#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96LT7	uniprotkb:Q9Z2X2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-8377084|uniprotkb:Q8R0G2|intact:MINT-4108931|uniprotkb:Q9D383|uniprotkb:Q9D7N8|ensembl:ENSMUSP00000033805	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:psd10_mouse(display_long)|uniprotkb:Psmd10(gene name)|psi-mi:Psmd10(display_short)|uniprotkb:26S proteasome regulatory subunit p28(gene name synonym)|uniprotkb:Gankyrin(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001157649.1|refseq:NP_058579.2|dip:DIP-29273N|ensembl:ENSMUSG00000031429(gene)|ensembl:ENSMUST00000033805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR039334|mint:Q9Z2X2|rcsb pdb:2DVW|rcsb pdb:2DWZ|rcsb pdb:3AJI|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168	-	-	comment:mint|function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:R68sNKuim/wxhCNtlGeZKUJFS+I10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q5EG47	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-7282395|intact:UNK-5438461|ensembl:ENSMUSP00000063166	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:aapk1_mouse(display_long)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001013385.3|ensembl:ENSMUSG00000050697(gene)|ensembl:ENSMUST00000051186(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q5EG47|rcsb pdb:5UFU|reactome:R-MMU-1632852|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6804756|dip:DIP-47622N	-	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint|comment:homomint	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:9VI1u7JfAe+OsB+ncOxDv5ujYuE10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:O08547	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-8400083|intact:MINT-1865345|uniprotkb:Q91VU3|ensembl:ENSMUSP00000029476	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:sc22b_mouse(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:Sec22l1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_035472.1|dip:DIP-60852N|ensembl:ENSMUSG00000027879(gene)|ensembl:ENSMUST00000029476(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O08547|rcsb pdb:1IFQ|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-MMU-1236974|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6811434	-	-	comment:mint|function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DRKtD169T9eYZ2kFufLapidvcKs10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q6P8X1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-8393689|uniprotkb:Q9CZ03|intact:MINT-2634295|intact:MINT-4126065|ensembl:ENSMUSP00000005798	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:snx6_mouse(display_long)|uniprotkb:Snx6(gene name)|psi-mi:Snx6(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_081274.2|ensembl:ENSMUSG00000005656(gene)|ensembl:ENSMUST00000005798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030904"(retromer complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034452"(dynactin binding)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097422"(tubular endosome)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR001683(Phox-like)|interpro:IPR014637(Sorting nexin, Snx5/Snx6 types)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028657|interpro:IPR036871|interpro:IPR042136|mint:Q6P8X1	-	-	comment:mint|function:May be involved in several stages of intracellular trafficking	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:RwXaINdRkGvsfz3rn4UT00VXECE10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P46467	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-8376721|uniprotkb:Q9R1C9|intact:MINT-4134751|uniprotkb:Q91W22|ensembl:ENSMUSP00000092230|ensembl:ENSMUSP00000108356	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:vps4b_mouse(display_long)|uniprotkb:Vps4b(gene name)|psi-mi:Vps4b(display_short)|uniprotkb:Skd1(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_033216.2|ensembl:ENSMUSG00000009907(gene)|ensembl:ENSMUST00000094646(transcript)|ensembl:ENSMUST00000112736(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|mint:P46467|rcsb pdb:2ZAM|rcsb pdb:2ZAN|rcsb pdb:2ZAO|reactome:R-MMU-917729|go:"GO:0060548"(negative regulation of cell death)	-	-	comment:mint|function:Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:tFsDkaTSjYzjusKyc8i4dyAAaWA10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q6PA06	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-26613672|ensembl:ENSMUSP00000064758|uniprotkb:Q3UX01|uniprotkb:Q7TMM3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:atla2_mouse(display_long)|uniprotkb:ADP-ribosylation factor-like protein 6-interacting protein 2(gene name synonym)|uniprotkb:Atl2(gene name)|psi-mi:Atl2(display_short)|uniprotkb:Arl6ip2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000059811(gene)|ensembl:ENSMUST00000068282(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|mint:Q6PA06|refseq:NP_062691.3|refseq:NP_835151.2	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:WgZoAP8sIyCoXFIhfxLQLWWbSu010090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8BGH2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2934811|ensembl:ENSMUSP00000023071|uniprotkb:Q3TIL3|uniprotkb:Q3TTG7|uniprotkb:Q3TWD3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:sam50_mouse(display_long)|uniprotkb:Samm50(gene name)|psi-mi:Samm50(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000022437(gene)|ensembl:ENSMUST00000023071(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q8BGH2|reactome:R-MMU-9013404|refseq:NP_848729.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:OWxecVBGU7/ayT7jqSrqeKmr5fw10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8R5A6	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-26613651|ensembl:ENSMUSP00000065721|uniprotkb:Q3U268|uniprotkb:Q3U3T0|uniprotkb:Q8CA49	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:tb22a_mouse(display_long)|uniprotkb:Tbc1d22a(gene name)|psi-mi:Tbc1d22a(display_short)|uniprotkb:D15Ertd781e(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000051864(gene)|ensembl:ENSMUST00000063414(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|mint:Q8R5A6|refseq:NP_663451.2|refseq:XP_017172065.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:nY0u3PQ25y6Y8jRBiHoSMjCo63I10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q91YL2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-26613619|ensembl:ENSMUSP00000039486	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rn126_mouse(display_long)|uniprotkb:RING finger protein 126(gene name synonym)|uniprotkb:Rnf126(gene name)|psi-mi:Rnf126(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000035890(gene)|ensembl:ENSMUST00000047203(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR039525|interpro:IPR039571|interpro:IPR039572|mint:Q91YL2|rcsb pdb:2ECT|reactome:R-MMU-983168|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|refseq:NP_653111.