:E2 ubiquitin-conjugating enzyme G2(gene name synonym)|uniprotkb:UBC7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001189418.1|refseq:NP_003334.2|refseq:NP_872630.1|refseq:XP_016883958.1|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2CYX|rcsb pdb:2KLY|rcsb pdb:2LXP|rcsb pdb:3H8K|rcsb pdb:4LAD|reactome:R-HSA-8866652|reactome:R-HSA-983168|ensembl:ENSG00000184787(gene)|ensembl:ENST00000345496(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-50750N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Q/uslqX/WH/SxKEPYeMmU9CjTBI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P50502 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357285|ensembl:ENSP00000216218|uniprotkb:O14999|uniprotkb:Q2TU77 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:f10a1_human(display_long)|uniprotkb:ST13(gene name)|psi-mi:ST13(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:SNC6(gene name synonym)|uniprotkb:AAG2(gene name synonym)|uniprotkb:Aging-associated protein 2(gene name synonym)|uniprotkb:FAM10A1(gene name synonym)|uniprotkb:Suppression of tumorigenicity 13 protein(gene name synonym)|uniprotkb:Putative tumor suppressor ST13(gene name synonym)|uniprotkb:Protein FAM10A1(gene name synonym)|uniprotkb:Progesterone receptor-associated p48 protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100380(gene)|ensembl:ENST00000216218(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034649|interpro:IPR041243|mint:P50502|rcsb pdb:1UZS|reactome:R-HSA-3371453|refseq:NP_003923.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:yqG5t4Kuj7ZzfNwlJzGZYscKiM89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:R4GMR5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27103185|ensembl:ENSP00000473312 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:r4gmr5_human(display_long)|uniprotkb:PSMD8(gene name)|psi-mi:PSMD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000099341(gene)|ensembl:ENST00000602911(transcript)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006508"(proteolysis)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:o5oRWv+0F1/iCYThh6UQDmRCiNo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q3ZCM7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-302558|ensembl:ENSP00000456206|intact:EBI-1390656|uniprotkb:Q5SQX9|uniprotkb:Q8WZ78 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tbb8_human(display_long)|uniprotkb:TUBB8(gene name)|psi-mi:TUBB8(display_short)|uniprotkb:Tubulin beta 8 class VIII(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-9619483|ensembl:ENSG00000261456(gene)|ensembl:ENST00000568584(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007056"(spindle assembly involved in female meiosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072687"(meiotic spindle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q3ZCM7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|refseq:NP_817124.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:bTJnhl0qEm2ACoHQ7IOcn5Rx7xM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P12004 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99707 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045782|uniprotkb:Q99713|uniprotkb:Q99723|uniprotkb:A9Z1W4|uniprotkb:B9EGF7|uniprotkb:A1L4N8|uniprotkb:B7ZLW7|ensembl:ENSP00000355536 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:meth_human(display_long)|uniprotkb:5-methyltetrahydrofolate--homocysteine methyltransferase(gene name synonym)|uniprotkb:Vitamin-B12 dependent methionine synthase(gene name synonym)|uniprotkb:MTR(gene name)|psi-mi:MTR(display_short)|uniprotkb:Cobalamin-dependent methionine synthase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001278869.1|refseq:NP_000245.2|ensembl:ENSG00000116984(gene)|ensembl:ENST00000366577(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008705"(methionine synthase activity)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031103"(axon regeneration)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032259"(methylation)|go:"GO:0042558"(pteridine-containing compound metabolic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR000489(Dihydropteroate synthase, DHPS)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR003759("Methionine synthase, cobalamin (vitamin B12)-binding module, cap")|interpro:IPR004223(Vitamin B12 dependent methionine synthase, activation region)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR011005(Dihydropteroate synthase-like)|interpro:IPR011822(5-methyltetrahydrofolate--homocysteine methyltransferase)|interpro:IPR033706|interpro:IPR036589|interpro:IPR036594|interpro:IPR036724|interpro:IPR037010|rcsb pdb:2O2K|rcsb pdb:4CCZ|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-196741|reactome:R-HSA-3359467|reactome:R-HSA-3359469|reactome:R-HSA-9013407|refseq:NP_001278868.1|dip:DIP-40306N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wfY9f5C2d1neO4MQeVdVrVGzrrs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75396 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1058865|ensembl:ENSP00000463393|uniprotkb:A8K1G0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sc22b_human(display_long)|uniprotkb:SEC22B(gene name)|psi-mi:SEC22B(display_short)|uniprotkb:SEC22L1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000265808(gene)|ensembl:ENST00000578049(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O75396|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:3EGD|rcsb pdb:3EGX|refseq:NP_004883.3|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6811434|reactome:R-HSA-1236974|dip:DIP-50458N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DRKtD169T9eYZ2kFufLapidvcKs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00743 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359751|uniprotkb:Q5U0A2|uniprotkb:Q9UIC9|uniprotkb:B2R5V6|uniprotkb:B7Z5K9|uniprotkb:B7Z2W9|ensembl:ENSP00000362648 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ppp6_human(display_long)|uniprotkb:PPP6C(gene name)|psi-mi:PPP6C(display_short)|uniprotkb:PPP6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001116827.1|refseq:NP_001116841.1|refseq:NP_002712.1|dip:DIP-27581N|ensembl:ENSG00000119414(gene)|ensembl:ENST00000373547(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:O00743|reactome:R-HSA-171319|reactome:R-HSA-204005 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IdVJPgcG3d38BpLEPVGIaKqBRVI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P10316 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11337951|uniprotkb:B1PKZ3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:1a69_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:Aw-69(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-28 alpha chain(gene name synonym)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*69(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0055038"(recycling endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENST00000457879|interpro:IPR036179|interpro:IPR037055 - - no-uniprot-update:This interactor won't be updated using Uniprot. figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7OTCPtpzsA6j+fK+MoF+0EDFVZ49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P68431 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-79722|ensembl:ENSP00000352252|ensembl:ENSP00000358160|ensembl:ENSP00000366999|ensembl:ENSP00000480826|ensembl:ENSP00000482271|ensembl:ENSP00000483283|ensembl:ENSP00000484095|ensembl:ENSP00000484638|ensembl:ENSP00000484658|ensembl:ENSP00000484841|ensembl:ENSP00000489282|intact:EBI-1560041|uniprotkb:A0PJT7|uniprotkb:P02295|uniprotkb:P02296|uniprotkb:P16106|uniprotkb:Q6ISV8|uniprotkb:Q6NWP8|uniprotkb:Q6NWP9|uniprotkb:Q6NXU4|uniprotkb:Q71DJ3|uniprotkb:Q93081|uniprotkb:A5PLR1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h31_human(display_long)|uniprotkb:H3FA(gene name synonym)|uniprotkb:H3FL(gene name synonym)|uniprotkb:H3FD(gene name synonym)|uniprotkb:H3FI(gene name synonym)|uniprotkb:H3FH(gene name synonym)|uniprotkb:H3FK(gene name synonym)|uniprotkb:H3FF(gene name synonym)|uniprotkb:H3FJ(gene name synonym)|uniprotkb:H3FB(gene name synonym)|uniprotkb:Histone H3/a(gene name synonym)|uniprotkb:Histone H3/b(gene name synonym)|uniprotkb:Histone H3/c(gene name synonym)|uniprotkb:Histone H3/d(gene name synonym)|uniprotkb:Histone H3/f(gene name synonym)|uniprotkb:Histone H3/h(gene name synonym)|uniprotkb:Histone H3/i(gene name synonym)|uniprotkb:Histone H3/j(gene name synonym)|uniprotkb:Histone H3/k(gene name synonym)|uniprotkb:Histone H3/l(gene name synonym)|uniprotkb:H3C1(gene name)|psi-mi:H3C1(display_short)|uniprotkb:HIST1H3A(gene name synonym)|uniprotkb:H3C2(gene name)|psi-mi:H3C2(display_short)|uniprotkb:HIST1H3B(gene name synonym)|uniprotkb:H3C3(gene name)|psi-mi:H3C3(display_short)|uniprotkb:H3FC HIST1H3C(gene name synonym)|uniprotkb:H3C4(gene name)|psi-mi:H3C4(display_short)|uniprotkb:HIST1H3D(gene name synonym)|uniprotkb:H3C6(gene name)|psi-mi:H3C6(display_short)|uniprotkb:HIST1H3E(gene name synonym)|uniprotkb:H3C7(gene name)|psi-mi:H3C7(display_short)|uniprotkb:HIST1H3F(gene name synonym)|uniprotkb:H3C8(gene name)|psi-mi:H3C8(display_short)|uniprotkb:HIST1H3G(gene name synonym)|uniprotkb:H3C10(gene name)|psi-mi:H3C10(display_short)|uniprotkb:HIST1H3H(gene name synonym)|uniprotkb:H3C11(gene name)|psi-mi:H3C11(display_short)|uniprotkb:HIST1H3I(gene name synonym)|uniprotkb:H3C12(gene name)|psi-mi:H3C12(display_short)|uniprotkb:HIST1H3J(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) rcsb pdb:4TN7|rcsb pdb:4U68|rcsb pdb:4UP0|rcsb pdb:4UY4|rcsb pdb:4X3K|rcsb pdb:4Y6L|rcsb pdb:4YHP|rcsb pdb:4YHZ|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z0R|rcsb pdb:4Z2M|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:4QBS|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B31|rcsb pdb:5C11|rcsb pdb:5C13|rcsb pdb:5C3I|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5D6Y|rcsb pdb:5DAH|rcsb pdb:5FB0|rcsb pdb:5FB1|rcsb pdb:5FFV|rcsb pdb:5GH9|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5H6Q|rcsb pdb:5H6R|rcsb pdb:5HJB|rcsb pdb:5HJC|rcsb pdb:5HJD|rcsb pdb:5HYN|rcsb pdb:5IQL|rcsb pdb:5J3V|rcsb pdb:5J9S|rcsb pdb:5JHN|rcsb pdb:5JIN|rcsb pdb:5JIY|rcsb pdb:5JJ0|rcsb pdb:5B2J|rcsb pdb:5JRG|rcsb pdb:5KJH|rcsb pdb:5KJI|rcsb pdb:5KKL|rcsb pdb:5LUG|rcsb pdb:5M5G|rcsb pdb:5MR8|rcsb pdb:5NNC|rcsb pdb:5OY3|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:5SZB|rcsb pdb:5SZC|rcsb pdb:5T0K|rcsb pdb:5T0M|rcsb pdb:5T1G|rcsb pdb:5T1I|rcsb pdb:5T8R|rcsb pdb:5TBN|rcsb pdb:5TDR|rcsb pdb:5TDW|rcsb pdb:5U2J|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:5VA6|rcsb pdb:5VAB|rcsb pdb:5VGE|rcsb pdb:5VNB|rcsb pdb:5NND|rcsb pdb:5WLE|rcsb pdb:5WVO|rcsb pdb:5WXG|rcsb pdb:5WXH|rcsb pdb:5WYI|rcsb pdb:5X60|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5XFQ|rcsb pdb:5XFR|rcsb pdb:5XNV|rcsb pdb:5XTZ|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Y20|rcsb pdb:5Y2F|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:6AXJ|rcsb pdb:6AZE|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6D07|rcsb pdb:6D08|rcsb pdb:6E83|rcsb pdb:6E86|rcsb pdb:5WFC|rcsb pdb:6F6D|rcsb pdb:6HTS|rcsb pdb:6IEU|rcsb pdb:6IIS|rcsb pdb:6IIT|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6JXD|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6LS6|rcsb pdb:6LSD|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MIL|rcsb pdb:6MIM|rcsb pdb:6MIN|rcsb pdb:6MIO|rcsb pdb:6MIQ|rcsb pdb:6PA1|rcsb pdb:6PAG|rcsb pdb:6HKT|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2H|rcsb pdb:6V2K|rcsb pdb:6V3N|rcsb pdb:6V41|rcsb pdb:6V92|rcsb pdb:6VIL|rcsb pdb:6WAV|rcsb pdb:6WW4|rcsb pdb:6YIF|rcsb pdb:6YIH|rcsb pdb:6YOV|rcsb pdb:7BWD|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:6R92|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7DBP|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7KLR|rcsb pdb:7LYC|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|ensembl:ENSG00000197153(gene)|ensembl:ENSG00000197409(gene)|ensembl:ENSG00000273983(gene)|ensembl:ENSG00000274750(gene)|ensembl:ENSG00000275379(gene)|ensembl:ENSG00000275714(gene)|ensembl:ENSG00000277775(gene)|ensembl:ENSG00000278828(gene)|ensembl:ENSG00000286522(gene)|ensembl:ENSG00000287080(gene)|ensembl:ENST00000356476(transcript)|ensembl:ENST00000359303(transcript)|ensembl:ENST00000369163(transcript)|ensembl:ENST00000612966(transcript)|ensembl:ENST00000613854(transcript)|ensembl:ENST00000614378(transcript)|ensembl:ENST00000614911(transcript)|ensembl:ENST00000616365(transcript)|ensembl:ENST00000618052(transcript)|ensembl:ENST00000621411(transcript)|ensembl:ENST00000634733(transcript)|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-3247509|reactome:R-HSA-9710421|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P68431|rcsb pdb:1CS9|rcsb pdb:1CT6|rcsb pdb:1O9S|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|rcsb pdb:1Q3L|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|rcsb pdb:2B2T|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|rcsb pdb:2B2U|rcsb pdb:2B2V|rcsb pdb:2B2W|rcsb pdb:2C1J|rcsb pdb:2C1N|go:"GO:0016020"(membrane)|rcsb pdb:2CO0|rcsb pdb:2CV5|rcsb pdb:2FSA|rcsb pdb:2KWJ|rcsb pdb:2KWK|rcsb pdb:2L75|rcsb pdb:2LBM|rcsb pdb:2LGG|rcsb pdb:2M0O|reactome:R-HSA-983231|reactome:R-HSA-977225|rcsb pdb:2NDG|rcsb pdb:2OQ6|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2RI7|rcsb pdb:2RR4|rcsb pdb:2UXN|rcsb pdb:2V85|rcsb pdb:2V89|rcsb pdb:2VNF|rcsb pdb:2VPG|rcsb pdb:2X0L|rcsb pdb:3A1B|rcsb pdb:2NDF|rcsb pdb:3AFA|rcsb pdb:3AVR|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3B95|rcsb pdb:3FDT|rcsb pdb:3KMT|rcsb pdb:3KQI|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3MP1|rcsb pdb:3O34|rcsb pdb:3O35|rcsb pdb:3O37|rcsb pdb:3QJ6|rcsb pdb:3RIG|rcsb pdb:3RIY|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3U31|rcsb pdb:3U3D|rcsb pdb:3U4S|rcsb pdb:3U5N|rcsb pdb:3U5O|rcsb pdb:3AZK|rcsb pdb:3U5P|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UII|rcsb pdb:3UIK|rcsb pdb:3V43|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:3ZG6|rcsb pdb:3ZVY|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:4A7J|rcsb pdb:3UIG|rcsb pdb:4BD3|rcsb pdb:4C1Q|rcsb pdb:4F4U|rcsb pdb:4F56|rcsb pdb:4FWF|rcsb pdb:4HON|rcsb pdb:4I51|rcsb pdb:4L7X|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:4LXL|rcsb pdb:4N4H|rcsb pdb:4QBQ|rcsb pdb:4QBR|refseq:NP_003520.1|refseq:NP_003521.2|refseq:NP_003522.1|refseq:NP_003523.1|refseq:NP_003524.1|refseq:NP_003525.1|refseq:NP_003526.1|refseq:NP_003527.1|refseq:NP_003528.1|refseq:NP_066298.1|dip:DIP-29371N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ood0OohxZHuhsWZtO7U7GMc+LwM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q71DI3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-750650|uniprotkb:A2BDF6|uniprotkb:A6NFS4|uniprotkb:Q6B053|ensembl:ENSP00000333277|ensembl:ENSP00000358154|ensembl:ENSP00000385479 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h32_human(display_long)|uniprotkb:H3C13(gene name)|psi-mi:H3C13(display_short)|uniprotkb:H3C14(gene name)|psi-mi:H3C14(display_short)|uniprotkb:H3C15(gene name)|psi-mi:H3C15(display_short)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3F2(gene name synonym)|uniprotkb:H3FM(gene name synonym)|uniprotkb:HIST2H3A(gene name synonym)|uniprotkb:HIST2H3C(gene name synonym)|uniprotkb:HIST2H3D(gene name synonym)|uniprotkb:Histone H3/m(gene name synonym)|uniprotkb:Histone H3/o(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001005464.1|refseq:NP_001116847.1|refseq:NP_066403.2|dip:DIP-48606N|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|rcsb pdb:7BU9|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-983231|rcsb pdb:7JZV|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|ensembl:ENSG00000183598(gene)|ensembl:ENSG00000203811(gene)|ensembl:ENSG00000203852(gene)|ensembl:ENST00000331491(transcript)|ensembl:ENST00000369158(transcript)|ensembl:ENST00000403683(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q71DI3|rcsb pdb:2IIJ|rcsb pdb:2X4W|rcsb pdb:2X4X|rcsb pdb:2X4Y|rcsb pdb:3AV1|rcsb pdb:3DB3|rcsb pdb:3MO8|rcsb pdb:3QO2|rcsb pdb:3R93|rcsb pdb:4MZF|rcsb pdb:4MZG|rcsb pdb:4MZH|rcsb pdb:4OUC|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B40|rcsb pdb:5BO0|rcsb pdb:5CIU|rcsb pdb:5VAC|rcsb pdb:6ACE|rcsb pdb:6FML|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6Y5E|rcsb pdb:7BQZ - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6YHU6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2824523|uniprotkb:Q3KR04|uniprotkb:Q53RC6|uniprotkb:Q6ZU38|uniprotkb:Q9H6W7|uniprotkb:Q6YHU2|uniprotkb:Q9C096|uniprotkb:Q96I88|uniprotkb:Q8TAU8|uniprotkb:Q9H6U0|uniprotkb:B7WNS6|uniprotkb:Q53TB2|uniprotkb:A8K1V8|intact:EBI-3213832|uniprotkb:Q9BZF7|ensembl:ENSP00000385995|ensembl:ENSP00000386088|uniprotkb:Q8IY32 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:thada_human(display_long)|uniprotkb:THADA(gene name)|psi-mi:THADA(display_short)|uniprotkb:GITA(gene name synonym)|uniprotkb:KIAA1767(gene name synonym)|uniprotkb:Gene inducing thyroid adenomas protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001332854.1|ensembl:ENSG00000115970(gene)|ensembl:ENST00000405006(transcript)|ensembl:ENST00000405975(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0030488"(tRNA methylation)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019442|rcsb pdb:5T6Y|reactome:R-HSA-6782315|refseq:XP_006712128.1|refseq:NP_001077422.1|refseq:NP_071348.3|refseq:NP_001258572.1|refseq:NP_001258573.