#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46934	uniprotkb:Q99732	intact:EBI-726944|ensembl:ENSP00000424827|uniprotkb:A1KY35|uniprotkb:A6ND72|uniprotkb:A7MD29|uniprotkb:B4E2R7|uniprotkb:B7ZM59|uniprotkb:B7ZM60|uniprotkb:B9EGN5|uniprotkb:D6RF89|intact:EBI-28969445	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	psi-mi:nedd4_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:NEDD4(gene name)|psi-mi:NEDD4(display_short)|uniprotkb:KIAA0093(gene name synonym)|uniprotkb:NEDD4-1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 53 protein(gene name synonym)|uniprotkb:PIG53(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2016)	pubmed:27927196|imex:IM-29109	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27040606|imex:IM-29109-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001271267.1|refseq:NP_001271268.1|refseq:NP_001271269.1|ensembl:ENSG00000069869(gene)|ensembl:ENST00000508342(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010768"(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043197"(dendritic spine)|go:"GO:0044111"(formation of structure involved in a symbiotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046755"(viral budding)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46934|rcsb pdb:2KPZ|rcsb pdb:2KQ0|go:"GO:0050815"(phosphoserine residue binding)|rcsb pdb:2M3O|rcsb pdb:2XBB|rcsb pdb:2XBF|rcsb pdb:3B7Y|rcsb pdb:4BBN|rcsb pdb:4BE8|rcsb pdb:4N7F|rcsb pdb:4N7H|rcsb pdb:5AHT|rcsb pdb:5C7J|rcsb pdb:5C91|reactome:R-HSA-1169408|reactome:R-HSA-1253288|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-983168|refseq:NP_006145.2|refseq:NP_940682.2|ensembl:ENST00000338963|ensembl:ENSP00000345530|ensembl:ENST00000435532|ensembl:ENSP00000410613|ensembl:ENST00000506154|ensembl:ENSP00000422705|ensembl:ENSP00000424827|refseq:NP_001316141.1|dip:DIP-29815N	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	-	-	-	figure legend:7a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/22	2021/07/22	rogid:R0IvurHHFLE8EYZK1hRLsSwbs5I9606	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	rigid:SEmoma9ZZVmS0vcoKt1AA6Y2USE	false	-	mutation disrupting interaction strength:23-23,61-61|sufficient binding region:1-77|glutathione s tranferase tag:n-n|mutation with no effect:61-61|mutation disrupting interaction strength:23-23	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P46934	uniprotkb:Q99732	intact:EBI-726944|ensembl:ENSP00000424827|uniprotkb:A1KY35|uniprotkb:A6ND72|uniprotkb:A7MD29|uniprotkb:B4E2R7|uniprotkb:B7ZM59|uniprotkb:B7ZM60|uniprotkb:B9EGN5|uniprotkb:D6RF89|intact:EBI-28969445	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	psi-mi:nedd4_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:NEDD4(gene name)|psi-mi:NEDD4(display_short)|uniprotkb:KIAA0093(gene name synonym)|uniprotkb:NEDD4-1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 53 protein(gene name synonym)|uniprotkb:PIG53(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ho et al. (2016)	pubmed:27927196|imex:IM-29109	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27047193|imex:IM-29109-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001271267.1|refseq:NP_001271268.1|refseq:NP_001271269.1|ensembl:ENSG00000069869(gene)|ensembl:ENST00000508342(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010768"(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043197"(dendritic spine)|go:"GO:0044111"(formation of structure involved in a symbiotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046755"(viral budding)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46934|rcsb pdb:2KPZ|rcsb pdb:2KQ0|go:"GO:0050815"(phosphoserine residue binding)|rcsb pdb:2M3O|rcsb pdb:2XBB|rcsb pdb:2XBF|rcsb pdb:3B7Y|rcsb pdb:4BBN|rcsb pdb:4BE8|rcsb pdb:4N7F|rcsb pdb:4N7H|rcsb pdb:5AHT|rcsb pdb:5C7J|rcsb pdb:5C91|reactome:R-HSA-1169408|reactome:R-HSA-1253288|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-983168|refseq:NP_006145.2|refseq:NP_940682.2|ensembl:ENST00000338963|ensembl:ENSP00000345530|ensembl:ENST00000435532|ensembl:ENSP00000410613|ensembl:ENST00000506154|ensembl:ENSP00000422705|ensembl:ENSP00000424827|refseq:NP_001316141.1|dip:DIP-29815N	