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:lTvV1ekJ9tr7GX+gOiLBA8bUIW810090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9R1P0	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-772804|uniprotkb:Q3THT1|ensembl:ENSMUSP00000034848	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:psa4_mouse(display_long)|uniprotkb:Proteasome component C9(gene name synonym)|uniprotkb:Macropain subunit C9(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C9(gene name synonym)|uniprotkb:Proteasome subunit L(gene name synonym)|uniprotkb:Psma4(gene name)|psi-mi:Psma4(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_036096.1|refseq:XP_006511261.1|ensembl:ENSMUSG00000032301(gene)|ensembl:ENSMUST00000034848(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034647|mint:Q9R1P0|rcsb pdb:3UNB|rcsb pdb:3UNE|rcsb pdb:3UNF|rcsb pdb:3UNH|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:6Dp8VODK8RbwARcOjjpMbvCN1pU10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:O35963	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-6379521|ensembl:ENSMUSP00000063054|uniprotkb:Q3TWI8	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rb33b_mouse(display_long)|uniprotkb:Rab33b(gene name)|psi-mi:Rab33b(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000027739(gene)|ensembl:ENSMUST00000054387(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0098793"(presynapse)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903434"(negative regulation of constitutive secretory pathway)|go:"GO:2000156"(regulation of retrograde vesicle-mediated transport, Golgi to ER)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041822|mint:O35963|rcsb pdb:1Z06|rcsb pdb:2G77|rcsb pdb:6SUR|reactome:R-MMU-6811438|reactome:R-MMU-8854214|reactome:R-MMU-8873719|dip:DIP-60512N|refseq:NP_058554.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:x4MceDjJ1Z+aDXtSU2c7iIc6iuQ10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9ESK9	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-647302|uniprotkb:E9QLQ2|uniprotkb:Q3TXX2|uniprotkb:Q61384|uniprotkb:Q8BRY9|uniprotkb:Q9JK14|ensembl:ENSMUSP00000027040	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rbcc1_mouse(display_long)|uniprotkb:Coiled-coil-forming protein 1(gene name synonym)|uniprotkb:LaXp180(gene name synonym)|uniprotkb:Rb1cc1(gene name)|psi-mi:Rb1cc1(display_short)|uniprotkb:Cc1(gene name synonym)|uniprotkb:Kiaa0203(gene name synonym)|uniprotkb:FAK family kinase-interacting protein of 200 kDa(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_033956.2|dip:DIP-49679N|ensembl:ENSMUSG00000025907(gene)|ensembl:ENSMUST00000027040(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007049"(cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0061723"(glycophagy)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR019460|interpro:IPR040040|mint:Q9ESK9|reactome:R-MMU-1632852	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DiOKxKS7K4NtKX4DqF9ZtpkcOcc10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8BHC1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-10767682|uniprotkb:Q3TUJ3|ensembl:ENSMUSP00000033545	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rb39b_mouse(display_long)|uniprotkb:Rab39b(gene name)|psi-mi:Rab39b(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_780331.1|ensembl:ENSMUSG00000031202(gene)|ensembl:ENSMUST00000033545(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|mint:Q8BHC1|reactome:R-MMU-8873719|reactome:R-MMU-8876198	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:yAgR+bATJvGN1eFagBTQAWV4ync10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q921F2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:j1U3NZd8O/lAclOPSRt10NY58e810090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q64337	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-645025|uniprotkb:Q99JM8|ensembl:ENSMUSP00000099835	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:sqstm_mouse(display_long)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:STONE14(gene name synonym)|uniprotkb:Sqstm1(gene name)|psi-mi:Sqstm1(display_short)|uniprotkb:A170(gene name synonym)|uniprotkb:STAP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001277698.1|refseq:NP_035148.1|ensembl:ENSMUSG00000015837(gene)|ensembl:ENSMUST00000102774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033741|interpro:IPR034866|interpro:IPR043145|mint:Q64337|rcsb pdb:2RRU|rcsb pdb:2ZJD|rcsb pdb:3ADE|rcsb pdb:3B0F|rcsb pdb:3WDZ|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-5205685|reactome:R-MMU-9020702|reactome:R-MMU-9664873|dip:DIP-38490N	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:/BktZPkmiLsU1fKVqPSQ8ae2+SY10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:A2AH22	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-4284600|uniprotkb:Q3UF70|uniprotkb:Q6ZPJ1|uniprotkb:Q8BJJ8|uniprotkb:Q8BYW8|uniprotkb:A2AH21|uniprotkb:A2AH24|uniprotkb:Q3U239|uniprotkb:Q3TF60|ensembl:ENSMUSP00000049258	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:amra1_mouse(display_long)|uniprotkb:Ambra1(gene name)|psi-mi:Ambra1(display_short)|uniprotkb:Kiaa1736(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001074223.1|refseq:NP_766257.3|refseq:XP_006499316.1|ensembl:ENSMUSG00000040506(gene)|ensembl:ENSMUST00000045705(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0021915"(neural tube development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:A2AH22|reactome:R-MMU-1632852|go:"GO:0051020"(GTPase binding)	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:fKzPYvVBztq0TCsNtvLQyHU5Z8U10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9JKF1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-644633|ensembl:ENSMUSP00000128278|uniprotkb:G3UW45	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:iqga1_mouse(display_long)|uniprotkb:Iqgap1(gene name)|psi-mi:Iqgap1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|ensembl:ENSMUSG00000030536(gene)|ensembl:ENSMUST00000167377(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0031252"(cell leading edge)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:Q9JKF1|reactome:R-MMU-373753|reactome:R-MMU-5626467|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-MMU-9013149|refseq:NP_057930.2|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:qjWT+er4GkLOlebk3zzRHh2Iqoo10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P07901	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-78930|ensembl:ENSMUSP00000021698|ensembl:ENSMUSP00000091921	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:hs90a_mouse(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hsp86(gene name synonym)|uniprotkb:Hsp86-1(gene name synonym)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 86 kDa antigen(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_034610.1|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07901|rcsb pdb:5H22|reactome:R-MMU-1227986|reactome:R-MMU-1474151|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-203615|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-5218920|reactome:R-MMU-5620912|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8863795|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9013418|reactome:R-MMU-9018519|reactome:R-MMU-9652282|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|ensembl:ENSMUSG00000021270(gene)|ensembl:ENSMUST00000021698(transcript)|ensembl:ENSMUST00000094361(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042026"(protein refolding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|dip:DIP-30975N	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:t9XAeXdXezYOtJX0wp3IY9/ZMkQ10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9JHU4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P63017	