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HLP/DNXyeZkkWzwOjvl/6A+U6eU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q969V3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1056979|uniprotkb:O75252|uniprotkb:Q6FI60|uniprotkb:Q6ZMB7|uniprotkb:Q8TAT7|uniprotkb:Q96H48|uniprotkb:Q96IS7|uniprotkb:Q9BQH9|uniprotkb:Q9BTX4|uniprotkb:Q9NPP2|uniprotkb:D6W613|ensembl:ENSP00000246117 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ncln_human(display_long)|uniprotkb:NCLN(gene name)|psi-mi:NCLN(display_short)|uniprotkb:Nicastrin-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_064555.2|refseq:NP_001308392.1|ensembl:ENSG00000125912(gene)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR007484(Peptidase M28)|interpro:IPR016574(Nicalin)|mint:Q969V3|rcsb pdb:6W6L|ensembl:ENST00000246117(transcript) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:h2Md0pyypG6ZFLWOxHxQvJKFg/k9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q93084 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046185|uniprotkb:O60900|uniprotkb:O60901|uniprotkb:O75501|uniprotkb:O75502|uniprotkb:Q16115|uniprotkb:Q8TEX5|uniprotkb:Q8TEX6|uniprotkb:D3DTJ8|uniprotkb:A8MZG0|uniprotkb:Q6JHX1|ensembl:ENSP00000380234 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at2a3_human(display_long)|uniprotkb:Calcium pump 3(gene name synonym)|uniprotkb:ATP2A3(gene name)|psi-mi:ATP2A3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_777618.1|refseq:NP_005164.2|refseq:NP_777615.1|refseq:NP_777616.1|refseq:NP_777617.1|refseq:NP_777613.1|refseq:NP_777614.1|ensembl:ENSG00000074370(gene)|ensembl:ENST00000397041(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030899"(calcium-dependent ATPase activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Nvh6pdcL5m05Wgu5rINDl8bhvDM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y4R8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1043674|uniprotkb:O75168|uniprotkb:Q7LDV4|uniprotkb:Q9BR21|intact:EBI-725566|intact:EBI-1047721|ensembl:ENSP00000262319|uniprotkb:D3DU73 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:telo2_human(display_long)|uniprotkb:TELO2(gene name)|psi-mi:TELO2(display_short)|uniprotkb:KIAA0683(gene name synonym)|uniprotkb:Protein clk-2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100726(gene)|ensembl:ENST00000262319(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070209"(ASTRA complex)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019337|interpro:IPR038528|mint:Q9Y4R8|rcsb pdb:4PSI|refseq:NP_057195.2|refseq:XP_016879403.1|dip:DIP-40568N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:AnKk5b5Bc/tzEEz+p68m5uQUZVY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62333 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6ZNB6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-6117166|uniprotkb:B1Q2K1|uniprotkb:Q86VG1|uniprotkb:Q8WVH1|ensembl:ENSP00000333113|ensembl:ENSP00000370949|ensembl:ENSP00000422037 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nfxl1_human(display_long)|uniprotkb:NFXL1(gene name)|psi-mi:NFXL1(display_short)|uniprotkb:OZFP(gene name synonym)|uniprotkb:Ovarian zinc finger protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_694540.3|refseq:NP_001265552.1|refseq:NP_001265553.1|ensembl:ENSG00000170448(gene)|ensembl:ENST00000329043(transcript)|ensembl:ENST00000381538(transcript)|ensembl:ENST00000507489(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000967(Zinc finger, NF-X1-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR034078 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IYD8+e0p5antDKQ2E+5N7UduDLQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:J3KPS0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-25598329|ensembl:ENSP00000345575|ensembl:ENSP00000378363 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:j3kps0_human(display_long)|uniprotkb:DNAJB12(gene name)|psi-mi:DNAJB12(display_short)|uniprotkb:hCG_2024622(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000148719(gene)|ensembl:ENST00000338820(transcript)|ensembl:ENST00000394903(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031965"(nuclear membrane)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR015399(Protein of unknown function DUF1977, DnaJ-like)|interpro:IPR018253|interpro:IPR036869|refseq:NP_001002762.2|refseq:NP_060096.3|refseq:XP_005269989.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DqyKcJLZ4q/A/4V/09nMCS9E3Os9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14739 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1055147|uniprotkb:Q14740|uniprotkb:Q53GU7|uniprotkb:Q59FE6|uniprotkb:B2R5P3|ensembl:ENSP00000272163|ensembl:ENSP00000339883 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lbr_human(display_long)|uniprotkb:Integral nuclear envelope inner membrane protein(gene name synonym)|uniprotkb:LMN2R(gene name synonym)|uniprotkb:LBR(gene name)|psi-mi:LBR(display_short)|uniprotkb:"3-beta-hydroxysterol Delta (14)-reductase"(gene name synonym)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Lamin-B receptor(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002287.2|refseq:NP_919424.1|refseq:XP_011542487.1|ensembl:ENSP00000272163|ensembl:ENSP00000339883|ensembl:ENSG00000143815(gene)|ensembl:ENST00000272163(transcript)|ensembl:ENST00000338179(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:2DIG|reactome:R-HSA-191273|reactome:R-HSA-2995383|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9022692|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0070402"(NADPH binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR002999(Tudor)|interpro:IPR018083|interpro:IPR019023|mint:Q14739|dip:DIP-5987N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Ns5qFZb8njsTOK90hIddW2O+uQI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O94905 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-4400770|uniprotkb:A0JLQ1|uniprotkb:A8K5S9|uniprotkb:B4DM38|uniprotkb:D3DSW0|uniprotkb:Q6NW21|uniprotkb:Q86VS6|uniprotkb:Q86W49|ensembl:ENSP00000428112 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:erln2_human(display_long)|uniprotkb:ERLIN2(gene name)|psi-mi:ERLIN2(display_short)|uniprotkb:C8orf2(gene name synonym)|uniprotkb:SPFH2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)|uniprotkb:UNQ2441/PRO5003/PRO9924(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001003790.1|refseq:NP_001003791.1|refseq:NP_009106.1|refseq:XP_016868489.1|refseq:XP_005273449.1|ensembl:ENSG00000147475(gene)|ensembl:ENST00000519638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O94905|reactome:R-HSA-382556|reactome:R-HSA-5655302|reactome:R-HSA-5678895|reactome:R-HSA-8853336 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Evjg3G0FFeQ499BNlJxpK6t8to89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75787 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2512037|ensembl:ENSP00000490083|uniprotkb:B7Z9I3|uniprotkb:Q8NG15|uniprotkb:Q8NBP3|uniprotkb:Q5QTQ7|uniprotkb:Q9UG89|uniprotkb:Q96FV6|uniprotkb:Q9H2P8|uniprotkb:Q96LB5|uniprotkb:Q6T7F5 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:renr_human(display_long)|uniprotkb:ATP6AP2(gene name)|psi-mi:ATP6AP2(display_short)|uniprotkb:ATP6IP2(gene name synonym)|uniprotkb:CAPER(gene name synonym)|uniprotkb:ELDF10(gene name synonym)|uniprotkb:Renin/prorenin receptor(gene name synonym)|uniprotkb:"ATPase H(+)-transporting lysosomal accessory protein 2"(gene name synonym)|uniprotkb:"ATPase H(+)-transporting lysosomal-interacting protein 2"(gene name synonym)|uniprotkb:Vacuolar ATP synthase membrane sector-associated protein M8-9(gene name synonym)|uniprotkb:N14F(gene name synonym)|uniprotkb:Embryonic liver differentiation factor 10(gene name synonym)|uniprotkb:HT028(orf name)|uniprotkb:MSTP009(orf name)|uniprotkb:PSEC0072(orf name)|uniprotkb:ER-localized type I transmembrane adapter(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000182220(gene)|ensembl:ENST00000636580(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048069"(eye pigmentation)|go:"GO:0060323"(head morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR012493(Renin receptor-like)|mint:O75787|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:NP_005756.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:v4lEPX23LdYqPi8dQX4MZG+tQZg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8TEM1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-372826|uniprotkb:A6NN56|uniprotkb:O94980|uniprotkb:Q6NXG6|uniprotkb:Q8NBJ1|uniprotkb:Q9H6C8|uniprotkb:Q9UFP3|ensembl:ENSP00000254508 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:po210_human(display_long)|uniprotkb:KIAA0906(gene name synonym)|uniprotkb:NUP210(gene name)|psi-mi:NUP210(display_short)|uniprotkb:PSEC0245(orf name)|uniprotkb:Nuclear envelope pore membrane protein POM 210(gene name synonym)|uniprotkb:Pore membrane protein of 210 kDa(gene name synonym)|uniprotkb:Nucleoporin Nup210(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) reactome:R-HSA-9610379|refseq:NP_079199.2|ensembl:ENSG00000132182(gene)|ensembl:ENST00000254508(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003343(Bacterial Ig-like, group 2)|interpro:IPR008964(Invasin/intimin cell-adhesion)|mint:Q8TEM1|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:udIemFThWYk0VC21Ml4EDDQWXlg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P31689 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347834|ensembl:ENSP00000369127|uniprotkb:Q5T7Q0|uniprotkb:Q86TL9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnja1_human(display_long)|uniprotkb:DNAJA1(gene name)|psi-mi:DNAJA1(display_short)|uniprotkb:DNAJ2(gene name synonym)|uniprotkb:HDJ2(gene name synonym)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:HSPF4(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Human DnaJ protein 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:HSDJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000086061(gene)|ensembl:ENST00000330899(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P31689|rcsb pdb:2LO1|rcsb pdb:2M6Y|reactome:R-HSA-3371497|rcsb pdb:6E8M|refseq:NP_001530.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:YEHeLHYaG2ON2gwuFfqt9Le1Drg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P78527 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P13804 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1052886|uniprotkb:B4DT43|uniprotkb:Q53XN3|ensembl:ENSP00000452762 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:etfa_human(display_long)|uniprotkb:ETFA(gene name)|psi-mi:ETFA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000117.1|refseq:NP_001121188.1|dip:DIP-6161N|ensembl:ENSG00000140374(gene)|ensembl:ENST00000557943(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001308(Electron transfer flavoprotein, alpha subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR014731(Electron transfer flavoprotein, alpha subunit, C-terminal)|interpro:IPR018206|interpro:IPR029035|interpro:IPR033947|mint:P13804|rcsb pdb:1EFV|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:2A1U|reactome:R-HSA-611105 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:J2PUTTVN+nd8eHe6TXga+37CiPw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96T76 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044169|uniprotkb:Q9BYS9|uniprotkb:Q17RZ8|uniprotkb:Q5T455|uniprotkb:Q66K82|uniprotkb:Q7L4W8|uniprotkb:Q969Z1|uniprotkb:Q96DF1|uniprotkb:Q96MR1|uniprotkb:Q96RK5|uniprotkb:Q96SK1|uniprotkb:Q9BUE2|ensembl:ENSP00000359818|ensembl:ENSP00000412698|uniprotkb:D3DR55|uniprotkb:B0QZ75|uniprotkb:B3KPE5|uniprotkb:B4DQX2|uniprotkb:B4E2I3|uniprotkb:F8W9Y2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mms19_human(display_long)|uniprotkb:MMS19(gene name)|psi-mi:MMS19(display_short)|uniprotkb:MMS19L(gene name synonym)|uniprotkb:MMS19-like protein(gene name synonym)|uniprotkb:MET18 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000155229(gene)|ensembl:ENST00000370782(transcript)|ensembl:ENST00000438925(transcript)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024687|interpro:IPR029240|interpro:IPR039920|mint:Q96T76|reactome:R-HSA-2564830|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009725"(response to hormone)|go:"GO:0016020"(membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0019899"(enzyme binding)|refseq:NP_071757.4|refseq:NP_001276332.1|refseq:NP_001276333.1|refseq:NP_001276334.1|refseq:NP_001317057.1|refseq:XP_016872013.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:sujw9MQiwau6A0dumVM7gXVMGjE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q3ZCQ8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9ULX6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y2G8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11337986|uniprotkb:Q68D57|uniprotkb:Q8N5P4|uniprotkb:Q86X32|ensembl:ENSP00000365007 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:djc16_human(display_long)|uniprotkb:DNAJC16(gene name)|psi-mi:DNAJC16(display_short)|uniprotkb:KIAA0962(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001274740.1|refseq:NP_056106.1|ensembl:ENSG00000116138(gene)|ensembl:ENST00000375847(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR018253|interpro:IPR036249|interpro:IPR036869|interpro:IPR043361 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Do5Edj7JXMo78ldLPgx0cxavUM49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43681 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2515857|ensembl:ENSP00000349887|ensembl:ENSP00000466379|uniprotkb:Q53FC6|uniprotkb:A8K740|uniprotkb:A6NHP8|uniprotkb:Q92849|intact:EBI-2818109 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:get3_human(display_long)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARSA(gene name synonym)|uniprotkb:ASNA1(gene name synonym)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins factor 3, ATPase(gene name synonym)|uniprotkb:TRC40(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 40 kDa ATPase subunit(gene name synonym)|uniprotkb:hARSA-I(gene name synonym)|uniprotkb:hASNA-I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000198356(gene)|ensembl:ENST00000357332(transcript)|ensembl:ENST00000591090(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0015105"(arsenite transmembrane transporter activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0043529"(GET complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|mint:O43681|rcsb pdb:6SO5|reactome:R-HSA-9609523|refseq:NP_004308.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:j2jKZb3MH8Bd3hnoQhDO6bjbyxI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q16891 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15293 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBX3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-750394|uniprotkb:Q96BA1|uniprotkb:Q96IP1|uniprotkb:Q542Z3|ensembl:ENSP00000345580 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dic_human(display_long)|uniprotkb:Solute carrier family 25 member 10(gene name synonym)|uniprotkb:SLC25A10(gene name)|psi-mi:SLC25A10(display_short)|uniprotkb:DIC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036272.2|refseq:NP_001257817.1|refseq:NP_001257882.1|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0070221"("sulfide oxidation, using sulfide:quinone oxidoreductase")|go:"GO:0071422"(succinate transmembrane transport)|ensembl:ENSG00000183048(gene)|ensembl:ENST00000350690(transcript)|go:"GO:0005310"(dicarboxylic acid transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006811"(ion transport)|go:"GO:0006835"(dicarboxylic acid transport)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|reactome:R-HSA-70263|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR002030(Mitochondrial brown fat uncoupling protein)|interpro:IPR018108|interpro:IPR023395|mint:Q9UBX3|reactome:R-HSA-1614517|reactome:R-HSA-428643 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Z9a7UxJbOLZqoCyz+5L+mbkXFqk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NRR5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711226|intact:EBI-722657|uniprotkb:Q9BR98|uniprotkb:Q9UHX4|ensembl:ENSP00000357292|uniprotkb:Q5VYA1|uniprotkb:B2RAY7|uniprotkb:A6ND44|uniprotkb:Q5VYA0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ubql4_human(display_long)|uniprotkb:UBQLN4(gene name)|psi-mi:UBQLN4(display_short)|uniprotkb:C1orf6(gene name synonym)|uniprotkb:UBIN(gene name synonym)|uniprotkb:Ataxin-1 ubiquitin-like-interacting protein A1U(gene name synonym)|uniprotkb:Ataxin-1 interacting ubiquitin-like protein(gene name synonym)|uniprotkb:CIP75(gene name synonym)|uniprotkb:Connexin43-interacting protein of 75 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001291271.1|refseq:NP_064516.2|ensembl:ENSG00000160803(gene)|interpro:IPR029071|ensembl:ENST00000368309(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090734"(site of DNA damage)|go:"GO:1901097"(negative regulation of autophagosome maturation)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:H/kLIS8aSMue9jYu1Q4qTcBLt5o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P05141 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P50993 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2952691|ensembl:ENSP00000354490|uniprotkb:Q9UQ25|uniprotkb:Q86UZ5|uniprotkb:Q5JW74|uniprotkb:Q07059|uniprotkb:D3DVE4 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at1a2_human(display_long)|uniprotkb:ATP1A2(gene name)|psi-mi:ATP1A2(display_short)|uniprotkb:KIAA0778(gene name synonym)|uniprotkb:Sodium pump subunit alpha-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P50993|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005496"(steroid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0021764"(amygdala development)|go:"GO:0021989"(olfactory cortex development)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0040011"(locomotion)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|ensembl:ENST00000361216(transcript)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903170"(negative regulation of calcium ion transmembrane transport)|go:"GO:1903280"("negative regulation of calcium:sodium antiporter activity")|go:"GO:1903416"(response to glycoside)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|go:"GO:0071383"(cellular response to steroid hormone stimulus)|ensembl:ENSG00000018625(gene)|refseq:NP_000693.