#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9QX11 uniprotkb:P00441 intact:EBI-646678|uniprotkb:Q76MU4|uniprotkb:O88817|ensembl:ENSMUSP00000101912 intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4 psi-mi:cyh1_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:SEC7 homolog A(gene name synonym)|uniprotkb:Cyth1(gene name)|psi-mi:Cyth1(display_short)|uniprotkb:Pscd1(gene name synonym) psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhai et al. (2015) pubmed:26085633|imex:IM-29315 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27092377|imex:IM-29315-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106169.1|refseq:NP_035310.2|ensembl:ENSMUSG00000017132(gene)|ensembl:ENSMUST00000106305(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|reactome:R-MMU-6811438 ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N - - - figure legend:F6A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)") - 2021/09/27 2021/09/27 rogid:Cl1DtnqE/FsMVxm9QZko6yMX+Ds10090 rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606 rigid:aQj5gCkphZhgJdfSsRGKXRLhzBk false green fluorescent protein tag:?-? myc tag:?-?|mutation increasing interaction strength:94-94|mutation increasing interaction strength:86-86 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P63034 uniprotkb:P00441 intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423 intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4 psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym) psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhai et al. (2015) pubmed:26085633|imex:IM-29315 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27092503|imex:IM-29315-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1 ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N - - - figure legend:F6A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)") - 2021/09/27 2021/09/27 rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090 rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606 rigid:7QFAHR5WK2JyfJKvr9oaXlgAJqA false green fluorescent protein tag:?-? myc tag:?-?|mutation increasing interaction strength:94-94|mutation increasing interaction strength:86-86 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O08967 uniprotkb:P00441 intact:EBI-16725278|ensembl:ENSMUSP00000112157|uniprotkb:Q8CI93 intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4 psi-mi:cyh3_mouse(display_long)|uniprotkb:ARF nucleotide-binding site opener 3(gene name synonym)|uniprotkb:General receptor of phosphoinositides 1(gene name synonym)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 3(gene name synonym)|uniprotkb:SEC7 homolog C(gene name synonym)|uniprotkb:Cyth3(gene name)|psi-mi:Cyth3(display_short)|uniprotkb:Grp1(gene name synonym)|uniprotkb:Pscd3(gene name synonym) psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhai et al. (2015) pubmed:26085633|imex:IM-29315 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27092517|imex:IM-29315-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000018001(gene)|ensembl:ENSMUST00000116456(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0090162"(establishment of epithelial cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1FGY|rcsb pdb:1FGZ|rcsb pdb:1FHW|rcsb pdb:1FHX|rcsb pdb:1U2B|rcsb pdb:2R09|rcsb pdb:2R0D|rcsb pdb:6BBP|rcsb pdb:6BBQ|reactome:R-MMU-6811438|refseq:NP_035312.3 ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N - - - figure legend:F6A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)") - 2021/09/27 2021/09/27 rogid:SUSlHPxCGtFJpZM5a3R/pIpOFXU10090 rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606 rigid:ZZiD8cbo7KQTXHxIIkrSow4i+98 false green fluorescent protein tag:?-? myc tag:?-?|mutation increasing interaction strength:94-94|mutation increasing interaction strength:86-86 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P97696 uniprotkb:P00441 intact:EBI-27092866 intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4 psi-mi:cyh3_rat(display_long)|uniprotkb:Cyth3(gene name)|psi-mi:Cyth3(display_short)|uniprotkb:Pscd3(gene name synonym)|uniprotkb:Sec7c(gene name synonym)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 3(gene name synonym)|uniprotkb:SEC7 homolog C(gene name synonym) psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhai et al. (2015) pubmed:26085633|imex:IM-29315 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27092537|imex:IM-29315-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620399|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0090162"(establishment of epithelial cell polarity)|reactome:R-RNO-6811438|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR023394|interpro:IPR000904(SEC7-like)|interpro:IPR035999 ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N - - - figure legend:F6B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-spinal-cord)|taxid:10116(Rattus norvegicus spinal cord) - 2021/09/27 2021/09/27 rogid:KBx1BSeKdJNzEnnyOqCoIsbJUZ410116 rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606 rigid:iwWYcFazqwkzqfwTv8hVVA5i+uw false - mutation:86-86 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)