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-433443|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q3U6R0|uniprotkb:Q3U764|uniprotkb:Q3U7D7|uniprotkb:Q3U7E2|uniprotkb:Q3U9B4|uniprotkb:Q3U9G0|uniprotkb:Q3UGM0|uniprotkb:Q5FWJ6|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375|uniprotkb:Q6NZD0|ensembl:ENSMUSP00000015800	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:hsp7c_mouse(display_long)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_112442.2|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0030425"(dendrite)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005681"(spliceosomal complex)|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-450408|reactome:R-MMU-6798695|reactome:R-MMU-72163|reactome:R-MMU-8856828|reactome:R-MMU-8876725|reactome:R-MMU-888590|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P63017|rcsb pdb:3CQX|reactome:R-MMU-3371453|reactome:R-MMU-3371497|ensembl:ENSMUSG00000015656(gene)|ensembl:ENSMUST00000015800(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|dip:DIP-32353N	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q7TMY8	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8BND3	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-22226055|ensembl:ENSMUSP00000082895|uniprotkb:E9QLW3|uniprotkb:Q8CDL4	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr35_mouse(display_long)|uniprotkb:Wdr35(gene name)|psi-mi:Wdr35(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097421"(liver regeneration)|go:"GO:1905705"(cellular response to paclitaxel)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017233(WD repeat protein 35)|interpro:IPR024977|interpro:IPR036322|mint:Q8BND3|reactome:R-MMU-5610787|reactome:R-MMU-5620924|ensembl:ENSMUSG00000066643(gene)|ensembl:ENSMUST00000085745(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035721"(intraciliary retrograde transport)|refseq:NP_001152999.1|refseq:NP_766058.3	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:4KhFFny5IFgyeBXYu3FaGFkw93U10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9JIS5	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-911297|uniprotkb:Q80TT0|uniprotkb:Q8R0R5|ensembl:ENSMUSP00000037576	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:sv2a_mouse(display_long)|uniprotkb:Calcium regulator SV2A(gene name synonym)|uniprotkb:Sv2a(gene name)|psi-mi:Sv2a(display_short)|uniprotkb:Kiaa0736(gene name synonym)|uniprotkb:Sv2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_071313.1|ensembl:ENSMUSG00000038486(gene)|ensembl:ENSMUST00000035371(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014052"(regulation of gamma-aminobutyric acid secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR001646(Pentapeptide repeat)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR022308|interpro:IPR036259|mint:Q9JIS5	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:bIEjg35nYkj/s0a7BvwB8Q8gbbk10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8CFD4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-9987935|ensembl:ENSMUSP00000031539|uniprotkb:Q8BLI6|uniprotkb:Q8BUQ7	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:snx8_mouse(display_long)|uniprotkb:Snx8(gene name)|psi-mi:Snx8(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000029560(gene)|ensembl:ENSMUST00000031539(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001683(Phox-like)|interpro:IPR027267|interpro:IPR028662|interpro:IPR035704|interpro:IPR036871|mint:Q8CFD4|go:"GO:0035091"(phosphatidylinositol binding)|refseq:NP_758481.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:lpEXla4dFEb9U1Du6tud2giVy5U10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9WTV7	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-15657872|ensembl:ENSMUSP00000070662|ensembl:ENSMUSP00000112820|uniprotkb:Q8CE02|uniprotkb:Q91X19|uniprotkb:Q9CYY2	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rnf12_mouse(display_long)|uniprotkb:Rlim(gene name)|psi-mi:Rlim(display_short)|uniprotkb:Rnf12(gene name synonym)|uniprotkb:LIM domain-interacting RING finger protein(gene name synonym)|uniprotkb:RING finger LIM domain-binding protein(gene name synonym)|uniprotkb:RING finger protein 12(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RLIM(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0060816"(random inactivation of X chromosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1900095"(regulation of dosage compensation by inactivation of X chromosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q9WTV7|reactome:R-MMU-983168|ensembl:ENSMUSG00000056537(gene)|ensembl:ENSMUST00000070705(transcript)|ensembl:ENSMUST00000121153(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004842"(ubiquitin-protein transferase activity)|refseq:NP_035406.3|refseq:XP_006527981.1|refseq:XP_006527982.1|refseq:XP_006527983.1|refseq:XP_006527984.1|refseq:XP_011245853.1|refseq:XP_011245854.1|dip:DIP-46445N	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:0TiKb6g8OlXWV7/IpzFOAvgXkxg10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q99KJ8	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-776048|ensembl:ENSMUSP00000026479	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:dctn2_mouse(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:Growth cone membrane protein 23-48K(gene name synonym)|uniprotkb:Dctn2(gene name)|psi-mi:Dctn2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_081427.1|ensembl:ENSMUSG00000025410(gene)|ensembl:ENSMUST00000026479(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q99KJ8|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:D7u4MT5Zl5mRBQ/zsTwhYP0WHoU10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:O35226	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-992034|uniprotkb:Q91V59|uniprotkb:Q9JJM0|uniprotkb:Q9JJM1|uniprotkb:Q9JJM2|uniprotkb:Q9JJM3|ensembl:ENSMUSP00000102857	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:psmd4_mouse(display_long)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Psmd4(gene name)|psi-mi:Psmd4(display_short)|uniprotkb:Mcb1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_032977.1|ensembl:ENSMUSG00000005625(gene)|ensembl:ENSMUST00000107237(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR036465|mint:O35226|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-4608870|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-8948751|refseq:NP_001268946.