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ynyskooKgMdrxv5wwLQ1CFKQ8HE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35998 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P16615 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99460 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357874|uniprotkb:Q24JU0|uniprotkb:Q53TI2|uniprotkb:Q6GMU5|uniprotkb:Q6P2P4|uniprotkb:Q6PJM7|uniprotkb:Q6PKG9|uniprotkb:B8ZZH9|uniprotkb:Q86VU1|uniprotkb:Q8IV79|ensembl:ENSP00000309474|ensembl:ENSP00000503068 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psmd1_human(display_long)|uniprotkb:PSMD1(gene name)|psi-mi:PSMD1(display_short)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)|uniprotkb:26S proteasome subunit p112(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001177966.1|refseq:NP_002798.2|dip:DIP-27548N|ensembl:ENSG00000173692(gene)|ensembl:ENST00000308696(transcript)|ensembl:ENST00000677230(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR035266|interpro:IPR040623|mint:Q99460|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6CO4|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6OI4|rcsb pdb:6UYI|rcsb pdb:6UYJ|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-382556|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aGYxoT30PhzvF/CiurQLDb8Ewrs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P12235 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359074|uniprotkb:D3DP59|ensembl:ENSP00000281456 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:adt1_human(display_long)|uniprotkb:SLC25A4(gene name)|psi-mi:SLC25A4(display_short)|uniprotkb:ANT1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:AAC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001142.2|ensembl:ENST00000281456(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|ensembl:ENSG00000151729(gene)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12235|reactome:R-HSA-1268020|reactome:R-HSA-180897|reactome:R-HSA-83936|dip:DIP-33116N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:vs4XIUUUypcIHR9Lz4j1buDAnjM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14524 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2826531|uniprotkb:Q68DH0|uniprotkb:Q6IQ25|uniprotkb:Q17R72|ensembl:ENSP00000300128 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nemp1_human(display_long)|uniprotkb:NEMP1(gene name)|psi-mi:NEMP1(display_short)|uniprotkb:KIAA0286(gene name synonym)|uniprotkb:TMEM194(gene name synonym)|uniprotkb:TMEM194A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124435.1|refseq:NP_056072.2|ensembl:ENSG00000166881(gene)|ensembl:ENST00000300128(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR019358 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GgQ1xT+CMcnbQdDsEJa/kloxNGU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75190 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P56962 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62195 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N - - crc64:29C6410C4A85A7F7 figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q68CQ7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10968851|ensembl:ENSP00000266014|ensembl:ENSP00000378263|ensembl:ENSP00000418853|ensembl:ENSP00000419612|uniprotkb:Q9P0I5|uniprotkb:Q7Z4D1|uniprotkb:Q8N2J6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gl8d1_human(display_long)|uniprotkb:GLT8D1(gene name)|psi-mi:GLT8D1(display_short)|uniprotkb:GALA4A(gene name synonym)|uniprotkb:AD-017(orf name)|uniprotkb:MSTP137(orf name)|uniprotkb:UNQ572/PRO1134(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001010983.1|refseq:NP_001265209.1|refseq:NP_001265210.1|refseq:NP_060916.1|refseq:NP_690909.1|ensembl:ENSG00000016864(gene)|ensembl:ENST00000266014(transcript)|ensembl:ENST00000394783(transcript)|ensembl:ENST00000478968(transcript)|ensembl:ENST00000491606(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016757"(glycosyltransferase activity)|interpro:IPR002495(Glycosyl transferase, family 8)|interpro:IPR029044|refseq:XP_016862346.1|refseq:XP_016862347.1|refseq:XP_016862348.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:bNHwwjKtkXuaGtyt6ANcT6UkuGk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14818 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-603272|uniprotkb:Q9BR53|uniprotkb:Q9H4K5|uniprotkb:Q9UEU8|uniprotkb:B2R515|uniprotkb:Q5JXJ2|ensembl:ENSP00000359910 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psa7_human(display_long)|uniprotkb:PSMA7(gene name)|psi-mi:PSMA7(display_short)|uniprotkb:Proteasome subunit RC6-1(gene name synonym)|uniprotkb:Proteasome subunit XAPC7(gene name synonym)|uniprotkb:HSPC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002783.1|dip:DIP-29363N|ensembl:ENSG00000101182(gene)|ensembl:ENST00000370873(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098794"(postsynapse)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035190|mint:O14818|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:J1M+b+VK02BAn2OnZISjjlmO8dc9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7Z3U7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358882|uniprotkb:A5D8U7|uniprotkb:A7E2Y0|uniprotkb:Q86TA2|uniprotkb:Q8N3I5|uniprotkb:Q8NAI0|uniprotkb:Q9UPW1|intact:EBI-2829603|intact:EBI-358896|uniprotkb:Q8NHE2|uniprotkb:B9EGP5|uniprotkb:F8VWA6|uniprotkb:F8W1Z6|intact:EBI-10962461|ensembl:ENSP00000377250 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mon2_human(display_long)|uniprotkb:MON2(gene name)|psi-mi:MON2(display_short)|uniprotkb:KIAA1040(gene name synonym)|uniprotkb:SF21(gene name synonym)|uniprotkb:Protein SF21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001265399.1|refseq:NP_001265398.1|refseq:NP_055841.2|refseq:XP_016874530.1|ensembl:ENSG00000061987(gene)|ensembl:ENST00000393630(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026829|interpro:IPR032629|interpro:IPR032691|interpro:IPR032817|mint:Q7Z3U7 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pEkENsLrswc7Cb2WTKZfQdESrtQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5HYI8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2824032|uniprotkb:Q8WUD3|ensembl:ENSP00000273375 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rabl3_human(display_long)|uniprotkb:RABL3(gene name)|psi-mi:RABL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000144840(gene)|ensembl:ENST00000273375(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:1903059"(regulation of protein lipidation)|interpro:IPR027417|mint:Q5HYI8|go:"GO:0050821"(protein stabilization)|refseq:NP_776186.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wa/T6PILk7wiphCKdnT3OidKB0E9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O14929 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2339359|uniprotkb:Q53SU4|uniprotkb:Q53QF0|uniprotkb:Q49A44|uniprotkb:Q6P594|uniprotkb:Q8WWB9|ensembl:ENSP00000264108 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hat1_human(display_long)|uniprotkb:HAT1(gene name)|psi-mi:HAT1(display_short)|uniprotkb:KAT1(gene name synonym)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003633.1|dip:DIP-52811N|ensembl:ENSG00000128708(gene)|ensembl:ENST00000264108(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006323"(DNA packaging)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0007584"(response to nutrient)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|mint:O14929|rcsb pdb:2P0W|rcsb pdb:6VO5|reactome:R-HSA-3214847 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:80KgRaid3NeRfAUdTHMQ/r0VuGo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P49721 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359335|uniprotkb:P31145|uniprotkb:Q9BWZ9|uniprotkb:D3DPS0|ensembl:ENSP00000362334 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psb2_human(display_long)|uniprotkb:PSMB2(gene name)|psi-mi:PSMB2(display_short)|uniprotkb:Multicatalytic endopeptidase complex subunit C7-I(gene name synonym)|uniprotkb:Proteasome component C7-I(gene name synonym)|uniprotkb:Macropain subunit C7-I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002785.1|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5GJR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-5689603|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000126067(gene)|ensembl:ENST00000373237(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035206|mint:P49721|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|dip:DIP-33848N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PvXrk6RLayQ1zqmavn1cONfA9/A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NY65 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356246|ensembl:ENSP00000333326|uniprotkb:B3KPW9|uniprotkb:Q2M3N4|uniprotkb:B2RCX2|uniprotkb:B4DWG3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tba8_human(display_long)|uniprotkb:TUBA8(gene name)|psi-mi:TUBA8(display_short)|uniprotkb:TUBAL2(gene name synonym)|uniprotkb:Alpha-tubulin 8(gene name synonym)|uniprotkb:Tubulin alpha chain-like 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001180343.1|refseq:NP_061816.1|ensembl:ENSG00000183785(gene)|ensembl:ENST00000330423(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|dip:DIP-40751N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OGRoBAwLchNlK3LtAWkbSbCcxPQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P55060 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BW92 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045099|uniprotkb:Q53GW7|uniprotkb:Q96I50|ensembl:ENSP00000358060|uniprotkb:Q9H9V2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sytm_human(display_long)|uniprotkb:Threonyl-tRNA synthetase-like 1(gene name synonym)|uniprotkb:TARS2(gene name)|psi-mi:TARS2(display_short)|uniprotkb:TARSL1(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_079426.2|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|reactome:R-HSA-379726|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|ensembl:ENSG00000143374(gene)|ensembl:ENST00000369064(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070159"(mitochondrial threonyl-tRNA aminoacylation)|refseq:NP_001258825.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9osvUit1PmESv7edUxgA1cl3o/Y9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O60884 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P12236 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UNF1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-725832|uniprotkb:O76058|uniprotkb:Q5BJF3|uniprotkb:Q8NAL6|uniprotkb:Q9H218|uniprotkb:Q9P0U9|uniprotkb:A6NMX0|uniprotkb:Q9UM52|ensembl:ENSP00000218439|ensembl:ENSP00000364193|ensembl:ENSP00000364198|ensembl:ENSP00000364209|ensembl:ENSP00000379526 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:magd2_human(display_long)|uniprotkb:MAGE-D2 antigen(gene name synonym)|uniprotkb:Breast cancer-associated gene 1 protein(gene name synonym)|uniprotkb:11B6(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein JCL-1(gene name synonym)|uniprotkb:MAGED2(gene name)|psi-mi:MAGED2(display_short)|uniprotkb:BCG1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055414.2|refseq:NP_803182.1|refseq:NP_957516.1|ensembl:ENSG00000102316(gene)|ensembl:ENST00000218439(transcript)|ensembl:ENST00000375053(transcript)|ensembl:ENST00000375058(transcript)|ensembl:ENST00000375068(transcript)|ensembl:ENST00000396224(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0016020"(membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9UNF1|reactome:R-HSA-114608|dip:DIP-50722N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fXavezmKy58aGuVgzvDYjwNw3B89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P04843 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P28288 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P01889 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96GF1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2340249|uniprotkb:A8K5C1|uniprotkb:A9X3T8|uniprotkb:Q8N900|ensembl:ENSP00000320508|ensembl:ENSP00000427755 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rn185_human(display_long)|uniprotkb:RNF185(gene name)|psi-mi:RNF185(display_short)|uniprotkb:RING finger protein 185(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001129297.1|refseq:NP_689480.2|ensembl:ENSG00000138942(gene)|ensembl:ENST00000326132(transcript)|ensembl:ENST00000518626(transcript)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ivzbt31KPTKL/Rc1Wzs3h80XJac9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P24539 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NVI1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1013291|uniprotkb:Q96JN1|uniprotkb:Q96ST0|uniprotkb:Q9BT96|uniprotkb:A5YMH4|uniprotkb:A6NJZ0|uniprotkb:A4ZVE4|ensembl:ENSP00000310842 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:fanci_human(display_long)|uniprotkb:FANCI(gene name)|psi-mi:FANCI(display_short)|uniprotkb:KIAA1794(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011520058.1|refseq:XP_011520059.1|refseq:XP_011520066.1|refseq:NP_001106849.1|refseq:NP_060663.2|dip:DIP-29381N|ensembl:ENSG00000140525(gene)|ensembl:ENST00000310775(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0070182"(DNA polymerase binding)|interpro:IPR026171|interpro:IPR029305|interpro:IPR029308|interpro:IPR029310|interpro:IPR029312|interpro:IPR029313|interpro:IPR029314|interpro:IPR029315|mint:Q9NVI1|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|reactome:R-HSA-6783310|reactome:R-HSA-6796648 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:yJJMHIBOVPDIQcCBJ19DGitg3VA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NRG9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3912901|uniprotkb:Q9UG19|uniprotkb:Q9NWI6|uniprotkb:Q5JB47|ensembl:ENSP00000209873 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:aaas_human(display_long)|uniprotkb:AAAS(gene name)|psi-mi:AAAS(display_short)|uniprotkb:ADRACALA(gene name synonym)|uniprotkb:Adracalin(gene name synonym)|uniprotkb:GL003(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001166937.1|refseq:NP_056480.1|ensembl:ENSG00000094914(gene)|ensembl:ENST00000209873(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007612"(learning)|go:"GO:0009566"(fertilization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-8980692|reactome:R-HSA-9609690|reactome:R-HSA-9610379 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fdOcZ59NldwaQJ6nusjn8GAhszo9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43592 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-286683|uniprotkb:A6NLH1|uniprotkb:O43784|uniprotkb:Q8WUG2|uniprotkb:Q9BVS7|ensembl:ENSP00000327821 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:xpot_human(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:XPOT(gene name)|psi-mi:XPOT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_009166.2|refseq:XP_016874237.1|ensembl:ENSG00000184575(gene)|ensembl:ENST00000332707(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:O43592|reactome:R-HSA-6784531 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:S0p7em6zWNUHEuAYueP+ZTrKTKg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P55072 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62191 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P43686 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-743997|uniprotkb:Q96FV5|uniprotkb:Q9UBM3|uniprotkb:Q9UEX3|ensembl:ENSP00000157812|ensembl:ENSP00000487367 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prs6b_human(display_long)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:MB67-interacting protein(gene name synonym)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short)|uniprotkb:TBP7(gene name synonym)|uniprotkb:MIP224(gene name synonym)|uniprotkb:Tat-binding protein 7(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006494.1|refseq:NP_694546.1|dip:DIP-29274N|ensembl:ENSG00000013275(gene)|ensembl:ENSG00000281221(gene)|ensembl:ENST00000157812(transcript)|ensembl:ENST00000629691(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035256|interpro:IPR041569|mint:P43686|rcsb pdb:2DVW|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P06576 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P46977 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-719212|uniprotkb:Q86XU9|uniprotkb:Q8TE35|uniprotkb:Q8WUB4|ensembl:ENSP00000376472|ensembl:ENSP00000436962|ensembl:ENSP00000497336|uniprotkb:B4DJ24|uniprotkb:E9PNQ1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:stt3a_human(display_long)|uniprotkb:TMC(gene name synonym)|uniprotkb:B5(gene name synonym)|uniprotkb:Integral membrane protein 1(gene name synonym)|uniprotkb:Transmembrane protein TMC(gene name synonym)|uniprotkb:STT3A(gene name)|psi-mi:STT3A(display_short)|uniprotkb:ITM1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_689926.1|ensembl:ENSG00000134910(gene)|ensembl:ENST00000392708(transcript)|ensembl:ENST00000529196(transcript)|ensembl:ENST00000649491(transcript)|go:"GO:0004579"(dolichyl-diphosphooligosaccharide-protein glycotransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0035000"(oligosaccharyltransferase III complex)|go:"GO:0043686"(co-translational protein modification)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0046872"(metal ion binding)|interpro:IPR003674(Oligosaccharyl transferase, STT3 subunit)|mint:P46977|rcsb pdb:6S7O|reactome:R-HSA-446203|reactome:R-HSA-9694548|refseq:XP_011541109.1|refseq:NP_001265432.1|refseq:NP_001265433.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:DS4CIkIc7Ib6qxOFDBQNVRmmytU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13200 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92616 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P68366 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351772|uniprotkb:A8MUB1|uniprotkb:P05215|ensembl:ENSP00000248437|uniprotkb:B3KNQ6|intact:EBI-11134566 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tba4a_human(display_long)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Testis-specific alpha-tubulin(gene name synonym)|uniprotkb:Tubulin H2-alpha(gene name synonym)|uniprotkb:TUBA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005991.1|ensembl:ENSG00000127824(gene)|ensembl:ENST00000248437(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68366|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001265481.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00231 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q86Y56 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-719966|uniprotkb:Q69YL1|uniprotkb:Q96FI9|uniprotkb:Q9NX75|ensembl:ENSP00000297440 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:daaf5_human(display_long)|uniprotkb:DNAAF5(gene name)|psi-mi:DNAAF5(display_short)|uniprotkb:HEAT repeat-containing protein 2(gene name synonym)|uniprotkb:HEATR2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060272.3|ensembl:ENSG00000164818(gene)|ensembl:ENST00000297440(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0005737"(cytoplasm)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0036159"(inner dynein arm assembly)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|mint:Q86Y56 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5AmIkT2NW1/GyC8udQmrI5hRAsU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6PJG6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-10826195|uniprotkb:C9JY24|uniprotkb:Q8IW85|uniprotkb:Q8IZ43|uniprotkb:Q8WVR8|uniprotkb:A4D200|uniprotkb:Q96IV9|ensembl:ENSP00000339637|uniprotkb:Q9H7J8|uniprotkb:Q9UFA3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:brat1_human(display_long)|uniprotkb:BRAT1(gene name)|psi-mi:BRAT1(display_short)|uniprotkb:BAAT1(gene name synonym)|uniprotkb:C7orf27(gene name synonym)|uniprotkb:BRCA1-associated protein required for ATM activation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000106009(gene)|ensembl:ENST00000340611(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0051646"(mitochondrion localization)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038904|mint:Q6PJG6|rcsb pdb:4IFI|refseq:NP_689956.2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:fLa3Dz0KHxEolgfbI7cbPsqolpw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:F5H5D3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-16421287|ensembl:ENSP00000443475 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:f5h5d3_human(display_long)|uniprotkb:TUBA1C(gene name)|psi-mi:TUBA1C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000167553(gene)|ensembl:ENST00000541364(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|refseq:NP_001290043.