#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14520	uniprotkb:O60240	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-26906001|ensembl:ENSP00000300055|ensembl:ENSP00000402167|uniprotkb:Q8N5Y6	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:plin1_human(display_long)|uniprotkb:PLIN1(gene name)|psi-mi:PLIN1(display_short)|uniprotkb:PERI(gene name synonym)|uniprotkb:PLIN(gene name synonym)|uniprotkb:Lipid droplet-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26905987|imex:IM-28861-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	ensembl:ENSG00000166819(gene)|ensembl:ENST00000300055(transcript)|ensembl:ENST00000430628(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016042"(lipid catabolic process)|interpro:IPR004279(Perilipin)|interpro:IPR042998|reactome:R-HSA-163560|reactome:R-HSA-381340|reactome:R-HSA-9031528|refseq:NP_001138783.1|refseq:NP_002657.3|refseq:XP_005254991.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:EYytXkwqsrYQBbRueshCP56h8mg9606	rigid:SlXtgcsZISnltw1NZ/wigNw92Kk	false	maltose binding protein tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14520	uniprotkb:Q12797	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-2967294|ensembl:ENSP00000368767|uniprotkb:B4E2K4|uniprotkb:F5H667|uniprotkb:Q9NRI0|uniprotkb:Q9Y4J0|uniprotkb:Q9H2C4|uniprotkb:A6NDF4|uniprotkb:Q9NRI1|uniprotkb:A6NHI2|uniprotkb:B4DIC9|uniprotkb:B7ZM95|uniprotkb:E5RGP5|uniprotkb:Q6NXR7|uniprotkb:Q8TB28|uniprotkb:Q9H291|intact:EBI-8994140|uniprotkb:A0A0A0MSK8	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:asph_human(display_long)|uniprotkb:ASPH(gene name)|psi-mi:ASPH(display_short)|uniprotkb:Aspartate beta-hydroxylase(gene name synonym)|uniprotkb:Peptide-aspartate beta-dioxygenase(gene name synonym)|uniprotkb:BAH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26905987|imex:IM-28861-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	ensembl:ENSG00000198363(gene)|ensembl:ENST00000379454(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033198"(response to ATP)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0062101"(peptidyl-aspartic acid 3-dioxygenase activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR007803(Aspartyl/Asparaginyl beta-hydroxylase)|interpro:IPR007943(Aspartyl beta-hydroxylase, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5APA|rcsb pdb:5JQY|interpro:IPR019734|rcsb pdb:5JTC|interpro:IPR027443|interpro:IPR039038|rcsb pdb:5JZ6|mint:Q12797|rcsb pdb:5JZ8|rcsb pdb:5JZA|rcsb pdb:5JZU|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6QA5|rcsb pdb:6RK9|rcsb pdb:6YYU|rcsb pdb:6YYV|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|reactome:R-HSA-5578775|reactome:R-HSA-2672351|refseq:NP_001158222.1|refseq:NP_004309.2|refseq:NP_064549.1|refseq:NP_115855.1|refseq:NP_115856.1|refseq:NP_001158223.1|refseq:NP_001158225.1|refseq:NP_001158227.1|refseq:NP_001158228.1|refseq:NP_115857.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:8Sv1CuwqdVCK6/PF6kL0hkX3/tw9606	rigid:SlXtgcsZISnltw1NZ/wigNw92Kk	false	maltose binding protein tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14520	uniprotkb:P35908	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26905987|imex:IM-28861-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606	rigid:SlXtgcsZISnltw1NZ/wigNw92Kk	false	maltose binding protein tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14520	uniprotkb:P04259	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-740907|ensembl:ENSP00000252252|uniprotkb:P48669	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:k2c6b_human(display_long)|uniprotkb:Cytokeratin-6B(gene name synonym)|uniprotkb:Keratin-6B(gene name synonym)|uniprotkb:KRT6B(gene name)|psi-mi:KRT6B(display_short)|uniprotkb:K6B(gene name synonym)|uniprotkb:KRTL1(gene name synonym)|uniprotkb:Type-II keratin Kb10(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26905987|imex:IM-28861-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	refseq:NP_005546.2|ensembl:ENSG00000185479(gene)|ensembl:ENST00000252252(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0007398"(ectoderm development)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P04259|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:lFuNGZdQm4pftz53qbflLTyyAaQ9606	rigid:SlXtgcsZISnltw1NZ/wigNw92Kk	false	maltose binding protein tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14520	uniprotkb:Q8TF72	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-2622657|uniprotkb:Q9P247|uniprotkb:Q5QTQ3|uniprotkb:Q96IR9|uniprotkb:Q6ZRW3|ensembl:ENSP00000296043	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:shrm3_human(display_long)|uniprotkb:KIAA1481(gene name synonym)|uniprotkb:SHRML(gene name synonym)|uniprotkb:Shroom-related protein(gene name synonym)|uniprotkb:MSTP013(orf name)|uniprotkb:SHROOM3(gene name)|psi-mi:SHROOM3(display_short)	psi-mi:"MI:0096"(pull down)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26905987|imex:IM-28861-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	refseq:NP_065910.3|ensembl:ENSG00000138771(gene)|ensembl:ENST00000296043(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0002064"(epithelial cell development)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007389"(pattern specification process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043296"(apical junction complex)|go:"GO:0043482"(cellular pigment accumulation)|go:"GO:0045176"(apical protein