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:foAsSSZ5pvYhKvPA4XUyZCVjo3010090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P35279	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-444674|uniprotkb:Q542M6|uniprotkb:Q8R2Z7|uniprotkb:Q8VEE5|uniprotkb:Q9JJD4|ensembl:ENSMUSP00000032946	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rab6a_mouse(display_long)|uniprotkb:Rab6a(gene name)|psi-mi:Rab6a(display_short)|uniprotkb:Rab6(gene name synonym)|uniprotkb:MNCb-1660(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001157135.1|refseq:NP_077249.1|ensembl:ENSMUSG00000030704(gene)|ensembl:ENSMUST00000032946(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0051117"(ATPase binding)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P35279|reactome:R-MMU-6798695|reactome:R-MMU-6811436|reactome:R-MMU-6811440|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|dip:DIP-120N	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:dvs8ZexwDDVZ3QFifBZ+id2D0+k10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9WUN2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-764193|uniprotkb:Q9CT90|uniprotkb:Q9DC03|ensembl:ENSMUSP00000020316	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:tbk1_mouse(display_long)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:Tbk1(gene name)|psi-mi:Tbk1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_062760.3|dip:DIP-29880N|interpro:IPR041087|interpro:IPR041309|mint:Q9WUN2|rcsb pdb:4JL9|rcsb pdb:4JLC|rcsb pdb:6O8C|reactome:R-MMU-168928|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-9008059|reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000020115(gene)|ensembl:ENSMUST00000020316(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:yuQ8W5zOu+0zBDNIy3E3Ox8375410090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9D0I4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-6555785|ensembl:ENSMUSP00000068087|ensembl:ENSMUSP00000103348|uniprotkb:B1AVI3|uniprotkb:Q9D330	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:stx17_mouse(display_long)|uniprotkb:Stx17(gene name)|psi-mi:Stx17(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0030897"(HOPS complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:Q9D0I4|reactome:R-MMU-204005|ensembl:ENSMUSG00000061455(gene)|ensembl:ENSMUST00000064765(transcript)|ensembl:ENSMUST00000107720(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|refseq:XP_006538271.1|refseq:NP_080619.2	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:g/7oOJpb5lVRHLHudioH5iKIPaM10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q504M8	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-11567634|ensembl:ENSMUSP00000046089	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rab26_mouse(display_long)|uniprotkb:Rab26(gene name)|psi-mi:Rab26(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_796349.1|ensembl:ENSMUSG00000079657(gene)|ensembl:ENSMUST00000035797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q504M8|reactome:R-MMU-8873719	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:rmv0KSaLCFvGxU4/FDCVBB2grVQ10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9CX56	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-992174|ensembl:ENSMUSP00000051657|ensembl:ENSMUSP00000139514	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:psmd8_mouse(display_long)|uniprotkb:26S proteasome regulatory subunit S14(gene name synonym)|uniprotkb:Psmd8(gene name)|psi-mi:Psmd8(display_short)|uniprotkb:26S proteasome regulatory subunit RPN12(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_080821.3|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|ensembl:ENSMUSG00000030591(gene)|ensembl:ENSMUST00000059642(transcript)|ensembl:ENSMUST00000186182(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464|mint:Q9CX56|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-450408|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:UOsL1gyor8Egth0rODbs7kEMbRs10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q920Q4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-775797|uniprotkb:A2BI91|uniprotkb:Q8R3C3|uniprotkb:Q99KZ4	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:vps16_mouse(display_long)|uniprotkb:Vps16(gene name)|psi-mi:Vps16(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR038132|mint:Q920Q4|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033263"(CORVET complex)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:7XQzmHj2pjKXXSGR6yOyO+cUjfg10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8K4Q0	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-4567273|uniprotkb:Q8C9W9|uniprotkb:Q8CBY4|uniprotkb:Q8CDY8|uniprotkb:Q9D4H3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rptor_mouse(display_long)|uniprotkb:Rptor(gene name)|psi-mi:Rptor(display_short)|uniprotkb:Raptor(gene name synonym)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	mint:Q8K4Q0|dip:DIP-46324N|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-3371571|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:5e8iFGgviuWnhLs/d4+zuYX3bik10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P55258	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-398411|uniprotkb:Q8VCF6|ensembl:ENSMUSP00000003121	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rab8a_mouse(display_long)|uniprotkb:Rab8a(gene name)|psi-mi:Rab8a(display_short)|uniprotkb:Mel(gene name synonym)|uniprotkb:Rab8(gene name synonym)|uniprotkb:Oncogene c-mel(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_075615.2|dip:DIP-31053N|ensembl:ENSMUSG00000003037(gene)|ensembl:ENSMUST00000003121(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P55258|rcsb pdb:2FU5|reactome:R-MMU-2565942|reactome:R-MMU-5620912|reactome:R-MMU-5620916|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0098978"(glutamatergic synapse)	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:SE+1h+U6C8cAN2UTBIDapsUt4zA10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9WUD1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-773027|uniprotkb:Q9DCJ0|ensembl:ENSMUSP00000040431	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:chip_mouse(display_long)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:Stub1(gene name)|psi-mi:Stub1(display_short)|uniprotkb:Chip(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_062693.1|dip:DIP-29751N|ensembl:ENSMUSG00000039615(gene)|ensembl:ENSMUST00000044911(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006457"(protein folding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9WUD1|rcsb pdb:2C2L|rcsb pdb:2C2V|rcsb pdb:3Q47|rcsb pdb:3Q49|rcsb pdb:3Q4A|reactome:R-MMU-2173788|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-8939902|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:C5WR6X2IRpYeSijSpib3cquUaBQ10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:O08788	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-776180|uniprotkb:E9QLJ1|uniprotkb:Q3TZG7|ensembl:ENSMUSP00000109552	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:dctn1_mouse(display_long)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:Dctn1(gene name)|psi-mi:Dctn1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_031861.2|dip:DIP-32057N|ensembl:ENSMUSG00000031865(gene)|ensembl:ENSMUST00000113919(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032402"(melanosome transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:O08788|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:pqj7TtNDgexEbxqLwksW3eW41bo10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P46460	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q3UDP0	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-20938942|ensembl:ENSMUSP00000055145|ensembl:ENSMUSP00000124033|uniprotkb:Q8C4F1|uniprotkb:Q8C8K5	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_mouse(display_long)|uniprotkb:Wdr41(gene name)|psi-mi:Wdr41(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000042015(gene)|ensembl:ENSMUST00000056512(transcript)|ensembl:ENSMUST00000160801(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q3UDP0|refseq:NP_766178.2|refseq:XP_017170980.