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:BPFi0oTuMH5kqvYU8ASeyTdB+y89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P68363 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-487083|intact:EBI-1384226|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:Q27I68|ensembl:ENSP00000336799|uniprotkb:Q8WU19 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tba1b_human(display_long)|uniprotkb:TUBA1B(gene name)|psi-mi:TUBA1B(display_short)|uniprotkb:Tubulin alpha-ubiquitous chain(gene name synonym)|uniprotkb:Alpha-tubulin ubiquitous(gene name synonym)|uniprotkb:Tubulin K-alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006073.2|ensembl:ENSG00000123416(gene)|ensembl:ENST00000336023(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|reactome:R-HSA-983189|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|go:"GO:0045121"(membrane raft)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68363|rcsb pdb:2E4H|rcsb pdb:5IJ0|rcsb pdb:5IJ9|rcsb pdb:5N5N|rcsb pdb:6E7B|rcsb pdb:6E7C|rcsb pdb:6I2I|go:"GO:0051301"(cell division)|rcsb pdb:6J4V|rcsb pdb:6J8O|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|rcsb pdb:6S8L|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9013407|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-2132295|reactome:R-HSA-9668328 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:D4YpuLCXl/S+53qV7P7sF81aARY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99615 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5XKP0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1053887|uniprotkb:Q86YE5|uniprotkb:A0A0B4J2A5|uniprotkb:K7EKR0|ensembl:ENSP00000309561 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mic13_human(display_long)|uniprotkb:MICOS13(gene name)|psi-mi:MICOS13(display_short)|uniprotkb:C19orf70(gene name synonym)|uniprotkb:MIC13(gene name synonym)|uniprotkb:Protein P117(gene name synonym)|uniprotkb:QIL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_991330.1|ensembl:ENSG00000174917(gene)|ensembl:ENST00000309324(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0044284"(mitochondrial crista junction)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR026769|reactome:R-HSA-8949613|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|refseq:NP_001295169.1|refseq:XP_016881737.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WXuGrcp9zyQSBo/4yW2yQ1uSf/A9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UDY4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356960|uniprotkb:Q13431|uniprotkb:B2R824|ensembl:ENSP00000359799 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjb4_human(display_long)|uniprotkb:DNAJB4(gene name)|psi-mi:DNAJB4(display_short)|uniprotkb:DNAJW(gene name synonym)|uniprotkb:HLJ1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1 homolog(gene name synonym)|uniprotkb:Human liver DnaJ-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008965.2|refseq:NP_001304028.1|refseq:NP_001304029.1|refseq:NP_001304030.1|refseq:NP_001304031.1|refseq:NP_001304032.1|ensembl:ENSG00000162616(gene)|ensembl:ENST00000370763(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009408"(response to heat)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UDY4 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:gN0zBtJQiTN+YYSAtMk1mddNWLU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P46379 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8WVM8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722569|uniprotkb:O60754|uniprotkb:O94990|uniprotkb:Q7Z529|uniprotkb:Q9BZI3|uniprotkb:Q9UNL3|uniprotkb:Q9Y6A8|uniprotkb:A8K2Z5|uniprotkb:B7Z4U7|uniprotkb:B7Z594|ensembl:ENSP00000390783 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:scfd1_human(display_long)|uniprotkb:Syntaxin-binding protein 1-like 2(gene name synonym)|uniprotkb:SLY1 homolog(gene name synonym)|uniprotkb:FKSG23(orf name)|uniprotkb:SCFD1(gene name)|psi-mi:SCFD1(display_short)|uniprotkb:KIAA0917(gene name synonym)|uniprotkb:STXBP1L2(gene name synonym)|uniprotkb:C14orf163(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001269961.1|refseq:NP_057190.2|refseq:NP_001244305.1|refseq:NP_878255.1|mint:Q8WVM8|reactome:R-HSA-204005|reactome:R-HSA-8980692|ensembl:ENSG00000092108(gene)|ensembl:ENST00000458591(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1901998"(toxin transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7cD2Z6zhuKLCd3ERB+pVNRdVexY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P25788 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-348380|ensembl:ENSP00000216455|uniprotkb:Q86U83|uniprotkb:Q8N1D8|uniprotkb:Q9BS70|uniprotkb:B2RCK6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psa3_human(display_long)|uniprotkb:PSMA3(gene name)|psi-mi:PSMA3(display_short)|uniprotkb:PSC8(gene name synonym)|uniprotkb:Proteasome component C8(gene name synonym)|uniprotkb:Macropain subunit C8(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C8(gene name synonym)|uniprotkb:HC8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002779.1|refseq:NP_687033.1|ensembl:ENSG00000100567(gene)|ensembl:ENST00000216455(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR037555|mint:P25788|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:5DSV|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|rcsb pdb:7E55|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:5T0H|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-174084|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-174113|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|dip:DIP-29366N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9Er/PY50/GVoCr5yAPXlkfxtP0k9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y5V3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P05023 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358778|uniprotkb:Q16689|uniprotkb:Q6LDM4|uniprotkb:Q9UJ20|uniprotkb:Q9UJ21|uniprotkb:B2RBR6|uniprotkb:Q9UCN1|ensembl:ENSP00000295598|uniprotkb:B7Z3U6|uniprotkb:B7Z2T5|uniprotkb:F5H3A1|intact:EBI-10963133 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at1a1_human(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000692.2|refseq:NP_001153705.1|refseq:NP_001153706.1|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016791"(phosphatase activity)|ensembl:ENSG00000163399(gene)|ensembl:ENST00000295598(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031947"(negative regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036126"(sperm flagellum)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043531"(ADP binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903416"(response to glycoside)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P05023|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|refseq:XP_016856849.1|refseq:XP_016856850.1|dip:DIP-38196N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:uZf9iX38kcZh0Q+apz8uB17EtJw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y679 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1058701|ensembl:ENSP00000366748|uniprotkb:Q9H866|uniprotkb:Q9UNQ6|uniprotkb:Q9Y685|uniprotkb:C0H5W8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:aup1_human(display_long)|uniprotkb:AUP1(gene name)|psi-mi:AUP1(display_short)|uniprotkb:Ancient ubiquitous protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000115307(gene)|ensembl:ENST00000377526(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_853553.1|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990044"(protein localization to lipid droplet)|interpro:IPR003892(Ubiquitin system component Cue)|rcsb pdb:2EKF - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6yySfIPpRUlnm0upBDYyfBUOtIY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NZ01 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2877718|ensembl:ENSP00000215567|uniprotkb:Q9BWK3|uniprotkb:Q6IBB2|uniprotkb:O75350|uniprotkb:Q9Y6P0|uniprotkb:B2RD55 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tecr_human(display_long)|uniprotkb:TECR(gene name)|psi-mi:TECR(display_short)|uniprotkb:GPSN2(gene name synonym)|uniprotkb:SC2(gene name synonym)|uniprotkb:Synaptic glycoprotein SC2(gene name synonym)|uniprotkb:Trans-2,3-enoyl-CoA reductase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000099797(gene)|ensembl:ENST00000215567(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0102758"(very-long-chain enoyl-CoA reductase activity)|interpro:IPR001104(3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal)|interpro:IPR029071|interpro:IPR039357|mint:Q9NZ01|rcsb pdb:2DZJ|reactome:R-HSA-75876|refseq:NP_612510.1|refseq:NP_001308099.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:qk8o3QKxQuUvJ3SIlsICJoAnzXg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96D53 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3957978|uniprotkb:Q8TAJ1|uniprotkb:Q9HA52|ensembl:ENSP00000315118|ensembl:ENSP00000470876|ensembl:ENSP00000470916|ensembl:ENSP00000503480|ensembl:ENSP00000503944|ensembl:ENSP00000504072|ensembl:ENSP00000504085|ensembl:ENSP00000504845 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:coq8b_human(display_long)|uniprotkb:COQ8B(gene name)|psi-mi:COQ8B(display_short)|uniprotkb:ADCK4(gene name synonym)|uniprotkb:AarF domain-containing protein kinase 4(gene name synonym)|uniprotkb:Coenzyme Q protein 8B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001136027.1|refseq:NP_079152.3|ensembl:ENSG00000123815(gene)|ensembl:ENST00000324464(transcript)|ensembl:ENST00000594720(transcript)|ensembl:ENST00000601967(transcript)|ensembl:ENST00000677018(transcript)|ensembl:ENST00000678404(transcript)|ensembl:ENST00000678419(transcript)|ensembl:ENST00000678467(transcript)|ensembl:ENST00000679130(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034638|interpro:IPR034646|mint:Q96D53 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:UAfHqMHShcF12Ijycxi7OWs0KFE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43175 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P45880 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HAV4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q86UL3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3925330|uniprotkb:Q86V89|ensembl:ENSP00000380184|uniprotkb:Q2TU73 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gpat4_human(display_long)|uniprotkb:GPAT4(gene name)|psi-mi:GPAT4(display_short)|uniprotkb:1-acylglycerol-3-phosphate O-acyltransferase 6(gene name synonym)|uniprotkb:AGPAT6(gene name synonym)|uniprotkb:"Acyl-CoA:glycerol-3-phosphate acyltransferase 4"(gene name synonym)|uniprotkb:Lysophosphatidic acid acyltransferase zeta(gene name synonym)|uniprotkb:TSARG7(gene name synonym)|uniprotkb:Testis spermatogenesis apoptosis-related protein 7(gene name synonym)|uniprotkb:UNQ551/PRO1108(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011542694.1|refseq:XP_011542695.1|refseq:XP_011542696.1|refseq:NP_848934.1|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0007595"(lactation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0102420"("sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity")|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|reactome:R-HSA-1483166|ensembl:ENSG00000158669(gene)|ensembl:ENST00000396987(transcript)|go:"GO:0002071"(glandular epithelial cell maturation)|go:"GO:0003841"(1-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0004366"(glycerol-3-phosphate O-acyltransferase activity)|refseq:XP_016868531.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0j/B1lxhVshCx6yA7HNCsemsuD49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NF37 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-922595|uniprotkb:Q1HAQ1|uniprotkb:Q7Z4G6|uniprotkb:Q8N3U7|uniprotkb:Q8WUL8|uniprotkb:Q9GZW6|ensembl:ENSP00000283415|ensembl:ENSP00000423472 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pcat1_human(display_long)|uniprotkb:1-alkylglycerophosphocholine O-acetyltransferase(gene name synonym)|uniprotkb:Acyltransferase-like 2(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 3(gene name synonym)|uniprotkb:1-acylglycerol-3-phosphate O-acyltransferase(gene name synonym)|uniprotkb:1-alkenylglycerophosphocholine O-acyltransferase(gene name synonym)|uniprotkb:LPCAT1(gene name)|psi-mi:LPCAT1(display_short)|uniprotkb:AYTL2(gene name synonym)|uniprotkb:PFAAP3(gene name synonym)|uniprotkb:"Acetyl-CoA:lyso-platelet-activating factor acetyltransferase"(gene name synonym)|uniprotkb:1-acylglycerophosphocholine O-acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_079106.3|ensembl:ENSG00000153395(gene)|ensembl:ENST00000283415(transcript)|ensembl:ENST00000475622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003841"(1-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0036148"(phosphatidylglycerol acyl-chain remodeling)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047144"(2-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0047159"(1-alkenylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047191"(1-alkylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047192"(1-alkylglycerophosphocholine O-acetyltransferase activity)|go:"GO:0050200"(plasmalogen synthase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:2001246"(negative regulation of phosphatidylcholine biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|interpro:IPR011992(EF-Hand type)|reactome:R-HSA-1482788|reactome:R-HSA-1482925|reactome:R-HSA-1483166|reactome:R-HSA-1483191|reactome:R-HSA-6798695 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:sJPdIAauFmV71N/KwIUH75hTHv09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P17980 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359720|uniprotkb:Q3B757|ensembl:ENSP00000298852|ensembl:ENSP00000481029|uniprotkb:Q3B865|uniprotkb:Q53HU5|uniprotkb:Q6GPG8|uniprotkb:Q6IBS1|uniprotkb:Q96HD3|uniprotkb:B2R8V1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:prs6a_human(display_long)|uniprotkb:PSMC3(gene name)|psi-mi:PSMC3(display_short)|uniprotkb:TBP1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Proteasome subunit P50(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002795.2|ensembl:ENSG00000165916(gene)|ensembl:ENST00000298852(transcript)|ensembl:ENST00000619920(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:P17980|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|go:"GO:0036402"(proteasome-activating activity)|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-1236978|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27555N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:CejeauChmqeXNwBYF2cPz7mgMuw9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P54709 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054481|uniprotkb:B7Z1N7|ensembl:ENSP00000286371 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at1b3_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-3(gene name synonym)|uniprotkb:ATP1B3(gene name)|psi-mi:ATP1B3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001670.1|ensembl:ENSG00000069849(gene)|ensembl:ENST00000286371(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR038702|mint:P54709|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|dip:DIP-50717N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:M7gSVe1bjKF7LqCZh/raoHBvp7M9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00232 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5H9R7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355498|uniprotkb:Q3B7I1|uniprotkb:Q7L4R8|uniprotkb:Q8N3B2|uniprotkb:Q96MB2|uniprotkb:Q9H2K5|uniprotkb:Q9H2K6|uniprotkb:Q9HCL4|uniprotkb:Q9NUY3|uniprotkb:Q3I4Y0|uniprotkb:Q3KR35|uniprotkb:Q68CR3|intact:EBI-28971860|ensembl:ENSP00000377389 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pp6r3_human(display_long)|uniprotkb:PPP6R3(gene name)|psi-mi:PPP6R3(display_short)|uniprotkb:C11orf23(gene name synonym)|uniprotkb:KIAA1558(gene name synonym)|uniprotkb:PP6R3(gene name synonym)|uniprotkb:SAPL(gene name synonym)|uniprotkb:Sporulation-induced transcript 4-associated protein SAPL(gene name synonym)|uniprotkb:SAPS domain family member 3(gene name synonym)|uniprotkb:SAPS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001157632.1|refseq:NP_001157633.1|refseq:NP_001157634.1|refseq:NP_001157635.1|refseq:NP_001157636.1|refseq:NP_060782.2|ensembl:ENST00000265636|ensembl:ENSP00000265636|ensembl:ENSP00000377389|ensembl:ENST00000393801|ensembl:ENSP00000377390|ensembl:ENST00000524845|ensembl:ENSP00000431415|ensembl:ENST00000524904|ensembl:ENSP00000433058|ensembl:ENST00000529710|ensembl:ENSP00000437329|refseq:XP_011543442.1|refseq:XP_006718676.1|refseq:XP_006718677.1|refseq:XP_006718681.1|refseq:XP_006718687.1|refseq:XP_016873451.1|refseq:XP_016873452.1|refseq:XP_016873455.1|ensembl:ENSG00000110075(gene)|ensembl:ENST00000393800(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q5H9R7|reactome:R-HSA-171319|reactome:R-HSA-204005 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9hU14AmzYI9nORfchfMtLoyRecA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H936 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1050588|uniprotkb:Q8TBU8|uniprotkb:A8K366|uniprotkb:C9J1H6|uniprotkb:E9PJD3|uniprotkb:E9PKB2|uniprotkb:E9PL68|uniprotkb:E9PN26|uniprotkb:E9PNQ3|uniprotkb:E9PP01|uniprotkb:E9PR97|ensembl:ENSP00000322020|ensembl:ENSP00000437236|ensembl:ENSP00000486058 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ghc1_human(display_long)|uniprotkb:"Glutamate/H(+) symporter 1"(gene name synonym)|uniprotkb:Solute carrier family 25 member 22(gene name synonym)|uniprotkb:SLC25A22(gene name)|psi-mi:SLC25A22(display_short)|uniprotkb:GC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001177989.1|refseq:NP_001177990.1|refseq:NP_078974.1|ensembl:ENSG00000177542(gene)|ensembl:ENST00000320230(transcript)|ensembl:ENST00000531214(transcript)|ensembl:ENST00000628067(transcript)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006811"(ion transport)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0043490"(malate-aspartate shuttle)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-428643|refseq:XP_011518671.1|refseq:XP_011518672.1|refseq:XP_011518673.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:B1e6uu3Vx73qy/JrHS7p63p0QMM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P25786 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NBM4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-724045|uniprotkb:Q0VAB5|uniprotkb:Q5W0W6|uniprotkb:Q5W0W9|uniprotkb:Q6GQR2|uniprotkb:Q6P4B0|uniprotkb:Q8N2E8|uniprotkb:Q96NW2|uniprotkb:B3KNV7|ensembl:ENSP00000383911 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ubac2_human(display_long)|uniprotkb:PHGDHL1(gene name synonym)|uniprotkb:Phosphoglycerate dehydrogenase-like protein 1(gene name synonym)|uniprotkb:UBAC2(gene name)|psi-mi:UBAC2(display_short)|uniprotkb:PSEC0110(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001137544.1|refseq:NP_808882.1|ensembl:ENSG00000134882(gene)|ensembl:ENST00000403766(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR035952|interpro:IPR041928|mint:Q8NBM4|refseq:XP_011519386.1|refseq:XP_006720011.