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	-	-	-	figure legend:7b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/22	2021/07/26	rogid:R0IvurHHFLE8EYZK1hRLsSwbs5I9606	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	rigid:SEmoma9ZZVmS0vcoKt1AA6Y2USE	false	sufficient binding region:596-944|glutathione s tranferase tag:n-n	glutathione s tranferase tag:n-n|sufficient binding region:1-113,140-161|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16038"	uniprotkb:Q99732	intact:EBI-2936614|chebi:"CHEBI:26030"|chebi:"CHEBI:26031"|chebi:"CHEBI:14803"|chebi:"CHEBI:7661"|chebi:"CHEBI:45210"|chebi:"CHEBI:8129"|chebi:"CHEBI:12701"|chebi:"CHEBI:563080"	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	psi-mi:phosphatidylethanolamine(display_short)|psi-mi:"CHEBI:16038"(display_long)|intact:"phosphatidyl(amino)ethanols"(iupac name)|intact:phosphatidylethanolamines(iupac name)	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ho et al. (2016)	pubmed:27927196|imex:IM-29109	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27047210|imex:IM-29109-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	-	standard inchi:	-	figure legend:S10, S11, S13|comment:V144M pathogenic mutation possibly misfolds LITAF domain on the surface of membranes and potentially have deleterious effects on intracellular membranes involved in endocytic traffic.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/22	2021/07/27	-	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	-	false	-	glutathione s tranferase tag:n-n|15n label:?-?|sufficient binding region:1-113,140-161|mutation:144-144(rs121908615)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99732	uniprotkb:Q99732	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ho et al. (2016)	pubmed:27927196|imex:IM-29109	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27047264|imex:IM-29109-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	-	-	-	figure legend:S8|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/22	2021/07/26	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	rigid:q/W80xAlhht2yI72+2/ddS6CZ3k	false	sufficient binding region:108-143	glutathione s tranferase tag:n-n|15n label:?-?|sufficient binding region:1-113,140-161	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99732	uniprotkb:Q99732	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	intact:EBI-725647|uniprotkb:Q05DW0|uniprotkb:Q9C0L6|uniprotkb:D3DUG1|uniprotkb:G5E9K0|ensembl:ENSP00000340118|ensembl:ENSP00000459138|ensembl:ENSP00000461667|ensembl:ENSP00000461813|ensembl:ENSP00000483114|ensembl:ENSP00000459533	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:litaf_human(display_long)|uniprotkb:p53-induced gene 7 protein(gene name synonym)|uniprotkb:Small integral membrane protein of lysosome/late endosome(gene name synonym)|uniprotkb:LITAF(gene name)|psi-mi:LITAF(display_short)|uniprotkb:PIG7(gene name synonym)|uniprotkb:SIMPLE(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Ho et al. (2016)	pubmed:27927196|imex:IM-29109	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27047184|imex:IM-29109-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	refseq:NP_001129944.1|refseq:NP_001129945.1|refseq:NP_004853.2|ensembl:ENSP00000340118|ensembl:ENST00000413364|ensembl:ENSP00000397958|ensembl:ENSP00000459138|ensembl:ENSP00000459533|ensembl:ENSP00000461813|ensembl:ENSP00000461667|ensembl:ENSP00000483114|ensembl:ENSG00000189067(gene)|ensembl:ENST00000339430(transcript)|ensembl:ENST00000570904(transcript)|ensembl:ENST00000571688(transcript)|ensembl:ENST00000574763(transcript)|ensembl:ENST00000576036(transcript)|ensembl:ENST00000622633(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519|refseq:XP_006721047.1|refseq:XP_006721048.1|refseq:XP_006721045.1|refseq:XP_006721046.1|refseq:XP_016879385.1	go:"GO:0051260"(protein homooligomerization)	-	-	figure legend:S7c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/22	2021/07/26	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	rogid:HZ9UqRSriXYNDDuUJnnrIUJtKyo9606	rigid:q/W80xAlhht2yI72+2/ddS6CZ3k	false	sufficient binding region:108-143	sufficient binding region:108-142	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)