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:WekYDNvJ2uflDu5a33cMGsVOdL810090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q3UMB5	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-20938909|ensembl:ENSMUSP00000055926|uniprotkb:Q5U4H2|uniprotkb:Q8BNG6|uniprotkb:Q8C704	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_mouse(display_long)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog(gene name synonym)|uniprotkb:Smcr8(gene name)|psi-mi:Smcr8(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000049323(gene)|ensembl:ENSMUST00000056907(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q3UMB5|refseq:NP_001078909.1|refseq:NP_780700.1	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:xSnAlf28Hdm1U/HzFaWjR8GksjM10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9JLV1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-309231|uniprotkb:Q9JJC7|uniprotkb:Q9CQL3|ensembl:ENSMUSP00000033136	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:bag3_mouse(display_long)|uniprotkb:Bag3(gene name)|psi-mi:Bag3(display_short)|uniprotkb:Bis(gene name synonym)|uniprotkb:MNCb-2243(orf name)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_038891.4|ensembl:ENSMUSG00000030847(gene)|ensembl:ENSMUST00000033136(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0101031"(chaperone complex)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:Q9JLV1|rcsb pdb:1UK5|reactome:R-MMU-3371453	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:fShNmv3j2GyP9pJvNxZ7W0YG9sM10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:A2AN08	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P52332	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-646320|uniprotkb:Q62126	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:jak1_mouse(display_long)|uniprotkb:Janus kinase 1(gene name synonym)|uniprotkb:Jak1(gene name)|psi-mi:Jak1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	dip:DIP-41965N|mint:P52332|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-1169408|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020591|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-9674555|reactome:R-MMU-9705462	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:UIkyfJs6ggPxf4nXciyTLPqerSA10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:A2AKX3	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2532140|uniprotkb:A2AKX4|uniprotkb:A2AR33|uniprotkb:Q6IMG6|uniprotkb:Q6PED8|uniprotkb:Q6ZQ81|uniprotkb:Q80V90|uniprotkb:Q8C5P1|uniprotkb:Q8C859|uniprotkb:Q8C8P6|ensembl:ENSMUSP00000051492	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:setx_mouse(display_long)|uniprotkb:Setx(gene name)|psi-mi:Setx(display_short)|uniprotkb:Als4(gene name synonym)|uniprotkb:Kiaa0625(gene name synonym)|uniprotkb:SEN1 homolog(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 4 protein homolog(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26613562|imex:IM-28722-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000043535(gene)|ensembl:ENSMUST00000061578(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060566"(positive regulation of DNA-templated transcription, termination)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:2000806"("positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled")|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|mint:A2AKX3|refseq:NP_932150.2|dip:DIP-56995N	-	-	-	figure legend:fig. 1a table EV1|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/02	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:QQpfcvXSlNxIqCsJqONnS6sWQ2w10090	rigid:P7mx0/u1dQkLRv/wLIDHGkSMomo	false	tandem tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q8TEV9	uniprotkb:Q96LT7	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618010|imex:IM-28722-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	-	-	-	figure legend:fig.1b|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/09	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rigid:1v2bySI3IdYEQbx+lrOl1JSJ7to	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96LT7-1	uniprotkb:Q8TEV9	intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618026|imex:IM-28722-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	-	isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region.	-	figure legend:fig.1b EV1b|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rigid:AZnm9hsaO7Nw36gMcN6XM2yQpvA	false	ha tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96LT7-1	uniprotkb:Q9HAD4	intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618026|imex:IM-28722-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent)	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	-	isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region.	-	figure legend:fig.1b EV1b|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rigid:AZnm9hsaO7Nw36gMcN6XM2yQpvA	false	ha tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:P61006	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618938|imex:IM-28722-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:fig 1d EV1d-e|comment:"Further coimmunoprecipitation assays indicated that the interaction between  C9ORF72 complex and RAB8a or RAB39b is mainly dependent on  the presence of SMCR8 since C9ORF72 or WDR41 alone immunoprecipitated little RAB8a or no RAB39b (Fig EV1D)."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rigid:Hz1imcmCvX4MkY+m4lYm25VtBiY	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:Q96DA2	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-9089467|uniprotkb:Q5JT79|uniprotkb:Q8NEX3|ensembl:ENSP00000358466	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:rb39b_human(display_long)|uniprotkb:RAB39B(gene name)|psi-mi:RAB39B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618949|imex:IM-28722-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	refseq:NP_741995.1|ensembl:ENSG00000155961(gene)|mint:Q96DA2|rcsb pdb:6S5F|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|ensembl:ENST00000369454(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)	-	-	-	figure legend:fig. 1d EV1d-e|comment:"Further coimmunoprecipitation assays indicated that the interaction between  C9ORF72 complex and RAB8a or RAB39b is mainly dependent on  the presence of SMCR8 since C9ORF72 or WDR41 alone immunoprecipitated little RAB8a or no RAB39b (Fig EV1D)."