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wOJ8u9ZDDuqYRij5EjsFm4hLRUQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96CS3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P57088 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1048629|uniprotkb:Q9H953|uniprotkb:B3KSS8|ensembl:ENSP00000422473|ensembl:ENSP00000427006|ensembl:ENSP00000441455 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tmm33_human(display_long)|uniprotkb:Protein DB83(gene name synonym)|uniprotkb:TMEM33(gene name)|psi-mi:TMEM33(display_short)|uniprotkb:DB83(gene name synonym)|uniprotkb:SHINC-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060596.2|refseq:XP_005248173.1|refseq:XP_005248174.1|ensembl:ENSG00000109133(gene)|ensembl:ENST00000325094(transcript)|ensembl:ENST00000504986(transcript)|ensembl:ENST00000513702(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061024"(membrane organization)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|interpro:IPR005344(Protein of unknown function UPF0121)|mint:P57088 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FGc4/gpnYoRtlDJMxQWh5hXe5Ko9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O95816 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NTJ5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-3917235|uniprotkb:B4DK71|uniprotkb:Q7LA14|uniprotkb:A8K527|uniprotkb:Q96AX7|uniprotkb:Q9NQ46|uniprotkb:Q9NQ57|uniprotkb:O94935|uniprotkb:Q7LA22|ensembl:ENSP00000373713|ensembl:ENSP00000500361 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sac1_human(display_long)|uniprotkb:SACM1L(gene name)|psi-mi:SACM1L(display_short)|uniprotkb:KIAA0851(gene name synonym)|uniprotkb:Suppressor of actin mutations 1-like protein(gene name synonym)|uniprotkb:Phosphatidylinositol-4-phosphate phosphatase(gene name synonym)|uniprotkb:SAC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:XP_011531802.1|refseq:NP_054735.3|refseq:NP_001306001.1|refseq:NP_001306002.1|ensembl:ENSG00000211456(gene)|ensembl:ENST00000389061(transcript)|ensembl:ENST00000672477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034593"(phosphatidylinositol bisphosphate phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR002013(Synaptojanin, N-terminal)|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016791"(phosphatase activity) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:aaI+D/4SJcwZxWqoxDJ81dA60nU9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q53GQ0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2963255|uniprotkb:Q96EA9|ensembl:ENSP00000278353|uniprotkb:A8K9B0|uniprotkb:Q9Y6G8|uniprotkb:Q96JU2|uniprotkb:D3DR23 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dhb12_human(display_long)|uniprotkb:HSD17B12(gene name)|psi-mi:HSD17B12(display_short)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 12(gene name synonym)|uniprotkb:3-ketoacyl-CoA reductase(gene name synonym)|uniprotkb:SDR12C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 1(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000149084(gene)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008201"(heparin binding)|go:"GO:0009923"(fatty acid elongase complex)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0050062"(long-chain-fatty-acyl-CoA reductase activity)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|ensembl:ENST00000278353(transcript)|go:"GO:0102339"(3-oxo-arachidoyl-CoA reductase activity)|go:"GO:0102341"(3-oxo-lignoceroyl-CoA reductase activity)|go:"GO:0102342"(3-oxo-cerotoyl-CoA reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q53GQ0|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0102340"(3-oxo-behenoyl-CoA reductase activity)|refseq:NP_057226.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:2R2pFY0c9yRuCvLU2J8n2urR+0o9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00487 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O15260 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044848|uniprotkb:O60923|uniprotkb:Q9UNZ0|uniprotkb:Q9UNZ1|uniprotkb:Q5T8U6|ensembl:ENSP00000361057|ensembl:ENSP00000486049|uniprotkb:B7Z6A4 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:surf4_human(display_long)|uniprotkb:SURF4(gene name)|psi-mi:SURF4(display_short)|uniprotkb:SURF-4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_149351.1|ensembl:ENSG00000148248(gene)|ensembl:ENSG00000280951(gene)|ensembl:ENST00000629578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR002995(Surfeit locus 4)|mint:O15260|reactome:R-HSA-6798695|reactome:R-HSA-6811434|ensembl:ENST00000371989(transcript)|refseq:NP_001267718.1|refseq:NP_001267721.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VEkKSEfWLmSZx209HLRfoMMTzsg9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8NCK7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21840241|ensembl:ENSP00000310490 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P27824 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99942 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35613 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6PCB8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21518272|ensembl:ENSP00000302289|uniprotkb:B7Z6S3|uniprotkb:B7Z902 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:emb_human(display_long)|uniprotkb:EMB(gene name)|psi-mi:EMB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000170571(gene)|ensembl:ENST00000303221(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0030424"(axon)|go:"GO:0035879"(plasma membrane lactate transport)|go:"GO:0045202"(synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR027114|interpro:IPR036179|interpro:IPR043204|reactome:R-HSA-433692|refseq:NP_940851.1|refseq:XP_011541448.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0jOjATBmgyYtzlt3ZWhDpIfvMwM9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9H9S3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1172006|uniprotkb:B4DX72|uniprotkb:F8W773|uniprotkb:A8K8D0|ensembl:ENSP00000298428 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:s61a2_human(display_long)|uniprotkb:SEC61A2(gene name)|psi-mi:SEC61A2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001136099.1|refseq:NP_060614.2|ensembl:ENSG00000065665(gene)|ensembl:ENST00000298428(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|reactome:R-HSA-1236974|reactome:R-HSA-1799339|go:"GO:0005784"(Sec61 translocon complex)|refseq:NP_001136100.1 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:hZDOdPuauwpCSX5aDYdhLPqQsd89606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P39656 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q00325 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325 - - crc64:78714C85931B22D5 figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9P0I2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054670|uniprotkb:Q53GH8|uniprotkb:Q6ZMC2|uniprotkb:B2R4Z9|ensembl:ENSP00000245046 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:emc3_human(display_long)|uniprotkb:EMC3(gene name)|psi-mi:EMC3(display_short)|uniprotkb:TMEM111(gene name synonym)|uniprotkb:Transmembrane protein 111(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_060917.1|ensembl:ENSG00000125037(gene)|ensembl:ENST00000245046(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR002809(Protein of unknown function DUF106, transmembrane)|interpro:IPR008568(Protein of unknown function DUF850, transmembrane eukaryotic)|rcsb pdb:6WW7|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|reactome:R-HSA-8980692 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VbIl0nFhcDMIPTxmBclaIMtbVU09606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UBM7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1054468|uniprotkb:O60492|uniprotkb:O60717|uniprotkb:B2R6Z2|ensembl:ENSP00000347717|ensembl:ENSP00000384739 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dhcr7_human(display_long)|uniprotkb:"Sterol Delta(7)-reductase"(gene name synonym)|uniprotkb:DHCR7(gene name)|psi-mi:DHCR7(display_short)|uniprotkb:D7SR(gene name synonym)|uniprotkb:Delta7-sterol reductase(gene name synonym)|uniprotkb:Sterol reductase SR-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001157289.1|refseq:NP_001351.2|mint:Q9UBM7|reactome:R-HSA-2426168|reactome:R-HSA-6807047|reactome:R-HSA-6807062|interpro:IPR018083|ensembl:ENSG00000172893(gene)|ensembl:ENST00000355527(transcript)|ensembl:ENST00000407721(transcript)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0009918"(sterol delta7 reductase activity)|go:"GO:0016020"(membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016132"(brassinosteroid biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0045540"(regulation of cholesterol biosynthetic process)|go:"GO:0047598"(7-dehydrocholesterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein) - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:op53bBpGaOM0Ysy4Bn5q6qXcKgI9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:B4DR61 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21356779|ensembl:ENSP00000418493 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:b4dr61_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27103180|imex:IM-29297-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000058262(gene)|ensembl:ENST00000464451(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659 - - - figure legend:Supp Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/11/30 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5ImODrF8bnJT/CSqOJb1x6kK1iY9606 rigid:mRNng/jbe/FgdqzoyIbakei5bGg false mutation:2-2|v5 tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:J3KN16 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-8640159|ensembl:ENSP00000259335|intact:MINT-8163031 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:j3kn16_human(display_long)|uniprotkb:ECPAS(gene name)|psi-mi:ECPAS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000136813(gene)|ensembl:ENST00000259335(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043248"(proteasome assembly)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024372|refseq:NP_001073867.1 - - comment:mint figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:A8z9nT5VRn5nicTEpTnZcAXXjFs9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:E9PRG8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11324775|ensembl:ENSP00000432523|intact:EBI-21262272|uniprotkb:A0A0B4J220 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ck098_human(display_long)|uniprotkb:C11orf98(gene name)|psi-mi:C11orf98(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001273015.1|ensembl:ENSG00000278615(gene)|ensembl:ENST00000524958(transcript)|interpro:IPR037691|mint:E9PRG8 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VfLIp/LTQj4cvxS0emale/+FWJU9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5JWF2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-4400880|uniprotkb:A2A2S3|uniprotkb:E1P5G3|uniprotkb:O75684|uniprotkb:O75685|uniprotkb:Q5JW67|uniprotkb:Q5JWF1|uniprotkb:Q9NY42|ensembl:ENSP00000360141 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gnas1_human(display_long)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:Extra large alphas protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001296812.1|refseq:NP_536350.2|refseq:XP_016883302.1|ensembl:ENSG00000087460(gene)|ensembl:ENST00000371100(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0060348"(bone development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q5JWF2|reactome:R-HSA-163359|reactome:R-HSA-164378|reactome:R-HSA-381676|reactome:R-HSA-392851|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-432040|reactome:R-HSA-5610787|reactome:R-HSA-9660821 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:UmsO2DSEM3LmGMPwxSdkmlrKMLc9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q6IEG0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2876632|uniprotkb:Q5THM2|uniprotkb:Q96MK1|uniprotkb:Q5THM1|uniprotkb:Q14C91|uniprotkb:Q5T339|uniprotkb:A8K8P4|ensembl:ENSP00000339834 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:snr48_human(display_long)|uniprotkb:SNRNP48(gene name)|psi-mi:SNRNP48(display_short)|uniprotkb:C6orf151(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_689764.3|ensembl:ENSG00000168566(gene)|ensembl:ENST00000342415(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0046872"(metal ion binding)|interpro:IPR022776|interpro:IPR032845|interpro:IPR036236|rcsb pdb:2VY4|rcsb pdb:2VY5|reactome:R-HSA-72165 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:xKzG44rRn2jI0igYZDuk2eP7+Eg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7Z3U7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358882|uniprotkb:A5D8U7|uniprotkb:A7E2Y0|uniprotkb:Q86TA2|uniprotkb:Q8N3I5|uniprotkb:Q8NAI0|uniprotkb:Q9UPW1|intact:EBI-2829603|intact:EBI-358896|uniprotkb:Q8NHE2|uniprotkb:B9EGP5|uniprotkb:F8VWA6|uniprotkb:F8W1Z6|intact:EBI-10962461|ensembl:ENSP00000377250 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:mon2_human(display_long)|uniprotkb:MON2(gene name)|psi-mi:MON2(display_short)|uniprotkb:KIAA1040(gene name synonym)|uniprotkb:SF21(gene name synonym)|uniprotkb:Protein SF21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001265399.1|refseq:NP_001265398.1|refseq:NP_055841.2|refseq:XP_016874530.1|ensembl:ENSG00000061987(gene)|ensembl:ENST00000393630(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026829|interpro:IPR032629|interpro:IPR032691|interpro:IPR032817|mint:Q7Z3U7 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pEkENsLrswc7Cb2WTKZfQdESrtQ9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P54652 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P02538 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:feIxUFTSMnjattUda5vdGhiL9H89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75607 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-721544|uniprotkb:Q9UNY6|intact:EBI-28974425|ensembl:ENSP00000359128 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:npm3_human(display_long)|uniprotkb:NPM3(gene name)|psi-mi:NPM3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008924.1|ensembl:ENSP00000359128|ensembl:ENSG00000107833(gene)|ensembl:ENST00000370110(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0009303"(rRNA transcription)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042393"(histone binding)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR036824|mint:O75607 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:lryH+qFG3/zmXWyn25dmU44prpk9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UL15 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NQ29 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-473747|uniprotkb:Q96S32|uniprotkb:Q9NPH4|uniprotkb:B8ZZ13|ensembl:ENSP00000293872 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:luc7l_human(display_long)|uniprotkb:SR+89(gene name synonym)|uniprotkb:Putative SR protein LUC7B1(gene name synonym)|uniprotkb:LUC7L(gene name)|psi-mi:LUC7L(display_short)|uniprotkb:LUC7L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001307155.1|refseq:NP_001317349.1|refseq:NP_060502.1|refseq:NP_958815.1|ensembl:ENSG00000007392(gene)|ensembl:ENST00000293872(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0042802"(identical protein binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q9NQ29 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Hsl0VZTCTP6UrKlo/FHOVwZqCaw9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P63173 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359141|uniprotkb:P23411|uniprotkb:B2R5A8|ensembl:ENSP00000309830|ensembl:ENSP00000390279|ensembl:ENSP00000434243 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rl38_human(display_long)|uniprotkb:RPL38(gene name)|psi-mi:RPL38(display_short)|uniprotkb:Large ribosomal subunit protein eL38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000990.1|refseq:NP_001030335.1|ensembl:ENSG00000172809(gene)|ensembl:ENST00000311111(transcript)|ensembl:ENST00000439590(transcript)|ensembl:ENST00000533498(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0033291"(eukaryotic 80S initiation complex)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0048318"(axial mesoderm development)|interpro:IPR002675(Ribosomal protein L38e)|interpro:IPR038464|mint:P63173|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:5AJ0|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:6kUSGJll3ldTTRzgVTSwBjgV19Y9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75683 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2691252|uniprotkb:Q9UK24|uniprotkb:Q9BTZ5|uniprotkb:Q5T8U1|uniprotkb:Q9BRK9|ensembl:ENSP00000361092|ensembl:ENSP00000485909 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:surf6_human(display_long)|uniprotkb:SURF-6(gene name synonym)|uniprotkb:SURF6(gene name)|psi-mi:SURF6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006744.2|refseq:NP_001265871.1|ensembl:ENSG00000148296(gene)|ensembl:ENSG00000281309(gene)|ensembl:ENST00000372022(transcript)|ensembl:ENST00000629980(transcript)|go:"GO:0001652"(granular component)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR007019(Surfeit locus 6)|interpro:IPR029190 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:1Yzf0+p31xuzJXSoaiz9THfjF0c9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:B1ANR0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-9977484|ensembl:ENSP00000361953 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q00059 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y383 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-352851|ensembl:ENSP00000347005|uniprotkb:Q8IUP9|uniprotkb:Q9NVL3|uniprotkb:Q9NVN7|uniprotkb:Q9UQN1|uniprotkb:B7Z500 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lc7l2_human(display_long)|uniprotkb:LUC7L2(gene name)|psi-mi:LUC7L2(display_short)|uniprotkb:CGI-59(orf name)|uniprotkb:CGI-74(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000146963(gene)|ensembl:ENST00000354926(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q9Y383|refseq:NP_057103.2|refseq:NP_001231514.1|refseq:NP_001257572.1|dip:DIP-32513N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:WLp3u1YbXtdPGzIm6WxvAbrQKhM9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y5B9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046849|uniprotkb:Q6GMT8|uniprotkb:Q6P2F1|uniprotkb:Q6PJM1|uniprotkb:Q9NRX0|ensembl:ENSP00000216297 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sp16h_human(display_long)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:SUPT16H(gene name)|psi-mi:SUPT16H(display_short)|uniprotkb:FACT140(gene name synonym)|uniprotkb:FACTP140(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000092201(gene)|ensembl:ENST00000216297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|interpro:IPR029148|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|mint:Q9Y5B9|rcsb pdb:4Z2M|rcsb pdb:4Z2N|rcsb pdb:5E5B|rcsb pdb:5UMT|rcsb pdb:5UMU|rcsb