#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40199	uniprotkb:P40199	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26615868|wwpdb:4y8a|imex:IM-28715-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	-	-	-	figure legend:Supp Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/02/05	2021/02/08	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rigid:xwLb6uY4n2a3qz7xfahydKZeTY4	false	sufficient binding region:34-141	sufficient binding region:34-141	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31997	uniprotkb:P40199	intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym)	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26615916|imex:IM-28715-3|wwpdb:4YIQ	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	-	-	-	figure legend:Supp Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/05	2021/02/08	rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rigid:sJKDadsUMUiHPno0tackSfMOThA	false	sufficient binding region:34-141	sufficient binding region:34-141	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31997	uniprotkb:P31997	intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336	intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336	psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym)	psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26615991|imex:IM-28715-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS	refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS	-	-	-	figure legend:Fig. 2D, S2, Supp Table 3.|kinetics:Kdimerization=6.5x10-4M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/05	2021/02/05	rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606	rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606	rigid:x7G7hhcG4kwosuhVCVGAqHo8Jno	false	mutation disrupting interaction strength:123-123|mutation disrupting interaction strength:129-129|sufficient binding region:34-141|mutation disrupting interaction strength:77-77	mutation disrupting interaction strength:123-123|mutation disrupting interaction strength:129-129|sufficient binding region:34-141|mutation disrupting interaction strength:77-77	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40199	uniprotkb:P40199	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26616065|imex:IM-28715-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	-	-	-	figure legend:Fig. 2A, S2, Supp Table 3.|kinetics:Kdimerization=6.0x10-5M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/05	2021/02/05	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rigid:xwLb6uY4n2a3qz7xfahydKZeTY4	false	mutation disrupting interaction strength:63-63|sufficient binding region:34-141|mutation with no effect:78-78|mutation with no effect:123-123|mutation decreasing interaction strength:129-129	mutation disrupting interaction strength:63-63|sufficient binding region:34-141|mutation with no effect:78-78|mutation with no effect:123-123|mutation decreasing interaction strength:129-129	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06731	uniprotkb:P06731	intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7	intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7	psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym)	psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26616454|imex:IM-28715-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N	refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N	-	-	-	figure legend:Fig. 2B|kinetics:Kdimerization=1.5x10-6M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/05	2021/02/05	rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606	rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606	rigid:Yk8x3grruSIllt+jjDeQnnRGdfM	false	sufficient binding region:34-141	sufficient binding region:34-141	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13688	uniprotkb:P13688	intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559	intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559	psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)	psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26616579|imex:IM-28715-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N	refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N	-	-	-	figure legend:Fig. 2B|kinetics:Kdimerization=4.5x10-4M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/05	2021/02/05	rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606	rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606	rigid:2P2Yj1PLu9e/VB7TJ6WX1TQMqqc	false	sufficient binding region:34-141	sufficient binding region:34-141	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40199	uniprotkb:P31997	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26616594|imex:IM-28715-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS	-	-	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.5x10^-6(molar)	2021/02/05	2021/02/05	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606	rigid:sJKDadsUMUiHPno0tackSfMOThA	false	his tag:n-n|sufficient binding region:34-141|glycosylated residue:?-?	glycosylated residue:?-?|his tag:n-n|sufficient binding region:34-141	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40199	uniprotkb:P31997	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26616640|imex:IM-28715-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS	-	-	-	figure legend:Fig. 4A, SUpp. Fig.4, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-6(molar)	2021/02/05	2021/02/05	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606	rigid:sJKDadsUMUiHPno0tackSfMOThA	false	sufficient binding region:34-141	sufficient binding region:34-141|mutation disrupting interaction strength:77-77|mutation with no effect:123-123|mutation disrupting interaction strength:129-129	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40199	uniprotkb:P31997	intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764	intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336	psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym)	psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Bonsor et al. (2015)	imex:IM-28715|pubmed:26483485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26617630|imex:IM-28715-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration)	refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS	-	-	-	figure legend:Fig. 4A, Supp. Fig.4, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-6(molar)	2021/02/05	2021/02/08	rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606	rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606	rigid:sJKDadsUMUiHPno0tackSfMOThA	false	sufficient binding region:34-141|mutation disrupting interaction strength:63-63|mutation with no effect:78-78|mutation with no effect:123-123|mutation disrupting interaction strength:129-129	sufficient binding region:34-141	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)