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:2lE8eIl2KSFMUz/cOKCRZmHO9oA9606	rigid:C/Vzzy72xuCBAk8yMx8mOkj3O+o	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:Q969Q5	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-3060998|ensembl:ENSP00000304376|ensembl:ENSP00000377235|uniprotkb:Q7Z4Z7|uniprotkb:A0A024R7N9	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:rab24_human(display_long)|uniprotkb:RAB24(gene name)|psi-mi:RAB24(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618959|imex:IM-28722-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	ensembl:ENSG00000169228(gene)|ensembl:ENST00000303251(transcript)|ensembl:ENST00000393611(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0012505"(endomembrane system)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041828|mint:Q969Q5|reactome:R-HSA-6798695|reactome:R-HSA-8873719|go:"GO:0005525"(GTP binding)|refseq:NP_001026847.1|refseq:NP_570137.2	-	-	-	figure legend:EV1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:P15uXiMhrMXe76ceLdegZCubm/o9606	rigid:H1DqY3iO7u96p1JEX4MEZX35XY8	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:Q13637	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618976|imex:IM-28722-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:EV1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rigid:g0QQClNMF/i7QhT+7IKqQHqZF8s	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:O14966	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618985|imex:IM-28722-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:EV1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rigid:Vrs6IsL51x61+wutNSZiZMNXEfI	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:Q13501	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619272|imex:IM-28722-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:EV2a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:x7cYjWGRsNKubbevc9YDvjbPDQA	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HAD4	uniprotkb:Q13501	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619281|imex:IM-28722-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:EV2a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:zJBznvFVo9/sx1h/5pGeIHZ0EsM	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HAD4	uniprotkb:Q96CV9	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619290|imex:IM-28722-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	-	figure legend:EV2b|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	rigid:i6iCCOG2/MvVt70XNC90H2bqeyI	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61006	uniprotkb:Q13501	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619299|imex:IM-28722-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:EV2c|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:BJDl77DADq12x08KGgbjzEXvSRA	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96DA2	uniprotkb:Q13501	intact:EBI-9089467|uniprotkb:Q5JT79|uniprotkb:Q8NEX3|ensembl:ENSP00000358466	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:rb39b_human(display_long)|uniprotkb:RAB39B(gene name)|psi-mi:RAB39B(display_short)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619308|imex:IM-28722-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_741995.1|ensembl:ENSG00000155961(gene)|mint:Q96DA2|rcsb pdb:6S5F|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|ensembl:ENST00000369454(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	-	-	figure legend:EV2c|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:2lE8eIl2KSFMUz/cOKCRZmHO9oA9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:qYJPYXlqpa8OPdSDJm5Z9tUOjQ8	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEV9	uniprotkb:O75385	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	intact:EBI-908831|uniprotkb:Q9UQ28|ensembl:ENSP00000324560	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:ulk1_human(display_long)|uniprotkb:ULK1(gene name)|psi-mi:ULK1(display_short)|uniprotkb:KIAA0722(gene name synonym)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Autophagy-related protein 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619355|imex:IM-28722-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	refseq:NP_003556.1|dip:DIP-35196N|ensembl:ENSG00000177169(gene)|ensembl:ENST00000321867(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022708|mint:O75385|rcsb pdb:4WNO|rcsb pdb:4WNP|rcsb pdb:5CI7|rcsb pdb:6HYO|rcsb pdb:6MNH|rcsb pdb:6QAS|reactome:R-HSA-1632852|reactome:R-HSA-8854214|reactome:R-HSA-8876198|reactome:R-HSA-8934903	-	-	-	figure legend:EV3c|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/01/18	2021/02/10	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rogid:Q27JsEOr//zWM8N4jycsZdzbALM9606	rigid:yhOn624WpNmGgaIMsHy5/SmIEZc	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3UMB5	uniprotkb:Q8BHC1	intact:EBI-20938909|ensembl:ENSMUSP00000055926|uniprotkb:Q5U4H2|uniprotkb:Q8BNG6|uniprotkb:Q8C704	intact:EBI-10767682|uniprotkb:Q3TUJ3|ensembl:ENSMUSP00000033545	psi-mi:smcr8_mouse(display_long)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog(gene name synonym)|uniprotkb:Smcr8(gene name)|psi-mi:Smcr8(display_short)	psi-mi:rb39b_mouse(display_long)|uniprotkb:Rab39b(gene name)|psi-mi:Rab39b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618067|imex:IM-28722-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000049323(gene)|ensembl:ENSMUST00000056907(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q3UMB5|refseq:NP_001078909.1|refseq:NP_780700.1	refseq:NP_780331.1|ensembl:ENSMUSG00000031202(gene)|ensembl:ENSMUST00000033545(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|mint:Q8BHC1|reactome:R-MMU-8873719|reactome:R-MMU-8876198	-	-	-	figure legend:fig. 1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/01/18	2021/02/09	rogid:xSnAlf28Hdm1U/HzFaWjR8GksjM10090	rogid:yAgR+bATJvGN1eFagBTQAWV4ync10090	rigid:VK9pe4KaPvh9GMVVbEmK2H/rNC8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3UMB5	uniprotkb:P55258	intact:EBI-20938909|ensembl:ENSMUSP00000055926|uniprotkb:Q5U4H2|uniprotkb:Q8BNG6|uniprotkb:Q8C704	intact:EBI-398411|uniprotkb:Q8VCF6|ensembl:ENSMUSP00000003121	psi-mi:smcr8_mouse(display_long)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog(gene name synonym)|uniprotkb:Smcr8(gene name)|psi-mi:Smcr8(display_short)	psi-mi:rab8a_mouse(display_long)|uniprotkb:Rab8a(gene name)|psi-mi:Rab8a(display_short)|uniprotkb:Mel(gene name synonym)|uniprotkb:Rab8(gene name synonym)|uniprotkb:Oncogene c-mel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618067|imex:IM-28722-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000049323(gene)|ensembl:ENSMUST00000056907(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q3UMB5|refseq:NP_001078909.1|refseq:NP_780700.1	refseq:NP_075615.2|dip:DIP-31053N|ensembl:ENSMUSG00000003037(gene)|ensembl:ENSMUST00000003121(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P55258|rcsb pdb:2FU5|reactome:R-MMU-2565942|reactome:R-MMU-5620912|reactome:R-MMU-5620916|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0098978"(glutamatergic synapse)	-	-	-	figure legend:fig. 1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/01/18	2021/02/09	rogid:xSnAlf28Hdm1U/HzFaWjR8GksjM10090	rogid:SE+1h+U6C8cAN2UTBIDapsUt4zA10090	rigid:VK9pe4KaPvh9GMVVbEmK2H/rNC8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3UMB5	uniprotkb:Q3UDP0	intact:EBI-20938909|ensembl:ENSMUSP00000055926|uniprotkb:Q5U4H2|uniprotkb:Q8BNG6|uniprotkb:Q8C704	intact:EBI-20938942|ensembl:ENSMUSP00000055145|ensembl:ENSMUSP00000124033|uniprotkb:Q8C4F1|uniprotkb:Q8C8K5	psi-mi:smcr8_mouse(display_long)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog(gene name synonym)|uniprotkb:Smcr8(gene name)|psi-mi:Smcr8(display_short)	psi-mi:wdr41_mouse(display_long)|uniprotkb:Wdr41(gene name)|psi-mi:Wdr41(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618067|imex:IM-28722-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000049323(gene)|ensembl:ENSMUST00000056907(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q3UMB5|refseq:NP_001078909.1|refseq:NP_780700.1	ensembl:ENSMUSG00000042015(gene)|ensembl:ENSMUST00000056512(transcript)|ensembl:ENSMUST00000160801(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q3UDP0|refseq:NP_766178.2|refseq:XP_017170980.1	