pdb:5XM2|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|refseq:NP_009123.1|dip:DIP-42757N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jLK5dOF3mEyI0UbZhcNgtdlG+WI9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9GZN1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-769329|uniprotkb:Q9BY39|uniprotkb:Q9H8H6|uniprotkb:B3KW37|uniprotkb:B4DLG9|uniprotkb:Q53GH2|ensembl:ENSP00000188312 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:arp6_human(display_long)|uniprotkb:ACTR6(gene name)|psi-mi:ACTR6(display_short)|uniprotkb:CDA12(orf name)|uniprotkb:hARPX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_071941.1|refseq:XP_016875310.1|ensembl:ENSG00000075089(gene)|ensembl:ENST00000188312(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|interpro:IPR004000(Actin/actin-like)|interpro:IPR030054|interpro:IPR043129|rcsb pdb:6IGM - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:+V5Uh1tkAXlpjVd1QnDZxev45A49606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UPT5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-720048|uniprotkb:Q96FF0|uniprotkb:Q9H8C3|uniprotkb:Q9H9X3|uniprotkb:Q9HA32|uniprotkb:Q8ND93|uniprotkb:Q8WV91|uniprotkb:B5MC69|uniprotkb:B8XXP2|ensembl:ENSP00000334100 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:exoc7_human(display_long)|uniprotkb:EXOC7(gene name)|psi-mi:EXOC7(display_short)|uniprotkb:EXO70(gene name synonym)|uniprotkb:KIAA1067(gene name synonym)|uniprotkb:Exocyst complex component Exo70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001013861.1|refseq:NP_001138769.1|refseq:NP_001138770.1|refseq:NP_001138771.1|refseq:NP_056034.2|ensembl:ENSG00000182473(gene)|ensembl:ENST00000335146(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032584"(growth cone membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR004140(Exo70 exocyst complex subunit)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UPT5|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_001269242.1|dip:DIP-37604N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:f/uwscxIcAuG96QZzNMQtrzTmeU9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P02533 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-702178|uniprotkb:Q14715|uniprotkb:Q53XY3|uniprotkb:Q9BUE3|uniprotkb:Q9UBN2|uniprotkb:Q9UBN3|uniprotkb:Q9UCY4|ensembl:ENSP00000167586 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k1c14_human(display_long)|uniprotkb:Cytokeratin-14(gene name synonym)|uniprotkb:KRT14(gene name)|psi-mi:KRT14(display_short)|uniprotkb:Keratin-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000517.2|dip:DIP-33874N|ensembl:ENSG00000186847(gene)|ensembl:ENST00000167586(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007568"(aging)|go:"GO:0008544"(epidermis development)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042633"(hair cycle)|go:"GO:0045095"(keratin filament)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045178"(basal part of cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990254"(keratin filament binding)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P02533|rcsb pdb:3TNU|rcsb pdb:6JFV|reactome:R-HSA-446107|reactome:R-HSA-6805567|reactome:R-HSA-6809371 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:IO1k6S8FB65jQr4GNwhKuxZ1ohg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P04259 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-740907|ensembl:ENSP00000252252|uniprotkb:P48669 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k2c6b_human(display_long)|uniprotkb:Cytokeratin-6B(gene name synonym)|uniprotkb:Keratin-6B(gene name synonym)|uniprotkb:KRT6B(gene name)|psi-mi:KRT6B(display_short)|uniprotkb:K6B(gene name synonym)|uniprotkb:KRTL1(gene name synonym)|uniprotkb:Type-II keratin Kb10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005546.2|ensembl:ENSG00000185479(gene)|ensembl:ENST00000252252(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0007398"(ectoderm development)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P04259|reactome:R-HSA-6805567|reactome:R-HSA-6809371 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:lFuNGZdQm4pftz53qbflLTyyAaQ9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P62873 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43795 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351119|uniprotkb:O43794|uniprotkb:Q7Z6L5|ensembl:ENSP00000306382|ensembl:ENSP00000376132 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:myo1b_human(display_long)|uniprotkb:MYO1B(gene name)|psi-mi:MYO1B(display_short)|uniprotkb:Myosin I alpha(gene name synonym)|uniprotkb:MYH-1c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001123630.1|refseq:NP_001155291.1|refseq:NP_036355.2|ensembl:ENSG00000128641(gene)|ensembl:ENST00000304164(transcript)|ensembl:ENST00000392318(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030175"(filopodium)|go:"GO:0031982"(vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:O43795|go:"GO:0016459"(myosin complex)|refseq:XP_005246629.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FYYccaCMhkmUdTdtq4M8zdpFpV89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UN81 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722458|intact:EBI-8874490|uniprotkb:Q15605 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lorf1_human(display_long)|uniprotkb:L1RE1(gene name)|psi-mi:L1RE1(display_short)|uniprotkb:LINE retrotransposable element 1(gene name synonym)|uniprotkb:LINE1 retrotransposable element 1(gene name synonym)|uniprotkb:LRE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) dip:DIP-48676N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032197"(transposition, RNA-mediated)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004244(Transposase, L1)|interpro:IPR035300|interpro:IPR035301|interpro:IPR042566|interpro:IPR043636|rcsb pdb:2LDY|rcsb pdb:2W7A|rcsb pdb:2YKO|rcsb pdb:2YKP|rcsb pdb:2YKQ|rcsb pdb:6FIA - - caution:This sequence has been withdrawn from Uniprot.|crc64:C9ED80C33ED37523 figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pefRokDO38574Jo5bl2/49LYvaQ9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q09161 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P24539 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P63244 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q15434 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-721278|ensembl:ENSP00000262031 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rbms2_human(display_long)|uniprotkb:Suppressor of CDC2 with RNA-binding motif 3(gene name synonym)|uniprotkb:RBMS2(gene name)|psi-mi:RBMS2(display_short)|uniprotkb:SCR3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002889.1|refseq:XP_011536942.1|refseq:XP_006719607.1|go:"GO:0005634"(nucleus)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008143"("poly(A) binding")|ensembl:ENSG00000076067(gene)|ensembl:ENST00000262031(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:1X4E - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Xp/0q4sekgC32j5HNpSoZZq/Idg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9C005 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O94888 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1993627|uniprotkb:D3DXB3|uniprotkb:Q6ZP77|uniprotkb:Q86X20|uniprotkb:Q8N327|ensembl:ENSP00000296328 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ubxn7_human(display_long)|uniprotkb:UBXD7(gene name synonym)|uniprotkb:UBXN7(gene name)|psi-mi:UBXN7(display_short)|uniprotkb:KIAA0794(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_056377.1|dip:DIP-47029N|ensembl:ENSG00000163960(gene)|ensembl:ENST00000296328(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR017346(Uncharacterised conserved protein UCP037991, UAS, UBX)|interpro:IPR029071|interpro:IPR036249|rcsb pdb:1WJ4|rcsb pdb:2DAL|rcsb pdb:2DLX|rcsb pdb:5X3P|rcsb pdb:5X4L|reactome:R-HSA-8951664 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:TyFBtC4hXtG1WTSl8wLgPIoDxpg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q8N1N4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1056564|uniprotkb:Q7RTT2|uniprotkb:Q5HYM7|uniprotkb:A8K4D6|ensembl:ENSP00000306261 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k2c78_human(display_long)|uniprotkb:KRT78(gene name)|psi-mi:KRT78(display_short)|uniprotkb:K5B(gene name synonym)|uniprotkb:KB40(gene name synonym)|uniprotkb:Cytokeratin-78(gene name synonym)|uniprotkb:Type-II keratin Kb40(gene name synonym)|uniprotkb:Keratin-5b(gene name synonym)|uniprotkb:Keratin-78(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001287743.1|refseq:NP_775487.2|ensembl:ENSG00000170423(gene)|ensembl:ENST00000304620(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7DFQlPKPQ4Bu1Q5+nxLQufA7ghU9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q07065 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O15020 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-308449|uniprotkb:O14872|uniprotkb:O14873|ensembl:ENSP00000311489|ensembl:ENSP00000432568|ensembl:ENSP00000480692|ensembl:ENSP00000508362 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:sptn2_human(display_long)|uniprotkb:SPTBN2(gene name)|psi-mi:SPTBN2(display_short)|uniprotkb:KIAA0302(gene name synonym)|uniprotkb:Beta-III spectrin(gene name synonym)|uniprotkb:SCA5(gene name synonym)|uniprotkb:Spinocerebellar ataxia 5 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000173898(gene)|ensembl:ENST00000309996(transcript)|ensembl:ENST00000533211(transcript)|ensembl:ENST00000611817(transcript)|ensembl:ENST00000647510(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0008091"(spectrin)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0030534"(adult behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098918"(structural constituent of synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099189"(postsynaptic spectrin-associated cytoskeleton)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:O15020|rcsb pdb:1WJM|rcsb pdb:1WYQ|rcsb pdb:6ANU|reactome:R-HSA-2132295|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|refseq:XP_005274249.1|refseq:XP_005274250.1|refseq:XP_006718734.1|refseq:XP_016873663.1|refseq:XP_016873664.1|refseq:XP_016873665.1|refseq:XP_016873666.1|refseq:XP_016873667.1|dip:DIP-47270N|refseq:NP_008877.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Wfzccja70pnee8sDDc0TCmO6g0I9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P11940 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:XudTSPq2h9ckKAc48X88RVafPRU9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P33778 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357986|uniprotkb:Q4KN36|ensembl:ENSP00000482674 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2b1b_human(display_long)|uniprotkb:H2BC3(gene name)|psi-mi:H2BC3(display_short)|uniprotkb:H2B-clustered histone 3(gene name synonym)|uniprotkb:H2BFF(gene name synonym)|uniprotkb:HIST1H2BB(gene name synonym)|uniprotkb:Histone H2B.1(gene name synonym)|uniprotkb:Histone H2B.f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_066406.1|dip:DIP-47505N|ensembl:ENSG00000276410(gene)|ensembl:ENST00000615966(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P33778|rcsb pdb:3X1S|rcsb pdb:3X1U|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:l15lrchv4onuihbdZ+yWJQd35Ss9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P18859 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P26196 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UNM6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:iOxE62MMeGx+aqsrir/LukJqeho9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14669 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-308443|uniprotkb:Q15644|ensembl:ENSP00000283943|uniprotkb:D4HL82|uniprotkb:Q14CA3|uniprotkb:Q14CF1|uniprotkb:Q53R87|uniprotkb:Q53TE7 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:tripc_human(display_long)|uniprotkb:TRIP12(gene name)|psi-mi:TRIP12(display_short)|uniprotkb:Thyroid receptor-interacting protein 12(gene name synonym)|uniprotkb:KIAA0045(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase for Arf(gene name synonym)|uniprotkb:ULF(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase TRIP12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004229.1|refseq:NP_001271143.1|refseq:NP_001271144.1|refseq:NP_001271145.1|ensembl:ENSG00000153827(gene)|ensembl:ENST00000283943(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016607"(nuclear speck)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035983|interpro:IPR037197|mint:Q14669|reactome:R-HSA-983168|refseq:NP_001335244.1|refseq:NP_001335245.1|ensembl:ENSP00000283943|ensembl:ENST00000389044|ensembl:ENST00000389045|ensembl:ENSP00000373697|ensembl:ENSP00000373696|dip:DIP-58584N - - caution:This sequence has been withdrawn from Uniprot.|crc64:294A7C063A3332DE figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:wzXMKIUEDV4y7YE6PDU+LIPHl7U9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P52789 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O75947 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14746 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-389449|uniprotkb:Q86U99|ensembl:ENSP00000355629 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cog2_human(display_long)|uniprotkb:COG2(gene name)|psi-mi:COG2(display_short)|uniprotkb:LDLC(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 2(gene name synonym)|uniprotkb:Low density lipoprotein receptor defect C-complementing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_031383.1|refseq:NP_001138508.1|ensembl:ENSG00000135775(gene)|ensembl:ENST00000366669(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR009316(COG complex component, COG2)|interpro:IPR024602|interpro:IPR024603|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:LikqIIuX72shymiuUF977aVlfpE9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q96GM8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-717460|uniprotkb:Q6IA35|uniprotkb:Q8IWN5|uniprotkb:Q9H846|ensembl:ENSP00000361162|uniprotkb:B4DEM6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:toe1_human(display_long)|uniprotkb:TOE1(gene name)|psi-mi:TOE1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_079353.3|ensembl:ENSG00000132773(gene)|ensembl:ENST00000372090(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0034472"(snRNA 3'-end processing)|go:"GO:0046872"(metal ion binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|go:"GO:0005737"(cytoplasm)|mint:Q96GM8|rcsb pdb:2FC6 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:e4dCYcLroDp2t7E43MCEoq4Tm489606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q00577 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q93084 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1046185|uniprotkb:O60900|uniprotkb:O60901|uniprotkb:O75501|uniprotkb:O75502|uniprotkb:Q16115|uniprotkb:Q8TEX5|uniprotkb:Q8TEX6|uniprotkb:D3DTJ8|uniprotkb:A8MZG0|uniprotkb:Q6JHX1|ensembl:ENSP00000380234 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at2a3_human(display_long)|uniprotkb:Calcium pump 3(gene name synonym)|uniprotkb:ATP2A3(gene name)|psi-mi:ATP2A3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_777618.1|refseq:NP_005164.2|refseq:NP_777615.1|refseq:NP_777616.1|refseq:NP_777617.1|refseq:NP_777613.1|refseq:NP_777614.1|ensembl:ENSG00000074370(gene)|ensembl:ENST00000397041(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030899"(calcium-dependent ATPase activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Nvh6pdcL5m05Wgu5rINDl8bhvDM9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92615 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1052558|uniprotkb:Q5T3R3|uniprotkb:Q5T3R4|uniprotkb:Q5T3R5|uniprotkb:Q68CY4|uniprotkb:A7MD20|intact:EBI-28969094|ensembl:ENSP00000326128 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:lar4b_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 5(gene name synonym)|uniprotkb:LARP4B(gene name)|psi-mi:LARP4B(display_short)|uniprotkb:LARP5(gene name synonym)|uniprotkb:La-related protein 5(gene name synonym)|uniprotkb:KIAA0217(gene name synonym)|uniprotkb:La ribonucleoprotein domain family member 4B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_055970.1|ensembl:ENSP00000326128|ensembl:ENSG00000107929(gene)|ensembl:ENST00000316157(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034900|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3PTH - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:tVFpPu0vhCgdRt0lowfi5GzA8Do9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q92900 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:J3KPP4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-21359952|ensembl:ENSP00000376919 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:j3kpp4_human(display_long)|uniprotkb:LUC7L3(gene name)|psi-mi:LUC7L3(display_short)|uniprotkb:CROP(gene name synonym)|uniprotkb:hCG_27416(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000108848(gene)|ensembl:ENST00000393227(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0016607"(nuclear speck)|interpro:IPR004882(LUC7 related)|refseq:NP_001317259.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:W8x4J0RMKkOr4lv3iwvQ16VlXV09606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P17066 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355106|uniprotkb:Q8IYK7|uniprotkb:Q9BT95|uniprotkb:Q1HBA8|ensembl:ENSP00000310219 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:hsp76_human(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002146.2|ensembl:ENSG00000173110(gene)|ensembl:ENST00000309758(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P17066|rcsb pdb:3FE1|reactome:R-HSA-3371453|reactome:R-HSA-6798695 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:AcNwJ2S/RD3n/8iRNy5ioetVZ+U9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q99615 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BXW9 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O00303 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P21796 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9BSR8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-751253|intact:EBI-28982595|ensembl:ENSP00000238831 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:yipf4_human(display_long)|uniprotkb:YIP1 family member 4(gene name synonym)|uniprotkb:YIPF4(gene name)|psi-mi:YIPF4(display_short)|uniprotkb:Nbla11189(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_115688.1|ensembl:ENSP00000238831|ensembl:ENSG00000119820(gene)|ensembl:ENST00000238831(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR006977(Yip1 domain) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid://HHRgK4+OqWrvck7hJvm92cci89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O94761 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-722861|uniprotkb:Q3Y424|uniprotkb:Q96DW2|uniprotkb:A0A087WZ30|uniprotkb:Q96F55|ensembl:ENSP00000482313 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:recq4_human(display_long)|uniprotkb:RecQ protein-like 4(gene name synonym)|uniprotkb:RTS(gene name synonym)|uniprotkb:RECQL4(gene name)|psi-mi:RECQL4(display_short)|uniprotkb:RECQ4(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_004251.3|ensembl:ENSG00000160957(gene)|ensembl:ENST00000617875(transcript)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0016020"(membrane)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021110|interpro:IPR027417|rcsb pdb:2KMU|rcsb pdb:5LST|dip:DIP-48475N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:FMX8OqwUNPdPfNL6EsLucTQCNfQ9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O15260 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044848|uniprotkb:O60923|uniprotkb:Q9UNZ0|uniprotkb:Q9UNZ1|uniprotkb:Q5T8U6|ensembl:ENSP00000361057|ensembl:ENSP00000486049|uniprotkb:B7Z6A4 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:surf4_human(display_long)|uniprotkb:SURF4(gene name)|psi-mi:SURF4(display_short)|uniprotkb:SURF-4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_149351.1|ensembl:ENSG00000148248(gene)|ensembl:ENSG00000280951(gene)|ensembl:ENST00000629578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR002995(Surfeit locus 4)|mint:O15260|reactome:R-HSA-6798695|reactome:R-HSA-6811434|ensembl:ENST00000371989(transcript)|refseq:NP_001267718.1|refseq:NP_001267721.