#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62108	uniprotkb:Q80TG9	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-877092|ensembl:ENSMUSP00000047573|uniprotkb:Q9CYK3|uniprotkb:B9EIF8	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:lrfn2_mouse(display_long)|uniprotkb:Lrfn2(gene name)|psi-mi:Lrfn2(display_short)|uniprotkb:Kiaa1246(gene name synonym)|uniprotkb:Salm1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Morimura et al. (2017)	pubmed:28604739|imex:IM-29281	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27103888|imex:IM-29281-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	ensembl:ENSMUSG00000040490(gene)|ensembl:ENSMUST00000046254(transcript)|go:"GO:0009986"(cell surface)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099175"(regulation of postsynapse organization)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-8849932|refseq:NP_081728.2	-	-	-	figure legend:fig. 9d|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2021/10/04	2021/10/11	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:+cUqBv1IjzWOPhzGMtQzTaWDncs10090	rigid:8aNz3MmZ6ZquQWfkQXSwyed1dwA	false	flag tag:?-?	myc tag:?-?|mutation decreasing interaction:274-274|mutation decreasing interaction:462-462|necessary binding region:787-788	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62108	uniprotkb:Q01097	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Morimura et al. (2017)	pubmed:28604739|imex:IM-29281	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27103999|imex:IM-29281-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	-	-	-	figure legend:suppl. fig.1d|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/10/04	2021/10/11	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rigid:8bF43aL6oMsLO7g6jy3QrV5Rrzs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62108	uniprotkb:P35436	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Morimura et al. (2017)	pubmed:28604739|imex:IM-29281	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27103999|imex:IM-29281-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	-	-	figure legend:suppl. fig.1d|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/10/04	2021/10/11	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	rigid:8bF43aL6oMsLO7g6jy3QrV5Rrzs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62108	uniprotkb:P23819	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-77538|uniprotkb:Q61604|uniprotkb:Q61605|uniprotkb:Q8BG69|uniprotkb:Q8BXU3|uniprotkb:Q9D6D3	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gria2_mouse(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Morimura et al. (2017)	pubmed:28604739|imex:IM-29281	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27103999|imex:IM-29281-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|reactome:R-MMU-399710|reactome:R-MMU-416993|reactome:R-MMU-438066|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR028082|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|mint:P23819	-	-	-	figure legend:suppl. fig.1d|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/10/04	2021/10/11	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:v71xzThz9kadLOPBasVAc1y/FXs10090	rigid:8bF43aL6oMsLO7g6jy3QrV5Rrzs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62108	uniprotkb:P23818	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	intact:EBI-445486|ensembl:ENSMUSP00000044494	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:gria1_mouse(display_long)|uniprotkb:GluR-A(gene name synonym)|uniprotkb:GluR-K1(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 1(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 1(gene name synonym)|uniprotkb:Gria1(gene name)|psi-mi:Gria1(display_short)|uniprotkb:Glur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Morimura et al. (2017)	pubmed:28604739|imex:IM-29281	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27103999|imex:IM-29281-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	refseq:NP_001106796.1|dip:DIP-31970N|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0045202"(synapse)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:7LDD|rcsb pdb:7LDE|reactome:R-MMU-204005|reactome:R-MMU-399710|reactome:R-MMU-399719|reactome:R-MMU-416993|ensembl:ENSMUSG00000020524(gene)|ensembl:ENSMUST00000036315(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-438066|reactome:R-MMU-5694530|reactome:R-MMU-8849932	-	-	-	figure legend:suppl. fig.1d|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/10/04	2021/10/11	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	rogid:5hAcAV1UEfdgn7CNrrAHPIwUs/410090	rigid:8bF43aL6oMsLO7g6jy3QrV5Rrzs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)