-	-	-	figure legend:fig. 1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/01/18	2021/02/09	rogid:xSnAlf28Hdm1U/HzFaWjR8GksjM10090	rogid:WekYDNvJ2uflDu5a33cMGsVOdL810090	rigid:VK9pe4KaPvh9GMVVbEmK2H/rNC8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3UMB5	uniprotkb:Q6DFW0	intact:EBI-20938909|ensembl:ENSMUSP00000055926|uniprotkb:Q5U4H2|uniprotkb:Q8BNG6|uniprotkb:Q8C704	intact:EBI-21131150|ensembl:ENSMUSP00000103762|uniprotkb:A6PWW3|uniprotkb:Q3TJP2|uniprotkb:Q3U3D8	psi-mi:smcr8_mouse(display_long)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog(gene name synonym)|uniprotkb:Smcr8(gene name)|psi-mi:Smcr8(display_short)	psi-mi:ci072_mouse(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618067|imex:IM-28722-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000049323(gene)|ensembl:ENSMUST00000056907(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q3UMB5|refseq:NP_001078909.1|refseq:NP_780700.1	ensembl:ENSMUSG00000028300(gene)|ensembl:ENSMUST00000108127(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q6DFW0|refseq:NP_001074812.1|refseq:XP_006538355.1|refseq:XP_006538356.1	-	-	-	figure legend:fig. 1e|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/01/18	2021/02/09	rogid:xSnAlf28Hdm1U/HzFaWjR8GksjM10090	rogid:Qz747QgEmRKTjIq+lh5ChhBwglA10090	rigid:VK9pe4KaPvh9GMVVbEmK2H/rNC8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:P61006	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2252"(guanine nucleotide exchange factor reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618111|imex:IM-28722-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:fig.1f|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/22	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rigid:Wv3woQwK45YyezuP+e6S5dDSVxw	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:1197"(radioimmunoassay)	psi-mi:"MI:1197"(radioimmunoassay)
uniprotkb:Q96LT7	uniprotkb:Q8TEV9	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2252"(guanine nucleotide exchange factor reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618111|imex:IM-28722-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	-	-	-	figure legend:fig.1f|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/22	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rigid:Wv3woQwK45YyezuP+e6S5dDSVxw	false	his tag:?-?	-	-	-	psi-mi:"MI:1197"(radioimmunoassay)	psi-mi:"MI:1197"(radioimmunoassay)
uniprotkb:Q96LT7	uniprotkb:Q9HAD4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2252"(guanine nucleotide exchange factor reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618111|imex:IM-28722-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	-	-	-	figure legend:fig.1f|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/22	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rigid:Wv3woQwK45YyezuP+e6S5dDSVxw	false	his tag:?-?	-	-	-	psi-mi:"MI:1197"(radioimmunoassay)	psi-mi:"MI:1197"(radioimmunoassay)
uniprotkb:Q96LT7	uniprotkb:Q96DA2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-9089467|uniprotkb:Q5JT79|uniprotkb:Q8NEX3|ensembl:ENSP00000358466	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rb39b_human(display_long)|uniprotkb:RAB39B(gene name)|psi-mi:RAB39B(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2252"(guanine nucleotide exchange factor reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618130|imex:IM-28722-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_741995.1|ensembl:ENSG00000155961(gene)|mint:Q96DA2|rcsb pdb:6S5F|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|ensembl:ENST00000369454(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)	-	-	-	figure legend:fig.1g|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/22	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:2lE8eIl2KSFMUz/cOKCRZmHO9oA9606	rigid:8Oh8VPcjKvIxiuShYFtd/B6NNy4	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:1197"(radioimmunoassay)	psi-mi:"MI:1197"(radioimmunoassay)
uniprotkb:Q96LT7	uniprotkb:Q8TEV9	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2252"(guanine nucleotide exchange factor reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618130|imex:IM-28722-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	-	-	-	figure legend:fig.1g|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/22	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rigid:8Oh8VPcjKvIxiuShYFtd/B6NNy4	false	his tag:?-?	-	-	-	psi-mi:"MI:1197"(radioimmunoassay)	psi-mi:"MI:1197"(radioimmunoassay)
uniprotkb:Q96LT7	uniprotkb:Q9HAD4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2252"(guanine nucleotide exchange factor reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618130|imex:IM-28722-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	-	-	-	figure legend:fig.1g|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/22	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rigid:8Oh8VPcjKvIxiuShYFtd/B6NNy4	false	his tag:?-?	-	-	-	psi-mi:"MI:1197"(radioimmunoassay)	psi-mi:"MI:1197"(radioimmunoassay)
uniprotkb:Q96LT7	uniprotkb:Q8TEV9	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618650|imex:IM-28722-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	-	-	-	figure legend:fig 3c|comment:"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rigid:CnkfhycJ8bWzVXYyS4d52s8oCtw	false	his tag:?-?	O-phospho-L-serine:402-402|O-phospho-L-threonine:796-796	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9UHD2	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618650|imex:IM-28722-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	-	-	-	figure legend:fig 3c|comment:"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rigid:CnkfhycJ8bWzVXYyS4d52s8oCtw	false	his tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9HAD4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618650|imex:IM-28722-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	-	-	-	figure legend:fig 3c|comment:"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rigid:CnkfhycJ8bWzVXYyS4d52s8oCtw	false	his tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q8TEV9	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619372|imex:IM-28722-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062	-	-	-	figure legend:EV3e|comment:"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606	rigid:yeHEO0qHL9mXY0YbiluGz4quKMA	false	his tag:?-?	