localization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR014799(Apx/shroom, ASD2)|interpro:IPR014800(Apx/shroom, ASD1)|interpro:IPR027685|interpro:IPR030494|interpro:IPR036034|mint:Q8TF72|rcsb pdb:6FBB|rcsb pdb:6FCP|ensembl:ENSP00000296043	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:0MpUunWh5c6Wwa8ep6BgurgU8e89606	rigid:SlXtgcsZISnltw1NZ/wigNw92Kk	false	maltose binding protein tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14520	uniprotkb:P35527	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-356382|uniprotkb:O00109|uniprotkb:Q0IJ47|uniprotkb:Q14665|ensembl:ENSP00000246662	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:k1c9_human(display_long)|uniprotkb:KRT9(gene name)|psi-mi:KRT9(display_short)|uniprotkb:Keratin-9(gene name synonym)|uniprotkb:Cytokeratin-9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26905987|imex:IM-28861-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	refseq:NP_000217.2|ensembl:ENSG00000171403(gene)|ensembl:ENST00000246662(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0043588"(skin development)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P35527|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:m4EXfxbK2t1/EmI04YODKTJ02Zw9606	rigid:SlXtgcsZISnltw1NZ/wigNw92Kk	false	maltose binding protein tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14520	uniprotkb:O60240	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-26906001|ensembl:ENSP00000300055|ensembl:ENSP00000402167|uniprotkb:Q8N5Y6	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:plin1_human(display_long)|uniprotkb:PLIN1(gene name)|psi-mi:PLIN1(display_short)|uniprotkb:PERI(gene name synonym)|uniprotkb:PLIN(gene name synonym)|uniprotkb:Lipid droplet-associated protein(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26906047|imex:IM-28861-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	ensembl:ENSG00000166819(gene)|ensembl:ENST00000300055(transcript)|ensembl:ENST00000430628(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016042"(lipid catabolic process)|interpro:IPR004279(Perilipin)|interpro:IPR042998|reactome:R-HSA-163560|reactome:R-HSA-381340|reactome:R-HSA-9031528|refseq:NP_001138783.1|refseq:NP_002657.3|refseq:XP_005254991.1	-	-	-	figure legend:Figs. 2, 7|comment:Isoprenaline-stimulated adipocytes exhibited significantly less AQP7-PLIN1complexes as compared to adipocytes stimulated withinsulin|agonist:"Isoprenaline (CHEBI:64317)"|agonist:"Insulin (CHEBI:145810)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-adipocyte)|taxid:9606(human adipocyte)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:EYytXkwqsrYQBbRueshCP56h8mg9606	rigid:oAWrRe048YKaUtovmNvjMCjuxBY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O14520	uniprotkb:O60240	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-26906001|ensembl:ENSP00000300055|ensembl:ENSP00000402167|uniprotkb:Q8N5Y6	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:plin1_human(display_long)|uniprotkb:PLIN1(gene name)|psi-mi:PLIN1(display_short)|uniprotkb:PERI(gene name synonym)|uniprotkb:PLIN(gene name synonym)|uniprotkb:Lipid droplet-associated protein(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26906073|imex:IM-28861-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	ensembl:ENSG00000166819(gene)|ensembl:ENST00000300055(transcript)|ensembl:ENST00000430628(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016042"(lipid catabolic process)|interpro:IPR004279(Perilipin)|interpro:IPR042998|reactome:R-HSA-163560|reactome:R-HSA-381340|reactome:R-HSA-9031528|refseq:NP_001138783.1|refseq:NP_002657.3|refseq:XP_005254991.1	-	-	-	figure legend:Figs. 3, 4, 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:EYytXkwqsrYQBbRueshCP56h8mg9606	rigid:oAWrRe048YKaUtovmNvjMCjuxBY	false	his tag:c-c|necessary binding region:1-33|necessary binding region:279-342|mutation disrupting interaction strength:10-11|phosphorylated residue:?-?	maltose binding protein tag:n-n|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14520	uniprotkb:O60240	intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3	intact:EBI-26906001|ensembl:ENSP00000300055|ensembl:ENSP00000402167|uniprotkb:Q8N5Y6	psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym)	psi-mi:plin1_human(display_long)|uniprotkb:PLIN1(gene name)|psi-mi:PLIN1(display_short)|uniprotkb:PERI(gene name synonym)|uniprotkb:PLIN(gene name synonym)|uniprotkb:Lipid droplet-associated protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Hansen et al. (2016)	pubmed:27832861|imex:IM-28861	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26906173|imex:IM-28861-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1	ensembl:ENSG00000166819(gene)|ensembl:ENST00000300055(transcript)|ensembl:ENST00000430628(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016042"(lipid catabolic process)|interpro:IPR004279(Perilipin)|interpro:IPR042998|reactome:R-HSA-163560|reactome:R-HSA-381340|reactome:R-HSA-9031528|refseq:NP_001138783.1|refseq:NP_002657.3|refseq:XP_005254991.1	-	-	-	figure legend:Fig. 6|comment:In insulin-stimulated adipocytes, AQP7 and PLIN1co-distribute to apparent clusters, whereas this enrichment pattern disappears with isoprenaline treatment,resulting in a more homogenous distribution|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-adipocyte)|taxid:9606(human adipocyte)	-	2021/04/06	2021/04/09	rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606	rogid:EYytXkwqsrYQBbRueshCP56h8mg9606	rigid:oAWrRe048YKaUtovmNvjMCjuxBY	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)