#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q91WZ8	uniprotkb:P09172	intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43	intact:EBI-8589586|ensembl:ENSP00000376776|uniprotkb:Q96AG2|uniprotkb:Q5T381|intact:MINT-2843963	psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)	psi-mi:dopo_human(display_long)|uniprotkb:DBH(gene name)|psi-mi:DBH(display_short)|uniprotkb:Dopamine beta-monooxygenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046816|imex:IM-29116-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722	rcsb pdb:4ZEL|reactome:R-HSA-209905|ensembl:ENSG00000123454(gene)|ensembl:ENST00000393056(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002443"(leukocyte mediated immunity)|go:"GO:0003824"(catalytic activity)|go:"GO:0004500"(dopamine beta-monooxygenase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005576"(extracellular region)|go:"GO:0006589"(octopamine biosynthetic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034466"(chromaffin granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042309"(homoiothermy)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042711"(maternal behavior)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048265"(response to pain)|go:"GO:0050900"(leukocyte migration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000323(Copper type II, ascorbate-dependent monooxygenase, N-terminal)|interpro:IPR000945(Dopamine-beta-monooxygenase)|interpro:IPR005018(DOMON related)|interpro:IPR008977(PHM/PNGase F-fold)|interpro:IPR014783(Copper type II, ascorbate-dependent monooxygenase, C-terminal)|interpro:IPR014784(Copper type II, ascorbate-dependent monooxygenase-like, C-terminal)|interpro:IPR020611|interpro:IPR024548|interpro:IPR028460|interpro:IPR036939|mint:P09172|go:"GO:0042421"(norepinephrine biosynthetic process)|refseq:NP_000778.3	-	-	comment:mint|function:Conversion of dopamine to noradrenaline|function:"Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction"	figure legend:fig. 2c|comment:SH-SY5Y cells were treated with the cell permeant cross-linker DSP|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/07/26	rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090	rogid:sGE7UBh7MiBg8+deYLarftf2grI9606	rigid:Ar/HFdUvXiNwcuMLup5c/Q+a4WA	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91WZ8	uniprotkb:Q04656	intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046816|imex:IM-29116-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	-	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	figure legend:fig. 2c|comment:SH-SY5Y cells were treated with the cell permeant cross-linker DSP|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/07/26	rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rigid:Ar/HFdUvXiNwcuMLup5c/Q+a4WA	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91WZ8	uniprotkb:Q9UL45	intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43	intact:EBI-465781|ensembl:ENSP00000220531	psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)	psi-mi:bl1s6_human(display_long)|uniprotkb:BLOC1S6(gene name)|psi-mi:BLOC1S6(display_short)|uniprotkb:PA(gene name synonym)|uniprotkb:PLDN(gene name synonym)|uniprotkb:Pallid protein homolog(gene name synonym)|uniprotkb:Pallidin(gene name synonym)|uniprotkb:Syntaxin 13-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046816|imex:IM-29116-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722	ensembl:ENSG00000104164(gene)|ensembl:ENST00000220531(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0033299"(secretion of lysosomal enzymes)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0050942"(positive regulation of pigment cell differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR017242(BLOC-1 complex, pallidin subunit)|go:"GO:0031175"(neuron projection development)|interpro:IPR028119|mint:Q9UL45|reactome:R-HSA-432722|refseq:NP_036520.1	-	-	-	figure legend:fig. 2c|comment:SH-SY5Y cells were treated with the cell permeant cross-linker DSP|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/07/26	rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090	rogid:s5/ikwpqtA8Mm8gMd6ttfmBBKSA9606	rigid:Ar/HFdUvXiNwcuMLup5c/Q+a4WA	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04656	uniprotkb:P09172	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-8589586|ensembl:ENSP00000376776|uniprotkb:Q96AG2|uniprotkb:Q5T381|intact:MINT-2843963	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:dopo_human(display_long)|uniprotkb:DBH(gene name)|psi-mi:DBH(display_short)|uniprotkb:Dopamine beta-monooxygenase(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046846|imex:IM-29116-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	rcsb pdb:4ZEL|reactome:R-HSA-209905|ensembl:ENSG00000123454(gene)|ensembl:ENST00000393056(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002443"(leukocyte mediated immunity)|go:"GO:0003824"(catalytic activity)|go:"GO:0004500"(dopamine beta-monooxygenase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005576"(extracellular region)|go:"GO:0006589"(octopamine biosynthetic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034466"(chromaffin granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042309"(homoiothermy)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042711"(maternal behavior)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048265"(response to pain)|go:"GO:0050900"(leukocyte migration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000323(Copper type II, ascorbate-dependent monooxygenase, N-terminal)|interpro:IPR000945(Dopamine-beta-monooxygenase)|interpro:IPR005018(DOMON related)|interpro:IPR008977(PHM/PNGase F-fold)|interpro:IPR014783(Copper type II, ascorbate-dependent monooxygenase, C-terminal)|interpro:IPR014784(Copper type II, ascorbate-dependent