O-phospho-L-serine:400-400|O-phospho-L-threonine:666-666|O-phospho-L-serine:667-667|O-phospho-L-serine:562-562|O-phospho-L-serine:492-492	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:O75385	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-908831|uniprotkb:Q9UQ28|ensembl:ENSP00000324560	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:ulk1_human(display_long)|uniprotkb:ULK1(gene name)|psi-mi:ULK1(display_short)|uniprotkb:KIAA0722(gene name synonym)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Autophagy-related protein 1 homolog(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619372|imex:IM-28722-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_003556.1|dip:DIP-35196N|ensembl:ENSG00000177169(gene)|ensembl:ENST00000321867(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022708|mint:O75385|rcsb pdb:4WNO|rcsb pdb:4WNP|rcsb pdb:5CI7|rcsb pdb:6HYO|rcsb pdb:6MNH|rcsb pdb:6QAS|reactome:R-HSA-1632852|reactome:R-HSA-8854214|reactome:R-HSA-8876198|reactome:R-HSA-8934903	-	-	-	figure legend:EV3e|comment:"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:Q27JsEOr//zWM8N4jycsZdzbALM9606	rigid:yeHEO0qHL9mXY0YbiluGz4quKMA	false	his tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:Q9HAD4	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619372|imex:IM-28722-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)	-	-	-	figure legend:EV3e|comment:"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606	rigid:yeHEO0qHL9mXY0YbiluGz4quKMA	false	his tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q96LT7	uniprotkb:P55258	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-398411|uniprotkb:Q8VCF6|ensembl:ENSMUSP00000003121	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rab8a_mouse(display_long)|uniprotkb:Rab8a(gene name)|psi-mi:Rab8a(display_short)|uniprotkb:Mel(gene name synonym)|uniprotkb:Rab8(gene name synonym)|uniprotkb:Oncogene c-mel(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_075615.2|dip:DIP-31053N|ensembl:ENSMUSG00000003037(gene)|ensembl:ENSMUST00000003121(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P55258|rcsb pdb:2FU5|reactome:R-MMU-2565942|reactome:R-MMU-5620912|reactome:R-MMU-5620916|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0098978"(glutamatergic synapse)	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:SE+1h+U6C8cAN2UTBIDapsUt4zA10090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:Q8BHC1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-10767682|uniprotkb:Q3TUJ3|ensembl:ENSMUSP00000033545	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:rb39b_mouse(display_long)|uniprotkb:Rab39b(gene name)|psi-mi:Rab39b(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_780331.1|ensembl:ENSMUSG00000031202(gene)|ensembl:ENSMUST00000033545(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|mint:Q8BHC1|reactome:R-MMU-8873719|reactome:R-MMU-8876198	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:yAgR+bATJvGN1eFagBTQAWV4ync10090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:Q3UDP0	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-20938942|ensembl:ENSMUSP00000055145|ensembl:ENSMUSP00000124033|uniprotkb:Q8C4F1|uniprotkb:Q8C8K5	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:wdr41_mouse(display_long)|uniprotkb:Wdr41(gene name)|psi-mi:Wdr41(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000042015(gene)|ensembl:ENSMUST00000056512(transcript)|ensembl:ENSMUST00000160801(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q3UDP0|refseq:NP_766178.2|refseq:XP_017170980.1	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:WekYDNvJ2uflDu5a33cMGsVOdL810090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:Q64337	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-645025|uniprotkb:Q99JM8|ensembl:ENSMUSP00000099835	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:sqstm_mouse(display_long)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:STONE14(gene name synonym)|uniprotkb:Sqstm1(gene name)|psi-mi:Sqstm1(display_short)|uniprotkb:A170(gene name synonym)|uniprotkb:STAP(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_001277698.1|refseq:NP_035148.1|ensembl:ENSMUSG00000015837(gene)|ensembl:ENSMUST00000102774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033741|interpro:IPR034866|interpro:IPR043145|mint:Q64337|rcsb pdb:2RRU|rcsb pdb:2ZJD|rcsb pdb:3ADE|rcsb pdb:3B0F|rcsb pdb:3WDZ|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-5205685|reactome:R-MMU-9020702|reactome:R-MMU-9664873|dip:DIP-38490N	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:/BktZPkmiLsU1fKVqPSQ8ae2+SY10090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:Q9JLV1	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-309231|uniprotkb:Q9JJC7|uniprotkb:Q9CQL3|ensembl:ENSMUSP00000033136	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:bag3_mouse(display_long)|uniprotkb:Bag3(gene name)|psi-mi:Bag3(display_short)|uniprotkb:Bis(gene name synonym)|uniprotkb:MNCb-2243(orf name)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_038891.4|ensembl:ENSMUSG00000030847(gene)|ensembl:ENSMUST00000033136(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0101031"(chaperone complex)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:Q9JLV1|rcsb pdb:1UK5|reactome:R-MMU-3371453	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:fShNmv3j2GyP9pJvNxZ7W0YG9sM10090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:Q3UMB5	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-20938909|ensembl:ENSMUSP00000055926|uniprotkb:Q5U4H2|uniprotkb:Q8BNG6|uniprotkb:Q8C704	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:smcr8_mouse(display_long)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog(gene name synonym)|uniprotkb:Smcr8(gene name)|psi-mi:Smcr8(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	ensembl:ENSMUSG00000049323(gene)|ensembl:ENSMUST00000056907(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q3UMB5|refseq:NP_001078909.1|refseq:NP_780700.1	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:xSnAlf28Hdm1U/HzFaWjR8GksjM10090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96LT7	uniprotkb:P63017	intact:EBI-2961725|ensembl:ENSP00000369339|ensembl:ENSP00000482753|uniprotkb:Q6NUS9|uniprotkb:A8K5W0|uniprotkb:D3DRK6|uniprotkb:G8I0B6	intact:EBI-433443|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q3U6R0|uniprotkb:Q3U764|uniprotkb:Q3U7D7|uniprotkb:Q3U7E2|uniprotkb:Q3U9B4|uniprotkb:Q3U9G0|uniprotkb:Q3UGM0|uniprotkb:Q5FWJ6|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375|uniprotkb:Q6NZD0|ensembl:ENSMUSP00000015800	psi-mi:ci072_human(display_long)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short)	psi-mi:hsp7c_mouse(display_long)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Sellier et al. (2016)	imex:IM-28722|pubmed:27103069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26618757|imex:IM-28722-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0048675"(axon extension)|go:"GO:0090543"(Flemming body)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904425"(negative regulation of GTP binding)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR027819|mint:Q96LT7|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7MGE|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|refseq:NP_060795.1|refseq:NP_659442.2|refseq:NP_001242983.1	refseq:NP_112442.2|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0030425"(dendrite)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005681"(spliceosomal complex)|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-450408|reactome:R-MMU-6798695|reactome:R-MMU-72163|reactome:R-MMU-8856828|reactome:R-MMU-8876725|reactome:R-MMU-888590|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P63017|rcsb pdb:3CQX|reactome:R-MMU-3371453|reactome:R-MMU-3371497|ensembl:ENSMUSG00000015656(gene)|ensembl:ENSMUST00000015800(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|dip:DIP-32353N	-	-	-	figure legend:EV1a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2021/01/18	2021/02/10	rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10090	rigid:mkxFfAbGNwtUndMMRqtCT4i/wpg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)