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:VEkKSEfWLmSZx209HLRfoMMTzsg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q58EX7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-949255|uniprotkb:Q4G0J8|uniprotkb:Q4H485|uniprotkb:Q56A69|uniprotkb:Q9H7K4|uniprotkb:Q9UFW0|ensembl:ENSP00000353646|ensembl:ENSP00000368649|ensembl:ENSP00000401118 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:pkhg4_human(display_long)|uniprotkb:Pleckstrin homology domain-containing family G member 4(gene name synonym)|uniprotkb:Purkinje cell atrophy-associated protein 1(gene name synonym)|uniprotkb:PLEKHG4(gene name)|psi-mi:PLEKHG4(display_short)|uniprotkb:PRTPHN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001123199.1|refseq:NP_001123200.1|refseq:NP_001123201.1|refseq:NP_001123203.1|refseq:XP_011521287.1|refseq:XP_011521288.1|refseq:XP_011521289.1|refseq:XP_011521290.1|ensembl:ENSG00000196155(gene)|ensembl:ENST00000360461(transcript)|ensembl:ENST00000379344(transcript)|ensembl:ENST00000427155(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036865|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:SnuXZYAmifcqahtFQWTe/ZThU1k9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P60228 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P42677 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356336|ensembl:ENSP00000499044|uniprotkb:Q5T4L6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rs27_human(display_long)|uniprotkb:RPS27(gene name)|psi-mi:RPS27(display_short)|uniprotkb:MPS1(gene name synonym)|uniprotkb:Metallopan-stimulin 1(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS27(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001021.1|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000177954(gene)|ensembl:ENST00000651669(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:P42677|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-141444|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2500257|rcsb pdb:6OM7|reactome:R-HSA-5663220|reactome:R-HSA-6791226|reactome:R-HSA-68877|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-9648025|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-44182N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:U3KQK0 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-12142839|ensembl:ENSP00000475942 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:u3kqk0_human(display_long)|uniprotkb:H2BC15(gene name)|psi-mi:H2BC15(display_short)|uniprotkb:HIST1H2BN(gene name synonym)|uniprotkb:hCG_1743059(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000233822(gene)|ensembl:ENST00000606613(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Hs/lqO9F2951gmJ5sO1NOyNhMUI9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7Z3Y7 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11980489|ensembl:ENSP00000305263|uniprotkb:Q6ZP84 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k1c28_human(display_long)|uniprotkb:KRT28(gene name)|psi-mi:KRT28(display_short)|uniprotkb:Cytokeratin-28(gene name synonym)|uniprotkb:KRT25D(gene name synonym)|uniprotkb:Keratin-25D(gene name synonym)|uniprotkb:Keratin-28(gene name synonym)|uniprotkb:Type I inner root sheath-specific keratin-K25irs4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000173908(gene)|ensembl:ENST00000306658(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_853513.2 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:vLYUAm2Ojo2o/I9UHeqH/vfRePA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P13645 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:z100yyq3b63P0ARy2lE2ELyJeik9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P55084 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:H0YMV8 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27044086|ensembl:ENSP00000453764 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h0ymv8_human(display_long)|uniprotkb:RPS27L(gene name)|psi-mi:RPS27L(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000185088(gene)|ensembl:ENST00000462430(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:3AbXLKRpXDf0lwKKyeHZqPytBjA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O43809 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-355720|uniprotkb:Q6IB85|uniprotkb:Q6NE84|ensembl:ENSP00000300291 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:cpsf5_human(display_long)|uniprotkb:NUDT21(gene name)|psi-mi:NUDT21(display_short)|uniprotkb:CFIM25(gene name synonym)|uniprotkb:CPSF25(gene name synonym)|uniprotkb:CPSF5(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 25 kDa subunit(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 21(gene name synonym)|uniprotkb:Cleavage factor Im complex 25 kDa subunit(gene name synonym)|uniprotkb:Nudix hydrolase 21(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008937.1|ensembl:ENSG00000167005(gene)|ensembl:ENST00000300291(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031439"(positive regulation of mRNA cleavage)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2000975"(positive regulation of pro-B cell differentiation)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR016706(Cleavage and polyadenylation specificity factor, 25 kDa subunit)|mint:O43809|rcsb pdb:2CL3|rcsb pdb:2J8Q|rcsb pdb:3BAP|rcsb pdb:3BHO|rcsb pdb:3MDG|rcsb pdb:3MDI|rcsb pdb:3N9U|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:5R4P|rcsb pdb:5R4Q|rcsb pdb:5R4R|rcsb pdb:5R4S|rcsb pdb:5R4T|rcsb pdb:5R4U|rcsb pdb:5R64|rcsb pdb:5R65|rcsb pdb:5R66|rcsb pdb:5R67|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-42502N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Acad4mYVuS+Eox+X2CH8PYUkGAA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P25685 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HAU5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-372073|uniprotkb:A6NLJ5|uniprotkb:Q5W0J4|uniprotkb:Q14BM1|uniprotkb:Q8N8U1|uniprotkb:Q9H1J2|uniprotkb:Q9NWL1|uniprotkb:Q9P2D9|uniprotkb:Q9Y4M9|uniprotkb:D3DRS0|intact:EBI-28979373|ensembl:ENSP00000348708|ensembl:ENSP00000350221|ensembl:ENSP00000380244 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:rent2_human(display_long)|uniprotkb:Nonsense mRNA reducing factor 2(gene name synonym)|uniprotkb:Up-frameshift suppressor 2 homolog(gene name synonym)|uniprotkb:UPF2(gene name)|psi-mi:UPF2(display_short)|uniprotkb:KIAA1408(gene name synonym)|uniprotkb:RENT2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSP00000348708|ensembl:ENSP00000350221|ensembl:ENSP00000380244|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENSG00000151461(gene)|ensembl:ENST00000356352(transcript)|ensembl:ENST00000357604(transcript)|ensembl:ENST00000397053(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR007193(Up-frameshift suppressor 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039762|mint:Q9HAU5|rcsb pdb:1UW4|rcsb pdb:2WJV|rcsb pdb:4CEK|rcsb pdb:4CEM|dip:DIP-31148N|refseq:NP_056357.1|refseq:NP_542166.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:+hTMzl+IgYWyiDMSv5s4TeGt3D89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P06730 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-73440|uniprotkb:Q96E95|ensembl:ENSP00000389624|uniprotkb:D6RCQ6|uniprotkb:B7Z6V1|intact:EBI-28969298 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:if4e_human(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:EIF4E(gene name)|psi-mi:EIF4E(display_short)|uniprotkb:EIF4EL1(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001124151.1|refseq:NP_001959.1|ensembl:ENST00000280892|ensembl:ENSP00000280892|ensembl:ENSP00000389624|ensembl:ENST00000505992|ensembl:ENSP00000425561|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:2W97|rcsb pdb:3AM7|rcsb pdb:3TF2|rcsb pdb:3U7X|rcsb pdb:4AZA|rcsb pdb:4BEA|rcsb pdb:4DT6|rcsb pdb:4DUM|rcsb pdb:4TPW|rcsb pdb:4TQB|rcsb pdb:4TQC|rcsb pdb:4UED|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5EKV|rcsb pdb:5GW6|rcsb pdb:5T46|rcsb pdb:5ZJY|rcsb pdb:5ZJZ|rcsb pdb:5ZK5|rcsb pdb:5ZK7|rcsb pdb:5ZK9|ensembl:ENSG00000151247(gene)|rcsb pdb:5ZML|rcsb pdb:7MEU|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-159231|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-159230|reactome:R-HSA-159227|ensembl:ENST00000450253(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:P06730|rcsb pdb:1IPB|rcsb pdb:1IPC|rcsb pdb:1WKW|rcsb pdb:2GPQ|rcsb pdb:2V8W|refseq:NP_001124150.1|refseq:NP_001317946.1|dip:DIP-22N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9173bxjOdBfKj36pWVvzw7M6g1A9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P16615 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9HCU5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2553896|uniprotkb:Q9UH94|ensembl:ENSP00000260643|uniprotkb:Q53SZ8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:preb_human(display_long)|uniprotkb:SEC12(gene name synonym)|uniprotkb:Mammalian guanine nucleotide exchange factor mSec12(gene name synonym)|uniprotkb:PREB(gene name)|psi-mi:PREB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_037520.1|ensembl:ENSG00000138073(gene)|ensembl:ENST00000260643(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051020"(GTPase binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|rcsb pdb:5TF2|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|refseq:NP_001317414.1|refseq:NP_001317415.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:3xjABrP1KtfZUMb/BSbe8ZN6dJ49606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9NUD5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2954851|uniprotkb:Q3B7J3|ensembl:ENSP00000484056|uniprotkb:Q6NT79 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:zchc3_human(display_long)|uniprotkb:ZCCHC3(gene name)|psi-mi:ZCCHC3(display_short)|uniprotkb:C20orf99(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000247315(gene)|ensembl:ENST00000500893(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|interpro:IPR042509|refseq:NP_149080.2 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:7OjndwgSqExNYquAbdZ2zX2Ploc9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13823 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1043365|uniprotkb:Q9BWN7|ensembl:ENSP00000362153 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nog2_human(display_long)|uniprotkb:Autoantigen NGP-1(gene name synonym)|uniprotkb:GNL2(gene name)|psi-mi:GNL2(display_short)|uniprotkb:NGP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000134697(gene)|ensembl:ENST00000373062(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012971(NGP1, N-terminal)|interpro:IPR023179|interpro:IPR024929|interpro:IPR027417|interpro:IPR030378|mint:Q13823|rcsb pdb:6LSS|rcsb pdb:6LU8|refseq:NP_037417.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:CgIg/QNhk71SHIhV4iLvIuC/HUo9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35908 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:O95985 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-373403|uniprotkb:A0M8Q3|uniprotkb:Q9BUP5|ensembl:ENSP00000349705|ensembl:ENSP00000381773 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:top3b_human(display_long)|uniprotkb:TOP3B(gene name)|psi-mi:TOP3B(display_short)|uniprotkb:TOP3B1(gene name synonym)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003926.1|refseq:XP_011528784.1|refseq:XP_006724412.1|refseq:XP_006724413.1|refseq:NP_001269041.1|refseq:NP_001269042.1|refseq:XP_005261868.1|ensembl:ENSG00000100038(gene)|ensembl:ENST00000357179(transcript)|ensembl:ENST00000398793(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:O95985|rcsb pdb:5GVC|rcsb pdb:5GVE|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:R4lom6gXvFXkkGF+Hj94m9ecsXA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P0C0S5 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1199859|uniprotkb:P17317|uniprotkb:Q6I9U0|uniprotkb:B2RD56|ensembl:ENSP00000296417 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2az_human(display_long)|uniprotkb:H2AZ1(gene name)|psi-mi:H2AZ1(display_short)|uniprotkb:H2AFZ(gene name synonym)|uniprotkb:H2AZ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002097.1|ensembl:ENSG00000164032(gene)|ensembl:ENST00000296417(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S5|rcsb pdb:1F66|rcsb pdb:3WA9|rcsb pdb:4CAY|rcsb pdb:4NFT|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5CHL|rcsb pdb:5FUG|rcsb pdb:5Z30|rcsb pdb:6JOU|rcsb pdb:6KO2|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|dip:DIP-38593N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0FrzM1TXlduSQ0NNVl0C9uqCUGI9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P84243 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-120658|uniprotkb:P06351|uniprotkb:P33155|uniprotkb:Q5VV55|uniprotkb:Q5VV56|uniprotkb:Q66I33|uniprotkb:Q9V3W4|ensembl:ENSP00000254810|ensembl:ENSP00000355778|ensembl:ENSP00000355780|ensembl:ENSP00000355781|ensembl:ENSP00000465813|ensembl:ENSP00000466020|ensembl:ENSP00000468714|ensembl:ENSP00000499275|ensembl:ENSP00000499385|ensembl:ENSP00000499800 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h33_human(display_long)|uniprotkb:H3-3A(gene name)|psi-mi:H3-3A(display_short)|uniprotkb:H3-3B(gene name)|psi-mi:H3-3B(display_short)|uniprotkb:H3.3A(gene name synonym)|uniprotkb:H3.3B(gene name synonym)|uniprotkb:H3F3(gene name synonym)|uniprotkb:H3F3A(gene name synonym)|uniprotkb:H3F3B(gene name synonym)|uniprotkb:PP781(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_002098.1|refseq:NP_005315.1|rcsb pdb:4H9N|rcsb pdb:3QL9|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:3QLA|rcsb pdb:3QLC|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4L58|rcsb pdb:4N4I|rcsb pdb:3WTP|rcsb pdb:4O62|rcsb pdb:4QQ4|rcsb pdb:4TMP|rcsb pdb:4GNE|rcsb pdb:4GNF|rcsb pdb:4U7T|rcsb pdb:4GNG|rcsb pdb:4W5A|rcsb pdb:4GU0|rcsb pdb:4GUR|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:4GUS|rcsb pdb:4GY5|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5JA4|rcsb pdb:5JJY|ensembl:ENSG00000132475(gene)|ensembl:ENSG00000163041(gene)|rcsb pdb:5JLB|rcsb pdb:5KDM|rcsb pdb:5X7X|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:6A5P|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6HGT|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6J9J|rcsb pdb:6PZV|rcsb pdb:6QXZ|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6U04|rcsb pdb:7A08|reactome:R-HSA-427413|rcsb pdb:7CIZ|reactome:R-HSA-5250924|reactome:R-HSA-5334118|rcsb pdb:7CJ0|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-983231|rcsb pdb:7CWH|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-427359|reactome:R-HSA-427389|ensembl:ENST00000254810(transcript)|ensembl:ENST00000366813(transcript)|ensembl:ENST00000366815(transcript)|ensembl:ENST00000366816(transcript)|ensembl:ENST00000586607(transcript)|ensembl:ENST00000587560(transcript)|ensembl:ENST00000589599(transcript)|ensembl:ENST00000655399(transcript)|ensembl:ENST00000661429(transcript)|ensembl:ENST00000666609(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P84243|rcsb pdb:2L43|rcsb pdb:3ASK|rcsb pdb:3ASL|rcsb pdb:3AV2|rcsb pdb:3JVK|rcsb pdb:3MUK|rcsb pdb:3MUL|dip:DIP-40046N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:cRqA5/IBNfIbbxAnbwLqzXip20I9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UDY4 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-356960|uniprotkb:Q13431|uniprotkb:B2R824|ensembl:ENSP00000359799 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:dnjb4_human(display_long)|uniprotkb:DNAJB4(gene name)|psi-mi:DNAJB4(display_short)|uniprotkb:DNAJW(gene name synonym)|uniprotkb:HLJ1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1 homolog(gene name synonym)|uniprotkb:Human liver DnaJ-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_008965.2|refseq:NP_001304028.1|refseq:NP_001304029.1|refseq:NP_001304030.1|refseq:NP_001304031.1|refseq:NP_001304032.1|ensembl:ENSG00000162616(gene)|ensembl:ENST00000370763(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009408"(response to heat)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UDY4 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:gN0zBtJQiTN+YYSAtMk1mddNWLU9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q71RC2 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2878091|ensembl:ENSP00000381490|uniprotkb:Q96NF9|uniprotkb:A8K6T1|uniprotkb:Q6ZV14|uniprotkb:Q5CZ97|uniprotkb:G5E976|uniprotkb:E9PDG5|uniprotkb:G3XAA8 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:larp4_human(display_long)|uniprotkb:LARP4(gene name)|psi-mi:LARP4(display_short)|uniprotkb:La ribonucleoprotein domain family member 4(gene name synonym)|uniprotkb:PP13296(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000161813(gene)|ensembl:ENST00000398473(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR034903|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2CQK|rcsb pdb:3PKN|rcsb pdb:6I9B|refseq:XP_011536140.1|refseq:NP_001164279.1|refseq:NP_443111.4|refseq:NP_954658.2|refseq:NP_001317344.1|refseq:XP_016874240.1|refseq:XP_016874242.1|refseq:XP_016874243.1|refseq:NP_954660.1|refseq:XP_005268670.1|refseq:XP_011536141.1|refseq:XP_011536142.1|refseq:XP_011536143.1|refseq:XP_016874241.