monooxygenase-like, C-terminal)|interpro:IPR020611|interpro:IPR024548|interpro:IPR028460|interpro:IPR036939|mint:P09172|go:"GO:0042421"(norepinephrine biosynthetic process)|refseq:NP_000778.3	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	comment:mint|function:Conversion of dopamine to noradrenaline|function:"Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction"	figure legend:fig. 2b|antagonist:ATP7A peptide - range [42-61]|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/08/17	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:sGE7UBh7MiBg8+deYLarftf2grI9606	rigid:viX+kCgc3nGnwdxrLth6iGI46co	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04656	uniprotkb:Q9UL45	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-465781|ensembl:ENSP00000220531	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:bl1s6_human(display_long)|uniprotkb:BLOC1S6(gene name)|psi-mi:BLOC1S6(display_short)|uniprotkb:PA(gene name synonym)|uniprotkb:PLDN(gene name synonym)|uniprotkb:Pallid protein homolog(gene name synonym)|uniprotkb:Pallidin(gene name synonym)|uniprotkb:Syntaxin 13-interacting protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046846|imex:IM-29116-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	ensembl:ENSG00000104164(gene)|ensembl:ENST00000220531(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0033299"(secretion of lysosomal enzymes)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0050942"(positive regulation of pigment cell differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR017242(BLOC-1 complex, pallidin subunit)|go:"GO:0031175"(neuron projection development)|interpro:IPR028119|mint:Q9UL45|reactome:R-HSA-432722|refseq:NP_036520.1	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	-	figure legend:fig. 2b|antagonist:ATP7A peptide - range [42-61]|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/08/17	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:s5/ikwpqtA8Mm8gMd6ttfmBBKSA9606	rigid:viX+kCgc3nGnwdxrLth6iGI46co	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04656	uniprotkb:Q96EV8	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-465804|uniprotkb:Q5THY3|uniprotkb:Q5THY4|uniprotkb:Q96NV2|intact:EBI-28986386|ensembl:ENSP00000341680|uniprotkb:Q9H0U2|uniprotkb:Q9H3J5|uniprotkb:A8K3V3	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:dtbp1_human(display_long)|uniprotkb:My031(orf name)|uniprotkb:DTNBP1(gene name)|psi-mi:DTNBP1(display_short)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:BLOC1S8(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046846|imex:IM-29116-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	ensembl:ENSG00000047579(gene)|ensembl:ENST00000344537(transcript)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0005737"(cytoplasm)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-HSA-432722|go:"GO:0048490"(anterograde synaptic vesicle transport)|refseq:NP_115498.2|refseq:NP_898861.1|refseq:NP_001258597.1|refseq:NP_001258598.1|ensembl:ENST00000338950|ensembl:ENSP00000344718|ensembl:ENSP00000341680|refseq:NP_001258596.1	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	-	figure legend:fig. 2b|antagonist:ATP7A peptide - range [42-61]|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/08/17	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:PBwxp1vobm9l5yGoqev97lzkMHg9606	rigid:viX+kCgc3nGnwdxrLth6iGI46co	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09172	uniprotkb:Q04656	intact:EBI-8589586|ensembl:ENSP00000376776|uniprotkb:Q96AG2|uniprotkb:Q5T381|intact:MINT-2843963	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	psi-mi:dopo_human(display_long)|uniprotkb:DBH(gene name)|psi-mi:DBH(display_short)|uniprotkb:Dopamine beta-monooxygenase(gene name synonym)	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Gokhale et al. (2015)	pubmed:26199316|imex:IM-29116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27046858|imex:IM-29116-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4ZEL|reactome:R-HSA-209905|ensembl:ENSG00000123454(gene)|ensembl:ENST00000393056(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002443"(leukocyte mediated immunity)|go:"GO:0003824"(catalytic activity)|go:"GO:0004500"(dopamine beta-monooxygenase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005576"(extracellular region)|go:"GO:0006589"(octopamine biosynthetic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034466"(chromaffin granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042309"(homoiothermy)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042711"(maternal behavior)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048265"(response to pain)|go:"GO:0050900"(leukocyte migration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000323(Copper type II, ascorbate-dependent monooxygenase, N-terminal)|interpro:IPR000945(Dopamine-beta-monooxygenase)|interpro:IPR005018(DOMON related)|interpro:IPR008977(PHM/PNGase F-fold)|interpro:IPR014783(Copper type II, ascorbate-dependent monooxygenase, C-terminal)|interpro:IPR014784(Copper type II, ascorbate-dependent monooxygenase-like, C-terminal)|interpro:IPR020611|interpro:IPR024548|interpro:IPR028460|interpro:IPR036939|mint:P09172|go:"GO:0042421"(norepinephrine biosynthetic process)|refseq:NP_000778.3	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	-	comment:mint|function:Conversion of dopamine to noradrenaline|function:"Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction"	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	figure legend:fig. 2a|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2021/07/26	2021/08/17	rogid:sGE7UBh7MiBg8+deYLarftf2grI9606	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rigid:8r2yMDdaH8nVZVkoiaChDK3Bemw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)