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:9FwnSJmbM08zYGHJB3l61hB1lJk9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9Y3C1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-5453434|uniprotkb:Q6IAI6|uniprotkb:Q8IXL5|uniprotkb:Q6PIM0|uniprotkb:B4DV13|uniprotkb:D6RGD3|uniprotkb:Q05D05|ensembl:ENSP00000480832 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:nop16_human(display_long)|uniprotkb:NOP16(gene name)|psi-mi:NOP16(display_short)|uniprotkb:HBV pre-S2 trans-regulated protein 3(gene name synonym)|uniprotkb:CGI-117(orf name)|uniprotkb:HSPC111(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_057475.2|refseq:NP_001304904.1|refseq:NP_001243468.2|refseq:NP_001278234.1|refseq:NP_001278236.1|refseq:NP_001278237.1|refseq:NP_001243469.2|ensembl:ENSG00000048162(gene)|ensembl:ENST00000614830(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR019002|mint:Q9Y3C1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:HdIqgMgye+B+sa3XiPdqvLXbcR89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P20671 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-4407441|uniprotkb:A0PK91|uniprotkb:P57754|uniprotkb:Q6FGY6|ensembl:ENSP00000341094 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2a1d_human(display_long)|uniprotkb:H2AC7(gene name)|psi-mi:H2AC7(display_short)|uniprotkb:H2AFG(gene name synonym)|uniprotkb:HIST1H2AD(gene name synonym)|uniprotkb:Histone H2A.3(gene name synonym)|uniprotkb:Histone H2A/g(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_066409.1|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|ensembl:ENSG00000196866(gene)|ensembl:ENST00000341023(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:5GT3|rcsb pdb:6KBB|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:Geraq+dGw3pvAAhgzzXQnYxDOOw9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P04908 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-358971|uniprotkb:Q76P63|uniprotkb:P28001|ensembl:ENSP00000303373|ensembl:ENSP00000483842 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h2a1b_human(display_long)|uniprotkb:H2AC4(gene name)|psi-mi:H2AC4(display_short)|uniprotkb:H2AC8(gene name)|psi-mi:H2AC8(display_short)|uniprotkb:H2AFA(gene name synonym)|uniprotkb:H2AFM(gene name synonym)|uniprotkb:HIST1H2AB(gene name synonym)|uniprotkb:HIST1H2AE(gene name synonym)|uniprotkb:Histone H2A.2(gene name synonym)|uniprotkb:Histone H2A/a(gene name synonym)|uniprotkb:Histone H2A/m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_003504.2|refseq:NP_066390.1|ensembl:ENSG00000277075(gene)|ensembl:ENSG00000278463(gene)|ensembl:ENST00000303910(transcript)|ensembl:ENST00000615868(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P04908|rcsb pdb:2CV5|rcsb pdb:2RVQ|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1V|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B40|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5GSE|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JRG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Z23|rcsb pdb:5ZBX|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:6A5P|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACL|rcsb pdb:6AEE|rcsb pdb:6BUZ|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6KE9|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6O1D|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6USJ|rcsb pdb:6V92|rcsb pdb:6YOV|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|rcsb pdb:6JXD|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|dip:DIP-44197N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:4Qno1mMYZB6FdNoojrzulWLVq849606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P45880 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P68431 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-79722|ensembl:ENSP00000352252|ensembl:ENSP00000358160|ensembl:ENSP00000366999|ensembl:ENSP00000480826|ensembl:ENSP00000482271|ensembl:ENSP00000483283|ensembl:ENSP00000484095|ensembl:ENSP00000484638|ensembl:ENSP00000484658|ensembl:ENSP00000484841|ensembl:ENSP00000489282|intact:EBI-1560041|uniprotkb:A0PJT7|uniprotkb:P02295|uniprotkb:P02296|uniprotkb:P16106|uniprotkb:Q6ISV8|uniprotkb:Q6NWP8|uniprotkb:Q6NWP9|uniprotkb:Q6NXU4|uniprotkb:Q71DJ3|uniprotkb:Q93081|uniprotkb:A5PLR1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h31_human(display_long)|uniprotkb:H3FA(gene name synonym)|uniprotkb:H3FL(gene name synonym)|uniprotkb:H3FD(gene name synonym)|uniprotkb:H3FI(gene name synonym)|uniprotkb:H3FH(gene name synonym)|uniprotkb:H3FK(gene name synonym)|uniprotkb:H3FF(gene name synonym)|uniprotkb:H3FJ(gene name synonym)|uniprotkb:H3FB(gene name synonym)|uniprotkb:Histone H3/a(gene name synonym)|uniprotkb:Histone H3/b(gene name synonym)|uniprotkb:Histone H3/c(gene name synonym)|uniprotkb:Histone H3/d(gene name synonym)|uniprotkb:Histone H3/f(gene name synonym)|uniprotkb:Histone H3/h(gene name synonym)|uniprotkb:Histone H3/i(gene name synonym)|uniprotkb:Histone H3/j(gene name synonym)|uniprotkb:Histone H3/k(gene name synonym)|uniprotkb:Histone H3/l(gene name synonym)|uniprotkb:H3C1(gene name)|psi-mi:H3C1(display_short)|uniprotkb:HIST1H3A(gene name synonym)|uniprotkb:H3C2(gene name)|psi-mi:H3C2(display_short)|uniprotkb:HIST1H3B(gene name synonym)|uniprotkb:H3C3(gene name)|psi-mi:H3C3(display_short)|uniprotkb:H3FC HIST1H3C(gene name synonym)|uniprotkb:H3C4(gene name)|psi-mi:H3C4(display_short)|uniprotkb:HIST1H3D(gene name synonym)|uniprotkb:H3C6(gene name)|psi-mi:H3C6(display_short)|uniprotkb:HIST1H3E(gene name synonym)|uniprotkb:H3C7(gene name)|psi-mi:H3C7(display_short)|uniprotkb:HIST1H3F(gene name synonym)|uniprotkb:H3C8(gene name)|psi-mi:H3C8(display_short)|uniprotkb:HIST1H3G(gene name synonym)|uniprotkb:H3C10(gene name)|psi-mi:H3C10(display_short)|uniprotkb:HIST1H3H(gene name synonym)|uniprotkb:H3C11(gene name)|psi-mi:H3C11(display_short)|uniprotkb:HIST1H3I(gene name synonym)|uniprotkb:H3C12(gene name)|psi-mi:H3C12(display_short)|uniprotkb:HIST1H3J(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) rcsb pdb:4TN7|rcsb pdb:4U68|rcsb pdb:4UP0|rcsb pdb:4UY4|rcsb pdb:4X3K|rcsb pdb:4Y6L|rcsb pdb:4YHP|rcsb pdb:4YHZ|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z0R|rcsb pdb:4Z2M|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:4QBS|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B31|rcsb pdb:5C11|rcsb pdb:5C13|rcsb pdb:5C3I|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5D6Y|rcsb pdb:5DAH|rcsb pdb:5FB0|rcsb pdb:5FB1|rcsb pdb:5FFV|rcsb pdb:5GH9|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5H6Q|rcsb pdb:5H6R|rcsb pdb:5HJB|rcsb pdb:5HJC|rcsb pdb:5HJD|rcsb pdb:5HYN|rcsb pdb:5IQL|rcsb pdb:5J3V|rcsb pdb:5J9S|rcsb pdb:5JHN|rcsb pdb:5JIN|rcsb pdb:5JIY|rcsb pdb:5JJ0|rcsb pdb:5B2J|rcsb pdb:5JRG|rcsb pdb:5KJH|rcsb pdb:5KJI|rcsb pdb:5KKL|rcsb pdb:5LUG|rcsb pdb:5M5G|rcsb pdb:5MR8|rcsb pdb:5NNC|rcsb pdb:5OY3|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:5SZB|rcsb pdb:5SZC|rcsb pdb:5T0K|rcsb pdb:5T0M|rcsb pdb:5T1G|rcsb pdb:5T1I|rcsb pdb:5T8R|rcsb pdb:5TBN|rcsb pdb:5TDR|rcsb pdb:5TDW|rcsb pdb:5U2J|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:5VA6|rcsb pdb:5VAB|rcsb pdb:5VGE|rcsb pdb:5VNB|rcsb pdb:5NND|rcsb pdb:5WLE|rcsb pdb:5WVO|rcsb pdb:5WXG|rcsb pdb:5WXH|rcsb pdb:5WYI|rcsb pdb:5X60|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5XFQ|rcsb pdb:5XFR|rcsb pdb:5XNV|rcsb pdb:5XTZ|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Y20|rcsb pdb:5Y2F|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:6AXJ|rcsb pdb:6AZE|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6D07|rcsb pdb:6D08|rcsb pdb:6E83|rcsb pdb:6E86|rcsb pdb:5WFC|rcsb pdb:6F6D|rcsb pdb:6HTS|rcsb pdb:6IEU|rcsb pdb:6IIS|rcsb pdb:6IIT|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6JXD|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6LS6|rcsb pdb:6LSD|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MIL|rcsb pdb:6MIM|rcsb pdb:6MIN|rcsb pdb:6MIO|rcsb pdb:6MIQ|rcsb pdb:6PA1|rcsb pdb:6PAG|rcsb pdb:6HKT|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2H|rcsb pdb:6V2K|rcsb pdb:6V3N|rcsb pdb:6V41|rcsb pdb:6V92|rcsb pdb:6VIL|rcsb pdb:6WAV|rcsb pdb:6WW4|rcsb pdb:6YIF|rcsb pdb:6YIH|rcsb pdb:6YOV|rcsb pdb:7BWD|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:6R92|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7DBP|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7KLR|rcsb pdb:7LYC|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|ensembl:ENSG00000197153(gene)|ensembl:ENSG00000197409(gene)|ensembl:ENSG00000273983(gene)|ensembl:ENSG00000274750(gene)|ensembl:ENSG00000275379(gene)|ensembl:ENSG00000275714(gene)|ensembl:ENSG00000277775(gene)|ensembl:ENSG00000278828(gene)|ensembl:ENSG00000286522(gene)|ensembl:ENSG00000287080(gene)|ensembl:ENST00000356476(transcript)|ensembl:ENST00000359303(transcript)|ensembl:ENST00000369163(transcript)|ensembl:ENST00000612966(transcript)|ensembl:ENST00000613854(transcript)|ensembl:ENST00000614378(transcript)|ensembl:ENST00000614911(transcript)|ensembl:ENST00000616365(transcript)|ensembl:ENST00000618052(transcript)|ensembl:ENST00000621411(transcript)|ensembl:ENST00000634733(transcript)|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-3247509|reactome:R-HSA-9710421|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P68431|rcsb pdb:1CS9|rcsb pdb:1CT6|rcsb pdb:1O9S|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|rcsb pdb:1Q3L|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|rcsb pdb:2B2T|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|rcsb pdb:2B2U|rcsb pdb:2B2V|rcsb pdb:2B2W|rcsb pdb:2C1J|rcsb pdb:2C1N|go:"GO:0016020"(membrane)|rcsb pdb:2CO0|rcsb pdb:2CV5|rcsb pdb:2FSA|rcsb pdb:2KWJ|rcsb pdb:2KWK|rcsb pdb:2L75|rcsb pdb:2LBM|rcsb pdb:2LGG|rcsb pdb:2M0O|reactome:R-HSA-983231|reactome:R-HSA-977225|rcsb pdb:2NDG|rcsb pdb:2OQ6|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2RI7|rcsb pdb:2RR4|rcsb pdb:2UXN|rcsb pdb:2V85|rcsb pdb:2V89|rcsb pdb:2VNF|rcsb pdb:2VPG|rcsb pdb:2X0L|rcsb pdb:3A1B|rcsb pdb:2NDF|rcsb pdb:3AFA|rcsb pdb:3AVR|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3B95|rcsb pdb:3FDT|rcsb pdb:3KMT|rcsb pdb:3KQI|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3MP1|rcsb pdb:3O34|rcsb pdb:3O35|rcsb pdb:3O37|rcsb pdb:3QJ6|rcsb pdb:3RIG|rcsb pdb:3RIY|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3U31|rcsb pdb:3U3D|rcsb pdb:3U4S|rcsb pdb:3U5N|rcsb pdb:3U5O|rcsb pdb:3AZK|rcsb pdb:3U5P|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UII|rcsb pdb:3UIK|rcsb pdb:3V43|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:3ZG6|rcsb pdb:3ZVY|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:4A7J|rcsb pdb:3UIG|rcsb pdb:4BD3|rcsb pdb:4C1Q|rcsb pdb:4F4U|rcsb pdb:4F56|rcsb pdb:4FWF|rcsb pdb:4HON|rcsb pdb:4I51|rcsb pdb:4L7X|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:4LXL|rcsb pdb:4N4H|rcsb pdb:4QBQ|rcsb pdb:4QBR|refseq:NP_003520.1|refseq:NP_003521.2|refseq:NP_003522.1|refseq:NP_003523.1|refseq:NP_003524.1|refseq:NP_003525.1|refseq:NP_003526.1|refseq:NP_003527.1|refseq:NP_003528.1|refseq:NP_066298.1|dip:DIP-29371N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:ood0OohxZHuhsWZtO7U7GMc+LwM9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q14694 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q9UN86 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q5TEC6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-11156283|ensembl:ENSP00000476960|ensembl:ENSP00000499501 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h3ps2_human(display_long)|uniprotkb:H3-2(gene name)|psi-mi:H3-2(display_short)|uniprotkb:HIST2H3PS2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000273213(gene)|ensembl:ENST00000392948(transcript)|ensembl:ENST00000609879(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:4H75 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:5iHpsKKi7ckJhUKd9K8gnhdf8+g9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q71DI3 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-750650|uniprotkb:A2BDF6|uniprotkb:A6NFS4|uniprotkb:Q6B053|ensembl:ENSP00000333277|ensembl:ENSP00000358154|ensembl:ENSP00000385479 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:h32_human(display_long)|uniprotkb:H3C13(gene name)|psi-mi:H3C13(display_short)|uniprotkb:H3C14(gene name)|psi-mi:H3C14(display_short)|uniprotkb:H3C15(gene name)|psi-mi:H3C15(display_short)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3F2(gene name synonym)|uniprotkb:H3FM(gene name synonym)|uniprotkb:HIST2H3A(gene name synonym)|uniprotkb:HIST2H3C(gene name synonym)|uniprotkb:HIST2H3D(gene name synonym)|uniprotkb:Histone H3/m(gene name synonym)|uniprotkb:Histone H3/o(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001005464.1|refseq:NP_001116847.1|refseq:NP_066403.2|dip:DIP-48606N|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|rcsb pdb:7BU9|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-983231|rcsb pdb:7JZV|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|ensembl:ENSG00000183598(gene)|ensembl:ENSG00000203811(gene)|ensembl:ENSG00000203852(gene)|ensembl:ENST00000331491(transcript)|ensembl:ENST00000369158(transcript)|ensembl:ENST00000403683(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q71DI3|rcsb pdb:2IIJ|rcsb pdb:2X4W|rcsb pdb:2X4X|rcsb pdb:2X4Y|rcsb pdb:3AV1|rcsb pdb:3DB3|rcsb pdb:3MO8|rcsb pdb:3QO2|rcsb pdb:3R93|rcsb pdb:4MZF|rcsb pdb:4MZG|rcsb pdb:4MZH|rcsb pdb:4OUC|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B40|rcsb pdb:5BO0|rcsb pdb:5CIU|rcsb pdb:5VAC|rcsb pdb:6ACE|rcsb pdb:6FML|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6Y5E|rcsb pdb:7BQZ - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:F8W1S1 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-27105128|ensembl:ENSP00000447447 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:f8w1s1_human(display_long)|uniprotkb:KRT74(gene name)|psi-mi:KRT74(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000170484(gene)|ensembl:ENST00000549343(transcript)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:PmkG+F196w8a6RBWgj4TQnbxVlE9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q13283 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P50502 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-357285|ensembl:ENSP00000216218|uniprotkb:O14999|uniprotkb:Q2TU77 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:f10a1_human(display_long)|uniprotkb:ST13(gene name)|psi-mi:ST13(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:SNC6(gene name synonym)|uniprotkb:AAG2(gene name synonym)|uniprotkb:Aging-associated protein 2(gene name synonym)|uniprotkb:FAM10A1(gene name synonym)|uniprotkb:Suppression of tumorigenicity 13 protein(gene name synonym)|uniprotkb:Putative tumor suppressor ST13(gene name synonym)|uniprotkb:Protein FAM10A1(gene name synonym)|uniprotkb:Progesterone receptor-associated p48 protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) ensembl:ENSG00000100380(gene)|ensembl:ENST00000216218(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034649|interpro:IPR041243|mint:P50502|rcsb pdb:1UZS|reactome:R-HSA-3371453|refseq:NP_003923.2 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:yqG5t4Kuj7ZzfNwlJzGZYscKiM89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:Q7Z3C6 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-727146|uniprotkb:Q6P0N7|uniprotkb:Q7Z317|uniprotkb:Q7Z320|uniprotkb:Q8NDK6|uniprotkb:Q8WU65|uniprotkb:Q9BVL5|uniprotkb:Q9H6L1|uniprotkb:Q9HAG7|uniprotkb:Q3ZAQ6|ensembl:ENSP00000355173|ensembl:ENSP00000379983|ensembl:ENSP00000386710 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:atg9a_human(display_long)|uniprotkb:APG9-like 1(gene name synonym)|uniprotkb:ATG9A(gene name)|psi-mi:ATG9A(display_short)|uniprotkb:APG9L1(gene name synonym)|uniprotkb:mATG9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001070666.1|refseq:NP_076990.4|ensembl:ENSG00000198925(gene)|ensembl:ENST00000361242(transcript)|ensembl:ENST00000396761(transcript)|ensembl:ENST00000409618(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044805"(late nucleophagy)|go:"GO:0055037"(recycling endosome)|interpro:IPR007241(Autophagy protein 99)|mint:Q7Z3C6|rcsb pdb:6WQZ|rcsb pdb:6WR4|rcsb pdb:7JLO|rcsb pdb:7JLP|rcsb pdb:7JLQ|reactome:R-HSA-1632852 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:arvq+TjXETr14g/FkOITnLfYVh89606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NCK7 uniprotkb:P35613 intact:EBI-21840241|ensembl:ENSP00000310490 intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769 psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105115|imex:IM-29297-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2 - - - figure legend:Supp. Table 2|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606 rigid:UnleINWm+j9PGx2ihMU4CP3U/aY false v5 tag:c-c|mutation:2-2|mutation:113-113,127-127,340-340,443-443 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P35613 uniprotkb:Q8NCK7 intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769 intact:EBI-21840241|ensembl:ENSP00000310490 psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym) psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105250|imex:IM-29297-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2 refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) - - - figure legend:Fig. 5D|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rigid:rCnuHPQPGkBa+CJkixZThRjO2s0 false v5 tag:?-? ha tag:c-c|mutation decreasing interaction strength:443-443,340-340,127-127,113-113 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35613 uniprotkb:Q8NCK7 intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769 intact:EBI-21840241|ensembl:ENSP00000310490 psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym) psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105263|imex:IM-29297-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2 refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) - - - figure legend:Fig. 5E|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rigid:rCnuHPQPGkBa+CJkixZThRjO2s0 false v5 tag:?-? ha tag:c-c|mutation decreasing interaction strength:443-443,340-340,127-127,113-113 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35613 uniprotkb:Q8NCK7 intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769 intact:EBI-21840241|ensembl:ENSP00000310490 psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym) psi-mi:mot11_human(display_long)|uniprotkb:Solute carrier family 16 member 11(gene name synonym)|uniprotkb:SLC16A11(gene name)|psi-mi:SLC16A11(display_short)|uniprotkb:MCT11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rusu et al. (2017) imex:IM-29297|pubmed:28666119 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27105276|imex:IM-29297-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2 refseq:NP_699188.1|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030769|interpro:IPR036259|ensembl:ENSG00000174326(gene)|ensembl:ENST00000308009(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane) - - - figure legend:Fig. 5F|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/10/08 2021/10/13 rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606 rogid:snPc0Sbt+h9LK2sXRwSr9V1F7qY9606 rigid:rCnuHPQPGkBa+CJkixZThRjO2s0 false - ha tag:c-c|mutation decreasing interaction strength:443-443,340-340,127-127,113-113 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)